dihydroxyphenylalanine has been researched along with Chronic Disease in 44 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three of six patients with chronic hepatic encephalopathy treated with levodopa showed a significant improvement." | 2.64 | Treatment of chronic hepatic encephalopathy with levodopa. ( James, IM; Lunzer, M; Sherlock, S; Weinman, J, 1974) |
| " The influence of acute and chronic administration of alcohol was studied in experiments in animals as well as its discontinuation on the catecholamine structures in different areas of the CNS." | 1.25 | [The role of disorders in the functions of the cerebral catecholamine system in the pathogenesis of chronic alcoholism]. ( Anokhina, IP; Kogan, BM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (77.27) | 18.7374 |
| 1990's | 2 (4.55) | 18.2507 |
| 2000's | 8 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nigmatullina, RR | 1 |
| Kirillova, VV | 2 |
| Jourjikiya, RK | 1 |
| Mukhamedyarov, MA | 1 |
| Kudrin, VS | 2 |
| Klodt, PM | 2 |
| Palotás, A | 1 |
| Nigmatullin, RR | 1 |
| Dzhordzhikiia, RK | 1 |
| Goldstein, DS | 1 |
| Holmes, C | 1 |
| Frank, SM | 1 |
| Dendi, R | 1 |
| Cannon, RO | 1 |
| Sharabi, Y | 1 |
| Esler, MD | 1 |
| Eisenhofer, G | 1 |
| Prieto, M | 1 |
| Gómez, FM | 1 |
| Teresa Giralt, M | 1 |
| Fedorova, NV | 1 |
| Glozman, ZhM | 1 |
| Saltykova, NM | 1 |
| Elkashef, AM | 1 |
| Doudet, D | 1 |
| Bryant, T | 1 |
| Cohen, RM | 1 |
| Li, SH | 1 |
| Wyatt, RJ | 1 |
| Jääskeläinen, SK | 1 |
| Rinne, JO | 1 |
| Forssell, H | 1 |
| Tenovuo, O | 1 |
| Kaasinen, V | 1 |
| Sonninen, P | 1 |
| Bergman, J | 1 |
| Lauer, M | 1 |
| Schirrmeister, H | 1 |
| Gerhard, A | 1 |
| Ellitok, E | 1 |
| Beckmann, H | 1 |
| Reske, SN | 1 |
| Stöber, G | 1 |
| Esteban, S | 1 |
| Moranta, D | 1 |
| Sastre-Coll, A | 1 |
| Miralles, A | 1 |
| García-Sevilla, JA | 1 |
| Shelygina, NM | 1 |
| Osychniuk, VI | 1 |
| Mel'nikov, SA | 1 |
| Maddrey, WC | 1 |
| Weber, FL | 1 |
| Anokhina, IP | 1 |
| Kogan, BM | 1 |
| Nisenbaum, LK | 1 |
| Abercrombie, ED | 1 |
| Wolters, EC | 1 |
| Huang, CC | 1 |
| Clark, C | 1 |
| Peppard, RF | 1 |
| Okada, J | 1 |
| Chu, NS | 1 |
| Adam, MJ | 1 |
| Ruth, TJ | 1 |
| Li, D | 1 |
| Calne, DB | 1 |
| Castilla-Serna, L | 1 |
| Alva-González, D | 1 |
| Ramírez-López, E | 1 |
| Serrano-Money, F | 1 |
| Cravioto, J | 1 |
| Hegedus, ZL | 1 |
| Altschule, MD | 1 |
| Nayak, U | 1 |
| Neumayr, A | 1 |
| Keegan, DL | 1 |
| Rajput, AH | 1 |
| Cotzias, GC | 3 |
| Papavasiliou, PS | 3 |
| Gellene, R | 1 |
| Geller, LI | 2 |
| Kazimirchik, AP | 2 |
| Amatniak, AG | 2 |
| Kontsevaia, NG | 1 |
| Black, MM | 1 |
| Wilson-Jones, E | 1 |
| Lunzer, M | 1 |
| James, IM | 1 |
| Weinman, J | 1 |
| Sherlock, S | 1 |
| Spiers, AS | 1 |
| Jacobson, S | 1 |
| Bell, B | 1 |
| Kaliuzhnaia, RA | 1 |
| Tkachev, RA | 1 |
| Markova, ED | 1 |
| Gotovtseva, EV | 1 |
| Barkhatova, VP | 1 |
| Ivanova-Smolenskaia, IA | 1 |
| Krasnov, EA | 1 |
| Romenskaia, LKh | 1 |
