dihydroxyphenylalanine has been researched along with Basal Ganglia Diseases in 36 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Basal Ganglia Diseases: Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Seven months later he developed a left rest tremor associated with mild bilateral extrapyramidal symptoms and responsive to levodopa treatment." | 3.69 | Rest tremor and extrapyramidal symptoms after midbrain haemorrhage: clinical and 18F-dopa PET evaluation. ( Defer, GL; Degos, JD; Malapert, D; Remy, P; Ricolfi, F; Samson, Y, 1994) |
| "For example, in substantia nigra in Parkinson's diseases key alterations occur, in iron handling, mitochondrial function and antioxidant defences, particularly reduced glutathione." | 2.39 | Oxidative stress in Parkinson's disease and other neurodegenerative disorders. ( Jenner, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (77.78) | 18.7374 |
| 1990's | 3 (8.33) | 18.2507 |
| 2000's | 3 (8.33) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, T | 1 |
| Nakamura, M | 1 |
| Shimizu, T | 1 |
| Oda, K | 1 |
| Ishiwata, K | 1 |
| Ishii, K | 1 |
| Isse, K | 1 |
| Goldstein, DS | 1 |
| Rissanen, E | 1 |
| Paavilainen, T | 1 |
| Virta, J | 1 |
| Marttila, RJ | 1 |
| Rinne, JO | 1 |
| Airas, L | 1 |
| Binkofski, F | 1 |
| Reetz, K | 1 |
| Gaser, C | 1 |
| Hilker, R | 1 |
| Hagenah, J | 1 |
| Hedrich, K | 1 |
| van Eimeren, T | 1 |
| Thiel, A | 1 |
| Büchel, C | 1 |
| Pramstaller, PP | 1 |
| Siebner, HR | 1 |
| Klein, C | 1 |
| Bouilleret, V | 1 |
| Semah, F | 1 |
| Chassoux, F | 1 |
| Mantzaridez, M | 1 |
| Biraben, A | 1 |
| Trebossen, R | 1 |
| Ribeiro, MJ | 1 |
| Arushanian, EB | 1 |
| Dutov, AA | 1 |
| Defer, GL | 1 |
| Remy, P | 1 |
| Malapert, D | 1 |
| Ricolfi, F | 1 |
| Samson, Y | 1 |
| Degos, JD | 1 |
| Jenner, P | 1 |
| Nagasawa, H | 1 |
| Tanji, H | 1 |
| Nomura, H | 1 |
| Saito, H | 1 |
| Itoyama, Y | 1 |
| Kimura, I | 1 |
| Tuji, S | 1 |
| Fujiwara, T | 1 |
| Iwata, R | 1 |
| Itoh, M | 1 |
| Ido, T | 1 |
| Mosunova, TG | 1 |
| Janzik, HH | 1 |
| Soyka, D | 1 |
| Carlsson, A | 1 |
| Papeschi, R | 1 |
| Molina-Negro, P | 1 |
| Sourkes, TL | 1 |
| Erba, G | 1 |
| Steg, G | 1 |
| Klawans, HL | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Chase, TN | 1 |
| Levin, SL | 1 |
| Calne, DB | 1 |
| Reid, JL | 1 |
| Goldman, ME | 1 |
| Omori, K | 1 |
| Orima, H | 1 |
| Kojima, T | 1 |
| Takahira, H | 1 |
| Ferel, D | 1 |
| Hornykiewicz, O | 1 |
| Yahr, MD | 1 |
| Nittner, K | 1 |
| Fischer, PA | 1 |
| Sigwald, J | 1 |
| Tkachev, RA | 1 |
| Markova, ED | 1 |
| Gotovtseva, EV | 1 |
| Barkhatova, VP | 1 |
| Ivanova-Smolenskaia, IA | 1 |
| Nicholson, WJ | 1 |
| Mastaglia, FL | 1 |
| Grainger, K | 1 |
| Kee, F | 1 |
| Sadka, M | 1 |
| Lefroy, R | 1 |
| Sutcliffe, RL | 1 |
| Miller, EM | 1 |
| Wiener, L | 1 |
| Mars, H | 1 |
| Libman, I | 1 |
| Schwartz, AM | 1 |
| Gillo-Joffroy, L | 1 |
| Barbeau, A | 1 |
| Sharpe, J | 1 |
| Marquez-Julio, A | 1 |
| Ashby, P | 1 |
| Longo, V | 1 |
| Kemali, D | 1 |
| Pacini, A | 1 |
| Bertolino, A | 1 |
| Lamura, G | 1 |
11 reviews available for dihydroxyphenylalanine and Basal Ganglia Diseases
| Article | Year |
|---|---|
[Nigrostriatal system as a source of torsion extrapyramidal disorders (review)].
