dihydroxyphenylalanine has been researched along with Hypotension in 65 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Excerpt | Relevance | Reference |
---|---|---|
" All patients entering the trial were taking anticholinergic drugs in stable dosage and these were continued throughout." | 2.64 | L-dopa in Parkinsonism and the influence of previous thalamotomy. ( Hughes, RC; Polgar, JG; Walton, JN; Weightman, D, 1971) |
"The blood pressure and pulse rate have been compared in a 'double blind, cross over' study involving twenty patients with idiopathic Parkinsonism receiving maximum tolerated dosage of levodopa with and without an extracerebral decarboxylase inhibitor, L-alpha-methyldopahydrazine." | 2.64 | Action of L- -methyldopa-hydrazine on the blood pressure of patients receiving levodopa. ( Calne, DB; Petrie, A; Rao, S; Reid, JL; Vakil, SD, 1972) |
"One problem with DOPA therapy for Parkinson's disease is its cardiovascular side effects including hypotension and syncope, the underlying mechanisms of which are largely unknown." | 2.50 | Cardiovascular actions of DOPA mediated by the gene product of ocular albinism 1. ( Chen, S; Goshima, Y; Koga, M; Masukawa, D; Nakamura, F, 2014) |
"Heatstroke was induced by exposing the anesthetized rabbits to a high blanket temperature (T(blanket)) of 45 degrees C." | 1.33 | Dopamine overload visualized in the basal ganglia of rabbit brain during heatstroke can be suppressed by hypothermia. ( Chang, CW; Chen, JC; Chou, KL; Chou, YT; Lin, MT; Liu, RS, 2005) |
"Nausea and cardiac arrhythmias are lessened, as are the incidence and severity of hypotension." | 1.25 | Levodopa combined with peripheral decarboxylase inhibition in Parkinson's disease. ( Barbeau, A; Botez, MI; Joubert, M; Mars, H, 1972) |
"Low blood pressure is frequent in the akinetic form of Parkinson's disease." | 1.25 | Renin-aldosterone system in Parkinson's disease. ( Barbeau, A; Boucher, R; Genest, J; Gillo-Joffroy, L; Nowaczynski, W, 1969) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 62 (95.38) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (3.08) | 29.6817 |
2010's | 1 (1.54) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Goshima, Y | 1 |
Nakamura, F | 1 |
Masukawa, D | 1 |
Chen, S | 1 |
Koga, M | 1 |
PERRICONI, H | 1 |
DEL RIO, CA | 1 |
MAZZEI, CM | 1 |
SCHAER, H | 1 |
ZIEGLER, WH | 1 |
ALEKSANDROW, D | 1 |
JANUSZEWICZ, W | 1 |
WOCIAL, B | 1 |
SCHMITT, H | 2 |
Lu, CC | 1 |
Diedrich, A | 1 |
Tung, CS | 1 |
Paranjape, SY | 1 |
Harris, PA | 1 |
Byrne, DW | 1 |
Jordan, J | 1 |
Robertson, D | 2 |
Chou, YT | 1 |
Chen, JC | 1 |
Liu, RS | 1 |
Chou, KL | 1 |
Chang, CW | 1 |
Lin, MT | 1 |
Man'shikov, VV | 1 |
Rudoĭ, BD | 1 |
Bol'shakova, TD | 1 |
Shekhter, IM | 1 |
Lukicheva, TI | 1 |
Conlay, LA | 1 |
Maher, TJ | 1 |
Godley, BF | 1 |
Wurtman, RJ | 1 |
Hunter, KR | 2 |
Stern, GM | 3 |
Laurence, DR | 1 |
Glogner, P | 1 |
Fazio, C | 1 |
Agnoli, A | 1 |
Casacchia, M | 1 |
Reitano, M | 1 |
Ruggieri, S | 1 |
Barba, C | 1 |
Volante, F | 1 |
Desjacques, P | 1 |
Moret, P | 1 |
Gauthier, G | 2 |
Godwin-Austen, RB | 2 |
Lind, NA | 1 |
Turner, P | 1 |
Frears, CC | 1 |
Bergmann, S | 1 |
Parkes, JD | 1 |
Knill-Jones, RP | 1 |
Robson, RD | 1 |
Bolme, P | 1 |
Fuxe, K | 1 |
Lidbrink, P | 1 |
Boudin, G | 1 |
Pépin, B | 1 |
Guillard, A | 2 |
