dihydroxyphenylalanine has been researched along with Congenital Hyperinsulinism in 37 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Congenital Hyperinsulinism: A familial, nontransient HYPOGLYCEMIA with defects in negative feedback of GLUCOSE-regulated INSULIN release. Clinical phenotypes include HYPOGLYCEMIA; HYPERINSULINEMIA; SEIZURES; COMA; and often large BIRTH WEIGHT. Several sub-types exist with the most common, type 1, associated with mutations on an ATP-BINDING CASSETTE TRANSPORTERS (subfamily C, member 8).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies have reported the applications of F-dihydroxyphenylalanine (F-DOPA) PET in patients with congenital hyperinsulinism (CHI)." | 8.89 | Diagnostic role of 18F-dihydroxyphenylalanine positron emission tomography in patients with congenital hyperinsulinism: a meta-analysis. ( Hao, R; Yang, J; Zhu, X, 2013) |
| "We performed a meta-analysis on published data on the diagnostic performance of fluorine-18 dihydroxyphenylalanine ((18)F-DOPA) positron emission tomography (PET) in diagnosing and localizing focal congenital hyperinsulinism (CHI)." | 8.88 | Diagnostic performance of fluorine-18-dihydroxyphenylalanine positron emission tomography in diagnosing and localizing the focal form of congenital hyperinsulinism: a meta-analysis. ( Giordano, A; Mirk, P; Rufini, V; Treglia, G, 2012) |
| "In congenital hyperinsulinism (CHI) of infancy, the use of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine-positron emission tomography-computed tomography ((18)F-DOPA-PET-CT) scan has recently been reported." | 7.77 | The predictive value of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine positron emission tomography-computed tomography scans in children with congenital hyperinsulinism of infancy. ( Ashworth, M; Blankenstein, O; De Coppi, P; Eaton, S; Hussain, K; Ismail, D; Mohnike, W; Nah, SA; Pierro, A; Ron, O; Smith, VV; Totonelli, G; Zani, A, 2011) |
| "We aimed to elucidate the accuracy and limitations of [(18)F]-fluoro-L-dihydroxyphenylalanine ([(18) F]DOPA) positron emission tomography (PET) for Japanese patients with congenital hyperinsulinism." | 7.77 | Diagnostic accuracy of [¹⁸F]-fluoro-L-dihydroxyphenylalanine positron emission tomography scan for persistent congenital hyperinsulinism in Japan. ( Doi, R; Fukuyama, S; Kasai, T; Masue, M; Nishibori, H; Okamoto, S; Tokumi, T; Uemoto, S; Yorifuji, T; Yoshizawa, A, 2011) |
| "Focal congenital hyperinsulinism (CHI) is curable by surgery, which is why identification of the focal lesion is crucial." | 5.48 | 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT scans as diagnostic tools in focal congenital hyperinsulinism: a blinded evaluation. ( Brusgaard, K; Christesen, HT; Christiansen, CD; Detlefsen, S; Ekström, K; Globa, E; Hovendal, C; Melikyan, M; Nielsen, AL; Petersen, H; Rasmussen, AH; Rasmussen, L, 2018) |
| "Studies have reported the applications of F-dihydroxyphenylalanine (F-DOPA) PET in patients with congenital hyperinsulinism (CHI)." | 4.89 | Diagnostic role of 18F-dihydroxyphenylalanine positron emission tomography in patients with congenital hyperinsulinism: a meta-analysis. ( Hao, R; Yang, J; Zhu, X, 2013) |
| "We performed a meta-analysis on published data on the diagnostic performance of fluorine-18 dihydroxyphenylalanine ((18)F-DOPA) positron emission tomography (PET) in diagnosing and localizing focal congenital hyperinsulinism (CHI)." | 4.88 | Diagnostic performance of fluorine-18-dihydroxyphenylalanine positron emission tomography in diagnosing and localizing the focal form of congenital hyperinsulinism: a meta-analysis. ( Giordano, A; Mirk, P; Rufini, V; Treglia, G, 2012) |
