Page last updated: 2024-10-18

dihydroxyphenylalanine and Chronic Disease

dihydroxyphenylalanine has been researched along with Chronic Disease in 44 studies

Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"Three of six patients with chronic hepatic encephalopathy treated with levodopa showed a significant improvement."2.64Treatment of chronic hepatic encephalopathy with levodopa. ( James, IM; Lunzer, M; Sherlock, S; Weinman, J, 1974)
" The influence of acute and chronic administration of alcohol was studied in experiments in animals as well as its discontinuation on the catecholamine structures in different areas of the CNS."1.25[The role of disorders in the functions of the cerebral catecholamine system in the pathogenesis of chronic alcoholism]. ( Anokhina, IP; Kogan, BM, 1975)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199034 (77.27)18.7374
1990's2 (4.55)18.2507
2000's8 (18.18)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nigmatullina, RR1
Kirillova, VV2
Jourjikiya, RK1
Mukhamedyarov, MA1
Kudrin, VS2
Klodt, PM2
Palotás, A1
Nigmatullin, RR1
Dzhordzhikiia, RK1
Goldstein, DS1
Holmes, C1
Frank, SM1
Dendi, R1
Cannon, RO1
Sharabi, Y1
Esler, MD1
Eisenhofer, G1
Prieto, M1
Gómez, FM1
Teresa Giralt, M1
Fedorova, NV1
Glozman, ZhM1
Saltykova, NM1
Elkashef, AM1
Doudet, D1
Bryant, T1
Cohen, RM1
Li, SH1
Wyatt, RJ1
Jääskeläinen, SK1
Rinne, JO1
Forssell, H1
Tenovuo, O1
Kaasinen, V1
Sonninen, P1
Bergman, J1
Lauer, M1
Schirrmeister, H1
Gerhard, A1
Ellitok, E1
Beckmann, H1
Reske, SN1
Stöber, G1
Esteban, S1
Moranta, D1
Sastre-Coll, A1
Miralles, A1
García-Sevilla, JA1
Shelygina, NM1
Osychniuk, VI1
Mel'nikov, SA1
Maddrey, WC1
Weber, FL1
Anokhina, IP1
Kogan, BM1
Nisenbaum, LK1
Abercrombie, ED1
Wolters, EC1
Huang, CC1
Clark, C1
Peppard, RF1
Okada, J1
Chu, NS1
Adam, MJ1
Ruth, TJ1
Li, D1
Calne, DB1
Castilla-Serna, L1
Alva-González, D1
Ramírez-López, E1
Serrano-Money, F1
Cravioto, J1
Hegedus, ZL1
Altschule, MD1
Nayak, U1
Neumayr, A1
Keegan, DL1
Rajput, AH1
Cotzias, GC3
Papavasiliou, PS3
Gellene, R1
Geller, LI2
Kazimirchik, AP2
Amatniak, AG2
Kontsevaia, NG1
Black, MM1
Wilson-Jones, E1
Lunzer, M1
James, IM1
Weinman, J1
Sherlock, S1
Spiers, AS1
Jacobson, S1
Bell, B1
Kaliuzhnaia, RA1
Tkachev, RA1
Markova, ED1
Gotovtseva, EV1
Barkhatova, VP1
Ivanova-Smolenskaia, IA1
Krasnov, EA1
Romenskaia, LKh1
Frolova, IA1
Beiul, EA1
Volkova, IS1
Sirota, II1
Singer, E1
Karpenko, EI2
Kamyshan, IS1
Ginos, J1
Steck, A1
Düby, S1
Rosenstock, HA1
Simons, DG1
Meyer, JS1
Deĭneko, VS1
Hyman, MD1
Sergeev, VM1
Spektor, EB1
Granova, LV1
Kibrik, BS1
DiGiacomo, JN1
Fahn, S1
Glass, JB1
Westlake, RJ1
Mena, I1
Court, J1
Fuenzalida, S1
Skugarevskaia, EI1
Yaryura-Tobias, JA1
Wolpert, A1
Dana, L1
Merlis, S1
Gjerris, F1
Midelauri, BG1
Vjtĕchovský, M1
Skála, J1
Safratová, V1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Laboratory Evaluation of Chronic Orthostatic Intolerance[NCT00069693]200 participants Observational2003-09-26Completed
Propranolol for Syncope With Sympathoadrenal Imbalance[NCT00060866]Phase 424 participants Interventional2003-05-31Completed
Propranolol for Syncope With Sympathoadrenal Imbalance in Children[NCT00093860]Phase 250 participants Interventional2004-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for dihydroxyphenylalanine and Chronic Disease

