Page last updated: 2024-10-18

dihydroxyphenylalanine and Dementia Praecox

dihydroxyphenylalanine has been researched along with Dementia Praecox in 80 studies

Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.

Research Excerpts

ExcerptRelevanceReference
"In order to investigate possible disturbances of the blood-brain transport mechanisms of monoamine precursors in manic-depressive illness and schizophrenia, we have measured the brain arterio-venous difference of DOPA, or 5-HTP, or tyrosine and tryptophan in 36 patients, during the infusion of either L-DOPA or L-5-HTP."7.66Blood-brain movements of tryptophan and tyrosine in manic-depressive illness and schizophrenia. ( Gaillard, JM; Tissot, R, 1979)
"Clozapine is an atypical neuroleptic medication with superior efficacy to conventional antipsychotic agents for patients with chronic, symptomatic schizophrenia."5.07The effect of clozapine on plasma norepinephrine: relationship to clinical efficacy. ( Breier, A; Buchanan, RW; Goldstein, DS; Holmes, C; Listwak, S; Waltrip, RW, 1994)
"In order to investigate possible disturbances of the blood-brain transport mechanisms of monoamine precursors in manic-depressive illness and schizophrenia, we have measured the brain arterio-venous difference of DOPA, or 5-HTP, or tyrosine and tryptophan in 36 patients, during the infusion of either L-DOPA or L-5-HTP."3.66Blood-brain movements of tryptophan and tyrosine in manic-depressive illness and schizophrenia. ( Gaillard, JM; Tissot, R, 1979)
"Twelve patients with treatment-resistant schizophrenia, twelve patients with schizophrenia who had responded to antipsychotics, and twelve healthy volunteers matched for gender, age, ethnicity, weight, and cigarette smoking underwent [(18)F]-DOPA PET scanning."1.38Dopamine synthesis capacity in patients with treatment-resistant schizophrenia. ( Demjaha, A; Howes, OD; Kapur, S; McGuire, PK; Murray, RM, 2012)

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199056 (70.00)18.7374
1990's5 (6.25)18.2507
2000's7 (8.75)29.6817
2010's10 (12.50)24.3611
2020's2 (2.50)2.80