| "In congenital hyperinsulinism (CHI) of infancy, the use of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine-positron emission tomography-computed tomography ((18)F-DOPA-PET-CT) scan has recently been reported." | 3.77 | The predictive value of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine positron emission tomography-computed tomography scans in children with congenital hyperinsulinism of infancy. ( Ashworth, M; Blankenstein, O; De Coppi, P; Eaton, S; Hussain, K; Ismail, D; Mohnike, W; Nah, SA; Pierro, A; Ron, O; Smith, VV; Totonelli, G; Zani, A, 2011) |
| "We aimed to elucidate the accuracy and limitations of [(18)F]-fluoro-L-dihydroxyphenylalanine ([(18) F]DOPA) positron emission tomography (PET) for Japanese patients with congenital hyperinsulinism." | 3.77 | Diagnostic accuracy of [¹⁸F]-fluoro-L-dihydroxyphenylalanine positron emission tomography scan for persistent congenital hyperinsulinism in Japan. ( Doi, R; Fukuyama, S; Kasai, T; Masue, M; Nishibori, H; Okamoto, S; Tokumi, T; Uemoto, S; Yorifuji, T; Yoshizawa, A, 2011) |
| "To assess the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]-DOPA) PET scans to diagnose focal versus diffuse disease and to localize focal lesions in infants with congenital hyperinsulinism." | 3.74 | Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. ( Adzick, NS; Alavi, A; Freifelder, R; Ganguly, A; Hardy, OT; Hernandez-Pampaloni, M; Ruchelli, E; Saffer, JR; Stanley, CA; Suchi, M; Zhuang, H, 2007) |
| "Neonates with severe, persistent hyperinsulinemic hypoglycemia who are unresponsive to medical therapy require pancreatectomy to prevent brain damage from hypoglycemia." | 2.82 | Congenital hyperinsulinism: localization of a focal lesion with ( Becker, SA; De León, DD; States, LJ, 2022) |
| "For surgery in congenital hyperinsulinism (CHI), a distinct surgical strategy and technique is required for focal, diffuse and atypical CHI." | 2.47 | Techniques in pediatric surgery: congenital hyperinsulinism. ( Barthlen, W; Mohnike, K; Mohnike, W, 2011) |
| "Congenital hyperinsulinism is a leading cause of severe hypoglycaemia in the newborn period." | 2.46 | Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism. ( Hussain, K; Ismail, D, 2010) |
| "Congenital hyperinsulinism is characterized by abnormal regulation of insulin secretion from the pancreas causing profound hypoketotic hypoglycemia and is the leading cause of persistent hypoglycemia in infants and children." | 1.56 | Visual interpretation, not SUV ratios, is the ideal method to interpret 18F-DOPA PET scans to aid in the cure of patients with focal congenital hyperinsulinism. ( Garg, PK; Garg, S; Lokitz, SJ; Nazih, R; Nedrelow, JK; Putegnat, B; Reynolds, C; Sanchez, I; Thornton, PS; Truong, L; Uffman, J, 2020) |
| "Focal congenital hyperinsulinism (CHI) is curable by surgery, which is why identification of the focal lesion is crucial." | 1.48 | 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT scans as diagnostic tools in focal congenital hyperinsulinism: a blinded evaluation. ( Brusgaard, K; Christesen, HT; Christiansen, CD; Detlefsen, S; Ekström, K; Globa, E; Hovendal, C; Melikyan, M; Nielsen, AL; Petersen, H; Rasmussen, AH; Rasmussen, L, 2018) |
| " Except for growth deceleration at a higher dosage, no significant adverse effects were noted." | 1.39 | Efficacy and safety of long-term, continuous subcutaneous octreotide infusion for patients with different subtypes of KATP-channel hyperinsulinism. ( Aizu, K; Fujimaru, R; Hosokawa, Y; Kawakita, R; Masue, M; Matsubara, K; Nagasaka, H; Nishibori, H; Suzuki, S; Yorifuji, T, 2013) |