ArticleYear
[Advances in the treatment of liver disease].
    Wiener medizinische Wochenschrift (1946), 1973, Oct-06, Issue:40

    Topics: Amino Acids; Anti-Bacterial Agents; Chronic Disease; Dihydroxyphenylalanine; Enzyme Induction; Excha

1973
Recognition and management of acute and chronic hepatic encephalopathy.
    The Medical clinics of North America, 1973, Volume: 57, Issue:6

    Topics: Acute Disease; Amines; Ammonia; Animals; Brain Edema; Central Nervous System; Chronic Disease; Diet

1973
Metabolic modification of Parkinson's disease and of chronic manganese poisoning.
    Annual review of medicine, 1971, Volume: 22

    Topics: Animals; Brain; Choline; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Humans; Manganese

1971

Trials

4 trials available for dihydroxyphenylalanine and Chronic Disease

ArticleYear
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
    Circulation, 2002, Oct-29, Volume: 106, Issue:18

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Autonomic Nervous System Diseases; Chronic Disease;

2002
Modification of Parkinsonism--chronic treatment with L-dopa.
    The New England journal of medicine, 1969, Feb-13, Volume: 280, Issue:7

    Topics: Adult; Aged; Agranulocytosis; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Urea Nitrogen; Blo

1969
Treatment of chronic hepatic encephalopathy with levodopa.
    Gut, 1974, Volume: 15, Issue:7

    Topics: Adult; Aged; Brain; Cerebrovascular Circulation; Chronic Disease; Computers; Dihydroxyphenylalanine;

1974
Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane.
    The New England journal of medicine, 1970, Jan-01, Volume: 282, Issue:1

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Chronic Disease; Dihydroxyphenylalanine; Humans; Male; Manga

1970

Other Studies

37 other studies available for dihydroxyphenylalanine and Chronic Disease

ArticleYear
Disrupted serotonergic and sympathoadrenal systems in patients with chronic heart failure may serve as new therapeutic targets and novel biomarkers to assess severity, progression and response to treatment.
    Cardiology, 2009, Volume: 113, Issue:4

    Topics: Adrenal Glands; Adrenergic beta-Antagonists; Adult; Biomarkers; Chronic Disease; Dihydroxyphenylalan

2009
[The state of sympathetic-adrenal system in patients with chronic cardiac insufficiency].
    Klinicheskaia meditsina, 2009, Volume: 87, Issue:4

    Topics: Adrenal Glands; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Heart Failur

2009
Effects of acute, repeated and chronic variable stress on in vivo tyrosine hydroxylase activity and on alpha(2)-adrenoceptor sensitivity in the rat brain.
    Stress (Amsterdam, Netherlands), 2003, Volume: 6, Issue:4

    Topics: Acute Disease; Adrenergic alpha-Agonists; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Bra

2003
[The efficacy of the Umex treatment of parkinsonism patients in the initial stage of the disease].
    Terapevticheskii arkhiv, 1995, Volume: 67, Issue:10

    Topics: Adult; Aged; Antiparkinson Agents; Chronic Disease; Dihydroxyphenylalanine; Drug Evaluation; Drug Th

1995
6-(18)F-DOPA PET study in patients with schizophrenia. Positron emission tomography.
    Psychiatry research, 2000, Nov-20, Volume: 100, Issue:1

    Topics: Adult; Antipsychotic Agents; Aromatic-L-Amino-Acid Decarboxylases; Brain; Case-Control Studies; Chro

2000
Role of the dopaminergic system in chronic pain -- a fluorodopa-PET study.
    Pain, 2001, Feb-15, Volume: 90, Issue:3

    Topics: Adult; Aged; Burning Mouth Syndrome; Chronic Disease; Dihydroxyphenylalanine; Female; Humans; Middle

2001
Disturbed neural circuits in a subtype of chronic catatonic schizophrenia demonstrated by F-18-FDG-PET and F-18-DOPA-PET.
    Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:6

