dihydroxyphenylalanine has been researched along with Dementia in 24 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Braak's staging concept of Lewy body disease pathogenesis is based on a spatiotemporal sequence of alpha-synuclein deposition, with autonomic nervous system involvement before synucleinopathy in substantia nigra neurons." | 3.78 | Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy. ( Goldstein, DS; Holmes, C; Park, MY; Sewell, L; Sharabi, Y, 2012) |
| "A series of 203 patients with primary Parkinson's disease treated with L-DOPA, with adequate neurological documentation of mental status at serial intervals during their illness, constitutes the study population." | 1.27 | Dementia in idiopathic Parkinson's disease. Variables associated with its occurrence in 203 patients. ( Elizan, TS; Maker, H; Smith, H; Sroka, H; Yahr, MD, 1986) |
| "The subcortical dementias have a striking clinical resemblance to the dementia which occurs after bifrontal lobe disease." | 1.25 | The 'subcortical dementia' of progressive supranuclear palsy. ( Albert, ML; Feldman, RG; Willis, AL, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (79.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Pineda-Pardo, JA | 1 |
| Gasca-Salas, C | 1 |
| Fernández-Rodríguez, B | 1 |
| Rodríguez-Rojas, R | 1 |
| Del Álamo, M | 1 |
| Obeso, I | 1 |
| Hernández-Fernández, F | 1 |
| Trompeta, C | 1 |
| Martínez-Fernández, R | 1 |
| Matarazzo, M | 1 |
| Mata-Marín, D | 1 |
| Guida, P | 1 |
| Duque, A | 1 |
| Albillo, D | 1 |
| Plaza de Las Heras, I | 1 |
| Montero, JI | 1 |
| Foffani, G | 1 |
| Toltsis, G | 1 |
| Rachmilevitch, I | 1 |
| Blesa, J | 1 |
| Obeso, JA | 1 |
| Goldstein, DS | 1 |
| Holmes, C | 1 |
| Sewell, L | 1 |
| Park, MY | 1 |
| Sharabi, Y | 1 |
| Kato, T | 1 |
| Itoh, M | 1 |
| Meguro, K | 1 |
| Fujiwara, T | 1 |
| Hatazawa, J | 1 |
| Iwata, R | 1 |
| Ishiwata, K | 1 |
| Takahashi, T | 1 |
| Ido, T | 1 |
| Sasaki, H | 1 |
| Otsuka, M | 1 |
| Ichiya, Y | 1 |
| Kuwabara, Y | 1 |
| Hosokawa, S | 1 |
| Sasaki, M | 1 |
| Fukumura, T | 1 |
| Masuda, K | 1 |
| Goto, I | 1 |
| Kato, M | 1 |
| Elizan, TS | 1 |
| Sroka, H | 1 |
| Maker, H | 1 |
| Smith, H | 1 |
| Yahr, MD | 2 |
| Van Woert, MH | 2 |
| Heninger, G | 1 |
| Rathey, U | 1 |
| Bowers, MB | 2 |
| Sacks, OW | 1 |
| Messeloff, C | 1 |
| Schartz, W | 1 |
| Goldfarb, A | 1 |
| Kohl, M | 1 |
| Schnur, JA | 1 |
| Chase, TN | 3 |
| Brody, JA | 3 |
| Broe, GA | 1 |
| Caird, FI | 1 |
| Holden, EM | 2 |
| Lehmann, J | 2 |
| Powell, HC | 1 |
| London, GW | 1 |
| Lampert, PW | 1 |
| Albert, ML | 1 |
| Feldman, RG | 1 |
| Willis, AL | 1 |
| Lieberman, AN | 1 |
| Parkes, JD | 1 |
| Marsden, CD | 1 |
| Rees, JE | 1 |
| Curzon, G | 1 |
| Kantamaneni, BD | 1 |
| Knill-Jones, R | 1 |
| Akbar, A | 1 |
| Das, S | 1 |
| Kataria, M | 1 |
| Klawans, HL | 2 |
| Garron, DC | 1 |
| Narin, F | 1 |
| Cia Madariaga, FM | 1 |
| Rud, C | 1 |
| Rovira, B | 1 |
| Mantilaro, E | 1 |
| Alvarez, O | 1 |
| Baretic, E | 1 |
| Moro, R | 1 |
| McDowell, F | 1 |
| Lee, JE | 1 |
| Swift, T | 1 |
| Sweet, RD | 1 |
| Ogsbury, JS | 1 |
| Kessler, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Feasibility of Temporary Blood Brain Barrier Disruption (BBBD) Using Exablate MR Guided Focused Ultrasound in Patients With Parkinson's Disease Dementia[NCT03608553] | 10 participants (Anticipated) | Interventional | 2018-11-26 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dihydroxyphenylalanine and Dementia
| Article | Year |
|---|---|
L-dopa in neurological disease: current status.
Topics: Aged; Amyotrophic Lateral Sclerosis; Basal Ganglia Diseases; Cerebellar Diseases; Cerebrovascular Di | 1972 |
Observations on the range of efficacy of L-dopa.
