dihydroxyphenylalanine has been researched along with Drug Withdrawal Symptoms in 28 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hence we would advise that if for any reason anticholinergic drugs are to be withdrawn in patients receiving a stable dosage of levodopa this must be done slowly." | 2.64 | Levodopa in Parkinsonism: the effects of withdrawal of anticholinergic drugs. ( Hughes, RC; Polgar, JG; Walton, JN; Weightman, D, 1971) |
| "Pretreatment with norharman (20 mg/kg) or LSL 60101 (20 mg/kg) (30 min before naloxone) fully prevented the stimulatory effect of opiate withdrawal on DOPA synthesis." | 1.33 | High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain. ( Asensio, VJ; Esteban, S; García-Sevilla, JA; Miralles, A; Moranta, D; Sastre-Coll, A, 2005) |
| "In summary, we conclude that morphine addiction is associated with supersensitivity of 5-HT1A serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) that modulate the synthesis of monoamines in brain." | 1.31 | Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats. ( Esteban, S; García-Sevilla, JA; Sastre-Coll, A, 2002) |
| "It has been shown that depakin, a GABA-ergic agonist, and alpha-methyl-DOPA that inhibits catecholamine synthesis are capable of removing the withdrawal syndrome (disturbed pavlovian behavior pattern and aggressiveness) occurring after discontinuance of long-term administration (30 days) of phenazepam to rats in a dose of 2 mg/kg." | 1.26 | [Role of GABA-ergic and dopaminergic mechanisms in the withdrawal syndrome after discontinuation of long-term phenazepam administration]. ( Garibova, TL; Voronina, TA, 1980) |
| "Pretreatment with haloperidol (0." | 1.25 | Narcotic withdrawal like mouse jumping produced by amphetamine and L-DOPA. ( Colpaert, FC; Laduron, P; Lal, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (64.29) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rademacher, L | 1 |
| Prinz, S | 1 |
| Winz, O | 1 |
| Henkel, K | 1 |
| Dietrich, CA | 1 |
| Schmaljohann, J | 1 |
| Mohammadkhani Shali, S | 1 |
| Schabram, I | 1 |
| Stoppe, C | 1 |
| Cumming, P | 2 |
| Hilgers, RD | 1 |
| Kumakura, Y | 1 |
| Coburn, M | 1 |
| Mottaghy, FM | 1 |
| Gründer, G | 1 |
| Vernaleken, I | 1 |
| Moranta, D | 3 |
| Esteban, S | 4 |
| García-Sevilla, JA | 4 |
| Casseron, W | 1 |
| Genton, P | 1 |
| Miralles, A | 2 |
| Sastre-Coll, A | 3 |
| Asensio, VJ | 1 |
| Black, RF | 1 |
| Hoffman, PL | 1 |
| Tabakoff, B | 1 |
| Persson, SA | 1 |
| Wahlström, G | 1 |
| Voronina, TA | 1 |
| Garibova, TL | 1 |
| Markelova, VF | 1 |
| Belitskaia, RA | 1 |
| Rudnev, SG | 1 |
| Bailey, R | 1 |
| Crisp, E | 1 |
| Jackson, DM | 1 |
| Jenkins, O | 1 |
| Scarzella, L | 1 |
| Delsedime, M | 1 |
| Ferrero, B | 1 |
| Giangrandi, C | 1 |
| Priano, L | 1 |
| Rizzone, M | 1 |
| Bergamasco, B | 1 |
| Wu, JC | 1 |
| Bell, K | 1 |
| Najafi, A | 1 |
| Widmark, C | 1 |
| Keator, D | 1 |
| Tang, C | 1 |
| Klein, E | 1 |
| Bunney, BG | 1 |
| Fallon, J | 1 |
| Bunney, WE | 1 |
| Reith, J | 1 |
| Gjedde, A | 1 |
| Liljequist, S | 1 |
| Engel, J | 1 |
| Lal, H | 2 |
| Colpaert, FC | 1 |
| Laduron, P | 1 |
| Ahlenius, S | 1 |
| Ericson, EL | 1 |
| Högberg, K | 1 |
| Wijkström, A | 1 |
| Hunter, KR | 1 |
| Shaw, KM | 1 |
| Laurence, DR | 1 |
| Stern, GM | 1 |
| Bläsig, J | 2 |
| Papeschi, R | 2 |
| Herz, A | 2 |
| Fehling, C | 1 |
| Sacks, OW | 2 |
| Kohl, MS | 1 |
| Messeloff, CR | 2 |
| Schwartz, WF | 2 |
| Puri, S | 1 |
| Burn, JH | 1 |
| Brokken, B | 1 |
| Lewis, FI | 1 |
| Martin, WE | 1 |
| Hughes, RC | 1 |
| Polgar, JG | 1 |
| Weightman, D | 1 |
| Walton, JN | 1 |
| Gunne, LM | 1 |
1 review available for dihydroxyphenylalanine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
The effect of chronic ethanol administration on central neurotransmitter mechanisms.
