dihydroxyphenylalanine has been researched along with Fibromyalgia in 4 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fibromyalgia is associated with reductions in gray matter density within brain regions ostensibly involved in phenomena related to the disorder, including enhanced pain perception, cognitive dysfunction, and abnormal stress reactivity." | 1.35 | Changes in gray matter density in fibromyalgia: correlation with dopamine metabolism. ( Glabus, MF; Patterson, JC; Simpson, R; Wood, PB, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ledermann, K | 1 |
| von Känel, R | 1 |
| Berna, C | 1 |
| Sprott, H | 1 |
| Burckhardt, M | 1 |
| Jenewein, J | 1 |
| Garland, EL | 1 |
| Martin-Sölch, C | 1 |
| Wood, PB | 1 |
| Glabus, MF | 1 |
| Simpson, R | 1 |
| Patterson, JC | 1 |
| Guilleminault, C | 1 |
| Sigwald, J | 1 |
| Castaigne, P | 1 |
| Trojaborg, W | 1 |
| Rowland, LP | 1 |
| Katz, RI | 1 |
| Wheaton, EA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Understanding and Restoring Dopaminergic Function in Fibromyalgia Patients Using a Mindfulness-based Psychological Intervention: A [18F]-DOPA Positron Emissions Tomography (PET) Study Study Protocol for the FIBRODOPA Study- a Randomized Controlled Trial[NCT04451564] | 80 participants (Anticipated) | Interventional | 2021-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for dihydroxyphenylalanine and Fibromyalgia
| Article | Year |
|---|---|
Understanding and restoring dopaminergic function in fibromyalgia patients using a mindfulness-based psychological intervention: a [18F]-DOPA PET study. Study protocol for the FIBRODOPA study-a randomized controlled trial.
Topics: Dihydroxyphenylalanine; Dopamine; Female; Fibromyalgia; Humans; Mindfulness; Positron-Emission Tomog | 2021 |
3 other studies available for dihydroxyphenylalanine and Fibromyalgia
| Article | Year |
|---|---|
Changes in gray matter density in fibromyalgia: correlation with dopamine metabolism.
Topics: Adult; Analysis of Variance; Brain; Cerebral Cortex; Dihydroxyphenylalanine; Dopamine; Female; Fibro | 2009 |
Sleep studies and therepeutic trial with L-dopa in a case of Stiffman syndrome.
Topics: Benzodiazepinones; Chlorobenzenes; Diazepam; Dihydroxyphenylalanine; Electrocardiography; Electromyo | 1973 |
Stiff muscles and bony tendons.
Topics: Adult; Affective Symptoms; Amobarbital; Diazepam; Dihydroxyphenylalanine; Electromyography; Female; | 1970 |