dihydroxyphenylalanine has been researched along with Hypertension in 140 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to investigate whether or not the development of hypertension is influenced by chronic treatment with bromocriptine and/or domperidone." | 7.67 | Attenuated development of hypertension by chronic administration of bromocriptine in Doca-salt hypertensive rats. ( Ijichi, H; Kambara, S; Okabayashi, H; Takahashi, H; Yoshimura, M, 1986) |
| "Juvenile spontaneously hypertensive rats (SHR) have higher plasma levels of catechols and markedly larger catechol responses to yohimbine than do normotensive Wistar-Kyoto rats, indicating increased sympathoadrenal outflow and increased alpha 2-adrenergic receptor-mediated restraint of peripheral catecholamine release during hypertension development in SHR." | 3.68 | In vivo hypothalamic release and synthesis of catecholamines in spontaneously hypertensive rats. ( Goldstein, DS; Jakab, G; Kopin, IJ; Lenders, JW; Pacák, K; Yadid, G, 1993) |
| "We studied the metabolic pathways of dihydroxyphenylalanine (DOPA) and dopamine as well as the cardiovascular and renal responses to a single administration of DOPA (500 mg orally) in stable essential hypertension." | 3.68 | Defective dopamine generation from dihydroxyphenylalanine in stable essential hypertensive patients. ( Kuchel, O; Shigetomi, S, 1992) |
| "To explore whether an altered metabolic pathway of dihydroxyphenylalanine (DOPA) may be related to some previously observed dopamine abnormalities in borderline hypertension, we measured basal and DOPA-induced (500 mg orally) changes in blood pressure and pulse rate as well as in three hourly plasma and urine samples." | 3.68 | Dopaminergic abnormalities in borderline essential hypertensive patients. ( Buu, NT; Kuchel, O; Shigetomi, S, 1991) |
| "The aim of the study was to investigate whether or not the development of hypertension is influenced by chronic treatment with bromocriptine and/or domperidone." | 3.67 | Attenuated development of hypertension by chronic administration of bromocriptine in Doca-salt hypertensive rats. ( Ijichi, H; Kambara, S; Okabayashi, H; Takahashi, H; Yoshimura, M, 1986) |
| " All patients entering the trial were taking anticholinergic drugs in stable dosage and these were continued throughout." | 2.64 | L-dopa in Parkinsonism and the influence of previous thalamotomy. ( Hughes, RC; Polgar, JG; Walton, JN; Weightman, D, 1971) |
| " Improvement was sustained during this period even though the average daily dosage of L-dopa was reduced." | 2.63 | Treatment of Parkinsonism with Laevo-dopa. ( Mawdsley, C, 1970) |
| "The hypertensive patients with chronic renal failure shared with their hypertensive counterparts without chronic renal failure an impaired DOPA decarboxylation to dopamine." | 1.29 | Dopaminergic abnormalities in hypertension associated with moderate renal insufficiency. ( Kuchel, OG; Shigetomi, S, 1994) |
| "Pyridoxine pretreatment accelerated DA generation from exogenous DOPA and attenuated the DOPA-induced increases in plasma and urinary DOPA and its metabolite 3-O-methyl-DOPA, but accentuated the increase in free DA and its main metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), while BP, ANF, cGMP, PRA, and PA remained unaffected." | 1.29 | Defective 3,4-dihydroxyphenylalanine decarboxylation to dopamine in hydralazine-treated hypertensive patients may be pyridoxine remediable. ( Kuchel, O; Shigetomi, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 118 (84.29) | 18.7374 |
| 1990's | 18 (12.86) | 18.2507 |
| 2000's | 2 (1.43) | 29.6817 |
| 2010's | 2 (1.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Calabrò, D | 1 |
| Allegri, V | 1 |
| Fanti, S | 1 |
| Ambrosini, V | 1 |
| Zhang, MZ | 1 |
| Wang, Y | 1 |
