dihydroxyphenylalanine has been researched along with Amentia in 24 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Braak's staging concept of Lewy body disease pathogenesis is based on a spatiotemporal sequence of alpha-synuclein deposition, with autonomic nervous system involvement before synucleinopathy in substantia nigra neurons." | 3.78 | Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy. ( Goldstein, DS; Holmes, C; Park, MY; Sewell, L; Sharabi, Y, 2012) |
| "A series of 203 patients with primary Parkinson's disease treated with L-DOPA, with adequate neurological documentation of mental status at serial intervals during their illness, constitutes the study population." | 1.27 | Dementia in idiopathic Parkinson's disease. Variables associated with its occurrence in 203 patients. ( Elizan, TS; Maker, H; Smith, H; Sroka, H; Yahr, MD, 1986) |
| "The subcortical dementias have a striking clinical resemblance to the dementia which occurs after bifrontal lobe disease." | 1.25 | The 'subcortical dementia' of progressive supranuclear palsy. ( Albert, ML; Feldman, RG; Willis, AL, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (79.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Pineda-Pardo, JA | 1 |
| Gasca-Salas, C | 1 |
| Fernández-Rodríguez, B | 1 |
| Rodríguez-Rojas, R | 1 |
| Del Álamo, M | 1 |
| Obeso, I | 1 |
| Hernández-Fernández, F | 1 |
| Trompeta, C | 1 |
| Martínez-Fernández, R | 1 |
| Matarazzo, M | 1 |
| Mata-Marín, D | 1 |
| Guida, P | 1 |
| Duque, A | 1 |
| Albillo, D | 1 |
| Plaza de Las Heras, I | 1 |
| Montero, JI | 1 |
| Foffani, G | 1 |
| Toltsis, G | 1 |
| Rachmilevitch, I | 1 |
| Blesa, J | 1 |
| Obeso, JA | 1 |
| Goldstein, DS | 1 |
| Holmes, C | 1 |
| Sewell, L | 1 |
| Park, MY | 1 |
| Sharabi, Y | 1 |
| Kato, T | 1 |
| Itoh, M | 1 |
| Meguro, K | 1 |
| Fujiwara, T | 1 |
| Hatazawa, J | 1 |
| Iwata, R | 1 |
| Ishiwata, K | 1 |
| Takahashi, T | 1 |
| Ido, T | 1 |
| Sasaki, H | 1 |
| Otsuka, M | 1 |
| Ichiya, Y | 1 |
| Kuwabara, Y | 1 |
| Hosokawa, S | 1 |
| Sasaki, M | 1 |
| Fukumura, T | 1 |
| Masuda, K | 1 |
| Goto, I | 1 |
| Kato, M | 1 |
| Elizan, TS | 1 |
| Sroka, H | 1 |
| Maker, H | 1 |
| Smith, H | 1 |
| Yahr, MD | 2 |
| Van Woert, MH | 2 |
| Heninger, G | 1 |
| Rathey, U | 1 |
| Bowers, MB | 2 |
| Sacks, OW | 1 |
| Messeloff, C | 1 |
| Schartz, W | 1 |
| Goldfarb, A | 1 |
| Kohl, M | 1 |
| Schnur, JA | 1 |
| Chase, TN | 3 |
| Brody, JA | 3 |
| Broe, GA | 1 |
| Caird, FI | 1 |
| Holden, EM | 2 |
| Lehmann, J | 2 |
| Powell, HC | 1 |
| London, GW | 1 |
| Lampert, PW | 1 |
| Albert, ML | 1 |
| Feldman, RG | 1 |
| Willis, AL | 1 |
| Lieberman, AN | 1 |
| Parkes, JD | 1 |
| Marsden, CD | 1 |
| Rees, JE | 1 |
| Curzon, G | 1 |
| Kantamaneni, BD | 1 |
| Knill-Jones, R | 1 |
| Akbar, A | 1 |
| Das, S | 1 |
| Kataria, M | 1 |
| Klawans, HL | 2 |
| Garron, DC | 1 |
| Narin, F | 1 |
| Cia Madariaga, FM | 1 |
| Rud, C | 1 |
| Rovira, B | 1 |
| Mantilaro, E | 1 |
| Alvarez, O | 1 |
| Baretic, E | 1 |
| Moro, R | 1 |
| McDowell, F | 1 |
| Lee, JE | 1 |
| Swift, T | 1 |
| Sweet, RD | 1 |
| Ogsbury, JS | 1 |
| Kessler, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Feasibility of Temporary Blood Brain Barrier Disruption (BBBD) Using Exablate MR Guided Focused Ultrasound in Patients With Parkinson's Disease Dementia[NCT03608553] | 10 participants (Anticipated) | Interventional | 2018-11-26 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dihydroxyphenylalanine and Amentia
| Article | Year |
|---|---|
L-dopa in neurological disease: current status.
Topics: Aged; Amyotrophic Lateral Sclerosis; Basal Ganglia Diseases; Cerebellar Diseases; Cerebrovascular Di | 1972 |
Observations on the range of efficacy of L-dopa.
