dihydroxyphenylalanine has been researched along with Hepatic Encephalopathy in 30 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
Excerpt | Relevance | Reference |
---|---|---|
"Three of six patients with chronic hepatic encephalopathy treated with levodopa showed a significant improvement." | 2.64 | Treatment of chronic hepatic encephalopathy with levodopa. ( James, IM; Lunzer, M; Sherlock, S; Weinman, J, 1974) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 29 (96.67) | 18.7374 |
1990's | 1 (3.33) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Takei, N | 1 |
Watanabe, A | 1 |
Sakata, T | 1 |
Hayashi, S | 1 |
Obata, T | 1 |
Shiota, T | 1 |
Nagashima, H | 1 |
Hadesman, R | 1 |
Wiesner, RH | 1 |
Go, VL | 1 |
Tyce, GM | 1 |
Bustamante Bustamante, J | 1 |
Maddrey, WC | 1 |
Weber, FL | 1 |
Parkes, JD | 1 |
Sharpstone, P | 1 |
Williams, R | 2 |
Fischer, JE | 6 |
Baldessarini, RJ | 1 |
Neumayr, A | 1 |
Chia, KM | 1 |
James, JH | 3 |
Lunzer, M | 1 |
James, IM | 1 |
Weinman, J | 1 |
Sherlock, S | 1 |
Abramsky, O | 1 |
Goldschmidt, Z | 1 |
Jorge, AD | 1 |
Sanchez, D | 1 |
Jacobson, S | 1 |
Bell, B | 1 |
Schenker, S | 1 |
Breen, KJ | 1 |
Hoyumpa, AM | 1 |
Kurihara, N | 1 |
Fujisawa, K | 1 |
Baldessarini, R | 1 |
Lereboullet, J | 1 |
Rosa, A | 1 |
OLivier Martin, R | 1 |
Colón, AR | 1 |
Sandburg, DH | 1 |
Harada, H | 1 |
Saito, Y | 1 |
Oya, G | 1 |
Omoto, R | 1 |
Takagi, A | 1 |
Lanzinger, G | 1 |
Kommerell, B | 1 |
Fiasse, R | 1 |
Collignon, R | 1 |
Bietlot, A | 1 |
Mahieu, P | 1 |
Otte, JB | 1 |
Legrain, Y | 1 |
Pillen, E | 1 |
Ossorio Castellanos, C | 1 |
Noguera Hernando, E | 1 |
Isasía Muñoz, T | 1 |
Aboy Martin, A | 1 |
Seoane, J | 1 |
González-Posada, J | 1 |
Hernández-Peniche, J | 1 |
Tirado-Arroyave, S | 1 |
Stefanini, M | 1 |
Hetherington, EN | 1 |
Sarrazin, A | 2 |
Emerit, J | 2 |
Olivier, L | 2 |
Rebelo, R | 1 |
Bousquet, O | 2 |
Rebelo, F | 1 |
7 reviews available for dihydroxyphenylalanine and Hepatic Encephalopathy
Article | Year |
---|---|
[Hepatic encephalopathy].
Topics: Blood Transfusion; Dihydroxyphenylalanine; Extracorporeal Circulation; Glucocorticoids; Hepatic Ence | 1976 |
[Advances in the treatment of liver disease].
Topics: Amino Acids; Anti-Bacterial Agents; Chronic Disease; Dihydroxyphenylalanine; Enzyme Induction; Excha | 1973 |
[New development in the study of infectious hepatitis].
Topics: Acute Disease; Acute Kidney Injury; Alkalosis; Ammonia; Clinical Enzyme Tests; Dihydroxyphenylalanin | 1973 |
Problems of fulminant hepatic failure.
Topics: Acute Disease; Adrenal Cortex Hormones; Amylases; Brain Diseases; Brain Stem; Diazepam; Dihydroxyphe | 1972 |
Recognition and management of acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Amines; Ammonia; Animals; Brain Edema; Central Nervous System; Chronic Disease; Diet | 1973 |
Hepatic encephalopathy: current status.
Topics: Adrenal Cortex Hormones; Amino Acids; Ammonia; Animals; Anti-Bacterial Agents; Biogenic Amines; Dihy | 1974 |
[Metabolic anomaly and management of hepatic coma].
Topics: Adrenal Cortex Hormones; Ammonia; Catecholamines; Dihydroxyphenylalanine; Electrolytes; Exchange Tra | 1973 |
2 trials available for dihydroxyphenylalanine and Hepatic Encephalopathy
Article | Year |
---|---|
Treatment of chronic hepatic encephalopathy with levodopa.
Topics: Adult; Aged; Brain; Cerebrovascular Circulation; Chronic Disease; Computers; Dihydroxyphenylalanine; | 1974 |
[Effect of L-dopa on hepatic coma].