| Yao, B | 1 |
| Gewin, L | 1 |
| Wei, S | 1 |
| Capdevila, JH | 1 |
| Harris, RC | 1 |
| Goldstein, DS | 5 |
| Holmes, C | 1 |
| Sewell, L | 1 |
| Kopin, IJ | 4 |
| PAYNE, RW | 1 |
| CLOSE, JH | 1 |
| WHITSETT, TL | 2 |
| GOGERTY, JG | 1 |
| ARNOLD, OH | 2 |
| BAUMGARTEN, A | 1 |
| BAYLISS, RI | 1 |
| HARVEY-SMITH, EA | 1 |
| BREST, AN | 2 |
| MOYER, JH | 2 |
| CANNON, PJ | 1 |
| WHITLOCK, RT | 1 |
| MORRIS, RC | 1 |
| ANGERS, M | 1 |
| LARAGH, JH | 1 |
| DOLLERY, CT | 2 |
| HARINGTON, M | 1 |
| DOYLE, A | 1 |
| TREVAKS, G | 1 |
| DURAND, E | 1 |
| ELLINGTON, EV | 1 |
| FENG, PC | 1 |
| HAYNES, LJ | 1 |
| MAGNUS, KE | 1 |
| PHILIP, N | 1 |
| FELLINGER, K | 1 |
| GRABNER, G | 1 |
| KRYGICZ, H | 1 |
| GILLESPIE, L | 1 |
| OATES, JA | 1 |
| CROUT, JR | 1 |
| SJOERDSMA, A | 4 |
| PERRICONI, H | 1 |
| DEL RIO, CA | 1 |
| MAZZEI, CM | 1 |
| GIFFORD, RW | 1 |
| TWEED, DC | 1 |
| GOLDBERG, LI | 3 |
| ZIMMERMAN, AM | 1 |
| BAILA, MR | 1 |
| CINTAS, JA | 1 |
| SCHAER, H | 2 |
| ZIEGLER, WH | 1 |
| SPERBER, RJ | 1 |
| DEGRAFF, AC | 1 |
| WELTI, JJ | 1 |
| SCHIMMEL, H | 1 |
| WILSON, WR | 2 |
| FISHER, FD | 1 |
| KIRKENDALL, WM | 3 |
| ALEKSANDROW, D | 1 |
| JANUSZEWICZ, W | 6 |
| WOCIAL, B | 6 |
| DAVIS, RA | 1 |
| DRAIN, DJ | 1 |
| HORLINGTON, M | 1 |
| LAZARE, R | 1 |
| URBANSKA, A | 1 |
| van DOMMELEN, C | 1 |
| COENEGRACHT, JM | 1 |
| HOLSHUYSEN, N | 1 |
| KOSTER, M | 1 |
| KISHIKAWA, M | 1 |
| UEMATSU, S | 1 |
| MAKINO, H | 1 |
| YAMAMOTO, T | 1 |
| TSUJI, S | 1 |
| SHIGENO, T | 1 |
| RAPADOERRAZTI, A | 1 |
| JIMENEZCASADO, M | 1 |
| RODRIGUEZSANTOS, A | 1 |
| NAVARRO, V | 1 |
| BRUSCA, A | 1 |
| FRITEL, D | 1 |
| SAINTJEAN, A | 1 |
| DONALD, MW | 1 |
| BAN, TA | 1 |
| HODGE, JV | 1 |
| NYE, ER | 1 |
| EMERSON, GW | 1 |
| MATHISEN, HS | 1 |
| ONESTI, G | 1 |
| NOVACK, P | 1 |
| SCHAUB, F | 1 |
| NAGER, F | 1 |
| ZIEGLER, W | 1 |
| LICHTLEN, P | 1 |
| Warren, SE | 1 |
| Mitas, JA | 1 |
| Swerdlin, AH | 1 |
| Chodakowska, J | 1 |
| Feltynowski, T | 2 |
| Lee, MR | 3 |
| Sznajderman, M | 1 |
| Niwa, M | 2 |
| Kawano, T | 1 |
| Fujita, Y | 1 |
| Maemura, S | 1 |
| Ozaki, M | 1 |
| Draaijer, P | 1 |
| de Leeuw, P | 1 |
| Maessen, J | 1 |
| van Hooff, J | 1 |
| Leunissen, K | 1 |
| Lambert, GW | 1 |
| Ferrier, C | 4 |
| Kaye, DM | 1 |
| Jennings, GL | 3 |
| Kalff, V | 2 |
| Kelly, MJ | 1 |
| Cox, HS | 3 |
| Turner, AG | 1 |
| Esler, MD | 3 |
| Saito, I | 1 |
| Itsuji, S | 1 |
| Takeshita, E | 1 |
| Kawabe, H | 1 |
| Nishino, M | 1 |
| Wainai, H | 1 |
| Hasegawa, C | 1 |
| Saruta, T | 1 |
| Nagano, S | 1 |
| Sekihara, T | 1 |
| Sigetomi, S | 1 |
| Fukuchi, S | 1 |
| Kuchel, OG | 1 |
| Shigetomi, S | 5 |
| Eisenhofer, G | 3 |
| Lambert, G | 2 |
| Kelly, M | 1 |
| Cox, H | 1 |
| Esler, M | 1 |
| Pacák, K | 1 |
| Yadid, G | 1 |
| Jakab, G | 1 |
| Lenders, JW | 1 |
| Kuchel, O | 5 |
| Zimlichman, R | 1 |
| Damasceno, A | 1 |
| Santos, A | 1 |
| Serrão, P | 1 |
| Caupers, P | 1 |
| Soares-da-Silva, P | 1 |
| Polónia, J | 1 |
| Januszewicz, A | 1 |
| Gryglas, P | 1 |
| Prejbisz, A | 1 |
| Sumarokov, AV | 1 |
| Bol'shakova, TD | 1 |
| Lukicheva, TI | 1 |
| Eristavi, NL | 1 |
| Mikhaĭlov, AA | 1 |
| Kiseleva, ZM | 3 |
| Parfenova, EV | 1 |
| Erina, EV | 1 |
| Shkhvatsabaia, IK | 1 |
| Henning, M | 1 |
| Lindqvist, M | 1 |
| Kehr, W | 1 |
| Carlsson, A | 1 |
| Tsfasman, AZ | 1 |
| Vasil'ev, VN | 1 |
| Brodskaia, TV | 1 |
| Vydrin, ML | 1 |
| Wallin, BG | 1 |
| Horne, M | 1 |
| Grossman, E | 2 |
| Hoffman, A | 1 |
| Tamrat, M | 1 |
| Armando, I | 1 |
| Keiser, HR | 2 |
| Buu, NT | 1 |
| Gill, JR | 1 |
| Garty, M | 1 |
| Folio, CJ | 1 |
| Stull, R | 1 |
| Brush, JE | 1 |
| Sax, FL | 1 |
| Bayorh, MA | 1 |
| McGee, L | 1 |
| Feuerstein, G | 1 |
| Worth, DP | 1 |
| Harvey, JN | 1 |
| Brown, J | 1 |
| Kondo, M | 1 |
| Koulu, M | 1 |
| Saavedra, JM | 1 |