Authors

AuthorsStudies
Sabaroedin, K1
Razi, A1
Chopra, S1
Tran, N2
Pozaruk, A1
Chen, Z1
Finlay, A1
Nelson, B1
Allott, K1
Alvarez-Jimenez, M1
Graham, J1
Yuen, HP1
Harrigan, S1
Cropley, V1
Sharma, S1
Saluja, B1
Williams, R1
Pantelis, C1
Wood, SJ1
O'Donoghue, B1
Francey, S1
McGorry, P1
Aquino, K1
Fornito, A1
Avram, M1
Brandl, F1
Knolle, F1
Cabello, J1
Leucht, C1
Scherr, M1
Mustafa, M1
Koutsouleris, N1
Leucht, S1
Ziegler, S1
Sorg, C1
Eisenberg, DP1
Yankowitz, L1
Ianni, AM1
Rubinstein, DY1
Kohn, PD2
Hegarty, CE1
Gregory, MD1
Apud, JA1
Berman, KF2
Jauhar, S3
Nour, MM1
Veronese, M4
Rogdaki, M2
Bonoldi, I3
Azis, M1
Turkheimer, F2
McGuire, P1
Young, AH1
Howes, OD9
Dahoun, T2
Pardiñas, AF2
Bloomfield, MAP2
Froudist-Walsh, S2
Nosarti, C1
Korth, C1
Hennah, W1
Walters, J1
Prata, D1
D'Ambrosio, E1
Walters, JTR1
Demjaha, A2
Egerton, A2
Murray, RM3
Kapur, S2
Stone, JM1
McGuire, PK5
Williams, M1
Ibrahim, K1
Leung, G1
Kim, E1
Beck, K1
Seo, S1
Park, JW1
Lee, JS1
Lee, YS1
Kwon, JS1
Montgomery, AJ1
Asselin, MC2
Valli, I2
Tabraham, P1
Bramon-Bosch, E1
Valmaggia, L1
Johns, L1
Broome, M2
Grasby, PM2
Fusar-Poli, P1
Allen, P1
Booij, J1
van Amelsvoort, T1
TAKESADA, M1
KAKIMOTO, Y1
SANO, I1
KANEKO, Z1
SAINTJEAN, A1
DONALD, MW1
BAN, TA1
KUEHL, FA2
HICHENS, M1
ORMOND, RE2
MEISINGER, MA2
GALE, PH1
CIRILLO, VJ2
BRINK, NG2
TURNER, WJ1
MERLIS, S5
LENZ, H1
Schönfeldt-Lecuona, C1
Juengling, FD1
Connemann, BJ1
Reske, SN1
Spitzer, M1
Kassubek, J1
McGowan, S1
Lawrence, AD1
Sales, T1
Quested, D1
Grasby, P1
Kumakura, Y1
Cumming, P2
Vernaleken, I1
Buchholz, HG1
Siessmeier, T1
Heinz, A1
Kienast, T1
Bartenstein, P1
Gründer, G1
Huttunen, J1
Heinimaa, M1
Svirskis, T1
Nyman, M1
Kajander, J1
Forsback, S1
Solin, O3
Ilonen, T1
Korkeila, J1
Ristkari, T1
McGlashan, T1
Salokangas, RK2
Hietala, J3
Krupenina, LB1
Vinogradov, MV1
Tegeler, J1
Wöller, W1
Misionzhnik, EIu1
Vertogradova, OP1
Krasnov, VN1
Salenko, BB1
Anokhina, IP1
Kogan, BM1
Young, SN1
Gauthier, S1
Chouinard, G2
Anderson, GM1
Purdy, WC1
Syvälahti, E2
Vuorio, K2
Räkköläinen, V2
Bergman, J2
Haaparanta, M2
Kuoppamäki, M2
Kirvelä, O1
Ruotsalainen, U2
Reith, J1
Benkelfat, C1
Sherwin, A1
Yasuhara, Y1
Kuwabara, H1
Andermann, F1
Bachneff, S1
Diksic, M1
Dyve, SE1
Etienne, P1
Evans, AC1
Lal, S1
Shevell, M1
Savard, G1
Wong, DF1
Gjedde, A1
Breier, A2
Buchanan, RW1
Waltrip, RW1
Listwak, S1
Holmes, C1
Goldstein, DS2
Elman, I1
Eisenhofer, G1
Folio, J1
Malhotra, AK1
Adler, CM1
Pickar, D1
Vilkman, H1
Eronen, E1
Elkashef, AM1
Doudet, D1
Bryant, T1
Cohen, RM1
Li, SH1
Wyatt, RJ1
Meyer-Lindenberg, A1
Miletich, RS1
Esposito, G1
Carson, RE1
Quarantelli, M1
Weinberger, DR1
Carlsson, A2
Mileikovskii, IuA1
Gaillard, JM1
Tissot, R2
Mato, M1
Uchiyama, Y1
Kurihara, K1
Karasawa, T1
Levin, SL1
Beaton, JM1
Fleming, P1
Makar, H1
Hunter, KR1
Hegedus, ZL1
Altschule, MD1
Nayak, U1
Roberts, E1
Keegan, DL1
Rajput, AH1
Lipton, MA1
Matthysse, S1
Stevens, J1
Wilson, K1
Foote, W1
Barchas, JD1
Ciaranello, RD1
Dominic, JA1
Deguchi, T1
Orenberg, EK1
Renson, J1
Kessler, S1
Crawford, JP1
Kanig, K1
Oesterle, W1
Klawans, HL1
Goetz, C1
Westheimer, R1
Bryson, G1
Snyder, SH1
Angrist, B2
Sathananthan, G3
Wilk, S1
Gershon, S3
Horvath, TB1
Meares, RA1
Israelstam, DM1
Yaryura-Tobias, JA3
Diamond, B2
Stancer, HC1
Angrist, BM1
Mathieu, P1
Charvet, JC1
Chazot, G1
Trouillas, P1
Inanaga, K2
Inoue, K1
Tachibana, H2
Oshima, M2
Kotorii, T1
Hökfelt, T1
Ljungdahl, A1
Fuxe, K1
Johansson, O1
Rysánek, K1
Matussek, N1
Tran-Manh, N1
Laplante, M2
Saint-Laurent, J1
LeBel, E2
Kimura, N1
Tsukue, I1
Nakamura, K1
Koketsu, K1
Persson, T1
Roos, BE1
Bruno, A2
Bruno, SC1
Wolpert, A1
Dana, L1
Bunney, WE1
Tobias, JA1
Allegranza, A1
Wagner, AF1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Controlled Double Blind Crossover Study of the Effect of a Single Dose of N-acetylcysteine Versus Placebo on Brain Glutamate in Patients With Psychotic Disorders[NCT02483130]20 participants (Actual)Observational2015-06-30Completed
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis[NCT05282277]Phase 4103 participants (Anticipated)Interventional2022-04-20Recruiting
Inpatient Evaluation of Neuropsychiatric Patients[NCT00001247]700 participants (Anticipated)Observational1989-09-15Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for dihydroxyphenylalanine and Dementia Praecox

