dihydroxyphenylalanine and Cancer of the Thyroid studies

Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.

Research Excerpts

Excerpt	Relevance	Reference
"(18)F-fluorodihydroxyphenylalanine (FDOPA) is a powerful tool for the diagnosis and detection of neuroendocrine tumors when planning and monitoring surgical and oncologic therapies."	8.90	18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. ( Forsback, S; Kauhanen, S; Kemppainen, J; Minn, H; Seppänen, M, 2014)
"In recent years, 6-l-18F-fluorodihydroxyphenylalanine (18F-DOPA) PET has emerged as a new diagnostic tool for the imaging of neuroendocrine tumors."	8.84	6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. ( Brouwers, AH; Chirakal, R; Gulenchyn, KY; Jager, PL; Koopmans, KP; Marriott, CJ, 2008)
"(18)F-fluorodihydroxyphenylalanine (FDOPA) is a powerful tool for the diagnosis and detection of neuroendocrine tumors when planning and monitoring surgical and oncologic therapies."	4.90	18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. ( Forsback, S; Kauhanen, S; Kemppainen, J; Minn, H; Seppänen, M, 2014)
"In recent years, 6-l-18F-fluorodihydroxyphenylalanine (18F-DOPA) PET has emerged as a new diagnostic tool for the imaging of neuroendocrine tumors."	4.84	6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. ( Brouwers, AH; Chirakal, R; Gulenchyn, KY; Jager, PL; Koopmans, KP; Marriott, CJ, 2008)
"11 C-methionine was most sensitive in lung lesions."	3.01	Sensitivities evaluation of five radiopharmaceuticals in four common medullary thyroid carcinoma metastatic sites on PET/CT: a network meta-analysis and systematic review. ( Li, P; Wei, T; Xu, T; Zhang, Y; Zhao, W; Zhu, J, 2023)
"Medullary thyroid cancer (MTC) is considered as a rare thyroid cancer."	2.50	18F-DOPA and 18F-FDG PET/CT, scintigraphic localization and radioguided surgery of recurrent medullary thyroid cancer: two case reports. ( Evangelista, L; Farsad, M; Pelizzo, MR; Piotto, A, 2014)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (5.41)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (10.81)	29.6817
2010's	29 (78.38)	24.3611
2020's	2 (5.41)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Use of Fluorodopa F 18 Positron Emission Tomography Combined With Computed Tomography in Congenital Hyperinsulinism and Insulinoma[NCT02021604]			Phase 1	250 participants (Anticipated)	Interventional	2013-10-09	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Sensitivities evaluation of five radiopharmaceuticals in four common medullary thyroid carcinoma metastatic sites on PET/CT: a network meta-analysis and systematic review. Nuclear medicine communications, 2023, Dec-01, Volume: 44, Issue:12 Topics: Dihydroxyphenylalanine; Humans; Methionine; Network Meta-Analysis; Positron Emission Tomography Comp	2023
18F-fluorodihydroxyphenylalanine vs other radiopharmaceuticals for imaging neuroendocrine tumours according to their type. European journal of nuclear medicine and molecular imaging, 2013, Volume: 40, Issue:6 Topics: 3-Iodobenzylguanidine; Bronchial Neoplasms; Carcinoma, Merkel Cell; Dihydroxyphenylalanine; Fluorode	2013
What is currently the best radiopharmaceutical for the hybrid PET/CT detection of recurrent medullary thyroid carcinoma? Current radiopharmaceuticals, 2013, Jun-06, Volume: 6, Issue:2 Topics: Amines; Blood Glucose; Bone and Bones; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Fluorine R	2013
18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. PET clinics, 2014, Volume: 9, Issue:1 Topics: Adrenal Gland Neoplasms; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Humans; Intestinal Neopl	2014
Role of (18) F-FDOPA PET/CT imaging in endocrinology. Clinical endocrinology, 2014, Volume: 81, Issue:6 Topics: Adrenal Gland Neoplasms; Carbidopa; Carcinoid Tumor; Carcinoma, Neuroendocrine; Dihydroxyphenylalani	2014
18F-DOPA and 18F-FDG PET/CT, scintigraphic localization and radioguided surgery of recurrent medullary thyroid cancer: two case reports. Current radiopharmaceuticals, 2014, Volume: 7, Issue:2 Topics: Adult; Aged; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Huma	2014
PET/Computed Tomography in Neuroendocrine Tumor: Value to Patient Management and Survival Outcomes. PET clinics, 2015, Volume: 10, Issue:3 Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Gallium Radioisotopes; Gast	2015
Detection rate of recurrent medullary thyroid carcinoma using fluorine-18 dihydroxyphenylalanine positron emission tomography: a meta-analysis. Academic radiology, 2012, Volume: 19, Issue:10 Topics: Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Humans; Neoplasm Recurrence, Local; Positron-Emis	2012
Comparison of different positron emission tomography tracers in patients with recurrent medullary thyroid carcinoma: our experience and a review of the literature. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2013, Volume: 194 Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Fluorodeo	2013
6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49, Issue:4 Topics: Adenoma, Islet Cell; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Neuroendocrine Tumors; Pancrea	2008