| Linnoila, M | 1 |
| Kambara, S | 1 |
| Yoshimura, M | 1 |
| Okabayashi, H | 1 |
| Takahashi, H | 1 |
| Ijichi, H | 1 |
| Tsai, CF | 1 |
| Lin, MT | 1 |
| Hunter, KR | 2 |
| Stern, GM | 2 |
| Laurence, DR | 2 |
| Glogner, P | 1 |
| Birket-Smith, E | 1 |
| Andersen, JV | 1 |
| Desjacques, P | 1 |
| Moret, P | 1 |
| Gauthier, G | 1 |
| Yamabe, H | 2 |
| De Jong, W | 2 |
| Lovenberg, W | 2 |
| Goldenberg, MM | 1 |
| Pappas, BA | 1 |
| Peters, DA | 1 |
| Saari, M | 1 |
| Sobrian, SK | 1 |
| Minch, E | 1 |
| Chang, CP | 1 |
| Birkmayer, W | 1 |
| Altschule, MD | 1 |
| Hegedus, ZL | 1 |
| Robson, RD | 1 |
| Naftchi, NE | 1 |
| Mendlowitz, M | 1 |
| DeQuattro, V | 3 |
| Miura, Y | 1 |
| Lentini, S | 1 |
| Cagli, V | 1 |
| Bock, KD | 1 |
| Parade, D | 1 |
| Jahnecke, J | 1 |
| Collins, IS | 1 |
| King, IW | 1 |
| Axelrod, J | 1 |
| Weinshilboum, R | 1 |
| Yamori, Y | 2 |
| Spector, S | 2 |
| Tarver, J | 2 |
| Berkowitz, B | 2 |
| Shvatsabaia, IK | 1 |
| Yashima, O | 1 |
| Ozawa, M | 1 |
| Sato, M | 1 |
| Suzuki, K | 1 |
| Kimura, T | 1 |
| Leon, AS | 1 |
| Spiegel, HE | 1 |
| Boudin, G | 1 |
| Pépin, B | 1 |
| Guillard, A | 1 |
| Fabiani, JM | 1 |
| Haguenau, M | 1 |
| Nakamura, K | 2 |
| Iisalo, E | 1 |
| Louis, WJ | 1 |
| Doyle, AE | 1 |
| Heath, WC | 1 |
| Robinson, MJ | 1 |
| Kaliuzhnaia, RA | 1 |
| Wilber, JA | 1 |
| Reveno, WS | 1 |
| Bauer, RB | 1 |
| Rosenbaum, H | 1 |
| Bevan, DR | 1 |
| Monks, PS | 1 |
| Calne, DB | 1 |
| Hashida, J | 1 |
| Vignalou, J | 1 |
| Beck, H | 1 |
| Gehlen, W | 1 |
| Frolova, IA | 1 |
| Beiul, EA | 1 |
| Volkova, IS | 1 |
| Sirota, II | 1 |
| Gawellek, F | 1 |
| Faulhaber, HD | 1 |
| Singer, P | 1 |
| Mawdsley, C | 1 |
| Sotskova, TV | 1 |
| Hughes, RC | 1 |
| Polgar, JG | 1 |
| Weightman, D | 1 |
| Walton, JN | 1 |
| Finlay, GD | 1 |
| Cucinell, EA | 1 |
| Sen, S | 1 |
| Hoffman, GC | 1 |
| Stowe, NT | 1 |
| Smeby, RR | 1 |
| Bumpus, FM | 1 |
| Karpenko, EI | 1 |
| Deĭneko, VS | 1 |
| Barjon, P | 1 |
| Fourcade, J | 1 |
| Mimran, A | 1 |
| Charra, B | 1 |
| Vishnepol'skiĭ, IuIa | 1 |
| Wood, CD | 1 |
| Perkins, GF | 1 |
| Boakes, AJ | 1 |
| Yoshiue, S | 1 |
| Watanabe, AM | 1 |
| Parks, LC | 1 |
| Speranskiĭ, MD | 1 |
| Midelauri, BG | 1 |
| Bounhoure, JP | 1 |
| Suc, JM | 1 |
| Conte, J | 1 |
| Salvador, M | 1 |
| Pozet, N | 1 |
| Zech, P | 1 |
| Banssillon, V | 1 |
| Traeger, J | 1 |
| Kassil', GN | 1 |
| Gugumiivili, TsG | 1 |
| Zumler, AS | 1 |
| Kolesov, DV | 1 |
| Brass, H | 1 |
| Heintz, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1b, Randomized, Single-blind, Placebo-controlled, Multiple Ascending Dose (MAD) Study to Assess the Steady-State Pharmacokinetics and DQ8 Blocking Efficacy of Orally Administered IMT-002 in Patients With Type 1 Diabetes and HLA-DQ8[NCT04625595] | Phase 1 | 30 participants (Actual) | Interventional | 2020-11-09 | Completed | ||
| Essential Arterial Hypotension and Allostasis Registry[NCT02018497] | 5,000 participants (Anticipated) | Observational [Patient Registry] | 1995-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for dihydroxyphenylalanine and Hypertension
| Article | Year |
|---|---|
[THERAPY OF ESSENTIAL HYPERTENSION].
Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Coronary Disease; Diazoxide; Diet; Dihydr | 1963 |
[THE MEDICAMENTOUS TREATMENT OF COMMON ARTERIAL HYPERTENSION].
Topics: Antihypertensive Agents; Benzothiadiazines; Dihydroxyphenylalanine; Ganglionic Blockers; Guanethidin | 1963 |
Dopamine and the kidney.
Topics: Animals; Dihydroxyphenylalanine; Dogs; Dopamine; Edema; Female; Glutamates; Humans; Hypertension; Ki | 1982 |
[Dopamine and hypertension].
Topics: Animals; Catecholamines; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Humans; Hypertension; | 1993 |
Central sympathetic transmitters and hypertension.
