dihydrotestosterone has been researched along with Prostatic Neoplasms, Castration-Resistant in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 28 (71.79) | 24.3611 |
| 2020's | 11 (28.21) | 2.80 |
| Authors | Studies |
|---|---|
| Felder, S; Grunow, N; Gunatilaka, AA; Kris, RM; Liu, MX; Paine-Murrieta, G; Wijeratne, EM; Xu, YM | 1 |
| Wang, S; Xiang, W | 1 |
| Chang, C; Chen, L; Huang, CP; Liu, B; Sun, Y; Tang, M; Wang, Z; You, B | 1 |
| Caron, P; Guillemette, C; Lacombe, L; Lévesque, É; Morin, F; Neveu, B; Pouliot, F; Rouleau, M; Toren, P; Turcotte, V | 1 |
| Ellis, CS; Kolesar, JM; McCorkle, JR; Myint, ZW; Otto, DE; Wang, P; Wu, J | 1 |
| Blas, L; Endo, S; Eto, M; Fujimoto, N; Shiota, M | 1 |
| Birbrair, A; Camargo, JA; Candido, P; Chiovatto, C; Dos Santos, GA; Ghazarian, V; Gonçalves, GL; Guimarães, VR; Leite, KR; Mioshi, CM; Nahas, WC; Pimenta, R; Reis, ST; Romão, P; Silva, IA; Srougi, M; Viana, NI | 1 |
| Cao, Q; Chen, K; Deng, T; Dong, X; Fazli, L; Jiang, W; Li, C; Li, Q; Li, Y; Liu, Q; Meng, Q; Wang, G; Wang, R; Wang, W; Yi, Y; Yu, J; Zhang, L; Zhang, M; Zhao, D; Zhao, W; Zhu, S; Zu, X | 1 |
| Caino, MC; Chan Chae, Y; Jang, J; Joung, JY; Lee, S; Lee, YG; Nam, D; Nam, Y; Park, WS; Seo, JK; Shin, KJ; Suh, PG; Yoon, S | 1 |
| Cao, DH; Chen, B; Guo, JB; Liu, LR; Wei, Q | 1 |
| Begemann, D; Kyprianou, N; Wang, Y; Yang, W | 1 |
| Bortolotti, D; Dean, M; Gagliano, T; Garland, L; Gentili, V; Giamas, G; O'Hanlon, T; Rizzo, R; Shah, K | 1 |
| Brás, LA; Cardoso, HJ; Carvalho, TMA; Figueira, MI; Madureira, PA; Oliveira, PJ; Sardão, VA; Socorro, S; Vaz, CV | 1 |
| Chen, CL; Chen, WY; Huang, J; Liu, YN; Siu, MK; Tsai, YC; Yeh, HL; Yin, JJ | 1 |
| Aittokallio, T; Auriola, S; Elo, LL; Häkkinen, MR; Handelsman, DJ; Huhtaniemi, R; Knuuttila, M; Laajala, TD; Laiho, A; Mäkelä, SI; Mehmood, A; Ohlsson, C; Oksala, R; Poutanen, M; Ryberg, H; Sipilä, P; Yatkin, E | 1 |
| Berk, M; Chung, YM; DiFilippo, FP; Kepe, V; Ko, HK; Lee, Z; Li, J; Li, Z; Petro, M; Sergeeva, O; Sharifi, N; Zhu, Z | 1 |
| Hamid, ARAH; Mochtar, CA; Schalken, JA; Sesari, SS; Tendi, W; Umbas, R; Verhaegh, G | 1 |
| Castellón, EA; Contreras, HR; Herrera, D; Orellana-Serradell, O; Paciucci, R; Torres, MJ; Villar, P | 1 |
| Beijnen, JH; Rosing, H; van Nuland, M; van Rossum, HH; Venekamp, N; Wouters, WME | 1 |
| Ha, YS; Jung, YS; Kim, IY; Kim, JH; Kim, WJ; Lee, GT | 1 |
| Audenet, F; Basset, V; Branchereau, J; Lebret, T; Murez, T | 1 |
| Abdel-Mageed, AB; Datta, A; Freeman, ML; Hagan, SS; Mondal, D; Schultz, MA; Sikka, SC; Zhang, Y | 1 |
| Adomat, H; Beheshti, EH; Chin, MY; Deb, S; Guns, ET; Kharmate, G; Locke, J; Ming, DS; Pham, S | 1 |
| Baron, B; Baskin-Bey, E; De Bono, JS; Fizazi, K; Heeringa, M; Holtkamp, GM; James, ND; Jones, RJ; Loriot, Y; Molife, RL; Omlin, A; Ouatas, T; Van den Brande, J | 1 |
| Penning, TM | 1 |
| Chang, KH; Ercole, CE; Sharifi, N | 1 |
