dihydroxyphenylalanine has been researched along with Hepatic Encephalopathy in 30 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three of six patients with chronic hepatic encephalopathy treated with levodopa showed a significant improvement." | 2.64 | Treatment of chronic hepatic encephalopathy with levodopa. ( James, IM; Lunzer, M; Sherlock, S; Weinman, J, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (96.67) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takei, N | 1 |
| Watanabe, A | 1 |
| Sakata, T | 1 |
| Hayashi, S | 1 |
| Obata, T | 1 |
| Shiota, T | 1 |
| Nagashima, H | 1 |
| Hadesman, R | 1 |
| Wiesner, RH | 1 |
| Go, VL | 1 |
| Tyce, GM | 1 |
| Bustamante Bustamante, J | 1 |
| Maddrey, WC | 1 |
| Weber, FL | 1 |
| Parkes, JD | 1 |
| Sharpstone, P | 1 |
| Williams, R | 2 |
| Fischer, JE | 6 |
| Baldessarini, RJ | 1 |
| Neumayr, A | 1 |
| Chia, KM | 1 |
| James, JH | 3 |
| Lunzer, M | 1 |
| James, IM | 1 |
| Weinman, J | 1 |
| Sherlock, S | 1 |
| Abramsky, O | 1 |
| Goldschmidt, Z | 1 |
| Jorge, AD | 1 |
| Sanchez, D | 1 |
| Jacobson, S | 1 |
| Bell, B | 1 |
| Schenker, S | 1 |
| Breen, KJ | 1 |
| Hoyumpa, AM | 1 |
| Kurihara, N | 1 |
| Fujisawa, K | 1 |
| Baldessarini, R | 1 |
| Lereboullet, J | 1 |
| Rosa, A | 1 |
| OLivier Martin, R | 1 |
| Colón, AR | 1 |
| Sandburg, DH | 1 |
| Harada, H | 1 |
| Saito, Y | 1 |
| Oya, G | 1 |
| Omoto, R | 1 |
| Takagi, A | 1 |
| Lanzinger, G | 1 |
| Kommerell, B | 1 |
| Fiasse, R | 1 |
| Collignon, R | 1 |
| Bietlot, A | 1 |
| Mahieu, P | 1 |
| Otte, JB | 1 |
| Legrain, Y | 1 |
| Pillen, E | 1 |
| Ossorio Castellanos, C | 1 |
| Noguera Hernando, E | 1 |
| Isasía Muñoz, T | 1 |
| Aboy Martin, A | 1 |
| Seoane, J | 1 |
| González-Posada, J | 1 |
| Hernández-Peniche, J | 1 |
| Tirado-Arroyave, S | 1 |
| Stefanini, M | 1 |
| Hetherington, EN | 1 |
| Sarrazin, A | 2 |
| Emerit, J | 2 |
| Olivier, L | 2 |
| Rebelo, R | 1 |
| Bousquet, O | 2 |
| Rebelo, F | 1 |
7 reviews available for dihydroxyphenylalanine and Hepatic Encephalopathy
| Article | Year |
|---|---|
[Hepatic encephalopathy].
Topics: Blood Transfusion; Dihydroxyphenylalanine; Extracorporeal Circulation; Glucocorticoids; Hepatic Ence | 1976 |
[Advances in the treatment of liver disease].
Topics: Amino Acids; Anti-Bacterial Agents; Chronic Disease; Dihydroxyphenylalanine; Enzyme Induction; Excha | 1973 |
[New development in the study of infectious hepatitis].
Topics: Acute Disease; Acute Kidney Injury; Alkalosis; Ammonia; Clinical Enzyme Tests; Dihydroxyphenylalanin | 1973 |
Problems of fulminant hepatic failure.
Topics: Acute Disease; Adrenal Cortex Hormones; Amylases; Brain Diseases; Brain Stem; Diazepam; Dihydroxyphe | 1972 |
Recognition and management of acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Amines; Ammonia; Animals; Brain Edema; Central Nervous System; Chronic Disease; Diet | 1973 |
Hepatic encephalopathy: current status.
Topics: Adrenal Cortex Hormones; Amino Acids; Ammonia; Animals; Anti-Bacterial Agents; Biogenic Amines; Dihy | 1974 |
[Metabolic anomaly and management of hepatic coma].
Topics: Adrenal Cortex Hormones; Ammonia; Catecholamines; Dihydroxyphenylalanine; Electrolytes; Exchange Tra | 1973 |
2 trials available for dihydroxyphenylalanine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Treatment of chronic hepatic encephalopathy with levodopa.
Topics: Adult; Aged; Brain; Cerebrovascular Circulation; Chronic Disease; Computers; Dihydroxyphenylalanine; | 1974 |
[Effect of L-dopa on hepatic coma].