ArticleYear
Imaging as tool to investigate psychoses and antipsychotics.
    Handbook of experimental pharmacology, 2012, Issue:212

    Topics: Antipsychotic Agents; Diagnostic Imaging; Dihydroxyphenylalanine; Dopamine; Dopamine Plasma Membrane

2012
The common pathophysiology of monaminergic psychoses: a new hypothesis.
    Neuropsychobiology, 1975, Volume: 1, Issue:4

    Topics: 5-Hydroxytryptophan; Amino Acids; Biological Transport, Active; Bipolar Disorder; Blood-Brain Barrie

1975
Methylation & schizophrenia.
    The Alabama journal of medical sciences, 1975, Volume: 12, Issue:2

    Topics: Amines; Amino Acids; Animals; Behavior, Animal; Catecholamines; Cats; Cystathionine; Cysteine; Dihyd

1975
Implications of catecholamine systems of the brain in schizophrenia.
    Research publications - Association for Research in Nervous and Mental Disease, 1974, Volume: 53

    Topics: Amphetamine; Brain; Catecholamines; Chlorpromazine; Dihydroxyphenylalanine; Dopamine; Histamine H1 A

1974
[Biochemical treatment possibilities in psychoses].
    Die Medizinische Welt, 1969, Sep-06, Volume: 36

    Topics: Amino Acids; Ascorbic Acid; Dihydroxyphenylalanine; Humans; Methionine; Niacinamide; Nicotinic Acids

1969
Pathophysiology of schizophrenia and the striatum.
    Diseases of the nervous system, 1972, Volume: 33, Issue:11

    Topics: Adult; Amphetamine; Animals; Basal Ganglia; Catalepsy; Caudate Nucleus; Dihydroxyphenylalanine; Dopa

1972
Catecholamines in the brain as mediators of amphetamine psychosis.
    Archives of general psychiatry, 1972, Volume: 27, Issue:2

    Topics: Amphetamine; Animals; Antidepressive Agents; Brain Chemistry; Bromides; Catecholamines; Cats; Cocain

1972
Psychopharmacology. Yesterday, today and tomorrow: a point of view.
    Canadian Psychiatric Association journal, 1973, Volume: 18, Issue:5

    Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Canada; Carbonates; Depression; Dihydroxyp

1973
[Relation of monoamines to mental disorders].
    Activitas nervosa superior, 1970, Volume: 12, Issue:2

    Topics: Amines; Animals; Bipolar Disorder; Catecholamines; Central Nervous System; Depression; Dihydroxyphen

1970

Trials

9 trials available for dihydroxyphenylalanine and Dementia Praecox

ArticleYear
The effect of clozapine on plasma norepinephrine: relationship to clinical efficacy.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1994, Volume: 10, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenocorticotropic Hormone; Adult; Analysis of Variance; Clozapine;

1994
Mechanism of peripheral noradrenergic stimulation by clozapine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:1

    Topics: Adult; Analysis of Variance; Antipsychotic Agents; Catechols; Clozapine; Dihydroxyphenylalanine; Fem

1999
Levodopa in drug-induced extrapyramidal disorders.
    Lancet (London, England), 1970, Dec-05, Volume: 2, Issue:7684

    Topics: Dihydroxyphenylalanine; Extrapyramidal Tracts; Fluphenazine; Humans; Movement Disorders; Orphenadrin

1970
Psychiatric manifestations of levodopa.
    Canadian Psychiatric Association journal, 1972, Volume: 17, Issue:2

    Topics: Adult; Affect; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Evaluation Studies as T

1972
Behavioral effects of L-dopa in schizophrenic patients.
    Psychopharmacologia, 1973, Jul-04, Volume: 31, Issue:1

    Topics: Adult; Analysis of Variance; Behavior; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Hum