Fabiani, JM | 1 |
Haguenau, M | 1 |
Völler, GW | 1 |
Muschard, F | 1 |
Wälzholz, U | 1 |
Boshes, B | 1 |
Iisalo, E | 1 |
Vetrova, LP | 1 |
Studnitsyna, LA | 1 |
Frenkel', ID | 2 |
Groneberg, P | 1 |
Struppler, A | 1 |
Bevan, DR | 1 |
Monks, PS | 1 |
Calne, DB | 3 |
Schneider, E | 1 |
Fischer, PA | 1 |
Jacobi, P | 1 |
Maxion, H | 1 |
Battista, AF | 1 |
Wolff, BB | 1 |
Hirschmann, J | 1 |
Sutcliffe, RL | 1 |
Brennan, J | 1 |
Spiers, AS | 1 |
Hughes, RC | 1 |
Polgar, JG | 1 |
Weightman, D | 1 |
Walton, JN | 1 |
Finlay, GD | 1 |
Whitsett, TL | 1 |
Cucinell, EA | 1 |
Goldberg, LI | 1 |
Rinne, UK | 1 |
Sonninen, V | 1 |
Siirtola, T | 1 |
Reef, HE | 1 |
Joffe, R | 1 |
Milletz, H | 1 |
Weiss, JL | 1 |
Chase, TN | 1 |
Petrie, A | 1 |
Rao, S | 1 |
Reid, JL | 1 |
Vakil, SD | 1 |
Barbeau, A | 3 |
Mars, H | 2 |
Botez, MI | 1 |
Joubert, M | 1 |
Libman, I | 1 |
Schwartz, AM | 1 |
Gillo-Joffroy, L | 2 |
MacIntyre, IM | 1 |
Strange, DM | 1 |
Beavis, JP | 1 |
Reveno, WS | 1 |
Bauer, RB | 1 |
Rosenbaum, H | 1 |
Guidetti, B | 1 |
Giuffrè, R | 1 |
Jenkins, AC | 1 |
Schwieger, AC | 1 |
O'Doherty, DS | 1 |
Skobba, TJ | 1 |
Newkirk, TA | 1 |
Magee, KR | 1 |
Düby, SE | 1 |
Dahl, LK | 1 |
Cotzias, GC | 1 |
Hashimoto, Y | 1 |
Lydtin, H | 1 |
Klawans, HL | 1 |
Garvin, JS | 1 |
Mones, RJ | 1 |
Duvoisin, RC | 2 |
Burn, JH | 1 |
McDowell, FH | 1 |
Lee, JE | 1 |
Shanks, RG | 1 |
Michelakis, AM | 1 |
Siegfried, J | 1 |
Landy, PJ | 1 |
Whitnack, E | 1 |
Leff, A | 1 |
Mohammed, S | 1 |
Gaffney, TE | 1 |
Jelsma, F | 1 |
Roth, R | 1 |
Ross, P | 1 |
Davis, J | 1 |
Kalandarov, SK | 1 |
Studnitsina, LA | 1 |
Tissot, R | 1 |
Gaillard, JM | 1 |
Guggisberg, M | 1 |
de Ajuriaguerra, J | 1 |
Boucher, R | 1 |
Nowaczynski, W | 1 |
Genest, J | 1 |
Yahr, MD | 1 |
Schear, MJ | 1 |
Barrett, RE | 1 |
Hoehn, MM | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effect of Drinking Water on the Pressor Response to Pseudoephedrine in Patients With Autonomic Failure[NCT02149901] | Early Phase 1 | 35 participants (Anticipated) | Interventional | 2014-10-31 | Terminated (stopped due to funding terminated) | ||
The Effect of Water Carbonation on Orthostatic Tolerance[NCT05621460] | 25 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
5 reviews available for dihydroxyphenylalanine and Hypotension
Article | Year |
---|---|
Cardiovascular actions of DOPA mediated by the gene product of ocular albinism 1.
Topics: Animals; Baroreflex; Dihydroxyphenylalanine; Eye Proteins; Humans; Hypotension; Membrane Glycoprotei | 2014 |
On the function of central catecholamine neurons--their role in cardiovascular and arousal mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Brain; Cardiovascular Physiological Phenomena; C | 1972 |
Therapeutic uses and side effects of L-dopa.
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Barbiturates; Dihydroxyphenylalanine; Drug Synergism; | 1972 |
[Cardiovascular side effects of drugs].
Topics: Antidepressive Agents; Arrhythmias, Cardiac; Contraceptives, Oral; Dihydroxyphenylalanine; Female; H | 1974 |
Levodopa in Parkinsonism.
Topics: Brain; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Humans; Hypotension; Movem | 1971 |
9 trials available for dihydroxyphenylalanine and Hypotension
Article | Year |
---|---|
Water ingestion as prophylaxis against syncope.
