dihydroxyphenylalanine has been researched along with Hypotension, Orthostatic in 38 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used PET with the tracers [18F]fluorodeoxyglucose (FDG), [18F]fluorodopa (FDOPA) and [11C]raclopride (RACLO) to study striatal glucose and dopa metabolism, and dopamine D2 receptor binding, respectively, in nine patients with multiple system atrophy." | 3.69 | Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease. ( Antonini, A; Günther, I; Leenders, KL; Maguire, RP; Missimer, J; Psylla, M; Vontobel, P, 1997) |
| "This could be the explantion for the orthostatic hypotension found in patients taking L-dopa for Parkinsonism." | 2.63 | Action of dopamine on the human iris. ( Calne, DB; Spiers, AS, 1969) |
| "In PD, orthostatic hypotension reflects sympathetic noradrenergic denervation." | 1.32 | Neurotransmitter specificity of sympathetic denervation in Parkinson's disease. ( Dendi, R; Goldstein, DS; Holmes, C; Li, ST; Sharabi, Y, 2003) |
| "Patients with neurogenic orthostatic hypotension can have deficits in sympathetic neural function at any of several levels of the sympathetic neuraxis." | 1.28 | Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. ( Biaggioni, I; Brown, RT; Garty, M; Goldstein, DS; Kopin, IJ; Polinsky, RJ; Robertson, D; Stull, R, 1989) |
| " Patients with postencephalitic Parkinsonism may respond as well as patients with Parkinson's disease to levodopa but they develop both favourable responses and side-effects at a lower dosage and require careful dosage adjustments and close surveillance." | 1.25 | Response of patients with postencephalitic Parkinsonism to levodopa. ( Duvoisin, RC; Lobo-Antunes, J; Yahr, MD, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (86.84) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 2 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldstein, DS | 5 |
| Holmes, C | 3 |
| Frank, SM | 1 |
| Dendi, R | 2 |
| Cannon, RO | 1 |
| Sharabi, Y | 2 |
| Esler, MD | 1 |
| Eisenhofer, G | 1 |
| Li, ST | 1 |
| Kopp, N | 1 |
| Denoroy, L | 1 |
| Tommasi, M | 1 |
| Gay, N | 1 |
| Chazot, G | 1 |
| Renaud, B | 1 |
| Yamamoto, T | 1 |
| Polinsky, RJ | 2 |
| Baucom, CE | 1 |
| Kopin, IJ | 3 |
| Axelrod, FB | 1 |
| Antonini, A | 1 |
| Leenders, KL | 1 |
| Vontobel, P | 1 |
| Maguire, RP | 1 |
| Missimer, J | 1 |
| Psylla, M | 1 |
| Günther, I | 1 |
| Garty, M | 1 |
| Robertson, D | 1 |
| Brown, RT | 1 |
| Biaggioni, I | 1 |
| Stull, R | 1 |
| Fehling, C | 1 |
| Hunter, KR | 1 |
| Shaw, KM | 1 |
| Laurence, DR | 3 |
| Stern, GM | 3 |
| Irvine, RE | 1 |
| Grunstein, JA | 1 |
| Calne, DB | 3 |
| Sharkey, J | 1 |
| Armitage, P | 1 |
| Spiers, AS | 2 |
| Schnur, JA | 1 |
| Chase, TN | 1 |
| Brody, JA | 1 |
| Maier, C | 1 |
| Uono, M | 1 |
| Miller, E | 1 |
| Wiener, L | 1 |
| Bloomfield, D | 1 |
| Mahoudeau, D | 1 |
| Singer, B | 1 |
| Gilbert, JC | 1 |
| Goulon, M | 1 |
| Gajdos, P | 1 |
| Lhermitte, F | 1 |
| Degos, CF | 1 |
| Aminoff, MJ | 1 |
| Wilcox, CS | 1 |
| Woakes, MM | 1 |
| Kremer, M | 1 |
| Ballantyne, JP | 1 |
| Baker, HM | 1 |
| Kaeser, HE | 1 |
| Ferel, D | 1 |
| Wurmser, P | 1 |
| Lipman, IJ | 1 |
| Godwin-Austen, RB | 1 |
| Bergmann, S | 1 |
| Frears, CC | 1 |
| Albert, E | 1 |
| Duvoisin, RC | 1 |
| Lobo-Antunes, J | 1 |
| Yahr, MD | 1 |
| Sharpe, J | 1 |
| Marquez-Julio, A | 1 |
| Ashby, P | 1 |
| Goldberg, LI | 2 |
| Whitsett, TL | 1 |
| Tyce, GM | 1 |
| Muenter, MD | 1 |
| Owen, CA | 1 |
| Martin, WE | 1 |
| McDowell, FH | 1 |
| Lee, JE | 1 |
| Barbeau, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Laboratory Evaluation of Chronic Orthostatic Intolerance[NCT00069693] | 200 participants | Observational | 2003-09-26 | Completed | |||
| Propranolol for Syncope With Sympathoadrenal Imbalance[NCT00060866] | Phase 4 | 24 participants | Interventional | 2003-05-31 | Completed | ||
| Propranolol for Syncope With Sympathoadrenal Imbalance in Children[NCT00093860] | Phase 2 | 50 participants | Interventional | 2004-10-31 | Completed | ||
| Norepinephrine Transporter Blockade as a Pathophysiological Biomarker in Neurogenic Orthostatic Hypotension[NCT01316666] | 50 participants (Actual) | Observational | 2011-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dihydroxyphenylalanine and Hypotension, Orthostatic
| Article | Year |
|---|---|
[Clinical studies of autonomic centers].