1973
Response threshold to levodopa in psychiatric patients.
    Biological psychiatry, 1973, Volume: 7, Issue:2

    Topics: Adult; Brain Chemistry; Clinical Trials as Topic; Cognition Disorders; Dihydroxyphenylalanine; Dopam

1973
Clinical and animal experiments concerning the function of brain catecholamines.
    International pharmacopsychiatry, 1971, Volume: 6, Issue:3

    Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Ca

1971
The action of L-dopa on schizophrenic patients (a preliminary report).
    Current therapeutic research, clinical and experimental, 1970, Volume: 12, Issue:8

    Topics: Adult; Clinical Trials as Topic; Dihydroxyphenylalanine; Humans; Male; Middle Aged; Placebos; Schizo

1970
Effects of L-DOPA on pharmacological parkinsonism.
    Acta psychiatrica Scandinavica, 1966, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Haloper

1966

Other Studies

62 other studies available for dihydroxyphenylalanine and Dementia Praecox

ArticleYear
Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum.
    Brain : a journal of neurology, 2023, 01-05, Volume: 146, Issue:1

    Topics: Dihydroxyphenylalanine; Dopamine; Humans; Magnetic Resonance Imaging; Neural Pathways; Psychotic Dis

2023
Aberrant striatal dopamine links topographically with cortico-thalamic dysconnectivity in schizophrenia.
    Brain : a journal of neurology, 2020, 12-05, Volume: 143, Issue:11

    Topics: Adult; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Humans; Magnetic

2020
Presynaptic Dopamine Synthesis Capacity in Schizophrenia and Striatal Blood Flow Change During Antipsychotic Treatment and Medication-Free Conditions.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:11

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Do

2017
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia.
    JAMA psychiatry, 2017, 12-01, Volume: 74, Issue:12

    Topics: Adult; Bipolar Disorder; Case-Control Studies; Cross-Sectional Studies; Dihydroxyphenylalanine; Dopa

2017
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.
    Human molecular genetics, 2018, 10-15, Volume: 27, Issue:20

    Topics: Adult; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Genetic Predisposition to Disease;

2018
The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study.
    Psychiatry research. Neuroimaging, 2019, 09-30, Volume: 291

    Topics: Adult; Chromosomes, Human, Pair 10; Corpus Striatum; Cytoskeletal Proteins; Dihydroxyphenylalanine;

2019
Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function.
    Biological psychiatry, 2014, Mar-01, Volume: 75, Issue:5

    Topics: Analysis of Variance; Antipsychotic Agents; Aspartic Acid; Dihydroxyphenylalanine; Dopamine; Female;

2014
Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study.
    Brain : a journal of neurology, 2013, Volume: 136, Issue:Pt 11

    Topics: Adult; Depressive Disorder, Major; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Female; Humans

2013
Presynaptic Dopamine Capacity in Patients with Treatment-Resistant Schizophrenia Taking Clozapine: An [
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:4

    Topics: Antipsychotic Agents; Biomarkers; Clozapine; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male;

2017
Elevated striatal dopamine function linked to prodromal signs of schizophrenia.
    Archives of general psychiatry, 2009, Volume: 66, Issue:1

    Topics: Adult; Brain Mapping; Cognition Disorders; Corpus Striatum; Diagnostic and Statistical Manual of Men

2009
Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study.
    Archives of general psychiatry, 2010, Volume: 67, Issue:7

    Topics: Adult; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Frontal Lobe; Functional Laterality; Human

2010
Dopamine synthesis capacity in patients with treatment-resistant schizophrenia.
    The American journal of psychiatry, 2012, Volume: 169, Issue:11

    Topics: Adult; Antipsychotic Agents; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Drug Resistance; Fem

2012
3,4-DIMETHOXYPHENYLETHYLAMINE AND OTHER AMINES IN THE URINE OF SCHIZOPHRENIC PATIENTS.
    Nature, 1963, Jul-13, Volume: 199

    Topics: Amines; Chlorpromazine; Chromatography; Dihydroxyphenylalanine; Dimethoxyphenylethylamine; Dopamine;

1963
[THE PSYCHOPHYSIOLOGICAL EFFECTS OF METHYLDOPA].
    L'union medicale du Canada, 1963, Volume: 92

    Topics: Blood Pressure; Blood Pressure Determination; Depression; Depressive Disorder; Dihydroxyphenylalanin