Topics: 5-Hydroxytryptophan; Acetylcholine; Animals; Basal Ganglia Diseases; Cats; Caudate Nucleus; Corpus S | 1980 |
Oxidative stress in Parkinson's disease and other neurodegenerative disorders.
Topics: Alzheimer Disease; Basal Ganglia Diseases; Cell Death; Dihydroxyphenylalanine; Dopamine Agents; Glut | 1996 |
Pathological aspects on Parkinson's syndrome.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Central Nervous System; Chlorpromazine; Corpus Stria | 1972 |
The pharmacology of extrapyramidal movement disorders.
Topics: Basal Ganglia Diseases; Chorea; Dihydroxyphenylalanine; Dopamine; Dystonia Musculorum Deformans; Hep | 1973 |
Levodopa: a review of its pharmacological properties and therapeutic use with particular reference to Parkinsonism.
Topics: Amantadine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Basal Ganglia Diseases; Brain Che | 1971 |
Drug-induced extrapyramidal disorders.
Topics: Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Benztropine; Dihydroxyphenylalanine; Dopa | 1972 |
[Dopaminergic conception of Parkinsonism and its treatment with L-DOPA].
Topics: Acetylcholine; Animals; Basal Ganglia Diseases; Brain Chemistry; Corpus Striatum; Dihydroxyphenylala | 1972 |
Antiparkinsonian drugs: pharmacological and therapeutic aspects.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Amantadine; Amphetamine; Antiparkinson Agents; Apomorphi | 1972 |
Dopamine and extrapyramidal motor function and dysfunction.
Topics: Animals; Apomorphine; Basal Ganglia Diseases; Butyrophenones; Caudate Nucleus; Dihydroxyphenylalanin | 1972 |
L-dopa in neurological disease: current status.
Topics: Aged; Amyotrophic Lateral Sclerosis; Basal Ganglia Diseases; Cerebellar Diseases; Cerebrovascular Di | 1972 |
[Therapy of Parkinsonian syndrome using L-dopa. Current state and problems].
Topics: Administration, Oral; Basal Ganglia Diseases; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; Dr | 1974 |
2 trials available for dihydroxyphenylalanine and Basal Ganglia Diseases
| Article | Year |
|---|---|
Basal ganglia involvement in temporal lobe epilepsy: a functional and morphologic study.
Topics: Adolescent; Adult; Basal Ganglia; Basal Ganglia Diseases; Dihydroxyphenylalanine; Dopamine; Down-Reg | 2008 |
[Therapy of Parkinson's syndrome with L-dopa and a decarboxylase inhibitor (Ro 4-4602). Course in 71 patients].
Topics: Basal Ganglia Diseases; Carboxy-Lyases; Cardiovascular Diseases; Clinical Trials as Topic; Dihydroxy | 1972 |
23 other studies available for dihydroxyphenylalanine and Basal Ganglia Diseases
| Article | Year |
|---|---|
Neuroradiologic evidence of pre-synaptic and post-synaptic nigrostriatal dopaminergic dysfunction in idiopathic Basal Ganglia calcification: a case report.
Topics: Adult; Basal Ganglia Diseases; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Humans; Ra | 2010 |
Basal ganglia involvement in temporal lobe epilepsy: a functional and morphologic study.
Topics: Basal Ganglia; Basal Ganglia Diseases; Dihydroxyphenylalanine; Epilepsy, Temporal Lobe; Fluorine Rad | 2008 |
Carbon monoxide poisoning-induced nigrostriatal dopaminergic dysfunction detected using positron emission tomography (PET).
Topics: Adult; Basal Ganglia Diseases; Carbon Monoxide Poisoning; Corpus Striatum; Dihydroxyphenylalanine; D | 2010 |
Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia.
Topics: Adult; Basal Ganglia Diseases; Corpus Striatum; Dihydroxyphenylalanine; DNA Mutational Analysis; Dop | 2007 |
Rest tremor and extrapyramidal symptoms after midbrain haemorrhage: clinical and 18F-dopa PET evaluation.