| Goodman, MM; Kawai, K; Kobayashi, M; Nakanishi, T; Oka, S; Okudaira, H; Ono, M; Schuster, DM; Shirakami, Y; Tamai, I | 1 |
| Ahn, H; Kim, Y; Min, GE; Song, C | 1 |
| Chau, CH; Fernandez, EV; Figg, WD; Ley, AM; Price, DK; Reece, KM; Sissung, TM; Troutman, SM | 1 |
| Culine, S; Doucet, L; Gauthier, H; Le Maignan, C; Pouessel, D; Teixeira, L; Terrisse, S | 1 |
| Alyamani, M; Auchus, RJ; Bishop, AC; Bunch, D; Dreicer, R; Garcia, JA; Li, Z; Liu, J; Sharifi, N; Upadhyay, SK | 1 |
| Goodman, MM; Kawai, K; Kobayashi, M; Mizokami, A; Nakanishi, T; Oka, S; Okudaira, H; Ono, M; Schuster, DM; Shirakami, Y | 1 |
| Chaytor, L; Gaughan, L; Grey, J; Jones, D; Nakjang, S; Robson, CN; Wade, M | 1 |
| Mostaghel, EA; Plymate, S; Zhang, A; Zhang, J | 1 |
| Na, YG; Song, YT; Wang, XY; Wu, KJ; Yin, CM | 1 |
| Fox, JJ; Larson, SM; Morris, MJ; Pandit-Taskar, N; Scher, HI; Veach, DR | 1 |
| Albert, DH; Faivre, EJ; He, W; Hessler, P; Kati, W; Lin, X; McDaniel, K; Shen, Y; Torrent, M; Uziel, T; Wilcox, D | 1 |
| Chattopadhyay, I; Gao, L; Gelman, IH; Holtz, R; Leach, RW; Qin, M; Vessella, RL; Wang, J | 1 |
| Ahn, HJ; Faiena, I; Han, CS; Kim, IY; Kim, WJ; Kwon, SJ; Kwon, YS; Lee, GT; Modi, PK; Patel, N; Patel, R; Singer, EA | 1 |
9 review(s) available for dihydrotestosterone and Prostatic Neoplasms, Castration-Resistant
| Article | Year |
|---|---|
Therapeutic Strategies to Target the Androgen Receptor.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Humans; Male; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen | 2022 |
Steroidogenesis in castration-resistant prostate cancer.
Topics: Androgen Antagonists; Androgens; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Testosterone | 2023 |
[Androgen biosynthesis in castration-resistant prostate cancer: Advances in studies].
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Testosterone | 2019 |
The importance of targeting intracrinology in prostate cancer management.
Topics: Abiraterone Acetate; Androgen Antagonists; Androgens; Antineoplastic Agents; Benzamides; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Testosterone | 2019 |
[Qualitative and quantitative hormonal regulation in castration-resistant prostate cancer].
Topics: Androgen Antagonists; Androgens; Antineoplastic Agents, Hormonal; Dihydrotestosterone; Disease Progression; Humans; Male; Neoplasm Recurrence, Local; Prostatic Neoplasms, Castration-Resistant; Treatment Outcome | 2013 |
Androgen biosynthesis in castration-resistant prostate cancer.
Topics: Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Prostatic Neoplasms, Castration-Resistant; Testosterone | 2014 |
Androgen metabolism in prostate cancer: from molecular mechanisms to clinical consequences.
Topics: Androgens; Animals; Dihydrotestosterone; Drug Resistance, Neoplasm; Humans; Hydroxysteroid Dehydrogenases; Male; Molecular Targeted Therapy; Prostatic Neoplasms, Castration-Resistant; Testosterone | 2014 |
[Molecular biology of castration-resistant prostate cancer].