1963
PARA-O-METHYLATION OF DOPAMINE IN SCHIZOPHRENIC AND NORMAL INDIVIDUALS.
    Nature, 1964, Jul-11, Volume: 203

    Topics: Chromatography; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Metabolism; Methylation; Nore

1964
A CLINICAL TRIAL OF PARGYLINE AND DOPA IN PSYCHOTIC SUBJECTS.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Adolescent; Biomedical Research; Brain; Brain Damage, Chronic; Depression; Depressive Disorder, Majo

1964
[Paper chromatographic studies on the urine of schizophrenics and healthy subjects before and after DOPA administration].
    Psychopharmacologia, 1962, Volume: 3

    Topics: Chromatography; Chromatography, Paper; Dihydroxyphenylalanine; Healthy Volunteers; Humans; Schizophr

1962
Complete dopamine D2 receptor occupancy without extrapyramidal side effects under benperidol.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:1

    Topics: Adult; Basal Ganglia; Benperidol; Carbon Radioisotopes; Clozapine; Dihydroxyphenylalanine; Dyskinesi

2004
Presynaptic dopaminergic dysfunction in schizophrenia: a positron emission tomographic [18F]fluorodopa study.
    Archives of general psychiatry, 2004, Volume: 61, Issue:2

    Topics: Adult; Case-Control Studies; Cognition; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Humans; M

2004
Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Jul-25, Volume: 27, Issue:30

    Topics: Adult; Brain; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Male; Positron-Emission Tomogr

2007
Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia.
    Biological psychiatry, 2008, Jan-01, Volume: 63, Issue:1

    Topics: Adult; Analysis of Variance; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Rad

2008
[State of the adrenergic and cholinergic systems of schizophrenic patients during the process of psychopharmacotherapy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1980, Volume: 80, Issue:5

    Topics: Acetylcholine; Acetylcholinesterase; Adult; Antipsychotic Agents; Catecholamines; Dihydroxyphenylala

1980
[Therapeutic measures in tardive dyskinesia].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:6

    Topics: Age Factors; Amantadine; Antipsychotic Agents; Baclofen; Benzodiazepines; Bromocriptine; Deanol; Dih

1983
[Changes in the levels of adrenergic and serotoninergic indices in patients with depressive states].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1981, Volume: 81, Issue:4

    Topics: Adolescent; Adult; Biogenic Amines; Depression; Dihydroxyphenylalanine; Dopamine; Epinephrine; Homov

1981
[Various features of dopamine metabolism in schizophrenia].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1981, Volume: 81, Issue:9

    Topics: Dihydroxyphenylalanine; Dopamine; Epinephrine; Homovanillic Acid; Humans; Norepinephrine; Schizophre

1981
The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.
    Journal of neural transmission, 1982, Volume: 53, Issue:1

    Topics: 5-Hydroxytryptophan; Adult; Benserazide; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Humans;

1982
Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients.
    Lancet (London, England), 1995, Oct-28, Volume: 346, Issue:8983

    Topics: Adult; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radioisotopes; Humans; Ma

1995
Elevated dopa decarboxylase activity in living brain of patients with psychosis.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Nov-22, Volume: 91, Issue:24

    Topics: Adult; Animals; Brain; Dihydroxyphenylalanine; Dopa Decarboxylase; Epilepsy, Complex Partial; Female

1994
Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia.
    Schizophrenia research, 1999, Jan-04, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Corpus Striatum; Depressive Disorder; Dihydroxyphenylalanine; Dopamine; Female; F

1999
6-(18)F-DOPA PET study in patients with schizophrenia. Positron emission tomography.
    Psychiatry research, 2000, Nov-20, Volume: 100, Issue:1

    Topics: Adult; Antipsychotic Agents; Aromatic-L-Amino-Acid Decarboxylases; Brain; Case-Control Studies; Chro

2000
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia.
    Nature neuroscience, 2002, Volume: 5, Issue:3

    Topics: Cerebrovascular Circulation; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Fluorine Radioisotop

2002
[Cerebral amines].
    Nihon rinsho. Japanese journal of clinical medicine, 1976, Sep-10, Volume: 34, Issue:9

    Topics: Amines; Animals; Brain; Dihydroxyphenylalanine; Haplorhini; Humans; Mental Disorders; Mice; Neurons;