| Frolova, IA | 1 |
| Beiul, EA | 1 |
| Volkova, IS | 1 |
| Sirota, II | 1 |
| Singer, E | 1 |
| Karpenko, EI | 2 |
| Kamyshan, IS | 1 |
| Ginos, J | 1 |
| Steck, A | 1 |
| Düby, S | 1 |
| Rosenstock, HA | 1 |
| Simons, DG | 1 |
| Meyer, JS | 1 |
| Deĭneko, VS | 1 |
| Hyman, MD | 1 |
| Sergeev, VM | 1 |
| Spektor, EB | 1 |
| Granova, LV | 1 |
| Kibrik, BS | 1 |
| DiGiacomo, JN | 1 |
| Fahn, S | 1 |
| Glass, JB | 1 |
| Westlake, RJ | 1 |
| Mena, I | 1 |
| Court, J | 1 |
| Fuenzalida, S | 1 |
| Skugarevskaia, EI | 1 |
| Yaryura-Tobias, JA | 1 |
| Wolpert, A | 1 |
| Dana, L | 1 |
| Merlis, S | 1 |
| Gjerris, F | 1 |
| Midelauri, BG | 1 |
| Vjtĕchovský, M | 1 |
| Skála, J | 1 |
| Safratová, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Laboratory Evaluation of Chronic Orthostatic Intolerance[NCT00069693] | 200 participants | Observational | 2003-09-26 | Completed | |||
| Propranolol for Syncope With Sympathoadrenal Imbalance[NCT00060866] | Phase 4 | 24 participants | Interventional | 2003-05-31 | Completed | ||
| Propranolol for Syncope With Sympathoadrenal Imbalance in Children[NCT00093860] | Phase 2 | 50 participants | Interventional | 2004-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dihydroxyphenylalanine and Chronic Disease
| Article | Year |
|---|---|
[Advances in the treatment of liver disease].
Topics: Amino Acids; Anti-Bacterial Agents; Chronic Disease; Dihydroxyphenylalanine; Enzyme Induction; Excha | 1973 |
Recognition and management of acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Amines; Ammonia; Animals; Brain Edema; Central Nervous System; Chronic Disease; Diet | 1973 |
Metabolic modification of Parkinson's disease and of chronic manganese poisoning.
Topics: Animals; Brain; Choline; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Humans; Manganese | 1971 |
4 trials available for dihydroxyphenylalanine and Chronic Disease
| Article | Year |
|---|---|
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease; | 2002 |
Modification of Parkinsonism--chronic treatment with L-dopa.
Topics: Adult; Aged; Agranulocytosis; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Urea Nitrogen; Blo | 1969 |
Treatment of chronic hepatic encephalopathy with levodopa.
Topics: Adult; Aged; Brain; Cerebrovascular Circulation; Chronic Disease; Computers; Dihydroxyphenylalanine; | 1974 |
Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Chronic Disease; Dihydroxyphenylalanine; Humans; Male; Manga | 1970 |
37 other studies available for dihydroxyphenylalanine and Chronic Disease
| Article | Year |
|---|---|
Disrupted serotonergic and sympathoadrenal systems in patients with chronic heart failure may serve as new therapeutic targets and novel biomarkers to assess severity, progression and response to treatment.
Topics: Adrenal Glands; Adrenergic beta-Antagonists; Adult; Biomarkers; Chronic Disease; Dihydroxyphenylalan | 2009 |
[The state of sympathetic-adrenal system in patients with chronic cardiac insufficiency].