Topics: Autonomic Nervous System; Dihydroxyphenylalanine; Epilepsy, Temporal Lobe; Fecal Incontinence; Human | 1972 |
L-dopa therapy in Parkinson's disease.
Topics: Delirium; Depression; Dihydroxyphenylalanine; Gastrointestinal Hemorrhage; Hallucinations; Humans; H | 1971 |
[Therapy and problems of parkinsonism].
Topics: Adult; Aged; Amantadine; Animals; Antidepressive Agents; Apomorphine; Brain Chemistry; Brain Stem; D | 1971 |
6 trials available for dihydroxyphenylalanine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
L-dopa in postencephalitic parkinsonism.
Topics: Aged; Athetosis; Chorea; Clinical Trials as Topic; Delusions; Dihydroxyphenylalanine; Female; Humans | 1969 |
L-dopa in idiopathic parkinsonism.
Topics: Clinical Trials as Topic; Dihydroxyphenylalanine; Humans; Hypotension, Orthostatic; Mental Disorders | 1969 |
Etilefrine in the treatment of levodopa-induced orthostatic hypotension.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Dihydroxyphenylalanine; Evaluation Studies as Topic; | 1973 |
Effect of age and arteriosclerosis on the response of Parkinsonian patients to levodopa.
Topics: Age Factors; Aged; Antiemetics; Arteriosclerosis; Clinical Trials as Topic; Dihydroxyphenylalanine; | 1971 |
Action of dopamine on the human iris.
Topics: Adult; Aged; Dihydroxyphenylalanine; Dilatation; Dopamine; Dopamine Antagonists; Female; Guanethidin | 1969 |
29 other studies available for dihydroxyphenylalanine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Neurotransmitter specificity of sympathetic denervation in Parkinson's disease.
Topics: Acetylcholine; Autonomic Fibers, Postganglionic; Cholinergic Fibers; Dihydroxyphenylalanine; Fluorin | 2003 |
Increase in noradrenaline-synthesizing enzyme activity in medulla oblongata in Parkinson's disease.
Topics: Aged; Brain Stem; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Female; Humans; Hypotension, Or | 1982 |
Plasma sulfoconjugated dopamine levels are normal in patients with autonomic failure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autonomic Nervous System Diseases; Case-Control Studies; Dihydroxyph | 1996 |
Genotype and phenotype in familial dysautonomia.
Topics: Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Dysautonomia, Familial; Genes, Recessive; Genotyp | 1998 |
Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease.
Topics: Aged; Carbon Radioisotopes; Caudate Nucleus; Corpus Striatum; Diagnosis, Differential; Dihydroxyphen | 1997 |
Patterns of plasma levels of catechols in neurogenic orthostatic hypotension.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Catecholamines; Dihydroxyphenylalanine; Humans; Hypotension, | 1989 |
L-dopa. II.
Topics: Anorexia Nervosa; Cardiac Complexes, Premature; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypo | 1970 |
Treatment of Parkinson's syndrome with L-DOPA on an out-patient basis.
Topics: Age Factors; Aged; Ambulatory Care; Dihydroxyphenylalanine; Female; Humans; Hypotension, Orthostatic | 1972 |
Sustained levodopa therapy in parkinsonism.