Topics: Adolescent; Adult; Cross-Over Studies; Dihydroxyphenylalanine; Female; Heart Rate; Humans; Hypotensi | 2003 |
Water ingestion as prophylaxis against syncope.
Topics: Adolescent; Adult; Cross-Over Studies; Dihydroxyphenylalanine; Female; Heart Rate; Humans; Hypotensi | 2003 |
Water ingestion as prophylaxis against syncope.
Topics: Adolescent; Adult; Cross-Over Studies; Dihydroxyphenylalanine; Female; Heart Rate; Humans; Hypotensi | 2003 |
Water ingestion as prophylaxis against syncope.
Topics: Adolescent; Adult; Cross-Over Studies; Dihydroxyphenylalanine; Female; Heart Rate; Humans; Hypotensi | 2003 |
Combined treatment of parkinsonism with L-dopa and amantadine.
Topics: Aged; Amantadine; Chorea; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Hypotens | 1970 |
[Management of Parkinson's syndrome using levadopa. Results of a long-term study].
Topics: Administration, Oral; Adult; Aged; Antiparkinson Agents; Clinical Trials as Topic; Depression; Dihyd | 1972 |
Hypotension caused by L-dopa.
Topics: Central Nervous System; Clinical Trials as Topic; Dihydroxyphenylalanine; Dopamine; Humans; Hypotens | 1970 |
L-dopa in Parkinsonism and the influence of previous thalamotomy.
Topics: Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Hypertension; Hypotension; M | 1971 |
Augmentation of sodium and potassium excretion, glomerular filtration rate and renal plasma flow by levodopa.
Topics: Administration, Oral; Aged; Aminohippuric Acids; Blood Pressure; Clinical Trials as Topic; Dihydroxy | 1971 |
L-Dopa treatment in Parkinson's Disease.
Topics: Age Factors; Anorexia Nervosa; Cardiovascular Diseases; Clinical Trials as Topic; Dihydroxyphenylala | 1970 |
Treatment of severe parkinsonism with L-dopa.
Topics: Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Hypotension; Male; Middle Aged; Pa | 1971 |
Action of L- -methyldopa-hydrazine on the blood pressure of patients receiving levodopa.
Topics: Adult; Aged; Blood Pressure; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hydrazines; Hypotensi | 1972 |
51 other studies available for dihydroxyphenylalanine and Hypotension
Article | Year |
---|---|
[Methyl-dopa and mebutamate. Hypotensive action of guanethidine. Comparative study].
Topics: Anti-Anxiety Agents; Antihypertensive Agents; Carbamates; Dihydroxyphenylalanine; Guanethidine; Hype | 1963 |
[The effect of intravenously administered DOPA on the blood pressure in pretreated alpha-methyl-DOPA hypertensives. Studies on the blood pressure-lowering mechanism of alpha-methyl-DOPA].
Topics: Antihypertensive Agents; Blood Pressure; Carboxy-Lyases; Dihydroxyphenylalanine; Hypertension; Hypot | 1962 |
[Evaluation of the hypotensive effect of aldomet (alpha-methyl DOPA) in the treatment of arterial hypertension, with reference to its effect on the metabolism of catecholamines].
Topics: Catecholamines; Dihydroxyphenylalanine; Hypertension; Hypotension; Methyldopa | 1962 |
[ACTION OF 5-HYDROXYTRYPTAMINE AND ITS ANTAGONISTS ON THE VASOMOTOR CENTERS].
Topics: Blood Pressure; Bradycardia; Cats; Dihydroxyphenylalanine; Hypotension; Hypothalamus; Lysergic Acid | 1964 |
Dopamine overload visualized in the basal ganglia of rabbit brain during heatstroke can be suppressed by hypothermia.
Topics: Animals; Basal Ganglia; Blood Pressure; Body Temperature; Cerebellum; Dihydroxyphenylalanine; Diseas | 2005 |
[Functional state of the cortical and medullary layers of the adrenals in primary arterial hypotension].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenal Glands; Adrenal Medu | 1976 |
Spinal cord noradrenergic neurons are activated in hypotension.
Topics: Animals; Catecholamines; Dihydroxyphenylalanine; Hypotension; Male; Neurons; Norepinephrine; Rats; R | 1986 |
Use of levodopa with other drugs.
Topics: Adult; Aged; Antidepressive Agents; Antiemetics; Digoxin; Dihydroxyphenylalanine; Diuretics; Drug An | 1970 |
[Unfavorable and problematic drug combinations. IV].
