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dihydroxyphenylalanine and Hepatic Encephalopathy

dihydroxyphenylalanine has been researched along with Hepatic Encephalopathy in 30 studies

Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"Three of six patients with chronic hepatic encephalopathy treated with levodopa showed a significant improvement."2.64Treatment of chronic hepatic encephalopathy with levodopa. ( James, IM; Lunzer, M; Sherlock, S; Weinman, J, 1974)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199029 (96.67)18.7374
1990's1 (3.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Takei, N1
Watanabe, A1
Sakata, T1
Hayashi, S1
Obata, T1
Shiota, T1
Nagashima, H1
Hadesman, R1
Wiesner, RH1
Go, VL1
Tyce, GM1
Bustamante Bustamante, J1
Maddrey, WC1
Weber, FL1
Parkes, JD1
Sharpstone, P1
Williams, R2
Fischer, JE6
Baldessarini, RJ1
Neumayr, A1
Chia, KM1
James, JH3
Lunzer, M1
James, IM1
Weinman, J1
Sherlock, S1
Abramsky, O1
Goldschmidt, Z1
Jorge, AD1
Sanchez, D1
Jacobson, S1
Bell, B1
Schenker, S1
Breen, KJ1
Hoyumpa, AM1
Kurihara, N1
Fujisawa, K1
Baldessarini, R1
Lereboullet, J1
Rosa, A1
OLivier Martin, R1
Colón, AR1
Sandburg, DH1
Harada, H1
Saito, Y1
Oya, G1
Omoto, R1
Takagi, A1
Lanzinger, G1
Kommerell, B1
Fiasse, R1
Collignon, R1
Bietlot, A1
Mahieu, P1
Otte, JB1
Legrain, Y1
Pillen, E1
Ossorio Castellanos, C1
Noguera Hernando, E1
Isasía Muñoz, T1
Aboy Martin, A1
Seoane, J1
González-Posada, J1
Hernández-Peniche, J1
Tirado-Arroyave, S1
Stefanini, M1
Hetherington, EN1
Sarrazin, A2
Emerit, J2
Olivier, L2
Rebelo, R1
Bousquet, O2
Rebelo, F1

Reviews

7 reviews available for dihydroxyphenylalanine and Hepatic Encephalopathy

ArticleYear
[Hepatic encephalopathy].
    Revista clinica espanola, 1976, Jan-31, Volume: 140, Issue:2

    Topics: Blood Transfusion; Dihydroxyphenylalanine; Extracorporeal Circulation; Glucocorticoids; Hepatic Ence

1976
[Advances in the treatment of liver disease].
    Wiener medizinische Wochenschrift (1946), 1973, Oct-06, Issue:40

    Topics: Amino Acids; Anti-Bacterial Agents; Chronic Disease; Dihydroxyphenylalanine; Enzyme Induction; Excha

1973
[New development in the study of infectious hepatitis].
    Zhonghua yi xue za zhi, 1973, Volume: 3

    Topics: Acute Disease; Acute Kidney Injury; Alkalosis; Ammonia; Clinical Enzyme Tests; Dihydroxyphenylalanin

1973
Problems of fulminant hepatic failure.
    British medical bulletin, 1972, Volume: 28, Issue:2

    Topics: Acute Disease; Adrenal Cortex Hormones; Amylases; Brain Diseases; Brain Stem; Diazepam; Dihydroxyphe

1972
Recognition and management of acute and chronic hepatic encephalopathy.
    The Medical clinics of North America, 1973, Volume: 57, Issue:6

    Topics: Acute Disease; Amines; Ammonia; Animals; Brain Edema; Central Nervous System; Chronic Disease; Diet

1973
Hepatic encephalopathy: current status.
    Gastroenterology, 1974, Volume: 66, Issue:1

    Topics: Adrenal Cortex Hormones; Amino Acids; Ammonia; Animals; Anti-Bacterial Agents; Biogenic Amines; Dihy

1974
[Metabolic anomaly and management of hepatic coma].
    Nihon rinsho. Japanese journal of clinical medicine, 1973, Volume: 31, Issue:10

    Topics: Adrenal Cortex Hormones; Ammonia; Catecholamines; Dihydroxyphenylalanine; Electrolytes; Exchange Tra

1973

Trials

2 trials available for dihydroxyphenylalanine and Hepatic Encephalopathy

ArticleYear
Treatment of chronic hepatic encephalopathy with levodopa.
    Gut, 1974, Volume: 15, Issue:7

    Topics: Adult; Aged; Brain; Cerebrovascular Circulation; Chronic Disease; Computers; Dihydroxyphenylalanine;

1974
[Effect of L-dopa on hepatic coma].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Jul-03, Volume: 62, Issue:27

    Topics: Administration, Oral; Clinical Trials as Topic; Dihydroxyphenylalanine; Evaluation Studies as Topic;

1973

Other Studies

21 other studies available for dihydroxyphenylalanine and Hepatic Encephalopathy

ArticleYear
Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats.
    Gastroenterologia Japonica, 1983, Volume: 18, Issue:1

    Topics: Amino Acids; Animals; Carbon Tetrachloride Poisoning; Corpus Striatum; Dihydroxyphenylalanine; Hepat

