dihydroxyphenylalanine has been researched along with B16 Melanoma in 30 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we examined the inhibitory effects of ferulic acid and caffeic acid on melanin production using a murine B16 melanoma cell line." | 7.88 | Biochemical Characterization of Ferulic Acid and Caffeic Acid Which Effectively Inhibit Melanin Synthesis via Different Mechanisms in B16 Melanoma Cells. ( Imai, M; Kawakami, F; Lwin, TT; Maruyama, H; Shamsa, F, 2018) |
| "3,4-Dihydroxy-2-[18F]fluoro-L-phenylalanine (2-[18F]FDOPA) and [6-3H]thymidine ([3H]Thd) were simultaneously injected into mice transplanted with B16 melanomas of FM3A mammary carcinoma." | 7.68 | Active melanogenesis in non-S phase melanocytes in B16 melanomas in vivo investigated by double-tracer microautoradiography with 18F-fluorodopa and 3H-thymidine. ( Ido, T; Ishiwata, K; Kubota, K; Kubota, R; Yamada, S, 1992) |
| "It has been demonstrated that methotrexate forms stable complexes with melanin and melanosomes isolated from B16 melanoma." | 7.68 | Interaction of methotrexate with melanins and melanosomes from B16 melanoma. ( Buszman, E; Porebska-Budny, M; Stepień, K; Wilczok, T, 1990) |
| "Unexpectedly, B16 melanoma cells exposed to IB-MECA increased melanin levels in a dose-dependent manner." | 5.39 | Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants. ( Korenstein, R; Madi, L; Nyska, A; Rosenberg-Haggen, B, 2013) |
| "In this study, we examined the inhibitory effects of ferulic acid and caffeic acid on melanin production using a murine B16 melanoma cell line." | 3.88 | Biochemical Characterization of Ferulic Acid and Caffeic Acid Which Effectively Inhibit Melanin Synthesis via Different Mechanisms in B16 Melanoma Cells. ( Imai, M; Kawakami, F; Lwin, TT; Maruyama, H; Shamsa, F, 2018) |
| "3,4-Dihydroxy-2-[18F]fluoro-L-phenylalanine (2-[18F]FDOPA) and [6-3H]thymidine ([3H]Thd) were simultaneously injected into mice transplanted with B16 melanomas of FM3A mammary carcinoma." | 3.68 | Active melanogenesis in non-S phase melanocytes in B16 melanomas in vivo investigated by double-tracer microautoradiography with 18F-fluorodopa and 3H-thymidine. ( Ido, T; Ishiwata, K; Kubota, K; Kubota, R; Yamada, S, 1992) |
| "It has been demonstrated that methotrexate forms stable complexes with melanin and melanosomes isolated from B16 melanoma." | 3.68 | Interaction of methotrexate with melanins and melanosomes from B16 melanoma. ( Buszman, E; Porebska-Budny, M; Stepień, K; Wilczok, T, 1990) |
| "Unexpectedly, B16 melanoma cells exposed to IB-MECA increased melanin levels in a dose-dependent manner." | 1.39 | Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants. ( Korenstein, R; Madi, L; Nyska, A; Rosenberg-Haggen, B, 2013) |
| "The production of metastases and the differentiation of tumors in the present experiments appeared to be related to the genetic background of the mice and the epigenetic metabolic environment of tumors and cells." | 1.28 | Differentiation of new metastatic variants of B16 melanoma under different culture conditions. ( Ali-Mehidi, S; Aubert, C; Rouge, F; Voulot, C, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 15 (50.00) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maruyama, H | 1 |
| Kawakami, F | 1 |
| Lwin, TT | 1 |
| Imai, M | 1 |
| Shamsa, F | 1 |
| Kim, Y | 1 |
| Lee, S | 1 |
| Ryu, JH | 1 |
| Yoon, KD | 1 |
| Shin, SS | 1 |
| Ito, S | 2 |
| Okura, M | 1 |
| Nakanishi, Y | 1 |
| Ojika, M | 1 |
| Wakamatsu, K | 2 |
| Yamashita, T | 1 |
| An, SM | 1 |
| Koh, JS | 1 |
| Boo, YC | 1 |
| Ding, HY | 1 |
| Chou, TH | 1 |
| Lin, RJ | 1 |
| Chan, LP | 1 |
| Wang, GH | 1 |
| Liang, CH | 1 |
| Madi, L | 1 |
| Rosenberg-Haggen, B | 1 |
| Nyska, A | 1 |
| Korenstein, R | 1 |
| Masamoto, Y | 1 |
| Murata, Y | 1 |
| Baba, K | 1 |
| Shimoishi, Y | 1 |
| Tada, M | 1 |
| Takahata, K | 1 |
| Tsuji-Naito, K | 1 |