Topics: 4-Butyrolactone; Animals; Aromatic-L-Amino-Acid Decarboxylases; Behavior, Animal; Brain; Catecholami | 1979 |
3 trials available for dihydroxyphenylalanine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal.
Topics: Adult; Brain Chemistry; Cocaine; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans; Mal | 1997 |
The effect of adding amantadine to optimum L-dopa dosage in Parkinson's syndrome.
Topics: Aged; Amantadine; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; | 1973 |
Levodopa in Parkinsonism: the effects of withdrawal of anticholinergic drugs.
Topics: Dihydroxyphenylalanine; Drug Synergism; Drug Tolerance; Female; Humans; Male; Methods; Neurologic Ma | 1971 |
24 other studies available for dihydroxyphenylalanine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers.
Topics: Adult; Case-Control Studies; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine; Female; Functional N | 2016 |
Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Benzoxazines; B | 2009 |
DOPA-sensitive dystonia-plus syndrome.
Topics: Adolescent; Benserazide; Brain; Child; Child Behavior Disorders; Child, Preschool; Craniofacial Abno | 2005 |
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.
Topics: Animals; Benzofurans; Binding, Competitive; Brain; Carbolines; Cerebral Cortex; Dihydroxyphenylalani | 2005 |
Receptor-mediated dopaminergic function after ethanol withdrawal.
Topics: Alcoholism; Animals; Apomorphine; Brain; Dihydroxyphenylalanine; Dopamine; Haloperidol; Humans; Male | 1980 |
Studies on interactions between striatal dopaminergic and cholinergic mechanisms in the early abstinence after chronic treatment with barbital in the rat.
Topics: Acetylcholine; Animals; Barbital; Barbiturates; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; H | 1984 |
[Role of GABA-ergic and dopaminergic mechanisms in the withdrawal syndrome after discontinuation of long-term phenazepam administration].
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Dihydr | 1980 |
[Certain mechanisms of the effect of acupuncture on the sympatho-adrenal system of tobacco smokers].
Topics: Acupuncture Therapy; Adrenal Medulla; Adult; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; | 1981 |
Chronic L-DOPA treatment of mice: a behavioural and biochemical study.
Topics: Animals; Apomorphine; Benserazide; Body Temperature Regulation; Brain; Clonidine; Dihydroxyphenylala | 1981 |
Apomorphine SC treatment in parkinsonian patients with long-term L-dopa syndrome during L-dopa drug holiday.
Topics: Adult; Aged; Antiparkinson Agents; Apomorphine; Dihydroxyphenylalanine; Dopamine Agents; Drug Admini | 1995 |
Cocaine withdrawal and the cerebral influx of [18F]fluoro-L-DOPA (FDOPA)
Topics: Brain Chemistry; Cocaine; Dihydroxyphenylalanine; Dopamine Uptake Inhibitors; Fluorine Radioisotopes | 1999 |
Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Biogenic Monoam | 2002 |
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Cerebral Cor | 2002 |
Narcotic withdrawal like mouse jumping produced by amphetamine and L-DOPA.
Topics: Amphetamine; Animals; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Fluorometry; Haloperidol; H | 1975 |
Behavioural and biochemical effects of subchronic treatment with raclopride in the rat: tolerance and brain monoamine receptor sensitivity.
Topics: Animals; Apomorphine; Brain; Dihydroxyphenylalanine; Dopamine Antagonists; Drug Tolerance; Male; Mot | 1991 |
Sustained levodopa therapy in parkinsonism.
Topics: Activities of Daily Living; Aged; Cognition Disorders; Dihydroxyphenylalanine; Drug Evaluation; Faci | 1973 |
[Significance of catecholamines for the manifestation of morphine withdrawal in the rat].
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Catecholamines; Desipramine; D | 1974 |
Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Benserazide; Brain Chemistry; Catecholamines; Cocaine; Desip | 1974 |
Effects of levodopa in Parkinsonian patients with dementia.
Topics: Aged; Delirium; Dihydroxyphenylalanine; Evaluation Studies as Topic; Female; Humans; Male; Mental Di | 1972 |
Effect of dopaminergic stimulation or blockade on morphine-withdrawal aggression.
Topics: Aggression; Amphetamine; Animals; Apomorphine; Dihydroxyphenylalanine; Haloperidol; Humans; Male; Me | 1973 |
Levodopa and anticholinergic drugs in Parkinsonism.
Topics: Acetylcholine; Dihydroxyphenylalanine; Dopamine Antagonists; Drug Synergism; Humans; Norepinephrine; | 1971 |
L-DOPA: a nursing adventure.
Topics: Dihydroxyphenylalanine; Humans; Parkinson Disease; Substance Withdrawal Syndrome | 1969 |
Long-term effects of levodopa in the severely disabled patient.
Topics: Chorea; Dihydroxyphenylalanine; Female; Humans; Male; Movement Disorders; Parkinson Disease; Parkins | 1970 |
Some pharmacological agents modifying the morphine abstinence syndrome in dogs.
Topics: Animals; Dihydroxyphenylalanine; Dogs; Drug Tolerance; Humans; Methyldopa; Methyltyrosines; Morphine | 1965 |