Topics: Adrenal Glands; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Heart Failur | 2009 |
Effects of acute, repeated and chronic variable stress on in vivo tyrosine hydroxylase activity and on alpha(2)-adrenoceptor sensitivity in the rat brain.
Topics: Acute Disease; Adrenergic alpha-Agonists; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Bra | 2003 |
[The efficacy of the Umex treatment of parkinsonism patients in the initial stage of the disease].
Topics: Adult; Aged; Antiparkinson Agents; Chronic Disease; Dihydroxyphenylalanine; Drug Evaluation; Drug Th | 1995 |
6-(18)F-DOPA PET study in patients with schizophrenia. Positron emission tomography.
Topics: Adult; Antipsychotic Agents; Aromatic-L-Amino-Acid Decarboxylases; Brain; Case-Control Studies; Chro | 2000 |
Role of the dopaminergic system in chronic pain -- a fluorodopa-PET study.
Topics: Adult; Aged; Burning Mouth Syndrome; Chronic Disease; Dihydroxyphenylalanine; Female; Humans; Middle | 2001 |
Disturbed neural circuits in a subtype of chronic catatonic schizophrenia demonstrated by F-18-FDG-PET and F-18-DOPA-PET.
Topics: Adult; Brain; Chronic Disease; Dihydroxyphenylalanine; Fluorine Radioisotopes; Fluorodeoxyglucose F1 | 2001 |
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Cerebral Cor | 2002 |
[State of the sympathico-adrenal system in patients with pre-asthma conditions].
Topics: Adrenal Glands; Adult; Aged; Asthma; Bronchial Spasm; Catecholamines; Chronic Disease; Dihydroxyphen | 1976 |
Chronic hepatic encephalopathy.
Topics: Amino Acids, Essential; Ammonia; Analgesics; Anesthesia; Anti-Bacterial Agents; Biogenic Amines; Chr | 1975 |
[The role of disorders in the functions of the cerebral catecholamine system in the pathogenesis of chronic alcoholism].
Topics: Alcoholic Intoxication; Alcoholism; Brain; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; | 1975 |
Enhanced tyrosine hydroxylation in hippocampus of chronically stressed rats upon exposure to a novel stressor.
Topics: alpha-Methyltyrosine; Animals; Chronic Disease; Dihydroxyphenylalanine; Extracellular Space; Hippoca | 1992 |
Positron emission tomography in manganese intoxication.
Topics: Adult; Brain; Chronic Disease; Dihydroxyphenylalanine; Humans; Magnetic Resonance Imaging; Manganese | 1989 |
[Effect of nutrition and environment on noradrenergic metabolism in the central nervous system. I. Chronic malnutrition].
Topics: Animals; Body Weight; Brain; Chronic Disease; Dihydroxyphenylalanine; Male; Norepinephrine; Protein- | 1988 |
Studies on rheomelanins. 3. Excessive hemolysis associated with the production of rheomelanins from L-norepinephrine, from dopamine and from L-dopa in the blood of chronic schizophrenic patients.
Topics: Chromatography, Paper; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Erythrocytes; Hemolysis; H | 1971 |
Drug induced dystonia tarda: treatment with L-dopa.
Topics: Antipsychotic Agents; Chlorpromazine; Chronic Disease; Diazepam; Dihydroxyphenylalanine; Dystonia Mu | 1973 |
L-dopa in chronic manganese poisoning.
Topics: Chronic Disease; Dihydroxyphenylalanine; Humans; Manganese Poisoning | 1970 |
[Biogenic amines in chronic pancreatitis].
Topics: Amine Oxidase (Copper-Containing); Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine | 1973 |
The role of the epidermis in the histopathogenesis of lichen planus. Histochemical correlations.
Topics: Acid Phosphatase; Acute Disease; Biopsy; Catechol Oxidase; Chronic Disease; Depression, Chemical; Di | 1972 |
Ineffectiveness of dextrodopa in chronic granulocytic leukaemia.