Topics: Dihydrotestosterone; Epigenesis, Genetic; Humans; Male; Mutation; Prostate; Prostatic Neoplasms, Castration-Resistant; Protein Isoforms; Receptors, Androgen; Testosterone | 2015 |
Classical and Non-Classical Roles for Pre-Receptor Control of DHT Metabolism in Prostate Cancer Progression.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Dihydrotestosterone; Disease Progression; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase; Humans; Hydroxysteroid Dehydrogenases; Male; Minor Histocompatibility Antigens; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Racemases and Epimerases; Receptors, Androgen | 2016 |
1 trial(s) available for dihydrotestosterone and Prostatic Neoplasms, Castration-Resistant
| Article | Year |
|---|---|
Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study.
Topics: 3-Hydroxysteroid Dehydrogenases; Aged; Aldo-Keto Reductase Family 1 Member C3; Androgen Antagonists; Antineoplastic Agents; Cell Count; Dihydrotestosterone; Humans; Hydroxyprostaglandin Dehydrogenases; Indoles; Kallikreins; Male; Middle Aged; Piperidines; Prostate-Specific Antigen; Prostatic Neoplasms, Castration-Resistant; Testosterone; Treatment Outcome | 2014 |
29 other study(ies) available for dihydrotestosterone and Prostatic Neoplasms, Castration-Resistant
| Article | Year |
|---|---|
Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors.
Topics: Androgens; Animals; Antineoplastic Agents; Biological Products; Cell Line, Tumor; Drug Screening Assays, Antitumor; Gene Expression; Gene Expression Profiling; Heterografts; High-Throughput Screening Assays; Humans; Kallikreins; Male; Mice, SCID; Neoplasm Transplantation; Prostate-Specific Antigen; Prostatic Neoplasms, Castration-Resistant; Proto-Oncogene Proteins c-ets; Receptors, Androgen; Structure-Activity Relationship; Withanolides | 2015 |
High dose androgen suppresses natural killer cytotoxicity of castration-resistant prostate cancer cells via altering AR/circFKBP5/miRNA-513a-5p/PD-L1 signals.
Topics: Androgen Antagonists; Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; Humans; Killer Cells, Natural; Male; Mice; MicroRNAs; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen | 2022 |
Extensive Alteration of Androgen Precursor Levels After Castration in Prostate Cancer Patients and Their Association With Active Androgen Level.
Topics: Androgen Antagonists; Androgens; Androstenedione; Androsterone; Dehydroepiandrosterone; Dihydrotestosterone; Estrone; Humans; Male; Orchiectomy; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sulfates; Testosterone | 2022 |
Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer.
Topics: Abiraterone Acetate; Androstenes; Dihydrotestosterone; Humans; Male; Prospective Studies; Prostate-Specific Antigen; Prostatic Neoplasms, Castration-Resistant; Steroid 17-alpha-Hydroxylase; Testosterone; Treatment Outcome | 2022 |
Cholesterol Triggers Nuclear Co-Association of Androgen Receptor, p160 Steroid Coactivators, and p300/CBP-Associated Factor Leading to Androgenic Axis Transactivation in Castration-Resistant Prostate Cancer.
Topics: Androgens; Animals; Cholesterol; Dihydrotestosterone; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Steroids; Testosterone; Transcriptional Activation | 2022 |
BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer.
Topics: Animals; Binding Sites; Cell Proliferation; Dihydrotestosterone; DNA-Binding Proteins; Enhancer Elements, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Polycomb Repressive Complex 1; Promoter Regions, Genetic; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; RNA, Messenger; Tissue Array Analysis; Xenograft Model Antitumor Assays | 2020 |
Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Dihydrotestosterone; Dynamins; Gene Knockdown Techniques; Humans; Male; Mitochondria; Mitochondrial Dynamics; Mitochondrial Membrane Transport Proteins; Oxidative Phosphorylation; PC-3 Cells; Prostatic Neoplasms, Castration-Resistant; Pyruvates; Receptors, Androgen; Signal Transduction; Up-Regulation; Voltage-Dependent Anion Channels | 2020 |
Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer.
Topics: Androgen Antagonists; Animals; Antineoplastic Agents; Cell Line, Tumor; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Orchiectomy; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Random Allocation; Receptors, Androgen; Taxoids; Xenograft Model Antitumor Assays | 2020 |
Androgen receptor signaling regulates the transcriptome of prostate cancer cells by modulating global alternative splicing.