Topics: Amphetamine; Ataxia; Bone Marrow; Cerebral Hemorrhage; Depression, Chemical; Dicumarol; Dihydroxyphe | 1970 |
Treatment of Parkinson's disease with L-DOPA and an association L-DOPA plus a DOPA decarboxylase inhibitor.
Topics: Administration, Oral; Dihydroxyphenylalanine; Drug Synergism; Female; Gastrointestinal Diseases; Hum | 1972 |
[Cardiovascular effects of L-dopa and decarboxylase inhibitor on patients with Parkinson's disease].
Topics: Aged; Atrial Fibrillation; Bundle-Branch Block; Carboxy-Lyases; Cardiac Complexes, Premature; Cardio | 1973 |
Mydriatic responses to sympathomimetic amines in patients treated with L-dopa.
Topics: Adrenergic alpha-Antagonists; Dihydroxyphenylalanine; Humans; Hypotension; Mydriatics; Norepinephrin | 1969 |
Modification of the cardiovascular effects of L-dopa in anesthetized dogs by inhibitors of enzymes involved in catecholamine metabolism.
Topics: Angiotensin II; Animals; Blood Pressure; Bradycardia; Carboxy-Lyases; Cresols; Dihydroxyphenylalanin | 1971 |
Parkinsonism and the hypotension caused by L-dopa.
Topics: Adrenergic alpha-Antagonists; Blood-Brain Barrier; Dihydroxyphenylalanine; Dilatation; Drug Synergis | 1971 |
[Indications and results of monoamine treatment in parkinsonian syndromes].
Topics: Aged; Arrhythmias, Cardiac; Benserazide; Carboxy-Lyases; Dihydroxyphenylalanine; Drug Combinations; | 1972 |
Efficacy of and possible differences in tolerance to L-dopa tablets with different rates of release of the active substance.
Topics: Administration, Oral; Arrhythmias, Cardiac; Dihydroxyphenylalanine; Drug Tolerance; Feeding and Eati | 1974 |
[The state of the sympathetic-adrenal system in patients with primary arterial hypotension].
Topics: Adrenal Medulla; Adult; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Human | 1972 |
[Treatment of Parkinson syndromes with L-Dopa and the association of L-Dopa and a decarboxylase inhibitor].
Topics: Aged; Arrhythmias, Cardiac; Carboxy-Lyases; Dihydroxyphenylalanine; Drug Synergism; Female; Gastroin | 1972 |
[The therapeutic effect of L-dopa].
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Asthma; Brain; Dihydroxyphenylalanine; Dopamine; Human | 1972 |
Cardiovascular reactions to anaesthesia during treatment with levodopa.
Topics: Anesthesia, Dental; Anesthesia, General; Dihydroxyphenylalanine; Female; Halothane; Humans; Hyperten | 1973 |
[Comparison of the effect of L-Dopa and of an L-Dopa+decarboxylase inhibitor combination in Parkinson's disease].
Topics: Aged; Carboxy-Lyases; Dihydroxyphenylalanine; Drug Combinations; Drug Synergism; Female; Gastrointes | 1973 |
Levodopa and related drugs.
Topics: Amantadine; Apomorphine; Dihydroxyphenylalanine; Humans; Hydrazines; Hypotension; Mental Disorders; | 1973 |
Levodopa and induced-pain response. A study of patients with Parkinsonian and pain syndromes.
Topics: Aged; Cold Temperature; Dihydroxyphenylalanine; Electric Stimulation; Female; Hot Temperature; Human | 1973 |
[Therapy of Parkinson's syndrome].
Topics: Amantadine; Blood-Brain Barrier; Dihydroxyphenylalanine; Humans; Hypotension; Parkinson Disease | 1973 |
The treatment of parkinsonism with levodopa.
Topics: Aged; Anorexia Nervosa; Basal Ganglia Diseases; Depression; Dihydroxyphenylalanine; Extrapyramidal T | 1974 |
Levodopa combined with peripheral decarboxylase inhibition in Parkinson's disease.
Topics: Adult; Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Arrhythmias, Cardiac; Benzyl Compounds; D | 1972 |
L-DOPA in Parkinson's disease. Results of a co-operative study in the Montreal area.
Topics: Administration, Oral; Aged; Basal Ganglia Diseases; Constipation; Dihydroxyphenylalanine; Evaluation | 1972 |
L-dopa and general anaesthesia.
Topics: Anesthesia, General; Dihydroxyphenylalanine; Female; Humans; Hypotension; Middle Aged; Parkinson Dis | 1971 |
L-dopa treatment of parkinsonism. Clinical observations on the use of amantadine hydrochloride.