1976
Does dopamine play a role in schizophrenia?
    Psychological medicine, 1977, Volume: 7, Issue:4

    Topics: 5-Hydroxytryptophan; Acetylcholine; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Brain;

1977
[Excretion of catecholamines and tryptophan derivatives in schizophrenia].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:5

    Topics: Adolescent; Adult; Biogenic Amines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Humans; H

1976
Blood-brain movements of tryptophan and tyrosine in manic-depressive illness and schizophrenia.
    Journal of neural transmission. Supplementum, 1979, Issue:15

    Topics: Adult; Bipolar Disorder; Blood-Brain Barrier; Brain; Dihydroxyphenylalanine; Humans; Middle Aged; Sc

1979
Fluorescent substance in leukocytes and platelets of psychiatric patients.
    Biological psychiatry, 1977, Volume: 12, Issue:6

    Topics: Bipolar Disorder; Blood Platelets; Depression; Dihydroxyphenylalanine; Dopamine; Histocytochemistry;

1977
[Stein and Wise's neurochemical model of schizophrenia].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1977, Volume: 77, Issue:1

    Topics: Biogenic Amines; Brain; Brain Mapping; Catechol O-Methyltransferase; Chemical Phenomena; Chemistry;

1977
Studies on rheomelanins. 3. Excessive hemolysis associated with the production of rheomelanins from L-norepinephrine, from dopamine and from L-dopa in the blood of chronic schizophrenic patients.
    Archives internationales de physiologie et de biochimie, 1971, Volume: 79, Issue:2

    Topics: Chromatography, Paper; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Erythrocytes; Hemolysis; H

1971
Contributions of neurochemistry to neurology and psychiatry. Introduction.
    Federation proceedings, 1973, Volume: 32, Issue:2

    Topics: Aminobutyrates; Basal Ganglia; Brain; Dihydroxyphenylalanine; Humans; Neural Inhibition; Neurotransm

1973
Drug induced dystonia tarda: treatment with L-dopa.
    Diseases of the nervous system, 1973, Volume: 34, Issue:3

    Topics: Antipsychotic Agents; Chlorpromazine; Chronic Disease; Diazepam; Dihydroxyphenylalanine; Dystonia Mu

1973
Neuropsychopharmacology of monoamines and their regulatory enzymes.
    Advances in biochemical psychopharmacology, 1974, Volume: 12, Issue:0

    Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Apomorphine; Biogenic Amines; Brain; Cocaine; Dextroamphe

1974
GABA blockade, dopamine and schizophrenia: experimental studies in the cat.
    Psychopharmacologia, 1974, Volume: 39, Issue:2

    Topics: Alkaloids; Aminobutyrates; Amitriptyline; Animals; Atropine; Behavior, Animal; Cats; Dextroamphetami

1974
Genetic differences in mechanisms involving neuroregulators.
    Journal of psychiatric research, 1974, Volume: 11

    Topics: Adrenal Medulla; Animals; Brain; Catecholamines; Cyclic AMP; Dihydroxyphenylalanine; Dopamine; Dopam

1974
Antipsychotic drugs and catecholamine synapses.
    Journal of psychiatric research, 1974, Volume: 11

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Binding, Competitive; Brain; Catecholamines; Chlorprom

1974
Dopa in parkinson's disease.
    Lancet (London, England), 1969, Nov-08, Volume: 2, Issue:7628

    Topics: Chorea; Dihydroxyphenylalanine; Humans; Parkinson Disease; Schizophrenia

1969
Biogenic amines in normal and abnormal behavioral states.
    Clinical chemistry, 1971, Volume: 17, Issue:1

    Topics: Acetylcholine; Aggression; Aminobutyrates; Arousal; Blood-Brain Barrier; Brain; Brain Stem; Catechol

1971
Amphetamine psychosis: behavioral and biochemical aspects.
    Journal of psychiatric research, 1974, Volume: 11

    Topics: Adolescent; Adult; Affect; Alcoholism; Amphetamine; Brain; Cognition Disorders; Delusions; Depressio

1974
The relevance of the neurophysiological concepts of excitation and inhibition to clinical psychiatry.
    The Australian and New Zealand journal of psychiatry, 1973, Volume: 7, Issue:2

    Topics: Acoustic Stimulation; Adolescent; Adult; Aged; Alcohol Amnestic Disorder; Anxiety; Arousal; Dihydrox

