dihydroxyphenylalanine has been researched along with Anesthesia in 12 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We measured arterial and venous plasma DOPA concentrations in healthy subjects at rest, patients who had undergone regional sympathectomies or were undergoing general anesthesia, and subjects during procedures (tilt, oral clonidine, or iv isoproterenol, yohimbine, trimethaphan, or diazepam) known to affect plasma norepinephrine levels." | 3.67 | Neuronal source of plasma dihydroxyphenylalanine. ( Eisenhofer, G; Goldstein, DS; Keiser, HR; Kopin, IJ; Stull, R; Udelsman, R, 1987) |
| "Intraperitoneal injection of diazepam in moderate dosage (1--10mg/kg) to rats caused a decrease in dopa and 5-hydroxytryptophan (5-HTP) formation, measured as the accumulation of these intermediates induced by inhibition of the aromatic L-aminoacid decarboxylase by means of NSD 1015 (3-hydroxybenzylhydrazine (HCl), in limbic forebrain, striatum and the remaining hemisphere portion." | 1.26 | On the mode of action of diazepam on brain catecholamine metabolism. ( Biswas, B; Carlsson, A, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LEE, PK | 1 |
| CHO, MH | 1 |
| DOBKIN, AB | 1 |
| Hardy, OT | 1 |
| Litman, RS | 1 |
| Van Loon, GR | 1 |
| Murakawa, M | 1 |
| Adachi, T | 1 |
| Nakao, S | 1 |
| Seo, N | 1 |
| Shingu, K | 1 |
| Mori, K | 1 |
| Biswas, B | 1 |
| Carlsson, A | 1 |
| Maddrey, WC | 1 |
| Weber, FL | 1 |
| Goldstein, DS | 1 |
| Udelsman, R | 1 |
| Eisenhofer, G | 1 |
| Stull, R | 1 |
| Keiser, HR | 1 |
| Kopin, IJ | 1 |
| Jend, HH | 1 |
| Coper, H | 1 |
| Hatch, RC | 1 |
| Ngai, SH | 1 |
| Goldberg, LI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Localization of Focal Forms of Hyperinsulinism of Infancy With 18F-labeled L-fluoro-DOPA PET Scan[NCT00674440] | Phase 2 | 106 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| A Phase II Safety and Efficacy Study of 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Children With Hyperinsulinemic Hypoglycemia[NCT01468454] | Phase 2 | 130 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of Participants with Adverse Events (NCT00674440)
Timeframe: 72 hours maximum or prior to pancreatic surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| All Subjects Who Had PET | 0 |
Comparison of PET scan results with outcome of surgery and histopathology results confirmed as focal or diffuse (NCT00674440)
Timeframe: up to 1 month post surgical intervention
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| True Negatives (PET diffuse/surgery diffuse) | False negatives (PET diffuse/surgery focal): | False positives (PET focal/surgery diffuse): | True positives (PET focal/surgery focal): | |
| Subjects Who Had PET and Surgery | 40 | 6 | 3 | 46 |
"To further evaluate the safety of 18-labeled L-fluorodeoxyphenylalanine (18F-DOPA) PET/CT imaging in infants and children with congenital hyperinsulinism~- subjects are monitored clinically for any signs or symptoms of adverse events for 72 hours post PET. Adverse events are documented and followed to resolution" (NCT01468454)
Timeframe: evaluated with 72 hours or prior to pancreatic surgery (if any)
| Intervention | Participants (Count of Participants) |
|---|---|
| (18F-DOPA) PET/CT Imaging | 0 |
To determine the sensitivity and specificity of 18F-DOPA PET/CT for the detection of a focal pancreatic lesion in infants and children with poorly controlled hyperinsulinemic hypoglycemia. (NCT01468454)
Timeframe: Surgery typically occured within a week post PET
| Intervention | cases (Number) | |||
|---|---|---|---|---|
| True Negatives (PET diffuse/surgery diffuse) | False negatives (PET diffuse/surgery focal): | False positives (PET focal/surgery diffuse): | True positives (PET focal/surgery focal): | |
| PET/CT Imaging vs Surgical Result | 34 | 10 | 4 | 52 |
3 reviews available for dihydroxyphenylalanine and Anesthesia
| Article | Year |
|---|---|
Congenital hyperinsulinism - a review of the disorder and a discussion of the anesthesia management.
