dihydroxyphenylalanine has been researched along with Intellectual Disability in 13 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garraux, G | 1 |
| Caberg, JH | 1 |
| Vanbellinghen, JF | 1 |
| Jamar, M | 1 |
| Bours, V | 1 |
| Moonen, G | 1 |
| Dive, D | 1 |
| Biraben, A | 1 |
| Semah, F | 1 |
| Ribeiro, MJ | 1 |
| Douaud, G | 1 |
| Remy, P | 1 |
| Depaulis, A | 1 |
| Bulakhova, LA | 1 |
| Usherenko, LS | 1 |
| Archer, T | 1 |
| Patton, MA | 1 |
| Baraitser, M | 1 |
| Heagerty, AH | 1 |
| Eady, RA | 1 |
| Critchley, EM | 1 |
| Proctor, P | 1 |
| McGinness, JE | 1 |
| Bryson, G | 1 |
| McClure, DJ | 1 |
| Castaldo, V | 1 |
| Krynicki, VE | 1 |
| Crade, M | 1 |
| Mrochek, JE | 1 |
| Dinsmore, SR | 1 |
| Ohrt, DW | 1 |
| Oldendorf, WH | 1 |
| Roth, JC | 1 |
| Epstein, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Dopaminergic Reactivity In Idiopathic Generalized Epilepsy: A Proof Of Concept Clinical, Pharmacological And Neurophysiological Study"[NCT01432821] | 31 participants (Actual) | Interventional | 2011-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for dihydroxyphenylalanine and Intellectual Disability
| Article | Year |
|---|---|
Biochemistry of depression.
Topics: Brain; Catecholamines; Depression; Dihydroxyphenylalanine; Humans; Intellectual Disability; Serotoni | 1971 |
12 other studies available for dihydroxyphenylalanine and Intellectual Disability
| Article | Year |
|---|---|
Partial trisomy 4q associated with young-onset dopa-responsive parkinsonism.
Topics: Adult; Age of Onset; alpha-Synuclein; Antiparkinson Agents; Chromosomes, Human, Pair 4; Dihydroxyphe | 2012 |
PET evidence for a role of the basal ganglia in patients with ring chromosome 20 epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Caudate Nucleus; Chromosome Disorders; Chromosomes, Human, Pair | 2004 |
[Biogenic amine metabolism in patients with oligophrenia of different origins].
Topics: Adolescent; Autistic Disorder; Biogenic Amines; Child; Child, Preschool; Dihydroxyphenylalanine; Dop | 1983 |
Behavioural retardation in the neuropathology of mental retardation.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dihydroxyphenylalanine; Dopamine Agents; Female; Ha | 1993 |
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Topics: Cerebellar Ataxia; Child, Preschool; Dihydroxyphenylalanine; Humans; Intellectual Disability; Male; | 1987 |
Naturally occurring dyskinesias.
Topics: Dihydroxyphenylalanine; Female; Humans; Intellectual Disability; Male; Movement Disorders; Tranquili | 1970 |
Levodopa side-effects and the Lesch-Nyhan syndrome.
Topics: Athetosis; Chorea; Compulsive Behavior; Diagnosis, Differential; Dihydroxyphenylalanine; Humans; Int | 1970 |
Biogenic amines in normal and abnormal behavioral states.
Topics: Acetylcholine; Aggression; Aminobutyrates; Arousal; Blood-Brain Barrier; Brain; Brain Stem; Catechol | 1971 |
L-dopa and REM sleep in normal and mentally retarded subjects.
Topics: Adolescent; Adult; Child; Cognition; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Elect | 1973 |
Monitoring phenylalanine-tyrosine metabolism by high-resolution liquid chromatography of urine.
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Autistic Disorder; Carbidopa; Catechols; Child; Chroma | 1973 |
Saturation of blood brain barrier transport of amino acids in phenylketonuria.
Topics: Amino Acids; Animals; Arginine; Blood-Brain Barrier; Brain; Carbon Isotopes; Dihydroxyphenylalanine; | 1973 |
Infantile spasms and hypopigmented macules. Early manifestations of tuberous sclerosis.
Topics: Biopsy; Catechol Oxidase; Child; Child, Preschool; Dihydroxyphenylalanine; Female; Histocytochemistr | 1971 |