Topics: Acetylcholine; Animals; Blood Pressure; Cardiac Output; Cats; Clonidine; Dihydroxyphenylalanine; Dog | 1975 |
Implications of plasma levels of catechols in the evaluation of sympathoadrenomedullary function.
Topics: Catechols; Dihydroxyphenylalanine; Epinephrine; Humans; Hypertension; Sympathetic Nervous System | 1989 |
Dopamine, the kidney and essential hypertension studies with gludopa.
Topics: Dihydroxyphenylalanine; Dopamine; Humans; Hypertension; Kidney | 1987 |
Catecholamines.
Topics: Adrenal Medulla; Affective Symptoms; Animals; Brain; Catechol O-Methyltransferase; Catecholamines; D | 1972 |
Effects of drugs and physiological factors in the disposition of catecholamines in blood vessels.
Topics: Animals; Aorta; Blood Vessels; Catechol O-Methyltransferase; Catecholamines; Cocaine; Dihydroxypheny | 1972 |
Cardiovascular and renal actions of dopamine: potential clinical applications.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Cats; Coronary Circulation; Dihydroxyphenylalanine; Do | 1972 |
[Cardiovascular side effects of drugs].
Topics: Antidepressive Agents; Arrhythmias, Cardiac; Contraceptives, Oral; Dihydroxyphenylalanine; Female; H | 1974 |
[Therapy of hypertension. 1. Fundamentals and principles of high blood pressure therapy].
Topics: Antihypertensive Agents; Catecholamines; Dihydroxyphenylalanine; Epinephrine; Humans; Hypertension; | 1968 |
Use of drugs in the treatment of parkinsonism.
Topics: Amantadine; Depression; Dihydroxyphenylalanine; Feeding and Eating Disorders; Humans; Hypertension; | 1970 |
[The 3d catecholamine--dopamine].
Topics: Animals; Asthma; Brain Chemistry; Brain Injuries; Cardiovascular Diseases; Dihydroxyphenylalanine; D | 1970 |
[Role of central catecholamines in blood pressure regulation of spontaneously hypertensive rat].
Topics: Animals; Blood Pressure; Brain Chemistry; Brain Stem; Carboxy-Lyases; Catecholamines; Dihydroxypheny | 1971 |
7 trials available for dihydroxyphenylalanine and Hypertension
| Article | Year |
|---|---|
Dopamine deficiency--its potential contribution to chronic renal failure complicating hypertension.
Topics: Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Humans; Hypertension; Kidney Failure, Chronic; | 1995 |
Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects.
Topics: Adult; Black People; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Drug Resistance; Female | 1999 |
[10 years of L-DOPA therapy of Parkinson's syndrome].
Topics: Administration, Oral; Amphetamine; Animals; Brain Chemistry; Catecholamines; Clinical Trials as Topi | 1971 |
Pindolol, (Visken, LB46). A new treatment for hypertension: report of a multicentric open study.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Amino Alcohols; Antihypertensive Age | 1972 |
Treatment of Parkinsonism with Laevo-dopa.
Topics: Adult; Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Feeding and Eating Disorders; Female; | 1970 |
L-dopa in Parkinsonism and the influence of previous thalamotomy.
Topics: Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Hypertension; Hypotension; M | 1971 |
Augmentation of sodium and potassium excretion, glomerular filtration rate and renal plasma flow by levodopa.
Topics: Administration, Oral; Aged; Aminohippuric Acids; Blood Pressure; Clinical Trials as Topic; Dihydroxy | 1971 |
118 other studies available for dihydroxyphenylalanine and Hypertension
| Article | Year |
|---|---|
Topics: Abdominal Neoplasms; Dihydroxyphenylalanine; Head and Neck Neoplasms; Humans; Hypertension; Image Pr | 2019 |
Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney.
Topics: Animals; Arachidonic Acid; Aromatic-L-Amino-Acid Decarboxylases; Catechol O-Methyltransferase; Cells | 2013 |
Hypertension increases cerebral 6-18F-fluorodopa-derived radioactivity.
Topics: Aged; Brain; Dihydroxyphenylalanine; Female; Humans; Hypertension; Male; Metabolic Clearance Rate; M | 2009 |
Preliminary report on trial of l-alpha-methyl dopa (Aldomet) in the treatment of hypertension.
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa | 1961 |
[The therapy fo malignant hypertension].
Topics: Dihydroxyphenylalanine; Hypertension; Hypertension, Malignant | 1962 |
[Value of alpha-methyl-dopa for the treatment of chronic hypertension].
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa | 1962 |
Clinical trial of a new hypotensive drug, methyldopa ("aldomet").
Topics: Antihypertensive Agents; Dihydroxyphenylalanine; Hypertension; Methyldopa | 1962 |
Methyldopa in the treatment of hypertension.
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa | 1962 |
Decarboxylase inhibitors in the treatment of hypertension.
Topics: Antihypertensive Agents; Carboxy-Lyases; Dihydroxyphenylalanine; Humans; Hypertension; Lyases | 1962 |
Effect of alpha-methyl DOPA in severe and malignant hypertension.
Topics: Dihydroxyphenylalanine; Hypertension; Hypertension, Malignant; Methyldopa | 1962 |
Methyldopa in hypertension. Clinical and pharmacological studies.
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa; Research | 1962 |
Alpha methyl dopa in the treatment of hypertension.
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa | 1962 |
Simple hypotensive and hypertensive principles from some West Indian medicinal plants.
Topics: Amino Acids; Blood Pressure; Dihydroxyphenylalanine; Humans; Hypertension; Plants, Medicinal; Pressu | 1962 |
[Preliminary report on the clinical effectiveness of 1-alpha-methyl-DOPA (Aldomet) in the treatment of hypertension].
