dihydrouracil has been researched along with Sensitivity and Specificity in 8 studies
hexahydropyrimidine-2,4-dione: structure in first source
5,6-dihydrouracil : A pyrimidine obtained by formal addition of hydrogen across the 5,6-position of uracil.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic variables were determined using noncompartmental methods." | 1.33 | The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil. ( Desmond, RA; Diasio, RB; Fourie, J; Hirao, Y; King, JR; Koga, T; Mattison, LK; Shimizu, T, 2006) |
| " This method can be useful to evaluate the activity of dihydropyrimidine dehydrogenase (DPD), a rate-limiting enzyme of the chemotherapy drug fluoropyrimidine, which will be helpful in investigating subject variation of DPD and adjusting clinical dosage in pyrimidine chemotherapy." | 1.31 | Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry. ( Hu, P; Hu, Y; Jiang, H; Jiang, J, 2002) |
| "5-Fluorouracil (5-FU) is a commonly used anti-cancer drug with notable activity in clinical practice, yet it causes significant unpredictable and often serious toxicity." | 1.31 | Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity. ( Ackland, SP; Garg, MB; Sakoff, JA; Sevester, JC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pan, W | 1 |
| Li, Y | 1 |
| Feng, Y | 1 |
| Yang, F | 1 |
| Liu, H | 1 |
| van Staveren, MC | 1 |
| van Kuilenburg, AB | 2 |
| Guchelaar, HJ | 1 |
| Meijer, J | 1 |
| Punt, CJ | 1 |
| de Jong, RS | 1 |
| Gelderblom, H | 1 |
| Maring, JG | 1 |
| Beumer, JH | 1 |
| Joseph, E | 1 |
| Egorin, MJ | 1 |
| Covey, JM | 1 |
| Eiseman, JL | 1 |
| Mattison, LK | 1 |
| Fourie, J | 1 |
| Hirao, Y | 1 |
| Koga, T | 1 |
| Desmond, RA | 1 |
| King, JR | 1 |
| Shimizu, T | 1 |
| Diasio, RB | 1 |
| Déporte, R | 1 |
| Amiand, M | 1 |
| Moreau, A | 1 |
| Charbonnel, C | 1 |
| Campion, L | 1 |
| Van Lenthe, H | 1 |
| Van Gennip, AH | 1 |
| Jiang, H | 1 |
| Jiang, J | 1 |
| Hu, P | 1 |
| Hu, Y | 1 |
| Garg, MB | 1 |
| Sevester, JC | 1 |
| Sakoff, JA | 1 |
| Ackland, SP | 1 |
1 trial available for dihydrouracil and Sensitivity and Specificity
| Article | Year |
|---|---|
Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy.
Topics: Administration, Oral; Case-Control Studies; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouraci | 2016 |
7 other studies available for dihydrouracil and Sensitivity and Specificity
| Article | Year |
|---|---|
A new sample preparation and separation combination for the precise, accurate, and simultaneous determination of uracil and dihydrouracil in human plasma by reversed-phase HPLC.
Topics: Calibration; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Humans; Reproducibility of | 2017 |
Quantitative determination of zebularine (NSC 309132), a DNA methyltransferase inhibitor, and three metabolites in murine plasma by high-performance liquid chromatography coupled with on-line radioactivity detection.
Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cytidine; DNA Modification Meth | 2006 |
The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil.
Topics: Administration, Oral; Adult; Aged; Breath Tests; Carbon Dioxide; Carbon Isotopes; Chromatography, Hi | 2006 |
High-performance liquid chromatographic assay with UV detection for measurement of dihydrouracil/uracil ratio in plasma.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reference Standards; Reproducibility of | 2006 |
A radiochemical assay for beta-ureidopropionase using radiolabeled N-carbamyl-beta-alanine obtained via hydrolysis of [2-(14)C]5, 6-dihydrouracil.
Topics: Amidohydrolases; beta-Alanine; Carbon Dioxide; Carbon Radioisotopes; Humans; Hydrolysis; Kinetics; L | 1999 |
Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Reference Values; Sens | 2002 |
Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Fluorouracil; Humans; Referen | 2002 |