1983
Concentrations of 3,4-dihydroxyphenylalanine and catecholamines and metabolites in brain in an anhepatic model of hepatic encephalopathy.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Catecholamines; Dihydroxyphenylalan

1995
Chronic hepatic encephalopathy.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Amino Acids, Essential; Ammonia; Analgesics; Anesthesia; Anti-Bacterial Agents; Biogenic Amines; Chr

1975
Levodopa in hepatic coma.
    Lancet (London, England), 1970, Dec-26, Volume: 2, Issue:7687

    Topics: 5-Hydroxytryptophan; Atropine; Dihydroxyphenylalanine; Edrophonium; Electroencephalography; Epinephr

1970
False neurotransmitters and hepatic failure.
    Lancet (London, England), 1971, Jul-10, Volume: 2, Issue:7715

    Topics: Acute Disease; Adult; Animals; Central Nervous System; Dihydroxyphenylalanine; Dopamine; Female; Hep

1971
Treatment of hepatic coma and hepatorenal syndrome. Mechanism of action of L-dopa and aramine.
    American journal of surgery, 1972, Volume: 123, Issue:2

    Topics: Adult; Brain Chemistry; Carbon Isotopes; Cardiac Output; Dihydroxyphenylalanine; Female; Hepatic Enc

1972
Neurotransmitters and hepatic failure.
    Connecticut medicine, 1972, Volume: 36, Issue:10

    Topics: Acute Kidney Injury; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Liver Diseases; Neurotr

1972
Treatment and prevention of acute hepatic encephalopathy by intravenous levodopa.
    Surgery, 1974, Volume: 75, Issue:2

    Topics: Adult; Aged; Blood Transfusion; Brain; Budd-Chiari Syndrome; Dihydroxyphenylalanine; Drug Therapy, C

1974
Changes in brain amines following portal flow diversion and acute hepatic coma: effects of levodopa (L-dopa) and intestinal sterilization.
    Surgical forum, 1972, Volume: 23, Issue:0

    Topics: Animals; Brain; Dihydroxyphenylalanine; Hepatic Encephalopathy; Intestines; Kanamycin; Octopamine; P

1972
False neurotransmitters and hepatic coma.
    Research publications - Association for Research in Nervous and Mental Disease, 1974, Volume: 53

    Topics: Amines; Animals; Brain; Dihydroxyphenylalanine; Female; Hepatic Encephalopathy; Humans; Intestinal M

1974
[Hepatic coma and L. Dopa].
    La Revue du praticien, 1972, Apr-21, Volume: 22, Issue:12

    Topics: Dihydroxyphenylalanine; Hepatic Encephalopathy

1972
Hepatic encephalopathy treated with L-dopa, recovery followed for 18 months.
    Pediatrics, 1973, Volume: 51, Issue:6

    Topics: Adolescent; Dihydroxyphenylalanine; Female; Follow-Up Studies; Hepatic Encephalopathy; Humans; Intub

1973
[Successful treatment of hepatic coma with L-dopa].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1973, Volume: 70, Issue:6

    Topics: Adult; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Male

1973
[Levodopa treatment in hepatic coma (with special consideration of serial EEG changes (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Apr-05, Volume: 99, Issue:14

    Topics: Administration, Oral; Blood Circulation; Dihydroxyphenylalanine; Electroencephalography; Female; Hep

1974
[Treatment of fulminant hepatitis with coma by exchange transfusion. Study of 9 patients, including 1 with neurological sequelae in the cortical functions (author's transl)].
    Acta gastro-enterologica Belgica, 1974, Volume: 37, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Aged; Agnosia; Anti-Bacterial Agents; Brain; Cerebral Cortex; Dihydr

1974
[Use of L-Dopa in the treatment of hepatic coma. Comments and personal contributions].
    Revista espanola de las enfermedades del aparato digestivo, 1974, Jun-01, Volume: 43, Issue:5

    Topics: Adult; Dihydroxyphenylalanine; Drug Evaluation; Female; Hepatic Encephalopathy; Humans; Male; Middle

1974
[Effect of 3,4-dihydroxyphenylalanine (levodopa) in hepatic coma].
    Archivos de investigacion medica, 1972, Volume: 3, Issue:1

    Topics: Administration, Oral; Adult; Aged; Dihydroxyphenylalanine; Electroencephalography; Female; Hepatic E

1972
Levodopa in hepatic failure.
    JAMA, 1972, May-29, Volume: 220, Issue:9

    Topics: Ammonia; Dihydroxyphenylalanine; Dopamine; Hepatic Encephalopathy; Humans; Male; Middle Aged; Norepi

1972
Mechanism of action of L-dopa in hepatic coma.
    Surgical forum, 1971, Volume: 22

    Topics: Animals; Brain; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Metaraminol; Rats

1971
[Presentation of a female patient with hepatic coma cured by treatment with L-Dopa].
    Revue neurologique, 1971, Volume: 125, Issue:5

    Topics: Dihydroxyphenylalanine; Diuresis; Drug Tolerance; Electroencephalography; Female; Hepatic Encephalop

1971
[Treatment of hepatic coma with L-dopa. Preliminary results].
    La Presse medicale, 1971, Nov-20, Volume: 79, Issue:49

    Topics: Adult; Aged; Dihydroxyphenylalanine; Diuresis; Electroencephalography; Female; Hepatic Encephalopath

1971