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa; Treatment Outcome | 1961 |
Clinical and chemical studies with alpha-methyl-dopa in patients with hypertension.
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa | 1962 |
[Methyl-dopa and mebutamate. Hypotensive action of guanethidine. Comparative study].
Topics: Anti-Anxiety Agents; Antihypertensive Agents; Carbamates; Dihydroxyphenylalanine; Guanethidine; Hype | 1963 |
Spurious elevation of urinary catecholamines during therapy with alpha-methyl-dopa. A diagnostic pitfall.
Topics: Catecholamines; Dihydroxyphenylalanine; Humans; Hypertension; Methyldopa | 1962 |
Guanethidine and methyldopa as therapeutic agents in hypertension. A comparative review.
Topics: Dihydroxyphenylalanine; Guanethidine; Humans; Hypertension; Methyldopa | 1963 |
[The use of the combination of L-alpha-methyldopa and dichlorothiazide in the treatment of arterial hypertension].
Topics: Chlorothiazide; Dihydroxyphenylalanine; Hypertension; Methyldopa | 1962 |
[The effect of intravenously administered DOPA on the blood pressure in pretreated alpha-methyl-DOPA hypertensives. Studies on the blood pressure-lowering mechanism of alpha-methyl-DOPA].
Topics: Antihypertensive Agents; Blood Pressure; Carboxy-Lyases; Dihydroxyphenylalanine; Hypertension; Hypot | 1962 |
Clinical evaluation of alpha methyl-dopa.
Topics: Dihydroxyphenylalanine; Humans; Hypertension; Methyldopa | 1963 |
[Treatment of arterial hypertension by methyl-DOPA].
Topics: Antihypertensive Agents; Dihydroxyphenylalanine; Hypertension | 1962 |
The acute hemodynamic eeffects of alpha-methyldopa in man.
Topics: Dihydroxyphenylalanine; Hemodynamics; Hypertension; Methyldopa | 1962 |
[Evaluation of the hypotensive effect of aldomet (alpha-methyl DOPA) in the treatment of arterial hypertension, with reference to its effect on the metabolism of catecholamines].
Topics: Catecholamines; Dihydroxyphenylalanine; Hypertension; Hypotension; Methyldopa | 1962 |
The effect of L-alpha-methyl DOPA and N-2-hydroxybenzyl-N-methyl hydrazine (NSD 1039) on the blood pressure of renal hypertensive rates.
Topics: Blood Pressure; Dihydroxyphenylalanine; Hydrazines; Hypertension; Hypertension, Renal; Kidney; Methy | 1963 |
Methyldopa in hypertension.
Topics: Dihydroxyphenylalanine; Humans; Hypertension; Methyldopa | 1963 |
[Methyl-DOPA (Aldomet) in the treatment of high blood pressure].
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa | 1963 |
Indications for treatment and present-day drug therapy in essential hypertension.
Topics: Diet, Sodium-Restricted; Dihydroxyphenylalanine; Essential Hypertension; Ganglionic Blockers; Guanet | 1963 |
[Clinical trials of gamma-methyl DOPA in the treatment of hypertension].
Topics: Antihypertensive Agents; Dihydroxyphenylalanine; Gamma Rays; Humans; Hypertension | 1962 |
CHEMOTHERAPY OF HYPERTENSION: YESTERDAY--TODAY--TOMORROW.
Topics: Alkaloids; Amines; Antihypertensive Agents; Chlorisondamine; Chlorothiazide; Dihydroxyphenylalanine; | 1963 |
[PHEOCHROMOCYTOMA AS A CAUSE OF CURABLE ARTERIAL HYPERTENSION. PRESENTATION OF A NEW CASE].
Topics: Adolescent; Angiography; Antihypertensive Agents; Dihydroxyphenylalanine; Hypertension; Methyldopa; | 1963 |
[THE PSYCHOPHYSIOLOGICAL EFFECTS OF METHYLDOPA].
Topics: Blood Pressure; Blood Pressure Determination; Depression; Depressive Disorder; Dihydroxyphenylalanin | 1963 |
MONOAMINE-OXIDASE INHIBITORS, BROAD BEANS, AND HYPERTENSION.
Topics: Dihydroxyphenylalanine; Fabaceae; Headache; Hypertension; Monoamine Oxidase Inhibitors; Oxidoreducta | 1964 |
Pharmacodynamics and clinical use of guanethidine, bretylium and methyldopa.
Topics: Amidines; Antitubercular Agents; Bretylium Compounds; Dihydroxyphenylalanine; Guanethidine; Humans; | 1962 |
[Methyl-dopa (Aldomet), a new principle in the treatment of high blood pressure].
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa | 1962 |
Pharmacodynamic effects and clinical use of alpha methyldopa in the treatment of essential hypertension.
Topics: Antihypertensive Agents; Dihydroxyphenylalanine; Essential Hypertension; Humans; Hypertension; Methy | 1962 |
[alpha-Methyl-DOPA. Therapeutic experiences in hypertension and biochemical research on its mode of action].
Topics: Dihydroxyphenylalanine; Hypertension; Methyldopa; Research | 1962 |
Pancreatitis due to methyldopa: case report.
Topics: Adult; Dihydroxyphenylalanine; Female; Humans; Hypertension; Pancreatitis | 1980 |
Changes in the excretion of catecholamines and their metabolites in patients with essential hypertension during sodium intake restriction.
Topics: Adolescent; Adult; Aged; Catecholamines; Diet, Sodium-Restricted; Dihydroxyphenylalanine; Dopamine; | 1981 |
[Effect of atenolol on the excretion of catecholamines and their metabolites and dihydroxyphenylalanine (DOPA) in patients with essential hypertension].