Topics: Activities of Daily Living; Aged; Cognition Disorders; Dihydroxyphenylalanine; Drug Evaluation; Faci | 1973 |
When postural hypotension signals disease.
Topics: Adrenergic alpha-Antagonists; Aged; Antidepressive Agents; Blood Volume; Brain Diseases; Cardiac Out | 1973 |
The problem of postural hypotension.
Topics: Adrenergic beta-Antagonists; Aged; Dihydroxyphenylalanine; Diuretics; Female; Guanethidine; Humans; | 1974 |
Parkinsonism-dementia of Guam: treatment with L-dopa.
Topics: Adult; Dementia; Dihydroxyphenylalanine; Drug Eruptions; Female; Humans; Hydroxyindoleacetic Acid; H | 1971 |
[L-dopa treatment of idiopathic orthostatic hypotension (postural hypotension)].
Topics: Aged; Blood Pressure; Cerebellar Diseases; Cerebellopontine Angle; Dihydroxyphenylalanine; Female; H | 1972 |
[Shy-Drager disease. Hemodynamic and pharmacodynamic studies. Value of cyproheptadine].
Topics: Cyproheptadine; Dihydroxyphenylalanine; Fecal Incontinence; Female; Humans; Hypotension, Orthostatic | 1972 |
[Drug therapy of Parkinson's diseases].
Topics: Amantadine; Dihydroxyphenylalanine; Gastrointestinal Diseases; Humans; Hypotension, Orthostatic; Men | 1972 |
Levodopa therapy for Parkinsonism in the Shy-Drager syndrome.
Topics: Blood Pressure; Dihydroxyphenylalanine; Evaluation Studies as Topic; Fecal Incontinence; Female; Hum | 1973 |
Early and late effects of levodopa on the cardiovascular system in Parkinson's disease. A paired study.
Topics: Adult; Blood Pressure; Bradycardia; Cardiovascular System; Dihydroxyphenylalanine; Dose-Response Rel | 1973 |
Drug therapy in geriatrics.
Topics: Aged; Digoxin; Dihydroxyphenylalanine; Drug Prescriptions; Drug Therapy; Drug Tolerance; Female; Ger | 1974 |
[Treatment of Parkinson's syndrome with L-dopa].
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antihypertensive Agents; Barbiturates; | 1970 |
Response of patients with postencephalitic Parkinsonism to levodopa.
Topics: Aged; Dihydroxyphenylalanine; Encephalitis; Evaluation Studies as Topic; Female; Humans; Hypotension | 1972 |
Idiopathic orthostatic hypotension treated with levodopa and MAO inhibitor: a preliminary report.
Topics: Basal Ganglia Diseases; Brain Stem; Catecholamines; Dihydroxyphenylalanine; Drug Synergism; Fecal In | 1972 |
Cardiovascular effects of levodopa.
Topics: Arrhythmias, Cardiac; Blood Pressure; Capillary Resistance; Cardiac Output; Decarboxylation; Dihydro | 1971 |
Metabolism of L-dihydroxyphenylalanine by patients with Parkinson's disease.
Topics: 5-Hydroxytryptophan; Adult; Aged; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Female; Huma | 1970 |
Adverse reactions during treatment of Parkinson's disease with levodopa.
Topics: Adult; Aged; Coombs Test; Depression; Dihydroxyphenylalanine; Duodenal Ulcer; Female; Gastrointestin | 1971 |
A second report on Levodopa.
Topics: Amantadine; Arrhythmias, Cardiac; Cerebrovascular Disorders; Dihydroxyphenylalanine; Humans; Hypoten | 1969 |
Levodopa, Parkinson's disease, and hypotension.
Topics: Dihydroxyphenylalanine; Humans; Hypotension; Hypotension, Orthostatic; Parkinson Disease | 1970 |
Specific therapy in Parkinson's disease.
Topics: Amantadine; Dihydroxyphenylalanine; Humans; Hypotension, Orthostatic; Nausea; Parkinson Disease; Vom | 1970 |
[L-dopa and Parkinson's disease].
Topics: Administration, Oral; Blood-Brain Barrier; Dihydroxyphenylalanine; Humans; Hypotension, Orthostatic; | 1970 |
Levodopa and anesthesia.
Topics: Anesthesia; Cardiovascular System; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypotension, Orth | 1971 |