| Hatani, T | 1 |
| Okada, T | 1 |
| Tehara, T | 1 |
| Sato, K | 1 |
| Takahashi, H | 1 |
| Iraha, R | 1 |
| Toriyama, M | 1 |
| Orlow, SJ | 1 |
| Hearing, VJ | 3 |
| Sakai, C | 1 |
| Urabe, K | 2 |
| Zhou, BK | 1 |
| Silvers, WK | 1 |
| Mintz, B | 1 |
| Jimenez-Cervantes, C | 1 |
| Valverde, P | 1 |
| García-Borrón, JC | 2 |
| Solano, F | 2 |
| Lozano, JA | 2 |
| Aberdam, E | 1 |
| Roméro, C | 1 |
| Ortonne, JP | 1 |
| Gilchrest, BA | 1 |
| Zhai, S | 1 |
| Eller, MS | 1 |
| Yarosh, DB | 1 |
| Yaar, M | 1 |
| Thines, E | 1 |
| Anke, H | 1 |
| Sterner, O | 1 |
| Gadjeva, V | 1 |
| Zheleva, A | 1 |
| Raikova, E | 1 |
| Kubota, R | 2 |
| Yamada, S | 1 |
| Ishiwata, K | 2 |
| Kubota, K | 2 |
| Ido, T | 2 |
| Tsukamoto, K | 2 |
| Jackson, IJ | 1 |
| Montague, PM | 1 |
| Aubert, C | 1 |
| Ali-Mehidi, S | 1 |
| Rouge, F | 1 |
| Voulot, C | 1 |
| Chakraborty, AK | 1 |
| Ichihashi, M | 2 |
| Mishima, Y | 2 |
| Jiménez, M | 1 |
| Iwata, R | 1 |
| Takahashi, T | 1 |
| Jara, JR | 1 |
| Aroca, P | 1 |
| Wilczok, T | 1 |
| Stepień, K | 1 |
| Buszman, E | 1 |
| Porebska-Budny, M | 1 |
| Lejczak, B | 1 |
| Duś, D | 1 |
| Kafarski, P | 1 |
| Fujita, K | 1 |
| Slominski, A | 1 |
| Moellmann, G | 1 |
| Kuklinska, E | 1 |
| Chakraborty, C | 1 |
| Hatta, S | 1 |
| Hayashibe, K | 1 |
| Hu, F | 1 |
| Woodward, WR | 1 |
| Peterson, LL | 1 |
| van Langevelde, A | 1 |
| van der Molen, HD | 1 |
| Journée-de Korver, JG | 1 |
| Paans, AM | 1 |
| Pauwels, EK | 1 |
| Vaalburg, W | 1 |
| Duff, GA | 1 |
| Roberts, JE | 1 |
| Foster, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Cyclic On-off and Continuous Excimer Laser Treatment for Vitiligo: A Randomized Controlled Non-inferiority Trial[NCT03047733] | 12 participants (Actual) | Interventional | 2015-07-21 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
30 other studies available for dihydroxyphenylalanine and B16 Melanoma
| Article | Year |
|---|---|
Biochemical Characterization of Ferulic Acid and Caffeic Acid Which Effectively Inhibit Melanin Synthesis via Different Mechanisms in B16 Melanoma Cells.
Topics: Animals; Benzoquinones; Caffeic Acids; Casein Kinase II; Cell Line, Tumor; Coumaric Acids; Dihydroxy | 2018 |
Effect of Aurea Helianthus stem extract on anti-melanogenesis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzoquinones; Cell Line, Tumor; Coumaric Acids; Dihydro | 2018 |
Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins.
Topics: Acids; Animals; Benzoquinones; Biocatalysis; Butanols; Catechols; Cattle; Dihydroxyphenylalanine; Gl | 2015 |
p-coumaric acid not only inhibits human tyrosinase activity in vitro but also melanogenesis in cells exposed to UVB.
Topics: Agaricales; Animals; Arbutin; Cells, Cultured; Coumaric Acids; Dihydroxyphenylalanine; Epidermal Cel | 2010 |
Antioxidant and antimelanogenic behaviors of Paeonia suffruticosa.
Topics: Antioxidants; Cell Line; Chelating Agents; Dihydroxyphenylalanine; Down-Regulation; Flavonoids; Huma | 2011 |
Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants.
Topics: Adenosine; Androstadienes; Cell Line, Tumor; Cyclic AMP; Dihydroxyphenylalanine; Humans; In Vitro Te | 2013 |
Inhibitory effects of esculetin on melanin biosynthesis.
Topics: Agaricales; Animals; Cell Line, Tumor; Dihydroxyphenylalanine; Epidermal Cells; Guinea Pigs; Melanin | 2004 |
Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products.
Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Kinetics; Melanins | 2007 |
Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.
Topics: Animals; Aspirin; Cell Line, Tumor; Cell Proliferation; Dihydroxyphenylalanine; Down-Regulation; Mel | 2008 |
Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression.
Topics: Animals; Antigens, Neoplasm; Dihydroxyphenylalanine; Humans; Intramolecular Oxidoreductases; Isomera | 1995 |
Improved tyrosinase activity stains in polyacrylamide electrophoresis gels.
