dihydrouracil has been researched along with Neoplasms in 8 studies
hexahydropyrimidine-2,4-dione: structure in first source
5,6-dihydrouracil : A pyrimidine obtained by formal addition of hydrogen across the 5,6-position of uracil.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine and compare the ratio of uracil (U) to dihydrouracil (UH(2)) concentrations in plasma as an indicator of dihydropyrimidine dehydrogenase activity in clinically normal dogs and dogs with neoplasia or renal insufficiency." | 7.78 | Assessment of plasma uracil-to-dihydrouracil concentration ratio as an indicator of dihydropyrimidine dehydrogenase activity in clinically normal dogs and dogs with neoplasia or renal insufficiency. ( Edwards, GL; Freeman, KG; Saba, CF; Schmiedt, CW, 2012) |
| "To determine and compare the ratio of uracil (U) to dihydrouracil (UH(2)) concentrations in plasma as an indicator of dihydropyrimidine dehydrogenase activity in clinically normal dogs and dogs with neoplasia or renal insufficiency." | 3.78 | Assessment of plasma uracil-to-dihydrouracil concentration ratio as an indicator of dihydropyrimidine dehydrogenase activity in clinically normal dogs and dogs with neoplasia or renal insufficiency. ( Edwards, GL; Freeman, KG; Saba, CF; Schmiedt, CW, 2012) |
| "Uracil was superior to the dihydrouracil/uracil ratio as a predictor of severe toxicity." | 1.46 | Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity. ( Aliev, A; Beijnen, JH; Cats, A; de Boer, A; de Vries, N; Deenen, MJ; Henricks, LM; Jacobs, BAW; Mandigers, CMPW; Meulendijks, D; Rosing, H; Schellens, JHM; Soesan, M; van Werkhoven, E, 2017) |
| "5-Fluorouracil (5-FU) is a mainstay for treating various solid tumours in adults, including digestive and head and neck cancers." | 1.37 | 5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases. ( Ciccolini, J; Cordier, PY; Lacarelle, B; Mercier, C; Nau, A; Oliver, M; Peytel, E, 2011) |
| " Pharmacokinetic variables were determined using noncompartmental methods." | 1.33 | The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil. ( Desmond, RA; Diasio, RB; Fourie, J; Hirao, Y; King, JR; Koga, T; Mattison, LK; Shimizu, T, 2006) |
| "Some of these solid tumors contain greater amounts of activity than do their normal equivalents, which encourages the use of inhibitors of this enzyme in conjunction with treatment of these tumors by 5-fluorouracil." | 1.27 | Enzymes of uracil catabolism in normal and neoplastic human tissues. ( Cha, S; el Kouni, MH; Naguib, FN, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Basbous, J | 1 |
| Aze, A | 1 |
| Chaloin, L | 1 |
| Lebdy, R | 1 |
| Hodroj, D | 1 |
| Ribeyre, C | 1 |
| Larroque, M | 1 |
| Shepard, C | 1 |
| Kim, B | 1 |
| Pruvost, A | 1 |
| Moreaux, J | 1 |
| Maiorano, D | 1 |
| Mechali, M | 1 |
| Constantinou, A | 1 |
| Marin, C | 1 |
| Krache, A | 1 |
| Palmaro, C | 1 |
| Lucas, M | 1 |
| Hilaire, V | 1 |
| Ugdonne, R | 1 |
| De Victor, B | 1 |
| Quaranta, S | 1 |
| Solas, C | 1 |
| Lacarelle, B | 2 |
| Ciccolini, J | 2 |
| Meulendijks, D | 1 |
| Henricks, LM | 1 |
| Jacobs, BAW | 1 |
| Aliev, A | 1 |
| Deenen, MJ | 1 |
| de Vries, N | 1 |
| Rosing, H | 1 |
| van Werkhoven, E | 1 |
| de Boer, A | 1 |
| Beijnen, JH | 1 |
| Mandigers, CMPW | 1 |
| Soesan, M | 1 |
| Cats, A | 1 |
| Schellens, JHM | 1 |
| Cordier, PY | 1 |
| Nau, A | 1 |
| Oliver, M | 1 |
| Mercier, C | 1 |
| Peytel, E | 1 |
| Schmiedt, CW | 1 |
| Saba, CF | 1 |
| Freeman, KG | 1 |
| Edwards, GL | 1 |
| Mattison, LK | 1 |
| Fourie, J | 1 |
| Hirao, Y | 1 |
| Koga, T | 1 |
| Desmond, RA | 1 |
| King, JR | 1 |
| Shimizu, T | 1 |
| Diasio, RB | 1 |
| Sumi, S | 1 |
| Kidouchi, K | 1 |
| Hayashi, K | 1 |
| Imaeda, M | 1 |
| Asai, M | 1 |
| Wada, Y | 1 |
| Naguib, FN | 1 |
| el Kouni, MH | 1 |
| Cha, S | 1 |
8 other studies available for dihydrouracil and Neoplasms
| Article | Year |
|---|---|
Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; DNA Replication; H | 2020 |
A Simple and Rapid UPLC-UV Method for Detecting DPD Deficiency in Patients With Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; Chromatog | 2020 |
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; | 2017 |
5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases.
Topics: Aged; Antimetabolites, Antineoplastic; Brain; Dihydropyrimidine Dehydrogenase Deficiency; Electroenc | 2011 |
Assessment of plasma uracil-to-dihydrouracil concentration ratio as an indicator of dihydropyrimidine dehydrogenase activity in clinically normal dogs and dogs with neoplasia or renal insufficiency.
Topics: Animals; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Dog Diseases; Dog | 2012 |
The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil.
Topics: Administration, Oral; Adult; Aged; Breath Tests; Carbon Dioxide; Carbon Isotopes; Chromatography, Hi | 2006 |
Urinary screening for pyrimidine metabolism disorders. Reference ranges for dihydrouracil, uracil, and dihydrouracil/uracil ratio.
Topics: Adult; Cerebral Infarction; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Hypertension; Liver | 1998 |
Enzymes of uracil catabolism in normal and neoplastic human tissues.
Topics: Amidohydrolases; beta-Alanine; Dihydrouracil Dehydrogenase (NAD+); Fluorouracil; Humans; Kinetics; N | 1985 |