| "We report a case of congenital hyperinsulinism with diffuse pancreatic abnormality diagnosed preoperatively by using [18-F]-L-DOPA positron emission tomography (PET)." | 1.37 | Positron emission tomography in congenital hyperinsulinism. ( Agarwal, A; Kumar, A; Mathur, NB; Sharma, M, 2011) |
| "Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in infancy (HI), leading to severe neurologic disabilities if not promptly treated." | 1.35 | Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH gene. ( Chiumello, G; Di Candia, S; Gessi, A; Gianolli, L; Mangano, E; Mora, S; Pepe, G; Proverbio, MC; Sogno Valin, P, 2009) |
| " The aim of this article is to show the first case of focal CHI diagnosed in Spain using PET-CT imaging combined with genetic analysis." | 1.35 | [18F-fluoro-L-DOPA PET-CT imaging combined with genetic analysis for optimal classification and treatment in a child with severe congenital hyperinsulinism]. ( Arbizu Lostao, J; Azcona San Julián, C; Carracedo, A; Fernández-Marmiesse, A; Garrastachu Zumarrán, P; Martino Casado, E; Richter Echevarría, JA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (29.73) | 29.6817 |
| 2010's | 20 (54.05) | 24.3611 |
| 2020's | 6 (16.22) | 2.80 |
| Authors | Studies |
|---|---|
| Mitrofanova, LB | 2 |
| Perminova, AA | 1 |
| Ryzhkova, DV | 2 |
| Sukhotskaya, AA | 2 |
| Bairov, VG | 2 |
| Nikitina, IL | 2 |
| States, LJ | 3 |
| Becker, SA | 1 |
| De León, DD | 2 |
| Gubaeva, DN | 1 |
| Melikyan, MA | 1 |
| Poyda, MD | 1 |
| Sokolov, YY | 1 |
| Efremenkov, AM | 1 |
| Christesen, H | 1 |
| Saade-Lemus, S | 1 |
| Garg, PK | 1 |
| Putegnat, B | 1 |
| Truong, L | 1 |
| Reynolds, C | 1 |
| Sanchez, I | 1 |
| Nedrelow, JK | 1 |
| Uffman, J | 1 |
| Lokitz, SJ | 1 |
| Nazih, R | 1 |
| Garg, S | 1 |
| Thornton, PS | 1 |
| O'Brien, SR | 1 |
| Zhuang, H | 2 |
| Zhang, L | 1 |
| Xu, ZD | 1 |
| Liu, M | 1 |
| Zeng, Q | 1 |
| Li, RM | 1 |
| Wang, JY | 1 |
| Wang, HM | 1 |
| Li, L | 1 |
| Qin, H | 1 |
| Yan, J | 1 |
| Wu, YJ | 1 |
| Zhu, C | 1 |
| Ni, GC | 1 |
| Sang, YM | 1 |
| Christiansen, CD | 1 |
| Petersen, H | 1 |
| Nielsen, AL | 1 |
| Detlefsen, S | 1 |
| Brusgaard, K | 1 |
| Rasmussen, L | 1 |
| Melikyan, M | 1 |
| Ekström, K | 1 |
| Globa, E | 1 |
| Rasmussen, AH | 1 |
| Hovendal, C | 1 |
| Christesen, HT | 1 |
| Kanamori, Y | 1 |
| Watanabe, T | 1 |
| Yorifuji, T | 4 |
| Masue, M | 4 |
| Sasaki, H | 1 |
| Nio, M | 1 |
| Meintjes, M | 1 |
| Endozo, R | 1 |
| Dickson, J | 1 |
| Erlandsson, K | 1 |
| Hussain, K | 5 |
| Townsend, C | 1 |
| Menezes, L | 1 |
| Bomanji, J | 1 |
| Kühnen, P | 1 |
| Matthae, R | 1 |
| Arya, V | 1 |
| Hauptmann, K | 1 |
| Rothe, K | 1 |
| Wächter, S | 1 |
| Singer, M | 1 |
| Mohnike, W | 5 |
| Eberhard, T | 2 |
| Raile, K | 1 |
| Lauffer, LM | 1 |
| Iakoubov, R | 1 |
| Blankenstein, O | 5 |
| Chondrogiannis, S | 1 |
| Marzola, MC | 1 |
| Rubello, D | 1 |
| Zhang, W | 1 |
| Liu, L | 1 |
| Wen, Z | 1 |
| Cheng, J | 1 |
| Li, C | 2 |
| Li, X | 1 |
| Niu, H | 1 |
| Wang, F | 1 |
| Sheng, H | 1 |
| Liu, H | 1 |
| Mohnike, K | 3 |
| Minn, H | 1 |
| Fuchtner, F | 1 |
| Otonkoski, T | 1 |
| Di Candia, S | 1 |
| Gessi, A | 1 |
| Pepe, G | 1 |
| Sogno Valin, P | 1 |
| Mangano, E | 1 |
| Chiumello, G | 1 |
| Gianolli, L | 1 |
| Proverbio, MC | 1 |
| Mora, S | 1 |
| Capito, C | 1 |
| Khen-Dunlop, N | 1 |
| Ribeiro, MJ | 3 |
| Brunelle, F | 5 |
| Aigrain, Y | 1 |
| Crétolle, C | 1 |
| Jaubert, F | 4 |
| De Lonlay, P | 5 |
| Nihoul-Fékété, C | 4 |
| Ismail, D | 3 |
| Zani, A | 1 |
| Nah, SA | 1 |
| Ron, O | 1 |
| Totonelli, G | 1 |
| Smith, VV | 2 |
| Ashworth, M | 2 |
| De Coppi, P | 1 |
| Eaton, S | 1 |
| Pierro, A | 2 |
| Barthlen, W | 2 |
| Mathur, NB | 1 |
| Sharma, M | 1 |
| Agarwal, A | 1 |
| Kumar, A | 1 |