    Topics: Adult; Brain; Chronic Disease; Dihydroxyphenylalanine; Fluorine Radioisotopes; Fluorodeoxyglucose F1

2001
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo.
    Neuroscience letters, 2002, Jun-28, Volume: 326, Issue:2

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Cerebral Cor

2002
[State of the sympathico-adrenal system in patients with pre-asthma conditions].
    Vrachebnoe delo, 1976, Issue:10

    Topics: Adrenal Glands; Adult; Aged; Asthma; Bronchial Spasm; Catecholamines; Chronic Disease; Dihydroxyphen

1976
Chronic hepatic encephalopathy.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Amino Acids, Essential; Ammonia; Analgesics; Anesthesia; Anti-Bacterial Agents; Biogenic Amines; Chr

1975
[The role of disorders in the functions of the cerebral catecholamine system in the pathogenesis of chronic alcoholism].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:12

    Topics: Alcoholic Intoxication; Alcoholism; Brain; Catecholamines; Chronic Disease; Dihydroxyphenylalanine;

1975
Enhanced tyrosine hydroxylation in hippocampus of chronically stressed rats upon exposure to a novel stressor.
    Journal of neurochemistry, 1992, Volume: 58, Issue:1

    Topics: alpha-Methyltyrosine; Animals; Chronic Disease; Dihydroxyphenylalanine; Extracellular Space; Hippoca

1992
Positron emission tomography in manganese intoxication.
    Annals of neurology, 1989, Volume: 26, Issue:5

    Topics: Adult; Brain; Chronic Disease; Dihydroxyphenylalanine; Humans; Magnetic Resonance Imaging; Manganese

1989
[Effect of nutrition and environment on noradrenergic metabolism in the central nervous system. I. Chronic malnutrition].
    Boletin medico del Hospital Infantil de Mexico, 1988, Volume: 45, Issue:8

    Topics: Animals; Body Weight; Brain; Chronic Disease; Dihydroxyphenylalanine; Male; Norepinephrine; Protein-

1988
Studies on rheomelanins. 3. Excessive hemolysis associated with the production of rheomelanins from L-norepinephrine, from dopamine and from L-dopa in the blood of chronic schizophrenic patients.
    Archives internationales de physiologie et de biochimie, 1971, Volume: 79, Issue:2

    Topics: Chromatography, Paper; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Erythrocytes; Hemolysis; H

1971
Drug induced dystonia tarda: treatment with L-dopa.
    Diseases of the nervous system, 1973, Volume: 34, Issue:3

    Topics: Antipsychotic Agents; Chlorpromazine; Chronic Disease; Diazepam; Dihydroxyphenylalanine; Dystonia Mu

1973
L-dopa in chronic manganese poisoning.
    Lancet (London, England), 1970, Jan-31, Volume: 1, Issue:7640

    Topics: Chronic Disease; Dihydroxyphenylalanine; Humans; Manganese Poisoning

1970
[Biogenic amines in chronic pancreatitis].
    Voprosy meditsinskoi khimii, 1973, Volume: 19, Issue:6

    Topics: Amine Oxidase (Copper-Containing); Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine

1973
The role of the epidermis in the histopathogenesis of lichen planus. Histochemical correlations.
    Archives of dermatology, 1972, Volume: 105, Issue:1

    Topics: Acid Phosphatase; Acute Disease; Biopsy; Catechol Oxidase; Chronic Disease; Depression, Chemical; Di

1972
Ineffectiveness of dextrodopa in chronic granulocytic leukaemia.
    Australian and New Zealand journal of medicine, 1974, Volume: 4, Issue:5

    Topics: Adult; Chronic Disease; Dihydroxyphenylalanine; Female; Hemoglobins; Humans; Leukemia, Myeloid; Leuk

1974
[The syndrome of autonomic vascular dystonia in adolescents and young men with toxic-infectious processes].
    Kardiologiia, 1972, Volume: 12, Issue:10

    Topics: Adolescent; Adult; Autonomic Nervous System; Blood Pressure; Cardiovascular Diseases; Catecholamines

1972
[Principles of the pathogenetic therapy of congenital extrapyramidal diseases].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:4

    Topics: Adolescent; Adult; Atropine; Basal Ganglia Diseases; Chelating Agents; Chronic Disease; Dihydroxyphe

1973
[Clinical electroencephalographic studies during the treatment of parkinsonism with an L-DOPA preparation].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:4