Topics: Adult; Chronic Disease; Dihydroxyphenylalanine; Female; Hemoglobins; Humans; Leukemia, Myeloid; Leuk | 1974 |
[The syndrome of autonomic vascular dystonia in adolescents and young men with toxic-infectious processes].
Topics: Adolescent; Adult; Autonomic Nervous System; Blood Pressure; Cardiovascular Diseases; Catecholamines | 1972 |
[Principles of the pathogenetic therapy of congenital extrapyramidal diseases].
Topics: Adolescent; Adult; Atropine; Basal Ganglia Diseases; Chelating Agents; Chronic Disease; Dihydroxyphe | 1973 |
[Clinical electroencephalographic studies during the treatment of parkinsonism with an L-DOPA preparation].
Topics: Aged; Alpha Rhythm; Chronic Disease; Dihydroxyphenylalanine; Electroencephalography; Female; Humans; | 1973 |
[State of catecholamine and DOPA excretion in metabolic-alimentary obesity].
Topics: Adolescent; Adult; Arteriosclerosis; Catecholamines; Cholesterol; Chronic Disease; Circadian Rhythm; | 1974 |
Premature social aging: the social-psychological consequences of a chronic illness.
Topics: Aging; Anger; Attitude; Attitude to Health; Boredom; Chronic Disease; Dihydroxyphenylalanine; Emotio | 1974 |
[Diurnal rhythm of catecholamine excretion and reactivity of the symphathetic-adrenal system in patients with chronic pyelonephritis].
Topics: Adolescent; Adrenal Glands; Adult; Catecholamines; Chronic Disease; Circadian Rhythm; Dihydroxypheny | 1974 |
[Comparison of clinico-metabolic indicators in patients with chronic cholecystopancreatitis and chronic cholecystitis].
Topics: 17-Hydroxycorticosteroids; Catecholamines; Cholecystitis; Chronic Disease; Dihydroxyphenylalanine; D | 1974 |
Chronic manganism. Neurologic and laboratory studies during treatment with levodopa.
Topics: Administration, Oral; Adult; Chronic Disease; Dihydroxyphenylalanine; Edetic Acid; Facial Expression | 1971 |
[Excretion of catecholamines and their precursors and indices of electrolyte balance in patients with chronic glomerulonephritis].
Topics: Adolescent; Adult; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epinephrine; G | 1972 |
Sociopsychological obstacles to L-dopa therapy that may limit effectiveness in parkinsonism.
Topics: Attitude to Health; Chronic Disease; Dihydroxyphenylalanine; Humans; Interpersonal Relations; Parkin | 1972 |
[Condition of the sympatho-adrenal system in children with surgical forms of chronic non-specific lung diseases].
Topics: Adolescent; Adrenal Glands; Age Factors; Catecholamines; Child; Chronic Disease; Dihydroxyphenylalan | 1972 |
A case with Gilles de la Tourette's syndrome: recurrent refractoriness to haloperidol, and unsuccessful treatment with L-dopa.
Topics: Adult; Chlorpromazine; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Haloperidol; Humans; | 1971 |
[The relationship of the metabolism of biogenic amines to affective pathology in chronic alcoholism].
Topics: Affective Symptoms; Alcoholism; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; E | 1969 |
Action of L-Dopa in drug induced extrapyramidalism.
Topics: Adult; Chlorpromazine; Chronic Disease; Dihydroxyphenylalanine; Extrapyramidal Tracts; Female; Human | 1970 |
Transitory procaine-induced Parkinsonism.
Topics: Chronic Disease; Dihydroxyphenylalanine; Female; Humans; Middle Aged; Parkinson Disease; Parkinson D | 1971 |
[Urinary excretion of catecholamines and sodium and potassium levels in serum and erythrocytes in patients with renal hypertension].
Topics: Adrenocortical Hyperfunction; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epi | 1967 |
[Clinical picture of LSD psychosis following premedication with 1-tyrosine and dl-DOPA in chronic alcoholics].
Topics: Alcoholism; Chronic Disease; Dihydroxyphenylalanine; Humans; Lysergic Acid Diethylamide; Male; Psych | 1968 |