dihydroxyphenylalanine has been researched along with Albinism, Oculocutaneous in 8 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Albinism, Oculocutaneous: Heterogeneous group of autosomal recessive disorders comprising at least four recognized types, all having in common varying degrees of hypopigmentation of the skin, hair, and eyes. The two most common are the tyrosinase-positive and tyrosinase-negative types.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Tyrosine hydroxylase activity determined with cell lysates (in vitro), entire fixed cells (postfixation), or intact living cells (in situ), and 3,4-dihydroxyphenylalanine oxidase assayed spectrophotometrically or by 3,4-dihydroxyphenylalanine staining on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, demonstrated the following results: 1) The in situ assay displayed reduced tyrosine hydroxylase activity in all three tyrosinase-positive oculocutaneous albino (OCA) lines except for Chediak-Higashi Syndrome melanocytes, which displayed normal activity; 2) The in vitro assay had comparable activity of tyrosinase-positive OCA melanocytes as controls, except for one tyrosinase-positive OCA cell line, which demonstrated increased activity; 3) The postfixation assay, compared with the in situ assay, had elevated activity (ie." | 3.69 | Distinguishing between the catalytic potential and apparent expression of tyrosinase activities. ( Boissy, RE; Zhao, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halaban, R | 1 |
| Cheng, E | 1 |
| Hebert, DN | 1 |
| Shimizu, H | 1 |
| Ishiko, A | 1 |
| Kikuchi, A | 1 |
| Akiyama, M | 1 |
| Suzumori, K | 1 |
| Nishikawa, T | 1 |
| Zhao, H | 2 |
| Boissy, RE | 2 |
| Oetting, WS | 2 |
| Austin, LM | 1 |
| Wildenberg, SC | 1 |
| Boissy, YL | 1 |
| Zhao, Y | 1 |
| Sturm, RA | 1 |
| Hearing, VJ | 2 |
| King, RA | 2 |
| Nordlund, JJ | 1 |
| Schallreuter, KU | 1 |
| Tsukamoto, K | 1 |
| Jiménez, M | 1 |
| Gershoni-Baruch, R | 1 |
| Benderly, A | 1 |
| Brandes, JM | 1 |
| Gilhar, A | 1 |
2 reviews available for dihydroxyphenylalanine and Albinism, Oculocutaneous
| Article | Year |
|---|---|
A review of recent advances on the regulation of pigmentation in the human epidermis.
Topics: Albinism, Oculocutaneous; alpha-MSH; Biopterins; Dihydroxyphenylalanine; Enzyme Activation; Epidermi | 1999 |
The nature of tyrosinase isozymes.
Topics: Albinism, Oculocutaneous; Animals; Catalase; Dihydroxyphenylalanine; Genes; Glycoproteins; Isoenzyme | 1992 |
6 other studies available for dihydroxyphenylalanine and Albinism, Oculocutaneous
| Article | Year |
|---|---|
Coexpression of wild-type tyrosinase enhances maturation of temperature-sensitive tyrosinase mutants.
Topics: Albinism, Oculocutaneous; Animals; Cells, Cultured; Dihydroxyphenylalanine; Enzyme Stability; Glycos | 2002 |
Prenatal diagnosis of tyrosinase-negative oculocutaneous albinism by an electron microscopic dopa reaction test of fetal skin.
Topics: Adult; Albinism, Oculocutaneous; Child; Dihydroxyphenylalanine; Female; Humans; Male; Melanocytes; M | 1994 |
Distinguishing between the catalytic potential and apparent expression of tyrosinase activities.
Topics: Albinism, Oculocutaneous; Catalysis; Cell Line; Cells, Cultured; Chediak-Higashi Syndrome; Dihydroxy | 1994 |
Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3".
Topics: Albinism, Oculocutaneous; Base Sequence; Cells, Cultured; Dihydroxyphenylalanine; Diseases in Twins; | 1996 |
Molecular analysis of type I-A (tyrosinase negative) oculocutaneous albinism.
Topics: Albinism, Oculocutaneous; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cells, Culture | 1992 |
Dopa reaction test in hair bulbs of fetuses and its application to the prenatal diagnosis of albinism.
Topics: Albinism, Oculocutaneous; Dihydroxyphenylalanine; Fetal Diseases; Fetus; Gestational Age; Hair; Huma | 1991 |