Topics: Aged; Amantadine; Chlorides; Depression; Dihydroxyphenylalanine; Drug Hypersensitivity; Female; Foll | 1971 |
A year's experience of L-DOPA in the treatment of Parkinson's disease.
Topics: Adult; Age Factors; Aged; Dihydroxyphenylalanine; Female; Functional Laterality; Humans; Hypotension | 1971 |
Therapeutic guidelines and side effects encountered during L-dopa therapy in 100 cases of parkinsonism.
Topics: Carboxy-Lyases; Circadian Rhythm; Dihydroxyphenylalanine; Drug Resistance; Female; Gastrointestinal | 1971 |
Levodopa in treating Parkinsonism.
Topics: Adult; Aged; Athetosis; Dihydroxyphenylalanine; Female; Humans; Hypotension; Male; Middle Aged; Naus | 1971 |
[Adverse effects of interest].
Topics: Amenorrhea; Contraceptives, Oral; Dihydroxyphenylalanine; Female; Humans; Hypotension; Jaundice; Pos | 1971 |
Treatment of parkinsonism with levo-dopa: results in 302 cases.
Topics: Aged; Dihydroxyphenylalanine; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Hypotens | 1971 |
Coupling of hypotensive and anit-Parkinson effects with two dopaminergic drugs.
Topics: Apomorphine; Blood Pressure; Brain; Carbidopa; Carboxy-Lyases; Dihydroxyphenylalanine; Drug Synergis | 1971 |
Effect of dopa on the catecholamine content of dog heart after hemorrhagic hypotension.
Topics: Animals; Dihydroxyphenylalanine; Dogs; Epinephrine; Heart; Hypotension; In Vitro Techniques; Myocard | 1965 |
Treatment of parkinsonism with L-dopa (study of 105 patients).
Topics: Adolescent; Adult; Age Factors; Aged; Alkaline Phosphatase; Anorexia Nervosa; Aspartate Aminotransfe | 1969 |
An evaluation of L-dopa in Parkinson patients.
Topics: Deglutition; Dihydroxyphenylalanine; Gait; Humans; Hypotension; Movement Disorders; Parkinson Diseas | 1969 |
Hypotension caused by L-dopa.
Topics: Dihydroxyphenylalanine; Female; Humans; Hypotension; Middle Aged; Parkinson Disease; Propranolol | 1970 |
Hypotension caused by L-dopa.
Topics: Animals; Blood Pressure; Cats; Dihydroxyphenylalanine; Dopamine; Guinea Pigs; Humans; Hypotension; R | 1970 |
Levodopa, Parkinson's disease, and hypotension.
Topics: Dihydroxyphenylalanine; Humans; Hypotension; Hypotension, Orthostatic; Parkinson Disease | 1970 |
Hypotension caused by L-dopa.
Topics: Dihydroxyphenylalanine; Humans; Hypotension; Propranolol | 1970 |
Plasma renin activity and levodopa in Parkinson's disease.
Topics: Aged; Dihydroxyphenylalanine; Female; Humans; Hypotension; Male; Middle Aged; Parkinson Disease; Pos | 1970 |
[Two years experience with L-DOPA in association with a decarboxylase inhibitor].
Topics: Acute Disease; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Humans; Hypoten | 1970 |
L-Dopa in the treatment of Parkinson's disease.
Topics: Activities of Daily Living; Aged; Dihydroxyphenylalanine; Hallucinations; Humans; Hypotension; Middl | 1970 |
The effect of L-dopa on chronotropic responses to cardioaccelerator nerve stimulation in dogs.
Topics: Acidosis; Animals; Arteries; Blood Pressure; Dihydroxyphenylalanine; Disease Models, Animal; Dogs; E | 1971 |
Preliminary observations on L-dopa in the treatment of Parkinson's disease.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aspartate Aminotransferases; Dihydroxyphenylalanine; | 1971 |
[Urinary excretion of catecholamines and their precursors in hypotensive patients].
Topics: Adult; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Humans; Hypotension; Male; Middle Aged | 1968 |
[Treatment of Parkinsonism with oral L-DOPA combined with a decarboxylase inhibitor (Ro IV 46.02)].
Topics: Adult; Aged; Anemia, Hemolytic; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Cell Count; Carb | 1969 |
Renin-aldosterone system in Parkinson's disease.
Topics: Aldosterone; Catecholamines; Dihydroxyphenylalanine; Female; Humans; Hypotension; Male; Middle Aged; | 1969 |
Treatment of parkinsonism with levodopa.
Topics: Adult; Aged; Anorexia Nervosa; Arrhythmias, Cardiac; Dihydroxyphenylalanine; Female; Gait; Humans; H | 1969 |