Topics: Animals; Benzoquinones; Dihydroxyphenylalanine; Electrophoresis, Polyacrylamide Gel; Levodopa; Melan | 1993 |
Repeated UVB irradiations do not have the same potential to promote stimulation of melanogenesis in cultured normal human melanocytes.
Topics: Animals; Cells, Cultured; Child; Dihydroxyphenylalanine; Dose-Response Relationship, Radiation; Gene | 1993 |
Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation.
Topics: Cell Division; Cells, Cultured; Deoxyribonuclease (Pyrimidine Dimer); Dihydroxyphenylalanine; DNA Re | 1993 |
Scytalols A, B, C, and D and other modulators of melanin biosynthesis from Scytalidium sp. 36-93.
Topics: Animals; Dihydroxyphenylalanine; Fungi; Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Mel | 1998 |
Modulating effect of new potential antimelanomic agents, spin-labeled triazenes and nitrosoureas on the DOPA-oxidase activity of tyrosinase.
Topics: Animals; Antineoplastic Agents, Alkylating; Catalysis; Cyclic N-Oxides; Dacarbazine; Dihydroxyphenyl | 1999 |
Active melanogenesis in non-S phase melanocytes in B16 melanomas in vivo investigated by double-tracer microautoradiography with 18F-fluorodopa and 3H-thymidine.
Topics: Animals; Autoradiography; Cell Cycle; Dihydroxyphenylalanine; Male; Melanins; Melanocytes; Melanoma, | 1992 |
A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.
Topics: Amino Acid Sequence; Animals; Antibodies; Chromatography, Affinity; Dihydroxyphenylalanine; Female; | 1992 |
Differentiation of new metastatic variants of B16 melanoma under different culture conditions.
Topics: Animals; Cell Transformation, Neoplastic; Dihydroxyphenylalanine; Genetic Variation; Lung Neoplasms; | 1992 |
Effect of dopa-loading on glutathione metabolising enzymes and tyrosinase in relation to 5-S-cysteinyl-dopa genesis in cultured B-16 melanoma cells.
Topics: Animals; Cysteinyldopa; Dihydroxyphenylalanine; gamma-Glutamyltransferase; Glutathione; Glutathione | 1991 |
Tyrosinases from two different loci are expressed by normal and by transformed melanocytes.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Catalysis; Chromatography, Affinity; Chromosome Map | 1991 |
Selective 2-[18F]fluorodopa uptake for melanogenesis in murine metastatic melanomas.
Topics: Animals; Autoradiography; Dihydroxyphenylalanine; Fluorine Radioisotopes; Male; Melanins; Melanoma, | 1991 |
Regulation of mammalian melanogenesis. II: The role of metal cations.
Topics: Animals; Cations, Divalent; Dihydroxyphenylalanine; Female; Kinetics; Male; Melanins; Melanoma, Expe | 1990 |
Interaction of methotrexate with melanins and melanosomes from B16 melanoma.
Topics: Animals; Binding Sites; Dihydroxyphenylalanine; Hydrolysis; Kinetics; Melanins; Melanocytes; Melanom | 1990 |
Phosphonic and phosphinic acid analogues of tyrosine and 3,4-dihydroxyphenylalanine (dopa) as potential antimelanotic agents.
Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Dihydroxyphenylalanine; Humans; Melanoma, Experime | 1990 |
Melanin-related metabolites in urine of B16 melanoma-bearing mice.
Topics: Animals; Biomarkers, Tumor; Cysteinyldopa; Dihydroxyphenylalanine; Dopamine; Indoles; Melanins; Mela | 1988 |
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis.
Topics: Animals; Catechol Oxidase; Cell Division; Cricetinae; Cyclic AMP; Cyclic GMP; Dihydroxyphenylalanine | 1989 |
Effects of L-glutamine on tyrosinase and gamma-glutamyl transpeptidase of B-16 melanoma cells in culture.
Topics: Animals; Carbohydrates; Catechol Oxidase; Cattle; Culture Media; Dihydroxyphenylalanine; Fibroblasts | 1988 |
Plasma 5-S-cysteinyldopa correlates with tumor size in melanoma-bearing mice.
Topics: Animals; Cysteinyldopa; Dihydroxyphenylalanine; Male; Melanoma, Experimental; Mice; Mice, Inbred C57 | 1988 |
Potential radiopharmaceuticals for the detection of ocular melanoma. Part III. A study with 14C and 11C labelled tyrosine and dihydroxyphenylalanine.
Topics: Animals; Carbon Radioisotopes; Cricetinae; Dihydroxyphenylalanine; Eye Neoplasms; Melanoma, Experime | 1988 |
Analysis of the structure of synthetic and natural melanins by solid-phase NMR.
Topics: Animals; Dihydroxyphenylalanine; Magnetic Resonance Spectroscopy; Melanins; Melanoma, Experimental; | 1988 |