Topics: Brain Diseases; Brain Stem; Cerebellar Diseases; Dementia; Dihydroxyphenylalanine; Dopamine; Extrapy | 1971 |
1 trial available for dihydroxyphenylalanine and Dementia
| Article | Year |
|---|---|
Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Corpus Striatum; Dementia; Dihydroxyp | 2022 |
21 other studies available for dihydroxyphenylalanine and Dementia
| Article | Year |
|---|---|
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.
Topics: Aged; alpha-Synuclein; Autonomic Denervation; Dementia; Dihydroxyphenylalanine; Disease Progression; | 2012 |
[Evaluation of dopaminergic presynaptic function by [F-18] DOPA PET].
Topics: Dementia; Dihydroxyphenylalanine; Humans; Parkinson Disease; Positron-Emission Tomography; Presynapt | 2007 |
Assessment of dopamine metabolism in brain of patients with dementia by means of 18F-fluorodopa and PET.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Brain; Corpus Striatum; Dementia; Dementia, Vascular; | 1994 |
Cerebral glucose metabolism and striatal 18F-dopa uptake by PET in cases of chorea with or without dementia.
Topics: Adult; Aged; Brain; Caudate Nucleus; Chorea; Corpus Striatum; Dementia; Dihydroxyphenylalanine; Fema | 1993 |
Dementia in idiopathic Parkinson's disease. Variables associated with its occurrence in 203 patients.
Topics: Age Factors; Aged; Dementia; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Movement Dis | 1986 |
L-dopa in senile dementia.
Topics: Aged; Aphrodisiacs; Brain; Dementia; Dihydroxyphenylalanine; Female; Humans; Movement Disorders; Par | 1970 |
Effects of L-dopa in patients with dementia.
Topics: Delirium; Dementia; Dihydroxyphenylalanine; Humans; Parkinson Disease | 1970 |
Parkinsonism-dementia of Guam: treatment with L-dopa.
Topics: Adult; Dementia; Dihydroxyphenylalanine; Drug Eruptions; Female; Humans; Hydroxyindoleacetic Acid; H | 1971 |
Levodopa for parkinsonism in elderly and demented patients.
Topics: Activities of Daily Living; Aged; Cardiovascular Diseases; Dementia; Dihydroxyphenylalanine; Drug Sy | 1973 |
Levodopa-induced dyskinesias. Comparison in Parkinsonism-dementia and amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Carbidopa; Dementia; Dihydroxyphenylalanine; Female; Hum | 1973 |
Tryptophan malabsorption in levodopa-treated parkinsonian patients. Effect of tryptophan on mental disturbances.
Topics: Aged; Brain; Dementia; Depression, Chemical; Dihydroxyphenylalanine; Female; Humans; Hydroxyindoleac | 1973 |
Neurofibrillary tangles in progressive supranuclear palsy. Electron microscopic observations.
Topics: Aged; Amantadine; Brain; Brain Diseases; Bulbar Palsy, Progressive; Dementia; Dihydroxyphenylalanine | 1974 |
The 'subcortical dementia' of progressive supranuclear palsy.
Topics: Affective Symptoms; Aged; Brain; Brain Diseases; Bulbar Palsy, Progressive; Cognition Disorders; Dem | 1974 |
Parkinson's disease: a clinical review.
Topics: Adult; Aged; Brain Diseases; Bulbar Palsy, Progressive; Dementia; Diagnosis, Differential; Dihydroxy | 1974 |
Parkinson's disease, cerebral arteriosclerosis, and senile dementia. Clinical features and response to levodopa.
Topics: Aged; Dementia; Dihydroxyphenylalanine; Electroencephalography; Female; Gait; Homovanillic Acid; Hum | 1974 |
[Serum tryptophan in cases with senile dementia, parkinsonism and normal cases].
Topics: Adult; Aged; Dementia; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Parkinson Disease; | 1974 |
Parkinsonism-dementia of Guam: treatment with levodopa and L-alpha-methyldopahydrazine.
Topics: Adult; Aged; Carbidopa; Dementia; Dihydroxyphenylalanine; Drug Synergism; Evaluation Studies as Topi | 1974 |
Intellectual functioning of persons with idiopathic Parkinsonism.
Topics: Aged; Cerebral Cortex; Computers; Dementia; Dihydroxyphenylalanine; Evaluation Studies as Topic; Fem | 1972 |
[Preliminary report on the treatment of dementia syndromes with levodopa].
Topics: Adult; Aged; Dementia; Dihydroxyphenylalanine; Humans; Middle Aged | 1971 |
Treatment of Parkinson's syndrome with L dihydroxyphenylalanine (levodopa).
Topics: Aged; Dementia; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Male; Middle Aged; Parasympa | 1970 |
Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) during L-dopa therapy of Parkinson's disease.
Topics: Dementia; Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Parkinson Disease; Phenylacetate | 1970 |