Page last updated: 2024-10-18

dihydroxyphenylalanine and Insulinoma

dihydroxyphenylalanine has been researched along with Insulinoma in 11 studies

Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.

Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Research Excerpts

ExcerptRelevanceReference
"(18)F-fluorodihydroxyphenylalanine (FDOPA) PET seems to be of limited value to localize pancreatic insulin-secreting tumors in adult with hyperinsulinemic hypoglycemia."7.81Dynamic 18F-FDOPA PET Findings After Carbidopa Premedication in 2 Adult Patients With Insulinoma-Related Hyperinsulinemic Hypoglycemia. ( Bachellier, P; Bahougne, T; Goichot, B; Imperiale, A; Namer, IJ; Taïeb, D, 2015)
"A 65-year-old woman with suspected insulinoma on the basis of clinical, biochemical, and conventional imaging data underwent F-dihydroxyphenylalanine (DOPA) PET/CT and Ga-DOTANOC PET/CT."7.79A case of insulinoma detected by (68)Ga-DOTANOC PET/CT and missed by (18)F-dihydroxyphenylalanine PET/CT. ( Agnes, S; Campanini, N; Giordano, A; Inzani, F; Rindi, G; Rufini, V; Treglia, G, 2013)
"(18)F-fluorodihydroxyphenylalanine (FDOPA) PET seems to be of limited value to localize pancreatic insulin-secreting tumors in adult with hyperinsulinemic hypoglycemia."3.81Dynamic 18F-FDOPA PET Findings After Carbidopa Premedication in 2 Adult Patients With Insulinoma-Related Hyperinsulinemic Hypoglycemia. ( Bachellier, P; Bahougne, T; Goichot, B; Imperiale, A; Namer, IJ; Taïeb, D, 2015)
"A 65-year-old woman with suspected insulinoma on the basis of clinical, biochemical, and conventional imaging data underwent F-dihydroxyphenylalanine (DOPA) PET/CT and Ga-DOTANOC PET/CT."3.79A case of insulinoma detected by (68)Ga-DOTANOC PET/CT and missed by (18)F-dihydroxyphenylalanine PET/CT. ( Agnes, S; Campanini, N; Giordano, A; Inzani, F; Rindi, G; Rufini, V; Treglia, G, 2013)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's9 (81.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nakuz, TS1
Berger, E1
El-Rabadi, K1
Wadsak, W1
Haug, A1
Hacker, M1
Karanikas, G1
Cuccurullo, V1
Di Stasio, GD1
Mansi, L1
Sood, A1
Basher, RK1
Kang, M1
Shukla, J1
Behera, A1
Walia, R1
Nada, R1
Mittal, BR1
Bhattacharya, A1
Taieb, D4
Legmann, P1
Prat, F1
Chevallier, P1
Tenenbaum, F1
Imperiale, A3
Sebag, F2
Vix, M1
Castinetti, F1
Kessler, L2
Moreau, F1
Bachellier, P2
Guillet, B1
Namer, IJ3
Mundler, O2
Bahougne, T1
Goichot, B1
Detour, J1
Pierre, A1
Boisson, F1
Kreutter, G1
Lavaux, T1
Brasse, D1
Marchand, P1
Kauhanen, S2
Seppänen, M2
Nuutila, P2
Tessonnier, L1
Ghander, C1
De Micco, C1
Reynaud, R1
Palazzo, FF1
Conte-Devolx, B1
Henry, JF1
Treglia, G1
Inzani, F1
Campanini, N1
Rindi, G1
Agnes, S1
Giordano, A1
Rufini, V1
Minn, H1
Gullichsen, R1
Salonen, A1
Alanen, K1
Parkkola, R1
Solin, O1
Bergman, J1
Sane, T1
Salmi, J1
Välimäki, M1

Reviews

1 review available for dihydroxyphenylalanine and Insulinoma

ArticleYear
Physiopathological Premises to Nuclear Medicine Imaging of Pancreatic Neuroendocrine Tumours.
    Current radiopharmaceuticals, 2019, Volume: 12, Issue:2

    Topics: Animals; Dihydroxyphenylalanine; Dimerization; Edetic Acid; Fluorodeoxyglucose F18; Glucagon-Like Pe

2019

Other Studies

10 other studies available for dihydroxyphenylalanine and Insulinoma

ArticleYear
Clinical Value of
    Anticancer research, 2018, Volume: 38, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Dihydroxyph

2018
68Ga-DOTA-Exendin PET-MRI Fusion Imaging in a Case of Insulinoma.
    Clinical nuclear medicine, 2019, Volume: 44, Issue:7

    Topics: Adult; Dihydroxyphenylalanine; Female; Humans; Insulinoma; Magnetic Resonance Imaging; Multimodal Im

2019
Topographic diagnosis: respective roles of morphological and functional imaging.
    Annales d'endocrinologie, 2013, Volume: 74, Issue:3

    Topics: 5-Hydroxytryptophan; Anatomy, Cross-Sectional; Diagnostic Imaging; Dihydroxyphenylalanine; Fluorodeo

2013
18F-FDOPA PET/CT imaging of insulinoma revisited.
    European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Carbidopa; Dihydroxyphenylalanine; Female; Humans; Hyperinsulinism;

2015
Dynamic 18F-FDOPA PET Findings After Carbidopa Premedication in 2 Adult Patients With Insulinoma-Related Hyperinsulinemic Hypoglycemia.
    Clinical nuclear medicine, 2015, Volume: 40, Issue:8

    Topics: Adult; Carbidopa; Dihydroxyphenylalanine; Female; Humans; Hyperinsulinism; Hypoglycemia; Insulinoma;

2015
Effect of Carbidopa on 18F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017, Volume: 58, Issue:1

    Topics: Animals; Carbidopa; Cell Line, Tumor; Dihydroxyphenylalanine; Female; Image Enhancement; Insulinoma;

2017
Premedication with carbidopa masks positive finding of insulinoma and beta-cell hyperplasia in [(18)F]-dihydroxy-phenyl-alanine positron emission tomography.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Nov-10, Volume: 26, Issue:32

    Topics: Carbidopa; Diagnostic Errors; Dihydroxyphenylalanine; Enzyme Inhibitors; Fluorine Radioisotopes; Hum

2008
Limited value of 18F-F-DOPA PET to localize pancreatic insulin-secreting tumors in adults with hyperinsulinemic hypoglycemia.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Dihydroxyphenylalanine; Female; Humans; Hyperinsulinism; Hypoglycemi

2010
A case of insulinoma detected by (68)Ga-DOTANOC PET/CT and missed by (18)F-dihydroxyphenylalanine PET/CT.
    Clinical nuclear medicine, 2013, Volume: 38, Issue:6

    Topics: Aged; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans; Insulinoma; Multimodal Imaging

2013
Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) positron emission tomography as a tool to localize an insulinoma or beta-cell hyperplasia in adult patients.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:4

    Topics: Adult; Dihydroxyphenylalanine; Female; Humans; Hyperplasia; Insulin-Secreting Cells; Insulinoma; Mal

2007