    Topics: Aged; Alpha Rhythm; Chronic Disease; Dihydroxyphenylalanine; Electroencephalography; Female; Humans;

1973
[State of catecholamine and DOPA excretion in metabolic-alimentary obesity].
    Voprosy meditsinskoi khimii, 1974, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Arteriosclerosis; Catecholamines; Cholesterol; Chronic Disease; Circadian Rhythm;

1974
Premature social aging: the social-psychological consequences of a chronic illness.
    Social science & medicine, 1974, Volume: 8, Issue:3

    Topics: Aging; Anger; Attitude; Attitude to Health; Boredom; Chronic Disease; Dihydroxyphenylalanine; Emotio

1974
[Diurnal rhythm of catecholamine excretion and reactivity of the symphathetic-adrenal system in patients with chronic pyelonephritis].
    Sovetskaia meditsina, 1974, Volume: 37, Issue:3

    Topics: Adolescent; Adrenal Glands; Adult; Catecholamines; Chronic Disease; Circadian Rhythm; Dihydroxypheny

1974
[Comparison of clinico-metabolic indicators in patients with chronic cholecystopancreatitis and chronic cholecystitis].
    Sovetskaia meditsina, 1974, Volume: 37, Issue:3

    Topics: 17-Hydroxycorticosteroids; Catecholamines; Cholecystitis; Chronic Disease; Dihydroxyphenylalanine; D

1974
Chronic manganism. Neurologic and laboratory studies during treatment with levodopa.
    JAMA, 1971, Sep-06, Volume: 217, Issue:10

    Topics: Administration, Oral; Adult; Chronic Disease; Dihydroxyphenylalanine; Edetic Acid; Facial Expression

1971
[Excretion of catecholamines and their precursors and indices of electrolyte balance in patients with chronic glomerulonephritis].
    Vrachebnoe delo, 1972, Volume: 1

    Topics: Adolescent; Adult; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epinephrine; G

1972
Sociopsychological obstacles to L-dopa therapy that may limit effectiveness in parkinsonism.
    Journal of the American Geriatrics Society, 1972, Volume: 20, Issue:5

    Topics: Attitude to Health; Chronic Disease; Dihydroxyphenylalanine; Humans; Interpersonal Relations; Parkin

1972
[Condition of the sympatho-adrenal system in children with surgical forms of chronic non-specific lung diseases].
    Pediatriia, 1972, Volume: 51, Issue:7

    Topics: Adolescent; Adrenal Glands; Age Factors; Catecholamines; Child; Chronic Disease; Dihydroxyphenylalan

1972
A case with Gilles de la Tourette's syndrome: recurrent refractoriness to haloperidol, and unsuccessful treatment with L-dopa.
    The Journal of nervous and mental disease, 1971, Volume: 152, Issue:2

    Topics: Adult; Chlorpromazine; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Haloperidol; Humans;

1971
[The relationship of the metabolism of biogenic amines to affective pathology in chronic alcoholism].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1969, Volume: 69, Issue:6

    Topics: Affective Symptoms; Alcoholism; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; E

1969
Action of L-Dopa in drug induced extrapyramidalism.
    Diseases of the nervous system, 1970, Volume: 31, Issue:1

    Topics: Adult; Chlorpromazine; Chronic Disease; Dihydroxyphenylalanine; Extrapyramidal Tracts; Female; Human

1970
Transitory procaine-induced Parkinsonism.
    Journal of neurology, neurosurgery, and psychiatry, 1971, Volume: 34, Issue:1

    Topics: Chronic Disease; Dihydroxyphenylalanine; Female; Humans; Middle Aged; Parkinson Disease; Parkinson D

1971
[Urinary excretion of catecholamines and sodium and potassium levels in serum and erythrocytes in patients with renal hypertension].
    Kardiologiia, 1967, Volume: 7, Issue:7

    Topics: Adrenocortical Hyperfunction; Catecholamines; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Epi

1967
[Clinical picture of LSD psychosis following premedication with 1-tyrosine and dl-DOPA in chronic alcoholics].
    Activitas nervosa superior, 1968, Oct-03, Volume: 10, Issue:3

    Topics: Alcoholism; Chronic Disease; Dihydroxyphenylalanine; Humans; Lysergic Acid Diethylamide; Male; Psych

1968