Topics: Anesthesia; Dihydroxyphenylalanine; Hepatic Veins; Humans; Hyperinsulinism; Infant; Infant, Newborn; | 2007 |
Congenital hyperinsulinism - a review of the disorder and a discussion of the anesthesia management.
Topics: Anesthesia; Dihydroxyphenylalanine; Hepatic Veins; Humans; Hyperinsulinism; Infant; Infant, Newborn; | 2007 |
Congenital hyperinsulinism - a review of the disorder and a discussion of the anesthesia management.
Topics: Anesthesia; Dihydroxyphenylalanine; Hepatic Veins; Humans; Hyperinsulinism; Infant; Infant, Newborn; | 2007 |
Congenital hyperinsulinism - a review of the disorder and a discussion of the anesthesia management.
Topics: Anesthesia; Dihydroxyphenylalanine; Hepatic Veins; Humans; Hyperinsulinism; Infant; Infant, Newborn; | 2007 |
Plasma dopamine: regulation and significance.
Topics: Acromegaly; Anesthesia; Animals; Brain; Dihydroxyphenylalanine; Dogs; Dopamine; Endorphins; Female; | 1983 |
Parkinsonism, levodopa, and anesthesia.
Topics: Amantadine; Anesthesia; Animals; Apomorphine; Benperidol; Blood-Brain Barrier; Brain; Cardiovascular | 1972 |
9 other studies available for dihydroxyphenylalanine and Anesthesia
| Article | Year |
|---|---|
EFFECT OF CATECHOLAMINE PRECURSORS AND PHENYLETHYLAMINES ON SPONTANEOUS ACTIVITY AND ON THE RESPONSE TO METHOHEXITAL ANAESTHESIA.
Topics: Amphetamine; Amphetamines; Anesthesia; Anesthetics; Animals; Arousal; Behavior, Animal; Catecholamin | 1965 |
Activation of the cortical and medullary dopaminergic systems by nitrous oxide in rats: a possible neurochemical basis for psychotropic effects and postanesthetic nausea and vomiting.
Topics: Anesthesia; Animals; Biogenic Amines; Brain; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Hy | 1994 |
On the mode of action of diazepam on brain catecholamine metabolism.
Topics: 4-Butyrolactone; 5-Hydroxytryptophan; Anesthesia; Animals; Brain; Catecholamines; Diazepam; Dihydrox | 1978 |
Chronic hepatic encephalopathy.
Topics: Amino Acids, Essential; Ammonia; Analgesics; Anesthesia; Anti-Bacterial Agents; Biogenic Amines; Chr | 1975 |
Neuronal source of plasma dihydroxyphenylalanine.
Topics: Adolescent; Adrenalectomy; Adrenergic Fibers; Adult; Aged; alpha-Methyltyrosine; Anesthesia; Animals | 1987 |
On the mechanism of the synergistic effect of perazine and hexobarbital.
Topics: Acetylcholine; Anesthesia; Animals; Antipsychotic Agents; Biotransformation; Biperiden; Brain; Dihyd | 1974 |
Ketamine catalepsy and anesthesia in dogs pretreated with antiserotonergic or antidopaminergic neuroleptics or with anticholinergic agents.
Topics: Anesthesia; Animals; Atropine; Catalepsy; Chlorpromazine; Dibenzothiepins; Dihydroxyphenylalanine; D | 1974 |
Interruption of a drug regimen before anesthesia.
Topics: Anesthesia; Anti-Infective Agents; Anticoagulants; Anticonvulsants; Antidepressive Agents; Antihyper | 1974 |
Levodopa and anesthesia.
Topics: Anesthesia; Cardiovascular System; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypotension, Orth | 1971 |