dihydroxyphenylalanine has been researched along with Epilepsy in 17 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dill, P | 1 |
| Schneider, J | 1 |
| Weber, P | 1 |
| Trachsel, D | 1 |
| Tekin, M | 1 |
| Jakobs, C | 1 |
| Thöny, B | 1 |
| Blau, N | 1 |
| Biraben, A | 2 |
| Semah, F | 2 |
| Ribeiro, MJ | 2 |
| Douaud, G | 1 |
| Remy, P | 1 |
| Depaulis, A | 1 |
| Bouilleret, V | 1 |
| Taussig, D | 1 |
| Chassoux, F | 1 |
| Syrota, A | 1 |
| Karlov, VA | 1 |
| Gleĭzer, MA | 1 |
| Popova, NS | 1 |
| Kachalova, LM | 1 |
| Ustinovskaia, OV | 1 |
| Golodets, RG | 1 |
| Lando, LI | 1 |
| Afanas'ev, IuI | 1 |
| Kobayashi, K | 1 |
| Mori, A | 1 |
| Rohmer, F | 1 |
| Warter, JM | 1 |
| Coquillat, G | 1 |
| Maitrot, D | 1 |
| Kurtz, D | 1 |
| Micheletti, G | 1 |
| Mack, G | 1 |
| Mandel, P | 1 |
| Bernheimer, H | 1 |
| Birkmayer, W | 1 |
| Hornykiewicz, O | 1 |
| Papeschi, R | 1 |
| Molina-Negro, P | 1 |
| Sourkes, TL | 1 |
| Erba, G | 1 |
| Araki, S | 1 |
| Matthews, WB | 1 |
| Vuillon-Cacciuttolo, G | 1 |
| Meldrum, BS | 1 |
| Balzamo, E | 1 |
| Korten, JJ | 1 |
| Gabreels, FJ | 1 |
| Joosten, EM | 1 |
| Narabayashi, H | 1 |
| Florio, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Dopaminergic Reactivity In Idiopathic Generalized Epilepsy: A Proof Of Concept Clinical, Pharmacological And Neurophysiological Study"[NCT01432821] | 31 participants (Actual) | Interventional | 2011-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dihydroxyphenylalanine and Epilepsy
| Article | Year |
|---|---|
[Epilepsy and monoamines in the brain].
Topics: Animals; Biogenic Amines; Brain; Catecholamines; Cats; Dihydroxyphenylalanine; Dopamine; Drug Antago | 1975 |
[Recent trend in neurology].
Topics: Cerebrovascular Disorders; Demyelinating Diseases; Diet Therapy; Dihydroxyphenylalanine; Epilepsy; H | 1970 |
Advances in neurology.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticoagulants; Anticonvulsants; Antihypertens | 1972 |
2 trials available for dihydroxyphenylalanine and Epilepsy
| Article | Year |
|---|---|
Involvement of the basal ganglia in refractory epilepsy: an 18F-fluoro-L-DOPA PET study using 2 methods of analysis.
Topics: Adult; Algorithms; Anticonvulsants; Basal Ganglia; Brain Mapping; Dihydroxyphenylalanine; Drug Resis | 2005 |
[Pharmacological and biochemical approach to a syndrome of action and intention myoclonus in the course of degenerative disease of the nervous system].
Topics: 5-Hydroxytryptophan; Adult; Benzazepines; Cerebellar Ataxia; Clinical Trials as Topic; Diagnosis, Di | 1973 |
12 other studies available for dihydroxyphenylalanine and Epilepsy
| Article | Year |
|---|---|
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxypheny | 2011 |
PET evidence for a role of the basal ganglia in patients with ring chromosome 20 epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Caudate Nucleus; Chromosome Disorders; Chromosomes, Human, Pair | 2004 |
[Reactivity of the DOPA--dopamine--noradrenaline--adrenaline system in epileptics].
Topics: Adolescent; Adult; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epilepsies, Partial; Epilepsy; | 1983 |
[Peptide correction of disturbed relations in the central nervous system].
Topics: Acetylcholinesterase; Acoustic Stimulation; Animals; Brain; Cats; Convulsants; Delta Sleep-Inducing | 1998 |
[Catecholamine metabolism in various compensatory manifestations of epilepsy patients].
Topics: Adult; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epilepsy; Epinephrine; Humans; Insulin; Mid | 1979 |
[Homovanillic acid in the cerebrospinal fluid: studies in Parkinson's syndrome and other diseases of the CNS].
Topics: Adult; Aged; Central Nervous System Diseases; Cerebrospinal Fluid; Dihydroxyphenylalanine; Epilepsy; | 1966 |
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp | 1972 |
Electroretinogram and afferent visual transmission in the epileptic baboon Papio papio. Effects of drugs influencing monoaminergic systems.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Dihydroxyphenylalanine; Electroretinography; Epilepsy | 1973 |
Undesirable prepubertal effects of levodopa.
Topics: Administration, Oral; Age Factors; Child; Dihydroxyphenylalanine; Epilepsy; Genitalia, Male; Humans; | 1973 |
[Present status and future problems of stereoencephalotomy].
Topics: Athetosis; Brain; Brain Neoplasms; Chorea; Dihydroxyphenylalanine; Epilepsy; Humans; Myoclonus; Park | 1971 |
[Study of the central action of amantadine].
Topics: Amantadine; Animals; Butyrophenones; Central Nervous System; Chlorpromazine; Dihydroxyphenylalanine; | 1971 |
Concurrent session: current trends in neurology and psychiatry.
Topics: Amantadine; Behavior Therapy; Dihydroxyphenylalanine; Epilepsy; Female; Humans; Male; Neurology; Par | 1971 |