Topics: Brain Diseases; Brain Stem; Cerebellar Diseases; Dementia; Dihydroxyphenylalanine; Dopamine; Extrapy | 1971 |
1 trial available for dihydroxyphenylalanine and Amentia
| Article | Year |
|---|---|
Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Corpus Striatum; Dementia; Dihydroxyp | 2022 |
21 other studies available for dihydroxyphenylalanine and Amentia
| Article | Year |
|---|---|
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.
Topics: Aged; alpha-Synuclein; Autonomic Denervation; Dementia; Dihydroxyphenylalanine; Disease Progression; | 2012 |
[Evaluation of dopaminergic presynaptic function by [F-18] DOPA PET].
Topics: Dementia; Dihydroxyphenylalanine; Humans; Parkinson Disease; Positron-Emission Tomography; Presynapt | 2007 |
Assessment of dopamine metabolism in brain of patients with dementia by means of 18F-fluorodopa and PET.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Brain; Corpus Striatum; Dementia; Dementia, Vascular; | 1994 |
Cerebral glucose metabolism and striatal 18F-dopa uptake by PET in cases of chorea with or without dementia.
Topics: Adult; Aged; Brain; Caudate Nucleus; Chorea; Corpus Striatum; Dementia; Dihydroxyphenylalanine; Fema | 1993 |
Dementia in idiopathic Parkinson's disease. Variables associated with its occurrence in 203 patients.
Topics: Age Factors; Aged; Dementia; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Movement Dis | 1986 |
L-dopa in senile dementia.
Topics: Aged; Aphrodisiacs; Brain; Dementia; Dihydroxyphenylalanine; Female; Humans; Movement Disorders; Par | 1970 |
Effects of L-dopa in patients with dementia.
Topics: Delirium; Dementia; Dihydroxyphenylalanine; Humans; Parkinson Disease | 1970 |
Parkinsonism-dementia of Guam: treatment with L-dopa.
Topics: Adult; Dementia; Dihydroxyphenylalanine; Drug Eruptions; Female; Humans; Hydroxyindoleacetic Acid; H | 1971 |
Levodopa for parkinsonism in elderly and demented patients.
Topics: Activities of Daily Living; Aged; Cardiovascular Diseases; Dementia; Dihydroxyphenylalanine; Drug Sy | 1973 |
Levodopa-induced dyskinesias. Comparison in Parkinsonism-dementia and amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Carbidopa; Dementia; Dihydroxyphenylalanine; Female; Hum | 1973 |
Tryptophan malabsorption in levodopa-treated parkinsonian patients. Effect of tryptophan on mental disturbances.
Topics: Aged; Brain; Dementia; Depression, Chemical; Dihydroxyphenylalanine; Female; Humans; Hydroxyindoleac | 1973 |
Neurofibrillary tangles in progressive supranuclear palsy. Electron microscopic observations.
Topics: Aged; Amantadine; Brain; Brain Diseases; Bulbar Palsy, Progressive; Dementia; Dihydroxyphenylalanine | 1974 |
The 'subcortical dementia' of progressive supranuclear palsy.
Topics: Affective Symptoms; Aged; Brain; Brain Diseases; Bulbar Palsy, Progressive; Cognition Disorders; Dem | 1974 |
Parkinson's disease: a clinical review.
Topics: Adult; Aged; Brain Diseases; Bulbar Palsy, Progressive; Dementia; Diagnosis, Differential; Dihydroxy | 1974 |
Parkinson's disease, cerebral arteriosclerosis, and senile dementia. Clinical features and response to levodopa.
Topics: Aged; Dementia; Dihydroxyphenylalanine; Electroencephalography; Female; Gait; Homovanillic Acid; Hum | 1974 |
[Serum tryptophan in cases with senile dementia, parkinsonism and normal cases].
Topics: Adult; Aged; Dementia; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Parkinson Disease; | 1974 |
Parkinsonism-dementia of Guam: treatment with levodopa and L-alpha-methyldopahydrazine.
Topics: Adult; Aged; Carbidopa; Dementia; Dihydroxyphenylalanine; Drug Synergism; Evaluation Studies as Topi | 1974 |
Intellectual functioning of persons with idiopathic Parkinsonism.
Topics: Aged; Cerebral Cortex; Computers; Dementia; Dihydroxyphenylalanine; Evaluation Studies as Topic; Fem | 1972 |
[Preliminary report on the treatment of dementia syndromes with levodopa].
Topics: Adult; Aged; Dementia; Dihydroxyphenylalanine; Humans; Middle Aged | 1971 |
Treatment of Parkinson's syndrome with L dihydroxyphenylalanine (levodopa).
Topics: Aged; Dementia; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Male; Middle Aged; Parasympa | 1970 |
Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) during L-dopa therapy of Parkinson's disease.
Topics: Dementia; Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Parkinson Disease; Phenylacetate | 1970 |