Article	Year
Complementary roles of 18F-DOPA PET/CT and 18F-FDG PET/CT in medullary thyroid cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:12 Topics: Adult; Aged; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Neuroendocrine; Cell Proliferation; Di	2011
18F-DOPA positron emission tomography for tumour detection in patients with medullary thyroid carcinoma and elevated calcitonin levels. European journal of nuclear medicine, 2001, Volume: 28, Issue:1 Topics: Aged; Calcitonin; Carcinoma, Medullary; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Huma	2001

Article	Year
Synchronous bilateral pheochromocytomas and bilobar medullary thyroid carcinoma revealed by Endocrine, 2019, Volume: 66, Issue:3 Topics: Adrenal Gland Neoplasms; Adult; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Humans; M	2019
Which Is the Optimal Scan Time of 18F-DOPA PET/CT in Patients With Recurrent Medullary Thyroid Carcinoma?: Results From a Dynamic Acquisition Study. Clinical nuclear medicine, 2020, Volume: 45, Issue:3 Topics: Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Humans; Image Processing, Computer-Assist	2020
The value of 18F-DOPA PET/CT in patients with medullary thyroid carcinoma and increased calcitonin values. Nuclear medicine communications, 2017, Volume: 38, Issue:7 Topics: Adolescent; Adult; Aged; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Neuroendocrine; Dihydroxyp	2017
[ European journal of nuclear medicine and molecular imaging, 2018, Volume: 45, Issue:12 Topics: Adult; Aged; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; P	2018
Medullary Thyroid Carcinoma: Do Ultrasonography and F-DOPA-PET-CT Influence the Initial Surgical Strategy? Annals of surgical oncology, 2018, Volume: 25, Issue:13 Topics: Adolescent; Adult; Aged; Calcitonin; Carcinoma, Neuroendocrine; Child; Clinical Decision-Making; Dih	2018
Parathyroid Glands Hyperplasias Mimicking Medullary Thyroid Carcinoma Metastatic Lymph Nodes on 18F-DOPA PET/CT. Clinical nuclear medicine, 2019, Volume: 44, Issue:8 Topics: Adult; Carcinoma, Neuroendocrine; Diagnosis, Differential; Dihydroxyphenylalanine; Female; Fluorine	2019
Relevance of calcitonin cut-off in the follow-up of medullary thyroid carcinoma for conventional imaging and 18-fluorine-fluorodihydroxyphenylalanine PET. Anticancer research, 2014, Volume: 34, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Calcitonin; Carcinoma, Medullary; Dihydroxyphenylalanine; Female; Fo	2014
(18)F-DOPA PET/CT in the diagnosis and localization of persistent medullary thyroid carcinoma. European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Calcitonin; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Femal	2016
18F-DOPA PET/CT in Orbital Metastasis From Medullary Thyroid Carcinoma. Clinical nuclear medicine, 2016, Volume: 41, Issue:6 Topics: Adult; Calcitonin; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes	2016
The value of 18F-DOPA PET-CT in patients with medullary thyroid carcinoma: comparison with 18F-FDG PET-CT. European radiology, 2009, Volume: 19, Issue:6 Topics: Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission	2009
PET imaging of medullary thyroid carcinoma in MEN2A transgenic mice using 6-[(18)F]F-L-DOPA. European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:1 Topics: Animals; Carcinoma, Medullary; Dihydroxyphenylalanine; Mice; Mice, Transgenic; Multiple Endocrine Ne	2010
(68)Ga-somatostatin analogues PET and (18)F-DOPA PET in medullary thyroid carcinoma. European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:1 Topics: Carcinoma, Medullary; Dihydroxyphenylalanine; Humans; Neoplasm Recurrence, Local; Organometallic Com	2010