| Nishibori, H | 3 |
| Fukuyama, S | 1 |
| Yoshizawa, A | 1 |
| Okamoto, S | 1 |
| Doi, R | 1 |
| Uemoto, S | 1 |
| Tokumi, T | 1 |
| Kasai, T | 1 |
| Hosokawa, Y | 2 |
| Fujimaru, R | 2 |
| Kawakita, R | 2 |
| Doi, H | 1 |
| Matsumoto, T | 1 |
| Kapoor, RR | 1 |
| Flanagan, SE | 1 |
| Ellard, S | 1 |
| Blomberg, BA | 1 |
| Moghbel, MC | 1 |
| Saboury, B | 1 |
| Stanley, CA | 2 |
| Alavi, A | 2 |
| Treglia, G | 1 |
| Mirk, P | 1 |
| Giordano, A | 1 |
| Rufini, V | 1 |
| Matsubara, K | 1 |
| Aizu, K | 1 |
| Suzuki, S | 1 |
| Nagasaka, H | 1 |
| Yang, J | 2 |
| Yuan, L | 1 |
| Meeks, JK | 1 |
| Zhang, N | 1 |
| Hao, R | 2 |
| Banerjee, I | 1 |
| Avatapalle, B | 1 |
| Padidela, R | 1 |
| Stevens, A | 1 |
| Cosgrove, KE | 1 |
| Clayton, PE | 1 |
| Dunne, MJ | 1 |
| Zhu, X | 1 |
| Fékété, CN | 1 |
| Rahier, J | 1 |
| Saudubray, JM | 1 |
| Delzescaux, T | 2 |
| Boddaert, N | 3 |
| Bourgeois, S | 2 |
| Dollé, F | 1 |
| Syrota, A | 1 |
| Ribeiro, M | 1 |
| Touati, G | 1 |
| Mention, K | 1 |
| Valayanopoulos, V | 1 |
| Sperling, MA | 1 |
| Hardy, OT | 1 |
| Hernandez-Pampaloni, M | 1 |
| Saffer, JR | 1 |
| Suchi, M | 1 |
| Ruchelli, E | 1 |
| Ganguly, A | 1 |
| Freifelder, R | 1 |
| Adzick, NS | 1 |
| Bellanné-Chantelot, C | 1 |
| Valayannopoulos, V | 1 |
| Mau, H | 1 |
| Koch, M | 1 |
| Höhne, C | 1 |
| Fuechtner, F | 1 |
| Lorenz-Depiereux, B | 1 |
| Arbizu Lostao, J | 1 |
| Fernández-Marmiesse, A | 1 |
| Garrastachu Zumarrán, P | 1 |
| Martino Casado, E | 1 |
| Azcona San Julián, C | 1 |
| Carracedo, A | 1 |
| Richter Echevarría, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Fluorodopa F 18 Positron Emission Tomography Combined With Computed Tomography in Congenital Hyperinsulinism and Insulinoma[NCT02021604] | Phase 1 | 250 participants (Anticipated) | Interventional | 2013-10-09 | Recruiting | ||
| Localization of Focal Forms of Hyperinsulinism of Infancy With 18F-labeled L-fluoro-DOPA PET Scan[NCT00674440] | Phase 2 | 106 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| A Phase II Safety and Efficacy Study of 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Children With Hyperinsulinemic Hypoglycemia[NCT01468454] | Phase 2 | 130 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of Participants with Adverse Events (NCT00674440)
Timeframe: 72 hours maximum or prior to pancreatic surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| All Subjects Who Had PET | 0 |
Comparison of PET scan results with outcome of surgery and histopathology results confirmed as focal or diffuse (NCT00674440)
Timeframe: up to 1 month post surgical intervention
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| True Negatives (PET diffuse/surgery diffuse) | False negatives (PET diffuse/surgery focal): | False positives (PET focal/surgery diffuse): | True positives (PET focal/surgery focal): | |
| Subjects Who Had PET and Surgery | 40 | 6 | 3 | 46 |
"To further evaluate the safety of 18-labeled L-fluorodeoxyphenylalanine (18F-DOPA) PET/CT imaging in infants and children with congenital hyperinsulinism~- subjects are monitored clinically for any signs or symptoms of adverse events for 72 hours post PET. Adverse events are documented and followed to resolution" (NCT01468454)
Timeframe: evaluated with 72 hours or prior to pancreatic surgery (if any)
| Intervention | Participants (Count of Participants) |
|---|---|
| (18F-DOPA) PET/CT Imaging | 0 |
To determine the sensitivity and specificity of 18F-DOPA PET/CT for the detection of a focal pancreatic lesion in infants and children with poorly controlled hyperinsulinemic hypoglycemia. (NCT01468454)
Timeframe: Surgery typically occured within a week post PET
| Intervention | cases (Number) | |||