1973
From medical physicist to psychopharmacologist: a neo-renaissance interdisciplinary evolution of.
    Perspectives in biology and medicine, 1972,Spring, Volume: 15, Issue:3

    Topics: Dihydroxyphenylalanine; Disulfiram; Electroconvulsive Therapy; Enzyme Induction; History, 20th Centu

1972
[4-O-Methylated catecholamines: 3-hydroxy, 4-methoxyphenylacetic acid (homo-isovanillic acid, iso-HVA) in biological media: urine, cerebrospinal fluid, and brain tissue].
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 41

    Topics: Animals; Azo Compounds; Brain Chemistry; Caudate Nucleus; Cerebral Cortex; Chromatography, Paper; Di

1972
Effect of L-dopa in schizophrenia.
    Folia psychiatrica et neurologica japonica, 1972, Volume: 26, Issue:2

    Topics: Adult; Affective Symptoms; Behavior; Cognition Disorders; Communication; Delusions; Depersonalizatio

1972
Dopamine nerve terminals in the rat limbic cortex: aspects of the dopamine hypothesis of schizophrenia.
    Science (New York, N.Y.), 1974, Apr-12, Volume: 184, Issue:4133

    Topics: Animals; Carbidopa; Dihydroxyphenylalanine; Disulfides; Dopamine; Dopamine beta-Hydroxylase; Humans;

1974
Abnormalities in 14 CO 2 production from DL-3,4-dihydroxyphenylalanine-carboxyl- 14 C in schizophrenia and parkinsonism: a preliminary report.
    Revue canadienne de biologie, 1972, Volume: 31

    Topics: Carbon Dioxide; Carbon Isotopes; Cells, Cultured; Cognition Disorders; Decarboxylation; Dihydroxyphe

1972
L-DOPA therapy in drug-induced parkinsonism evaluated by the method measuring the facial expression.
    Hiroshima journal of medical sciences, 1971, Volume: 20, Issue:1

    Topics: Adult; Dihydroxyphenylalanine; Facial Expression; Female; Humans; Male; Movement; Parkinson Disease;

1971
Three cases of schizophrenia treated with L-dopa.
    The Kurume medical journal, 1971, Volume: 18, Issue:3

    Topics: Adult; Autistic Disorder; Delusions; Dihydroxyphenylalanine; Drug Synergism; Female; Hallucinations;

1971
Clinical and pharmacological effects of monoamine precursors or haloperidol in chronic schizophrenia.
    Nature, 1968, Mar-02, Volume: 217, Issue:5131

    Topics: 5-Hydroxytryptophan; Dihydroxyphenylalanine; Haloperidol; Humans; Hydroxyindoleacetic Acid; Phenylac

1968
Action of L-Dopa in drug induced extrapyramidalism.
    Diseases of the nervous system, 1970, Volume: 31, Issue:1

    Topics: Adult; Chlorpromazine; Chronic Disease; Dihydroxyphenylalanine; Extrapyramidal Tracts; Female; Human

1970
Present status of psychological reactions to L-DOPA.
    The American journal of psychiatry, 1970, Volume: 127, Issue:3

    Topics: Behavior; Depression; Dihydroxyphenylalanine; Humans; Parkinson Disease; Schizophrenia

1970
Levodopa and schizophrenia.
    JAMA, 1970, Mar-16, Volume: 211, Issue:11

    Topics: Brain; Dihydroxyphenylalanine; Humans; Parkinson Disease; Psychoses, Substance-Induced; Schizophreni

1970
Decarboxylation of radioactive DOPA by erythrocytes in schizophrenia.
    The British journal of psychiatry : the journal of mental science, 1971, Volume: 118, Issue:545

    Topics: Carbon Dioxide; Carbon Isotopes; Chemistry, Organic; Decarboxylation; Dihydroxyphenylalanine; Erythr

1971
The effect of haloperidol on the urinary excretion of dopamine, homovanillic and vanilmandelic acids in schizophrenics.
    Psychopharmacologia, 1965, Jun-01, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Dihydroxyphenylalanine; Dopamine; Haloperidol; Humans; Male; Mandelic Acids; Phen

1965
A further study of catecholamine omicron-methylation in schizophrenia.
    Nature, 1966, Aug-06, Volume: 211, Issue:5049

    Topics: Adult; Aged; Brain Chemistry; Catecholamines; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Fe

1966