Topics: Adult; Atenolol; Catecholamines; Dihydroxyphenylalanine; Humans; Hypertension; Male; Middle Aged; Pr | 1982 |
[Alpha-methyldopa and brain monoamines].
Topics: Animals; Antihypertensive Agents; Biotransformation; Brain; Catecholamines; Dihydroxyphenylalanine; | 1982 |
Salt-sensitivity testing in patients with borderline hypertension: reproducibility and potential mechanisms.
Topics: Adult; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Dihydroxyphenylalanine; Dopamine; Elect | 1995 |
Central nervous system norepinephrine turnover in essential hypertension.
Topics: Adult; Blood Pressure; Brain; Central Nervous System; Dihydroxyphenylalanine; Heart Rate; Humans; Hy | 1995 |
Increased urinary dopamine excretion in young patients with essential hypertension.
Topics: Adult; Age Factors; Dihydroxyphenylalanine; Dopamine; Humans; Hypertension; Male; Norepinephrine | 1994 |
Dopaminergic abnormalities in hypertension associated with moderate renal insufficiency.
Topics: 3,4-Dihydroxyphenylacetic Acid; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Diastole; Dih | 1994 |
Evidence for increased noradrenaline release from subcortical brain regions in essential hypertension.
Topics: Adult; Cerebral Cortex; Cerebrovascular Circulation; Dihydroxyphenylalanine; Humans; Hypertension; M | 1993 |
Elevated total body noradrenaline spillover in normotensive members of hypertensive families.
Topics: Adult; Dihydroxyphenylalanine; Family; Humans; Hypertension; Norepinephrine; Peripheral Nerves; Symp | 1993 |
In vivo hypothalamic release and synthesis of catecholamines in spontaneously hypertensive rats.
Topics: Aging; Animals; Brain; Catecholamines; Catechols; Dialysis; Dihydroxyphenylalanine; Hydrazines; Hype | 1993 |
Defective 3,4-dihydroxyphenylalanine decarboxylation to dopamine in hydralazine-treated hypertensive patients may be pyridoxine remediable.
Topics: Adult; Cardiovascular System; Decarboxylation; Dihydroxyphenylalanine; Diuresis; Dopamine; Female; H | 1993 |
Commentary on Shigetomi and Kuchel's work on DOPA decarboxylation.
Topics: Catecholamines; Decarboxylation; Dihydroxyphenylalanine; Humans; Hydralazine; Hypertension | 1993 |
Differential catecholamine responses to protein intake in healthy and hypertensive subjects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Dietary Prot | 1998 |
Dopamine and dopa urinary excretion in patients with pheochromocytoma--diagnostic implications.
Topics: Adult; Biomarkers, Tumor; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Homovanillic Acid; | 2001 |
[Some characteristics of the state of the sympatho-adrenal system in various hemodynamic variants of hypertension].
Topics: Adolescent; Adult; Aged; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Hemodynamics; Homova | 1975 |
[Administration of the catecholamine precursor, L-DOPA, for evaluating their in vivo biosynthesis in hypertension].
Topics: Administration, Oral; Adult; Catecholamines; Circadian Rhythm; Dihydroxyphenylalanine; Dopamine; Epi | 1979 |
Dopa, catecholamines and their metabolites in essential hypertension.
Topics: Adult; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Hypertension; Norepinephrine | 1975 |
Attempts to measure endogenous levels of dopa and 5-hydroxytryptophan in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Brain Chemistry; Chlorpromazine; Dihydroxyphenylalanine; | 1975 |
[Sympathico-adrenal system in elderly patients with systolic hypertension].
Topics: Adrenal Glands; Age Factors; Aged; Blood Pressure; Circadian Rhythm; Dihydroxyphenylalanine; Dopamin | 1975 |
Defective dopamine generation from dihydroxyphenylalanine in stable essential hypertensive patients.
Topics: Administration, Oral; Blood Pressure; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hypertension | 1992 |
Increased norepinephrine spillover into the jugular veins in essential hypertension.
Topics: Cerebrovascular Circulation; Dihydroxyphenylalanine; Female; Humans; Hypertension; Jugular Veins; Ma | 1992 |
Endogenous dopa and dopamine responses to dietary salt loading in salt-sensitive rats.
Topics: Animals; Dihydroxyphenylalanine; Dopamine; Hypertension; Kidney; Male; Natriuresis; Rats; Rats, Inbr | 1991 |
Dopaminergic abnormalities in borderline essential hypertensive patients.
Topics: Adult; Blood Pressure; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hypertension; Kidney; Male; | 1991 |
High urinary dopa and low urinary dopamine-to-dopa ratio in salt-sensitive hypertension.
Topics: Adolescent; Adult; Aged; Blood Pressure; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hypertens | 1991 |
Acute and chronic effects of eicosapentaenoic acid (EPA) on the cardiovascular system.
Topics: Animals; Blood Pressure; Body Weight; Cardiovascular System; Dicarboxylic Acids; Dihydroxyphenylalan | 1989 |
Patients with essential hypertension have an exaggerated natriuretic response to the dopamine pro-drug glutamyl-dopa.
Topics: Adult; Dihydroxyphenylalanine; Female; Humans; Hypertension; Male; Middle Aged; Natriuresis; Prodrug | 1985 |
Autoradiographic study of 3H-DOPA uptake by superior cervical and stellate ganglia of spontaneously hypertensive rats during the prehypertensive stage.
Topics: Animals; Autoradiography; Dihydroxyphenylalanine; Ganglia, Sympathetic; Hypertension; Male; Rats; Ra | 1987 |
Increased catecholamine metabolism in the locus coeruleus of young spontaneously hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Stem; Catecholamines; Dihydroxyphenylalanine; Dopamin | 1986 |
Attenuated development of hypertension by chronic administration of bromocriptine in Doca-salt hypertensive rats.