Topics: Administration, Oral; Clinical Trials as Topic; Dihydroxyphenylalanine; Evaluation Studies as Topic; | 1973 |
21 other studies available for dihydroxyphenylalanine and Hepatic Encephalopathy
Article | Year |
---|---|
Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats.
Topics: Amino Acids; Animals; Carbon Tetrachloride Poisoning; Corpus Striatum; Dihydroxyphenylalanine; Hepat | 1983 |
Concentrations of 3,4-dihydroxyphenylalanine and catecholamines and metabolites in brain in an anhepatic model of hepatic encephalopathy.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Catecholamines; Dihydroxyphenylalan | 1995 |
Chronic hepatic encephalopathy.
Topics: Amino Acids, Essential; Ammonia; Analgesics; Anesthesia; Anti-Bacterial Agents; Biogenic Amines; Chr | 1975 |
Levodopa in hepatic coma.
Topics: 5-Hydroxytryptophan; Atropine; Dihydroxyphenylalanine; Edrophonium; Electroencephalography; Epinephr | 1970 |
False neurotransmitters and hepatic failure.
Topics: Acute Disease; Adult; Animals; Central Nervous System; Dihydroxyphenylalanine; Dopamine; Female; Hep | 1971 |
Treatment of hepatic coma and hepatorenal syndrome. Mechanism of action of L-dopa and aramine.
Topics: Adult; Brain Chemistry; Carbon Isotopes; Cardiac Output; Dihydroxyphenylalanine; Female; Hepatic Enc | 1972 |
Neurotransmitters and hepatic failure.
Topics: Acute Kidney Injury; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Liver Diseases; Neurotr | 1972 |
Treatment and prevention of acute hepatic encephalopathy by intravenous levodopa.
Topics: Adult; Aged; Blood Transfusion; Brain; Budd-Chiari Syndrome; Dihydroxyphenylalanine; Drug Therapy, C | 1974 |
Changes in brain amines following portal flow diversion and acute hepatic coma: effects of levodopa (L-dopa) and intestinal sterilization.
Topics: Animals; Brain; Dihydroxyphenylalanine; Hepatic Encephalopathy; Intestines; Kanamycin; Octopamine; P | 1972 |
False neurotransmitters and hepatic coma.
Topics: Amines; Animals; Brain; Dihydroxyphenylalanine; Female; Hepatic Encephalopathy; Humans; Intestinal M | 1974 |
[Hepatic coma and L. Dopa].
Topics: Dihydroxyphenylalanine; Hepatic Encephalopathy | 1972 |
Hepatic encephalopathy treated with L-dopa, recovery followed for 18 months.
Topics: Adolescent; Dihydroxyphenylalanine; Female; Follow-Up Studies; Hepatic Encephalopathy; Humans; Intub | 1973 |
[Successful treatment of hepatic coma with L-dopa].
Topics: Adult; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Male | 1973 |
[Levodopa treatment in hepatic coma (with special consideration of serial EEG changes (author's transl)].
Topics: Administration, Oral; Blood Circulation; Dihydroxyphenylalanine; Electroencephalography; Female; Hep | 1974 |
[Treatment of fulminant hepatitis with coma by exchange transfusion. Study of 9 patients, including 1 with neurological sequelae in the cortical functions (author's transl)].
Topics: Adrenal Cortex Hormones; Adult; Aged; Agnosia; Anti-Bacterial Agents; Brain; Cerebral Cortex; Dihydr | 1974 |
[Use of L-Dopa in the treatment of hepatic coma. Comments and personal contributions].
Topics: Adult; Dihydroxyphenylalanine; Drug Evaluation; Female; Hepatic Encephalopathy; Humans; Male; Middle | 1974 |
[Effect of 3,4-dihydroxyphenylalanine (levodopa) in hepatic coma].
Topics: Administration, Oral; Adult; Aged; Dihydroxyphenylalanine; Electroencephalography; Female; Hepatic E | 1972 |
Levodopa in hepatic failure.
Topics: Ammonia; Dihydroxyphenylalanine; Dopamine; Hepatic Encephalopathy; Humans; Male; Middle Aged; Norepi | 1972 |
Mechanism of action of L-dopa in hepatic coma.
Topics: Animals; Brain; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Metaraminol; Rats | 1971 |
[Presentation of a female patient with hepatic coma cured by treatment with L-Dopa].
Topics: Dihydroxyphenylalanine; Diuresis; Drug Tolerance; Electroencephalography; Female; Hepatic Encephalop | 1971 |
[Treatment of hepatic coma with L-dopa. Preliminary results].
Topics: Adult; Aged; Dihydroxyphenylalanine; Diuresis; Electroencephalography; Female; Hepatic Encephalopath | 1971 |