dihydroxyphenylalanine has been researched along with Depressive Disorder in 16 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "With the exception of Parkinson's disease, there is little evidence that treatments which decrease DA function are potent inducers of depression, but it is argued that such a relationship might not necessarily be expected." | 2.36 | Dopamine and depression: a review of recent evidence. I. Empirical studies. ( Willner, P, 1983) |
| "Motor symptoms form the hallmark of Parkinson's disease (PD), although other features such as depression are often present." | 1.34 | Striatal dopaminergic activity (FDOPA-PET) associated with cognitive items of a depression scale (MADRS) in Parkinson's disease. ( Koerts, J; Koning, M; Leenders, KL; Portman, AT; van Beilen, M, 2007) |
| "Thirty newly diagnosed patients with Parkinson's disease and 30 patients with primary depressive illness showed slowing of response on a computerized digit symbol substitution test when compared with 30 matched normal control subjects." | 1.27 | Bradyphrenia in Parkinson's disease and psychomotor retardation in depressive illness. An experimental study. ( Lees, AJ; Rogers, D; Smith, E; Stern, GM; Trimble, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KLERMAN, GL | 1 |
| SCHILDKRAUT, JJ | 1 |
| HASENBUSH, LL | 1 |
| GREENBLATT, M | 1 |
| FRIEND, DG | 1 |
| SAINTJEAN, A | 1 |
| DONALD, MW | 1 |
| BAN, TA | 1 |
| Koerts, J | 1 |
| Leenders, KL | 1 |
| Koning, M | 1 |
| Portman, AT | 1 |
| van Beilen, M | 1 |
| Gelenberg, AJ | 1 |
| Gibson, CJ | 1 |
| Wojcik, JD | 1 |
| Willner, P | 3 |
| Patten, SB | 1 |
| Love, EJ | 1 |
| Hietala, J | 1 |
| Syvälahti, E | 1 |
| Vilkman, H | 1 |
| Vuorio, K | 1 |
| Räkköläinen, V | 1 |
| Bergman, J | 1 |
| Haaparanta, M | 1 |
| Solin, O | 1 |
| Kuoppamäki, M | 1 |
| Eronen, E | 1 |
| Ruotsalainen, U | 1 |
| Salokangas, RK | 1 |
| Popkova, EV | 1 |
| Krupina, NA | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Orlova, IN | 1 |
| Iordanskaia, TE | 1 |
| Martinot, M | 1 |
| Bragulat, V | 1 |
| Artiges, E | 1 |
| Dollé, F | 1 |
| Hinnen, F | 1 |
| Jouvent, R | 1 |
| Martinot, J | 1 |
| Agren, H | 1 |
| Reibring, L | 1 |
| Hartvig, P | 1 |
| Tedroff, J | 1 |
| Bjurling, P | 1 |
| Lundqvist, H | 1 |
| Långström, B | 1 |
| Markelova, VF | 1 |
| Belitskaia, RA | 1 |
| Mikhaĭlova, AA | 1 |
| Shumova, OV | 1 |
| Anokhina, ID | 1 |
| Bol'shakova, TD | 1 |
| Bremer, GP | 1 |
| Buniatian, AF | 1 |
| Ignatenko, LL | 1 |
| Rogers, D | 1 |
| Lees, AJ | 1 |
| Smith, E | 1 |
| Trimble, M | 1 |
| Stern, GM | 1 |
| Nosachev, GN | 1 |
| Borinskiĭ, IuN | 1 |
| Podkovkin, VG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis[NCT05282277] | Phase 4 | 103 participants (Anticipated) | Interventional | 2022-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for dihydroxyphenylalanine and Depressive Disorder
| Article | Year |
|---|---|
Neurotransmitter precursors for the treatment of depression.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Biogenic Amines; Catecholamines; Depressive Dis | 1982 |
Dopamine and depression: a review of recent evidence. I. Empirical studies.
Topics: Amphetamine; Antipsychotic Agents; Brain; Bromocriptine; Depressive Disorder; Dihydroxyphenylalanine | 1983 |
Dopamine and depression: a review of recent evidence. III. The effects of antidepressant treatments.
Topics: Amphetamine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Bra | 1983 |
The validity of animal models of depression.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Behavior, Animal; Circadian Rhythm; Depressive Disorder; | 1984 |
Drug-induced depression. Incidence, avoidance and management.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Anabolic Agents; Benzodiazepines; Calcium Chan | 1994 |
11 other studies available for dihydroxyphenylalanine and Depressive Disorder
| Article | Year |
|---|---|
CLINICAL EXPERIENCE WITH DIHYDROXYPHENYLALANINE (DOPA) IN DEPRESSION.
Topics: Depression; Depressive Disorder; Dihydroxyphenylalanine; Humans; Monoamine Oxidase Inhibitors; Place | 1963 |
[THE PSYCHOPHYSIOLOGICAL EFFECTS OF METHYLDOPA].
Topics: Blood Pressure; Blood Pressure Determination; Depression; Depressive Disorder; Dihydroxyphenylalanin | 1963 |
Striatal dopaminergic activity (FDOPA-PET) associated with cognitive items of a depression scale (MADRS) in Parkinson's disease.
Topics: Aged; Brain Chemistry; Caudate Nucleus; Cognition Disorders; Corpus Striatum; Depressive Disorder; D | 2007 |
Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia.
Topics: Adolescent; Adult; Corpus Striatum; Depressive Disorder; Dihydroxyphenylalanine; Dopamine; Female; F | 1999 |
[Monoamine level in the rat brain with MPTP-induced depressive syndrome].
Topics: Animals; Biogenic Monoamines; Brain; Depressive Disorder; Dihydroxyphenylalanine; Dopamine; Dopamine | 1999 |
Decreased presynaptic dopamine function in the left caudate of depressed patients with affective flattening and psychomotor retardation.
Topics: Adult; Caudate Nucleus; Depressive Disorder; Dihydroxyphenylalanine; Dopamine; Female; Functional La | 2001 |
PET studies with L-[11C]5-HTP and L-[11C]dopa in brains of healthy volunteers and patients with major depression.
Topics: 5-Hydroxytryptophan; Adult; Aged; Brain; Brain Chemistry; Carbon Isotopes; Depressive Disorder; Dihy | 1992 |
[Serotoninergic and catecholaminergic indices in patients with neurotic and depressive disorders and changes in them as a result of reflexotherapy].
Topics: Acupuncture Therapy; Adult; Catecholamines; Depressive Disorder; Dihydroxyphenylalanine; Female; Hum | 1986 |
[Features of the functioning of the catecholamine and adrenocortical systems of patients with depression and different degrees of emotional tension].
Topics: 11-Hydroxycorticosteroids; Adrenal Cortex; Catecholamines; Depressive Disorder; Dexamethasone; Dihyd | 1986 |
Bradyphrenia in Parkinson's disease and psychomotor retardation in depressive illness. An experimental study.
Topics: Brain; Depressive Disorder; Dihydroxyphenylalanine; Dopamine; Female; Humans; Intelligence Tests; Ma | 1987 |
[Characteristics of the catecholamine system in patients with endogenous depression before and after sleep deprivation therapy and tricyclic antidepressants].
Topics: Adult; Antidepressive Agents, Tricyclic; Catecholamines; Combined Modality Therapy; Depressive Disor | 1988 |