dihydroxyphenylalanine has been researched along with Adenomatosis, Familial Endocrine in 3 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| July, M | 1 |
| Santhanam, P | 1 |
| Giovanella, L | 1 |
| Treglia, G | 1 |
| Hardy, OT | 1 |
| Hernandez-Pampaloni, M | 1 |
| Saffer, JR | 1 |
| Scheuermann, JS | 1 |
| Ernst, LM | 1 |
| Freifelder, R | 1 |
| Zhuang, H | 1 |
| MacMullen, C | 1 |
| Becker, S | 1 |
| Adzick, NS | 1 |
| Divgi, C | 1 |
| Alavi, A | 1 |
| Stanley, CA | 1 |
| Pearse, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Localization of Focal Forms of Hyperinsulinism of Infancy With 18F-labeled L-fluoro-DOPA PET Scan[NCT00674440] | Phase 2 | 106 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| The Use of Fluorodopa F 18 Positron Emission Tomography Combined With Computed Tomography in Congenital Hyperinsulinism and Insulinoma[NCT02021604] | Phase 1 | 250 participants (Anticipated) | Interventional | 2013-10-09 | Recruiting | ||
| A Phase II Safety and Efficacy Study of 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Children With Hyperinsulinemic Hypoglycemia[NCT01468454] | Phase 2 | 130 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of Participants with Adverse Events (NCT00674440)
Timeframe: 72 hours maximum or prior to pancreatic surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| All Subjects Who Had PET | 0 |
Comparison of PET scan results with outcome of surgery and histopathology results confirmed as focal or diffuse (NCT00674440)
Timeframe: up to 1 month post surgical intervention
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| True Negatives (PET diffuse/surgery diffuse) | False negatives (PET diffuse/surgery focal): | False positives (PET focal/surgery diffuse): | True positives (PET focal/surgery focal): | |
| Subjects Who Had PET and Surgery | 40 | 6 | 3 | 46 |
"To further evaluate the safety of 18-labeled L-fluorodeoxyphenylalanine (18F-DOPA) PET/CT imaging in infants and children with congenital hyperinsulinism~- subjects are monitored clinically for any signs or symptoms of adverse events for 72 hours post PET. Adverse events are documented and followed to resolution" (NCT01468454)
Timeframe: evaluated with 72 hours or prior to pancreatic surgery (if any)
| Intervention | Participants (Count of Participants) |
|---|---|
| (18F-DOPA) PET/CT Imaging | 0 |
To determine the sensitivity and specificity of 18F-DOPA PET/CT for the detection of a focal pancreatic lesion in infants and children with poorly controlled hyperinsulinemic hypoglycemia. (NCT01468454)
Timeframe: Surgery typically occured within a week post PET
| Intervention | cases (Number) | |||
|---|---|---|---|---|
| True Negatives (PET diffuse/surgery diffuse) | False negatives (PET diffuse/surgery focal): | False positives (PET focal/surgery diffuse): | True positives (PET focal/surgery focal): | |
| PET/CT Imaging vs Surgical Result | 34 | 10 | 4 | 52 |
2 reviews available for dihydroxyphenylalanine and Adenomatosis, Familial Endocrine
| Article | Year |
|---|---|
Role of positron emission tomography imaging in Multiple Endocrine Neoplasia syndromes.
Topics: 5-Hydroxytryptophan; Biomarkers, Tumor; Dihydroxyphenylalanine; Ephedrine; Fluorodeoxyglucose F18; G | 2018 |
The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.
Topics: 5-Hydroxytryptophan; Animal Population Groups; APUD Cells; Dihydroxyphenylalanine; Histocytochemistr | 1969 |
1 other study available for dihydroxyphenylalanine and Adenomatosis, Familial Endocrine
| Article | Year |
|---|---|
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |
Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
Topics: Biopsy; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Image Interpretation, Computer-Assisted; In | 2007 |