|---|---|---|---|---|
| True Negatives (PET diffuse/surgery diffuse) | False negatives (PET diffuse/surgery focal): | False positives (PET focal/surgery diffuse): | True positives (PET focal/surgery focal): | |
| PET/CT Imaging vs Surgical Result | 34 | 10 | 4 | 52 |
12 reviews available for dihydroxyphenylalanine and Congenital Hyperinsulinism
| Article | Year |
|---|---|
Congenital hyperinsulinism: localization of a focal lesion with
Topics: Child; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Humans; Infant; Infant, Newborn; Mutation | 2022 |
18-F-L 3,4-Dihydroxyphenylalanine PET/Computed Tomography in the Management of Congenital Hyperinsulinism.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Humans; Infant; Positron Emission Tomography Com | 2020 |
¹⁸F-DOPA PET/computed tomography imaging.
Topics: Abdomen; Carbidopa; Congenital Hyperinsulinism; Corpus Striatum; Digestive System; Dihydroxyphenylal | 2014 |
[18F]-DOPA positron emission tomography for preoperative localization in congenital hyperinsulinism.
Topics: Algorithms; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Panc | 2008 |
Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Humans; Infant, Newborn; Models, Biological; Pos | 2010 |
Techniques in pediatric surgery: congenital hyperinsulinism.
Topics: Anastomosis, Roux-en-Y; Biopsy; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Fluorescent Dyes | 2011 |
The value of radiologic interventions and (18)F-DOPA PET in diagnosing and localizing focal congenital hyperinsulinism: systematic review and meta-analysis.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Pancreas; Positr | 2013 |
Diagnostic performance of fluorine-18-dihydroxyphenylalanine positron emission tomography in diagnosing and localizing the focal form of congenital hyperinsulinism: a meta-analysis.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Evidence-Based Medicine; Humans; Positron-Emissi | 2012 |
18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Infant; Multimod | 2012 |
Integrating genetic and imaging investigations into the clinical management of congenital hyperinsulinism.
Topics: ATP-Binding Cassette Transporters; Calcium; Child; Child, Preschool; Congenital Hyperinsulinism; Dec | 2013 |
Diagnostic role of 18F-dihydroxyphenylalanine positron emission tomography in patients with congenital hyperinsulinism: a meta-analysis.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Humans; Positron-Emission Tomography; Quality Co | 2013 |
[Radiological innovations in the screening and diagnosis of the inborn errors of metabolism].
Topics: Aldose-Ketose Isomerases; Amidinotransferases; Brain Chemistry; Congenital Hyperinsulinism; Creatine | 2005 |
1 trial available for dihydroxyphenylalanine and Congenital Hyperinsulinism
| Article | Year |
|---|---|
Characterization of hyperinsulinism in infancy assessed with PET and 18F-fluoro-L-DOPA.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; Infant, Newborn; Male; O | 2005 |
24 other studies available for dihydroxyphenylalanine and Congenital Hyperinsulinism
| Article | Year |
|---|---|
Differential Morphological Diagnosis of Various Forms of Congenital Hyperinsulinism in Children.
Topics: Adenoma; Adenoma, Islet Cell; Congenital Hyperinsulinism; Diagnosis, Differential; Dihydroxyphenylal | 2021 |
[Clinical, genetic, and radionuclide characteristics of the focal form of congenital hyperinsulinism].
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; Infant, Newborn; Male; P | 2019 |
Visual interpretation, not SUV ratios, is the ideal method to interpret 18F-DOPA PET scans to aid in the cure of patients with focal congenital hyperinsulinism.