Dual PET/CT with (18)F-DOPA and (18)F-FDG in metastatic medullary thyroid carcinoma and rapidly increasing calcitonin levels: Comparison with conventional imaging. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2010, Volume: 36, Issue:4 Topics: Adult; Aged; Biomarkers, Tumor; Calcitonin; Carcinoma, Medullary; Chi-Square Distribution; Dihydroxy	2010
Visualization of cardiac metastasis from medullary thyroid carcinoma on F-18 DOPA PET/CT scan. Clinical nuclear medicine, 2010, Volume: 35, Issue:4 Topics: Carcinoma; Dihydroxyphenylalanine; Female; Heart Neoplasms; Humans; Middle Aged; Positron-Emission T	2010
Clinical value of 18-fluorine-fluorodihydroxyphenylalanine positron emission tomography/computed tomography in the follow-up of medullary thyroid carcinoma. Thyroid : official journal of the American Thyroid Association, 2010, Volume: 20, Issue:5 Topics: Adolescent; Adult; Aged; Calcitonin; Carcinoma, Medullary; Child; Dihydroxyphenylalanine; Disease Pr	2010
Solitary hepatic metastasis from medullary thyroid carcinoma mimicking atypical hemangioma: insights from multimodality diagnostic approach by MRI, F-18 FDG and F-18 FDOPA PET/CT. Clinical nuclear medicine, 2010, Volume: 35, Issue:6 Topics: Diagnosis, Differential; Diagnostic Imaging; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18;	2010
Metabolic imaging allows early prediction of response to vandetanib. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:2 Topics: Aged; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclins; Dihydroxyphenylalanine; Do	2011
Comparison of 18F-DOPA, 18F-FDG and 68Ga-somatostatin analogue PET/CT in patients with recurrent medullary thyroid carcinoma. European journal of nuclear medicine and molecular imaging, 2012, Volume: 39, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Calcitonin; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Femal	2012
Added value of early 18F-FDOPA PET/CT acquisition time in medullary thyroid cancer. Nuclear medicine communications, 2012, Volume: 33, Issue:7 Topics: Adult; Aged; Carcinoma, Medullary; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Multim	2012
Terminal ileum neuroendocrine incidentaloma in a patient with sporadic medullary thyroid carcinoma: findings from 18F-FDOPA PET/CT investigation. Clinical nuclear medicine, 2012, Volume: 37, Issue:8 Topics: Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Humans; Ileal Neoplasms; Incidental Findi	2012
Clinical relevance of 18F-FDG PET and 18F-DOPA PET in recurrent medullary thyroid carcinoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:12 Topics: Adult; Aged; Carcinoembryonic Antigen; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Disease Pr	2012
(18)F-DOPA PET/CT revealed synchronous neuroendocrine tumors in two sisters with MEN2A syndrome. Endocrine, 2013, Volume: 43, Issue:2 Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Carcinoma, Medullary; Dihydroxyphenylalanine; Female;	2013
Diagnostic impact of PET with 18F-FDG, 18F-DOPA and 3-O-methyl-6-[18F]fluoro-DOPA in recurrent or metastatic medullary thyroid carcinoma. European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:10 Topics: Adult; Aged; Carcinoma, Medullary; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Humans; M	2007
Dopa decarboxylase in medullary carcinoma of the thyroid. The New England journal of medicine, 1973, Sep-13, Volume: 289, Issue:11 Topics: Adrenal Gland Neoplasms; Amine Oxidase (Copper-Containing); Aromatic Amino Acid Decarboxylase Inhibi	1973
[Hydroxytryptamine in human thyroid gland neoplasms developing from the C-cells]. Vestnik Akademii meditsinskikh nauk SSSR, 1971, Volume: 26, Issue:8 Topics: Amyloidosis; Dihydroxyphenylalanine; Humans; Microscopy, Fluorescence; Serotonin; Thyroid Neoplasms	1971