Topics: Animals; Blood Pressure; Bromocriptine; Desoxycorticosterone; Dihydroxyphenylalanine; Domperidone; D | 1986 |
Pain sensitivity, thermal capability, and brain monoamine turnover in hypertensive rats.
Topics: 5-Hydroxytryptophan; Amines; Animals; Body Temperature Regulation; Brain; Dihydroxyphenylalanine; Hy | 1987 |
[The heart and catecholamines from the viewpoint of the adaptive-trophic function of the sympathetico-adrenal system].
Topics: Adaptation, Physiological; Adrenal Glands; Cardiomyopathy, Dilated; Catecholamines; Death, Sudden; D | 1988 |
Clinical and biochemical aspects of pheochromocytoma. Report of 110 cases.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Child; Circadian Rhythm; Dihydroxyphenylalanine; D | 1985 |
Use of levodopa with other drugs.
Topics: Adult; Aged; Antidepressive Agents; Antiemetics; Digoxin; Dihydroxyphenylalanine; Diuretics; Drug An | 1970 |
[Unfavorable and problematic drug combinations. IV].
Topics: Amphetamine; Ataxia; Bone Marrow; Cerebral Hemorrhage; Depression, Chemical; Dicumarol; Dihydroxyphe | 1970 |
Treatment of side-effects of levodopa.
Topics: Dihydroxyphenylalanine; Disulfiram; Humans; Hyperkinesis; Hypertension; Parkinson Disease | 1973 |
[Cardiovascular effects of L-dopa and decarboxylase inhibitor on patients with Parkinson's disease].
Topics: Aged; Atrial Fibrillation; Bundle-Branch Block; Carboxy-Lyases; Cardiac Complexes, Premature; Cardio | 1973 |
Further studies on catecholamine synthesis in the spontaneously hypertensive rat: catecholamine synthesis in the central nervous system.
Topics: Animals; Brain Stem; Carbon Isotopes; Catecholamines; Central Nervous System; Dihydroxyphenylalanine | 1973 |
Stress-induced gastric lesions in spontaneously hypertensive rats. Involvement of autonomic neurotransmitter substances.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Cold Temperature; Denervation; Dihydroxyphenylalan | 1974 |
Neonatal 6-hydroxydopamine sympathectomy in normotensive and spontaneously hypertensive rat.
Topics: Adrenal Glands; Analysis of Variance; Animals; Animals, Newborn; Behavior; Behavior, Animal; Blood P | 1974 |
[Methyldopa and levodopa].
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Humans; Hypertension; Methyldo | 1974 |
Orthohydroxyhippuric (salicyluric) acid--its physiologic and clinical significance.
Topics: Anemia; Animals; Cattle; Dihydroxyphenylalanine; Dogs; Down Syndrome; Fever; Glycine; Humans; Hypert | 1974 |
Modification of the cardiovascular effects of L-dopa in anesthetized dogs by inhibitors of enzymes involved in catecholamine metabolism.
Topics: Angiotensin II; Animals; Blood Pressure; Bradycardia; Carboxy-Lyases; Cresols; Dihydroxyphenylalanin | 1971 |
Drug modification of digital vascular reactivity to vasoactive substances.
Topics: Aldosterone; Angiotensin II; Benzothiadiazines; Blood Pressure; Dihydroxyphenylalanine; Fingers; Gua | 1969 |
Neurogenic factors in human hypertension: mechanism or myth?
Topics: Angiotensin II; Blood Pressure; Catecholamines; Chemical Phenomena; Chemistry; Dihydroxyphenylalanin | 1973 |
[Therapy of essential arterial hypertension].
Topics: Age Factors; Diet Therapy; Dihydroxyphenylalanine; Diuretics; Ganglionic Blockers; Humans; Hydrazine | 1969 |
[Conservative treatment of hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aniline Compounds; Dihydroxyphenylalanine; Female; Guaneth | 1970 |
[Drug therapy of hypertension].
Topics: Digitalis Glycosides; Dihydroxyphenylalanine; Diuretics; Ganglionic Blockers; Humans; Hydralazine; H | 1971 |
Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline levels and blood pressure in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain Chemistry; Brain Stem; Carboxy-Lyases; Cresols; Dihydroxyphenylalanin | 1972 |
[Role of the sympathico-adrenal system in the pathogenesis of hypertensive disease].
Topics: Adolescent; Adrenal Glands; Adult; Arteriosclerosis; Dihydroxyphenylalanine; Dopamine; Epinephrine; | 1974 |
The role of serum dopamine-beta-hydroxylase in essential hypertension.
Topics: Blood Pressure; Catecholamines; Dihydroxyphenylalanine; Dopamine; Dopamine beta-Hydroxylase; Epineph | 1974 |
The effect of antacid administration on the absorption and metabolism of levodopa.
Topics: Administration, Oral; Adult; Antacids; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Female; | 1972 |
[Indications and results of monoamine treatment in parkinsonian syndromes].
Topics: Aged; Arrhythmias, Cardiac; Benserazide; Carboxy-Lyases; Dihydroxyphenylalanine; Drug Combinations; | 1972 |
Proceedings: Further studies on the mechanisms of blood pressure lowering effect of L-DOPA and a peripheral decarboxylase inhibitor in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Benserazide; Blood Pressure; Brain Chemistry; Carboxy-Lyases; Deso | 1974 |
Secretion of dopa in phaeochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; H | 1972 |
[The syndrome of autonomic vascular dystonia in adolescents and young men with toxic-infectious processes].