Topics: Administration, Oral; Clinical Trials as Topic; Dihydroxyphenylalanine; Evaluation Studies as Topic; | 1973 |
21 other studies available for dihydroxyphenylalanine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats.
Topics: Amino Acids; Animals; Carbon Tetrachloride Poisoning; Corpus Striatum; Dihydroxyphenylalanine; Hepat | 1983 |
Concentrations of 3,4-dihydroxyphenylalanine and catecholamines and metabolites in brain in an anhepatic model of hepatic encephalopathy.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Catecholamines; Dihydroxyphenylalan | 1995 |
Chronic hepatic encephalopathy.
Topics: Amino Acids, Essential; Ammonia; Analgesics; Anesthesia; Anti-Bacterial Agents; Biogenic Amines; Chr | 1975 |
Levodopa in hepatic coma.
Topics: 5-Hydroxytryptophan; Atropine; Dihydroxyphenylalanine; Edrophonium; Electroencephalography; Epinephr | 1970 |
False neurotransmitters and hepatic failure.
Topics: Acute Disease; Adult; Animals; Central Nervous System; Dihydroxyphenylalanine; Dopamine; Female; Hep | 1971 |
Treatment of hepatic coma and hepatorenal syndrome. Mechanism of action of L-dopa and aramine.
Topics: Adult; Brain Chemistry; Carbon Isotopes; Cardiac Output; Dihydroxyphenylalanine; Female; Hepatic Enc | 1972 |
Neurotransmitters and hepatic failure.
Topics: Acute Kidney Injury; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Liver Diseases; Neurotr | 1972 |
Treatment and prevention of acute hepatic encephalopathy by intravenous levodopa.
Topics: Adult; Aged; Blood Transfusion; Brain; Budd-Chiari Syndrome; Dihydroxyphenylalanine; Drug Therapy, C | 1974 |
Changes in brain amines following portal flow diversion and acute hepatic coma: effects of levodopa (L-dopa) and intestinal sterilization.
Topics: Animals; Brain; Dihydroxyphenylalanine; Hepatic Encephalopathy; Intestines; Kanamycin; Octopamine; P | 1972 |
False neurotransmitters and hepatic coma.
Topics: Amines; Animals; Brain; Dihydroxyphenylalanine; Female; Hepatic Encephalopathy; Humans; Intestinal M | 1974 |
[Hepatic coma and L. Dopa].
Topics: Dihydroxyphenylalanine; Hepatic Encephalopathy | 1972 |
Hepatic encephalopathy treated with L-dopa, recovery followed for 18 months.
Topics: Adolescent; Dihydroxyphenylalanine; Female; Follow-Up Studies; Hepatic Encephalopathy; Humans; Intub | 1973 |
[Successful treatment of hepatic coma with L-dopa].
Topics: Adult; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Male | 1973 |
[Levodopa treatment in hepatic coma (with special consideration of serial EEG changes (author's transl)].
Topics: Administration, Oral; Blood Circulation; Dihydroxyphenylalanine; Electroencephalography; Female; Hep | 1974 |
[Treatment of fulminant hepatitis with coma by exchange transfusion. Study of 9 patients, including 1 with neurological sequelae in the cortical functions (author's transl)].
Topics: Adrenal Cortex Hormones; Adult; Aged; Agnosia; Anti-Bacterial Agents; Brain; Cerebral Cortex; Dihydr | 1974 |
[Use of L-Dopa in the treatment of hepatic coma. Comments and personal contributions].
Topics: Adult; Dihydroxyphenylalanine; Drug Evaluation; Female; Hepatic Encephalopathy; Humans; Male; Middle | 1974 |
[Effect of 3,4-dihydroxyphenylalanine (levodopa) in hepatic coma].
Topics: Administration, Oral; Adult; Aged; Dihydroxyphenylalanine; Electroencephalography; Female; Hepatic E | 1972 |
Levodopa in hepatic failure.
Topics: Ammonia; Dihydroxyphenylalanine; Dopamine; Hepatic Encephalopathy; Humans; Male; Middle Aged; Norepi | 1972 |
Mechanism of action of L-dopa in hepatic coma.
Topics: Animals; Brain; Dihydroxyphenylalanine; Hepatic Encephalopathy; Humans; Metaraminol; Rats | 1971 |
[Presentation of a female patient with hepatic coma cured by treatment with L-Dopa].
Topics: Dihydroxyphenylalanine; Diuresis; Drug Tolerance; Electroencephalography; Female; Hepatic Encephalop | 1971 |
[Treatment of hepatic coma with L-dopa. Preliminary results].
Topics: Adult; Aged; Dihydroxyphenylalanine; Diuresis; Electroencephalography; Female; Hepatic Encephalopath | 1971 |