dihydroxyphenylalanine and Cancer of the Thyroid

Research Excerpts

Research

Studies (37)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Li, P	1
Zhang, Y	1
Xu, T	1
Zhu, J	1
Wei, T	1
Zhao, W	1
Rotania, M	1
Chabrier, G	2
Imperiale, A	4
Taralli, S	1
Lorusso, M	1
Capotosti, A	1
Lanni, V	1
Indovina, L	1
Rufini, V	5
Golubić, AT	1
Pasini Nemir, E	1
Žuvić, M	1
Mutvar, A	1
Kusačić Kuna, S	1
Despot, M	1
Samardžić, T	1
Huić, D	1
Rasul, S	1
Hartenbach, S	1
Rebhan, K	1
Göllner, A	1
Karanikas, G	3
Mayerhoefer, M	2
Mazal, P	1
Hacker, M	1
Hartenbach, M	1
Brammen, L	1
Niederle, MB	1
Riss, P	1
Scheuba, C	1
Selberherr, A	1
Bodner, G	1
Koperek, O	1
Niederle, B	1
Terroir, M	1
Grimaldi, S	1
Hartl, D	1
Leboulleux, S	1
Deandreis, D	1
Balogova, S	2
Talbot, JN	3
Nataf, V	2
Michaud, L	1
Huchet, V	1
Kerrou, K	2
Montravers, F	3
Slavikova, K	1
Treglia, G	5
Kunikowska, J	1
Kaliska, L	1
Vereb, M	1
Minn, H	2
Kemppainen, J	1
Kauhanen, S	2
Forsback, S	1
Seppänen, M	2
Santhanam, P	1
Taïeb, D	2
Evangelista, L	1
Farsad, M	1
Piotto, A	1
Pelizzo, MR	2
Sesti, A	1
Weber, M	1
Anner, P	1
Wadsak, W	1
Dudczak, R	1
Haug, A	1
Shamim, SA	1
Kumar, A	1
Kumar, R	1
Archier, A	1
Heimburger, C	1
Guerin, C	1
Morange, I	1
Palazzo, FF	1
Henry, JF	1
Schneegans, O	2
Mundler, O	1
Abdullah, AE	1
Sebag, F	1
Ruiz, JB	1
Orré, M	1
Cazeau, AL	1
Henriques de Figueiredo, B	1
Godbert, Y	1
Beheshti, M	1
Pöcher, S	1
Vali, R	1
Waldenberger, P	1
Broinger, G	1
Nader, M	1
Kohlfürst, S	1
Pirich, C	1
Dralle, H	2
Langsteger, W	1
Pestourie, C	1
Thézé, B	1
Kuhnast, B	1
Le Helleix, S	1
Gombert, K	1
Dollé, F	1
Tavitian, B	1
Ducongé, F	1
Ambrosini, V	4
Marzola, MC	2
Rubello, D	2
Fanti, S	4
Ferdeghini, M	1
Toniato, A	1
Massaro, A	1
Gross, MD	1
Al-Nahhas, A	1
Morel, O	1
Giraud, P	1
Cahouet, A	1
Lacoeuille, F	1
Girault, S	1
Luster, M	1
Karges, W	1
Zeich, K	1
Pauls, S	1
Verburg, FA	1
Glatting, G	1
Buck, AK	1
Solbach, C	1
Neumaier, B	1
Reske, SN	1
Mottaghy, FM	1
Greget, M	1
Keomany, J	1
Rust, E	2
Detour, J	1
Pessaux, P	1
Goichot, B	1
Walter, MA	1
Benz, MR	1
Hildebrandt, IJ	1
Laing, RE	1
Hartung, V	1
Damoiseaux, RD	1
Bockisch, A	1
Phelps, ME	1
Czernin, J	1
Weber, WA	1
Schalin-Jäntti, C	1
Kajander, S	1
Virtanen, S	1
Schildt, J	1
Lisinen, I	1
Ahonen, A	1
Heiskanen, I	1
Väisänen, M	1
Arola, J	1
Korsoff, P	1
Ebeling, T	1
Sane, T	1
Välimäki, MJ	1
Nuutila, P	1
Castaldi, P	3
Villani, MF	2
Perotti, G	2
de Waure, C	2
Filice, A	2
Cremonini, N	2
Santimaria, M	1
Versari, A	2
Giordano, A	3
Soussan, M	1
Grahek, D	1
Pascal, O	1
Boulanger, C	1
Roedlich, MN	1
Ollier, JC	1
Cocciolillo, F	1
Di Nardo, F	1
Poscia, A	1
Verbeek, HH	1
Plukker, JT	1
Koopmans, KP	2
de Groot, JW	1
Hofstra, RM	1
Muller Kobold, AC	1
van der Horst-Schrivers, AN	1
Brouwers, AH	2
Links, TP	1
Beuthien-Baumann, B	1
Strumpf, A	1
Zessin, J	1
Bredow, J	1
Kotzerke, J	1
Jager, PL	1
Chirakal, R	1
Marriott, CJ	1
Gulenchyn, KY	1
Hoegerle, S	1
Altehoefer, C	1
Ghanem, N	1
Brink, I	1
Moser, E	1
Nitzsche, E	1
Atkins, FL	1
Beaven, MA	1
Keiser, HR	1
Beskid, M	1