Topics: Adolescent; Adult; Autonomic Nervous System; Blood Pressure; Cardiovascular Diseases; Catecholamines | 1972 |
The management of hypertension during pregnancy.
Topics: Adolescent; Adult; Blood Pressure; Clinical Laboratory Techniques; Diagnosis, Differential; Dihydrox | 1972 |
L-dopa for parkinsonism.
Topics: Aged; Amantadine; Depression; Dihydroxyphenylalanine; Female; Follow-Up Studies; Hallucinations; Hum | 1973 |
Cardiovascular reactions to anaesthesia during treatment with levodopa.
Topics: Anesthesia, Dental; Anesthesia, General; Dihydroxyphenylalanine; Female; Halothane; Humans; Hyperten | 1973 |
[Hypertension: 3 H-catecholamine metabolism in the adrenal glands and brain and tissue metabolism of 3 3 H-DOPA during reserpine, alpha-methyl DOPA and ST-155 administration in spontaneously hypertensive rats].
Topics: Adrenal Glands; Animals; Blood Pressure; Body Weight; Brain; Catecholamines; Clonidine; Dihydroxyphe | 1973 |
[L-dopa in 122 cases of Parkinson's disease in patients over 70 years old. Comparative study with a group of Parkinsonian patients who are 41 to 69 years old].
Topics: Activities of Daily Living; Adult; Age Factors; Aged; Dihydroxyphenylalanine; Drug Tolerance; Female | 1973 |
[Differential treatment of Parkinson's disease, with special reference to the possibility of iatrogenic disorders (author's transl)].
Topics: Amantadine; Anesthetics; Anti-Bacterial Agents; Antidepressive Agents; Antihypertensive Agents; Anti | 1974 |
[State of catecholamine and DOPA excretion in metabolic-alimentary obesity].
Topics: Adolescent; Adult; Arteriosclerosis; Catecholamines; Cholesterol; Chronic Disease; Circadian Rhythm; | 1974 |
Erythrocytosis in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Body Weight; Cell Survival; Chromium Isotopes | 1972 |
[Excretion of catecholamines and their precursors and indices of electrolyte balance in patients with chronic glomerulonephritis].
Topics: Adolescent; Adult; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epinephrine; G | 1972 |
Paroxysmal hypertension during L-dopa treatment in parkinsonism: a metabolic error or a pharmacological effect?
Topics: Aged; Catecholamines; Dihydroxyphenylalanine; Epinephrine; Female; Humans; Hypertension; Metabolism, | 1972 |
L-dopa--MAO inhibitors.
Topics: Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Hypertension; Monoamine Oxidase Inhibitors; | 1971 |
Alterations in tyrosine hydroxylase and monoamine oxidase activity in blood vessels.
Topics: Adrenal Glands; Animals; Aorta; Blood Pressure; Blood Vessels; Dihydroxyphenylalanine; Female; Guine | 1971 |
[The effect of guanethidine upon the diurnal rhythm of cathecholamines, dopa and dopamine in patients with hypertension].
Topics: Circadian Rhythm; Dihydroxyphenylalanine; Dopamine; Epinephrine; Guanethidine; Humans; Hypertension; | 1969 |
Factors influencing hypertension and pulmonary edema produced by hyperbaric O2.
Topics: Animals; Capillaries; Carbon Dioxide; Dextroamphetamine; Dihydroxyphenylalanine; Hyperbaric Oxygenat | 1970 |
Monoamine oxidase inhibitors and L-dopa.
Topics: Blood Pressure; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypertension; Male; Middle Aged; Par | 1970 |
[Minor symptoms in internal medicine, with special reference to catecholamine secretion].
Topics: Adult; Catecholamines; Chromatography, Gas; Dihydroxyphenylalanine; Epinephrine; Humans; Hypertensio | 1970 |
Evaluation of increased norepinephrine excretion in hypertension using L-dopa-3H.
Topics: Adrenal Glands; Adult; Aged; Diagnosis, Differential; Dihydroxyphenylalanine; Epinephrine; Female; H | 1971 |
Modification of the cardiovascular effects of L-dopa by decarboxylase inhibitors.
Topics: Animals; Aorta; Aromatic Amino Acid Decarboxylase Inhibitors; Arrhythmias, Cardiac; Blood Pressure; | 1971 |
[The state of the sympathetico-adrenal system in the development of hypertension].
Topics: Adolescent; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Dihydroxyphenylalanine; Dopamine; E | 1967 |
[Urinary excretion of catecholamines and sodium and potassium levels in serum and erythrocytes in patients with renal hypertension].
Topics: Adrenocortical Hyperfunction; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epi | 1967 |
[Prolonged treatment of essential arterial hypertension. Results of the use of a hypotensive drug].
Topics: Dihydroxyphenylalanine; Female; Humans; Hypertension; Male; Middle Aged; Time Factors | 1967 |
Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs.
Topics: Adolescent; Adult; Blood Pressure; Catecholamines; Chromatography; Dihydroxyphenylalanine; Dopamine; | 1968 |
[Results obtained in the treament of arterial hypertension b the alpha-methyl-dopa with hydrochlorothiazide combination].
Topics: Adolescent; Adult; Aged; Dihydroxyphenylalanine; Humans; Hydrochlorothiazide; Hypertension; Middle A | 1968 |
[The use of an adrenalin test in evaluating the functional state of the sympathetic-adrenal system].
Topics: Adrenal Glands; Asthma; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Hypertension; Norepin | 1969 |
[The drug therapy of hypertension].
Topics: Antihypertensive Agents; Diet Therapy; Dihydroxyphenylalanine; Diuretics; Humans; Hydralazine; Hyper | 1966 |