dihydroxyphenylalanine has been researched along with Albinism, Tyrosinase-Negative in 8 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Tyrosine hydroxylase activity determined with cell lysates (in vitro), entire fixed cells (postfixation), or intact living cells (in situ), and 3,4-dihydroxyphenylalanine oxidase assayed spectrophotometrically or by 3,4-dihydroxyphenylalanine staining on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, demonstrated the following results: 1) The in situ assay displayed reduced tyrosine hydroxylase activity in all three tyrosinase-positive oculocutaneous albino (OCA) lines except for Chediak-Higashi Syndrome melanocytes, which displayed normal activity; 2) The in vitro assay had comparable activity of tyrosinase-positive OCA melanocytes as controls, except for one tyrosinase-positive OCA cell line, which demonstrated increased activity; 3) The postfixation assay, compared with the in situ assay, had elevated activity (ie." | 3.69 | Distinguishing between the catalytic potential and apparent expression of tyrosinase activities. ( Boissy, RE; Zhao, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halaban, R | 1 |
| Cheng, E | 1 |
| Hebert, DN | 1 |
| Shimizu, H | 1 |
| Ishiko, A | 1 |
| Kikuchi, A | 1 |
| Akiyama, M | 1 |
| Suzumori, K | 1 |
| Nishikawa, T | 1 |
| Zhao, H | 2 |
| Boissy, RE | 2 |
| Oetting, WS | 2 |
| Austin, LM | 1 |
| Wildenberg, SC | 1 |
| Boissy, YL | 1 |
| Zhao, Y | 1 |
| Sturm, RA | 1 |
| Hearing, VJ | 2 |
| King, RA | 2 |
| Nordlund, JJ | 1 |
| Schallreuter, KU | 1 |
| Tsukamoto, K | 1 |
| Jiménez, M | 1 |
| Gershoni-Baruch, R | 1 |
| Benderly, A | 1 |
| Brandes, JM | 1 |
| Gilhar, A | 1 |
2 reviews available for dihydroxyphenylalanine and Albinism, Tyrosinase-Negative
| Article | Year |
|---|---|
A review of recent advances on the regulation of pigmentation in the human epidermis.
Topics: Albinism, Oculocutaneous; alpha-MSH; Biopterins; Dihydroxyphenylalanine; Enzyme Activation; Epidermi | 1999 |
The nature of tyrosinase isozymes.
Topics: Albinism, Oculocutaneous; Animals; Catalase; Dihydroxyphenylalanine; Genes; Glycoproteins; Isoenzyme | 1992 |
6 other studies available for dihydroxyphenylalanine and Albinism, Tyrosinase-Negative
| Article | Year |
|---|---|
Coexpression of wild-type tyrosinase enhances maturation of temperature-sensitive tyrosinase mutants.
Topics: Albinism, Oculocutaneous; Animals; Cells, Cultured; Dihydroxyphenylalanine; Enzyme Stability; Glycos | 2002 |
Prenatal diagnosis of tyrosinase-negative oculocutaneous albinism by an electron microscopic dopa reaction test of fetal skin.
Topics: Adult; Albinism, Oculocutaneous; Child; Dihydroxyphenylalanine; Female; Humans; Male; Melanocytes; M | 1994 |
Distinguishing between the catalytic potential and apparent expression of tyrosinase activities.
Topics: Albinism, Oculocutaneous; Catalysis; Cell Line; Cells, Cultured; Chediak-Higashi Syndrome; Dihydroxy | 1994 |
Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3".
Topics: Albinism, Oculocutaneous; Base Sequence; Cells, Cultured; Dihydroxyphenylalanine; Diseases in Twins; | 1996 |
Molecular analysis of type I-A (tyrosinase negative) oculocutaneous albinism.
Topics: Albinism, Oculocutaneous; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cells, Culture | 1992 |
Dopa reaction test in hair bulbs of fetuses and its application to the prenatal diagnosis of albinism.
Topics: Albinism, Oculocutaneous; Dihydroxyphenylalanine; Fetal Diseases; Fetus; Gestational Age; Hair; Huma | 1991 |