Topics: Adult; Basal Ganglia Diseases; Dihydroxyphenylalanine; Electromyography; Fluorine Radioisotopes; Hum | 1994 |
PET study of cerebral glucose metabolism and fluorodopa uptake in patients with corticobasal degeneration.
Topics: Aged; Apraxias; Atrophy; Basal Ganglia; Basal Ganglia Diseases; Brain Diseases; Cerebral Cortex; Cer | 1996 |
[Catecholamines metabolism in extrapyramidal disorders in children].
Topics: Adolescent; Ataxia Telangiectasia; Basal Ganglia Diseases; Catecholamines; Child; Child, Preschool; | 1977 |
[Drug-induced extrapyramidal symptoms].
Topics: Anticonvulsants; Antidepressive Agents; Antihypertensive Agents; Basal Ganglia Diseases; Contracepti | 1975 |
[Syndrome involving the extrapyramidal motor systems and their drug treatment].
Topics: Amantadine; Antiparkinson Agents; Basal Ganglia Diseases; Dihydroxyphenylalanine; gamma-Aminobutyric | 1974 |
Antipsychotic drugs and catecholamine synapses.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Binding, Competitive; Brain; Catecholamines; Chlorprom | 1974 |
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp | 1972 |
Levo-dihydroxyphenylalanine--Parkinson's disease and manganese poisoning.
Topics: Basal Ganglia Diseases; Catecholamines; Dihydroxyphenylalanine; Humans; Manganese Poisoning; Parkins | 1972 |
[Pharmacological studies on 5-hydroxy-L-tryptophan (L-5HTP). 1. Influence of L-5HTP on the central nervous system].
Topics: 5-Hydroxytryptophan; Analgesics; Anesthesia, General; Animals; Anticonvulsants; Basal Ganglia Diseas | 1973 |
Hypokinetic syndromes and their therapy.
Topics: Basal Ganglia Diseases; Dihydroxyphenylalanine; Humans; Movement Disorders; Stereotaxic Techniques; | 1972 |
[Treatment of Parkinson's disease and extrapyramidal syndromes with classical drugs (what can be expected from them in the levodopa era and which should be used)].
Topics: Antiparkinson Agents; Basal Ganglia Diseases; Dihydroxyphenylalanine; Humans; Movement Disorders; Pa | 1972 |
[Principles of the pathogenetic therapy of congenital extrapyramidal diseases].
Topics: Adolescent; Adult; Atropine; Basal Ganglia Diseases; Chelating Agents; Chronic Disease; Dihydroxyphe | 1973 |
Medicine in old age. Diseases of the motor system.
Topics: Activities of Daily Living; Aged; Basal Ganglia Diseases; Brain Stem; Bulbar Palsy, Progressive; Cer | 1973 |
Progressive supranuclear palsy (the Steele-Richardson-Olszewski syndrome) clinical and electrophysiological observations in eleven cases.
Topics: Aged; Basal Ganglia Diseases; Bulbar Palsy, Progressive; Demyelinating Diseases; Dihydroxyphenylalan | 1973 |
The treatment of parkinsonism with levodopa.
Topics: Aged; Anorexia Nervosa; Basal Ganglia Diseases; Depression; Dihydroxyphenylalanine; Extrapyramidal T | 1974 |
Ro 4-4602 and levodopa in the treatment of Parkinsonism.
Topics: Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Basal Ganglia Diseases; Carbidopa; Dihydroxyphen | 1974 |
L-DOPA in Parkinson's disease. Results of a co-operative study in the Montreal area.
Topics: Administration, Oral; Aged; Basal Ganglia Diseases; Constipation; Dihydroxyphenylalanine; Evaluation | 1972 |
Idiopathic orthostatic hypotension treated with levodopa and MAO inhibitor: a preliminary report.
Topics: Basal Ganglia Diseases; Brain Stem; Catecholamines; Dihydroxyphenylalanine; Drug Synergism; Fecal In | 1972 |
[Evaluation in clinical trials of some drug associations. (L-dopa, neuroleptics and lithium carbonate)].
Topics: Basal Ganglia Diseases; Dihydroxyphenylalanine; Extrapyramidal Tracts; Humans; Lithium; Mental Disor | 1971 |