Topics: Child; Child, Preschool; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; | 2020 |
Neuroblastoma Shown on 18F-DOPA PET/CT Performed to Evaluate Congenital Hyperinsulinism.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Humans; Male; Neuroblastoma; Positron Emission T | 2021 |
Retrospective analysis of 23 Chinese children with congenital hyperinsulinism undergoing pancreatectomy.
Topics: Asian People; Blood Glucose; Child; China; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Femal | 2021 |
18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT scans as diagnostic tools in focal congenital hyperinsulinism: a blinded evaluation.
Topics: Child; Child, Preschool; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; | 2018 |
Congenital hyperinsulinism treated by surgical resection of the hyperplastic lesion which had been preoperatively diagnosed by 18F-DOPA PET examination in Japan: a nationwide survey.
Topics: Child; Child, Preschool; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Fluorine Radioi | 2018 |
18F-DOPA PET and enhanced CT imaging for congenital hyperinsulinism: initial UK experience from a technologist's perspective.
Topics: Child; Child, Preschool; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; | 2013 |
Occurrence of giant focal forms of congenital hyperinsulinism with incorrect visualization by (18) F DOPA-PET/CT scanning.
Topics: Child; Child, Preschool; Congenital Hyperinsulinism; Diagnostic Errors; Dihydroxyphenylalanine; Fema | 2014 |
A compound heterozygous mutation of ABCC8 gene causing a diazoxide-unresponsive congenital hyperinsulinism with an atypical form: Not a focal lesion in the pancreas reported by ¹⁸F-DOPA-PET/CT scan.
Topics: Congenital Hyperinsulinism; Diagnosis, Differential; Dihydroxyphenylalanine; Heterozygote; Humans; M | 2015 |
Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH gene.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Codon, Nonsense; Congenital Hyperinsulinism; Dihydroxyphenylalanin | 2009 |
Value of 18F-fluoro-L-dopa PET in the preoperative localization of focal lesions in congenital hyperinsulinism.
Topics: Congenital Hyperinsulinism; Diagnostic Errors; Dihydroxyphenylalanine; Female; Humans; Image Interpr | 2009 |
The predictive value of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine positron emission tomography-computed tomography scans in children with congenital hyperinsulinism of infancy.
Topics: Child, Preschool; Congenital Hyperinsulinism; Diagnostic Errors; Dihydroxyphenylalanine; Female; Flu | 2011 |
Positron emission tomography in congenital hyperinsulinism.
Topics: Blood Glucose; Breast Feeding; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; I | 2011 |
Diagnostic accuracy of [¹⁸F]-fluoro-L-dihydroxyphenylalanine positron emission tomography scan for persistent congenital hyperinsulinism in Japan.
Topics: Asian People; Child, Preschool; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Fluorine Radiois | 2011 |
Lasting 18F-DOPA PET uptake after clinical remission of the focal form of congenital hyperinsulinism.
Topics: ATP-Binding Cassette Transporters; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Follow-Up Stu | 2011 |
The heterogeneity of focal forms of congenital hyperinsulinism.
Topics: ATP-Binding Cassette Transporters; Congenital Hyperinsulinism; Dihydroxyphenylalanine; DNA Mutationa | 2012 |
Efficacy and safety of long-term, continuous subcutaneous octreotide infusion for patients with different subtypes of KATP-channel hyperinsulinism.
Topics: ATP-Binding Cassette Transporters; Child Development; Child, Preschool; Congenital Hyperinsulinism; | 2013 |
The surgical management of congenital hyperinsulinemic hypoglycemia in infancy.
Topics: ATP-Binding Cassette Transporters; Calcium Channels; Chromosomes, Human, Pair 11; Congenital Hyperin | 2004 |
PET scanning for infants with HHI: a small step for affected infants, a giant leap for the field.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; Infant, Newborn; Male; P | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
Topics: Confidence Intervals; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; In | 2007 |
The added value of [18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy: a retrospective study involving 49 children.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Humans; Infant; Infant, Newborn; Male; P | 2007 |
Evaluation of [18F]fluoro-L-DOPA positron emission tomography-computed tomography for surgery in focal congenital hyperinsulinism.
Topics: Child, Preschool; Congenital Hyperinsulinism; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes | 2008 |
[18F-fluoro-L-DOPA PET-CT imaging combined with genetic analysis for optimal classification and treatment in a child with severe congenital hyperinsulinism].
Topics: ATP-Binding Cassette Transporters; Congenital Hyperinsulinism; Dihydroxyphenylalanine; DNA Mutationa | 2008 |