Topics: Alternative Splicing; Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Male; Mice; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Transcriptome; Transfection | 2020 |
Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation.
Topics: Amino Acid Transport System ASC; Androgens; Anilides; Animals; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Lactic Acid; Lipid Metabolism; Male; Minor Histocompatibility Antigens; Models, Biological; Neoplasm Proteins; Nitriles; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rats; Sulfides; Thiadiazoles; Tosyl Compounds | 2021 |
Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis.
Topics: Androgen Receptor Antagonists; Animals; Benzamides; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Down-Regulation; Heterografts; Humans; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Transfection | 2017 |
Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts.
Topics: Androgen Antagonists; Androgens; Animals; Benzamides; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Male; Mice; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Testosterone; Up-Regulation; Xenograft Model Antitumor Assays | 2018 |
Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging.
Topics: Animals; Cell Line, Tumor; Dihydrotestosterone; Fluorine Radioisotopes; Glucuronosyltransferase; Glycosylation; Humans; Male; Mice; Minor Histocompatibility Antigens; Positron-Emission Tomography; Prostatic Neoplasms, Castration-Resistant; Radiopharmaceuticals; Receptors, Androgen; Signal Transduction; Testosterone | 2018 |
Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells.
Topics: Cell Line, Tumor; Dihydrotestosterone; Gene Silencing; Humans; Male; Prostate; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Testosterone; Zinc Finger E-box-Binding Homeobox 1 | 2019 |
LC-MS/MS assay for the quantification of testosterone, dihydrotestosterone, androstenedione, cortisol and prednisone in plasma from castrated prostate cancer patients treated with abiraterone acetate or enzalutamide.
Topics: Abiraterone Acetate; Androstenedione; Benzamides; Chromatography, Liquid; Dihydrotestosterone; Humans; Hydrocortisone; Male; Nitriles; Phenylthiohydantoin; Plasma; Prednisone; Prostatic Neoplasms, Castration-Resistant; Tandem Mass Spectrometry; Testosterone | 2019 |
Bone morphogenetic protein-6 induces castration resistance in prostate cancer cells through tumor infiltrating macrophages.
Topics: Androgen Receptor Antagonists; Androgens; Anilides; Animals; Benzamides; Benzofurans; Bone Morphogenetic Protein 6; Cell Line, Tumor; Dihydrotestosterone; Humans; Interleukin-6; Lymphocytes, Tumor-Infiltrating; Macrophages; Male; Mice; Nitriles; Phenylthiohydantoin; Promoter Regions, Genetic; Prostatic Neoplasms, Castration-Resistant; Quinolines; Receptors, Androgen; Tosyl Compounds; Up-Regulation | 2013 |
Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.
Topics: Analysis of Variance; Cell Line, Tumor; Chromatin Immunoprecipitation; Dihydrotestosterone; DNA Primers; Electrophoretic Mobility Shift Assay; Humans; Immunoblotting; Luciferases; Male; NF-E2-Related Factor 2; Nuclear Respiratory Factor 1; Prostatic Neoplasms, Castration-Resistant; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Transcriptional Activation | 2014 |
Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo.
Topics: Androgens; Androstenedione; Animals; Blotting, Western; Cell Proliferation; Dihydrotestosterone; Humans; In Vitro Techniques; Lythraceae; Male; Mice; Mice, Knockout; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; PTEN Phosphohydrolase; Receptors, Androgen; Testosterone; Tumor Cells, Cultured | 2014 |
Accumulation of trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid in prostate cancer due to androgen-induced expression of amino acid transporters.
Topics: Amino Acid Transport Systems; Androgens; Anilides; Carboxylic Acids; Cell Line, Tumor; Cyclobutanes; Dihydrotestosterone; Fluorine Radioisotopes; Gene Expression Regulation, Neoplastic; Humans; Male; Nitriles; Prostatic Neoplasms, Castration-Resistant; Radioactive Tracers; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Androgen; Tosyl Compounds | 2014 |
Dihydrotestosterone enhances castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms, Castration-Resistant; Receptors, Glucocorticoid; Signal Transduction; STAT5 Transcription Factor; Up-Regulation | 2014 |
Dual targeting of the androgen receptor and hypoxia-inducible factor 1α pathways synergistically inhibits castration-resistant prostate cancer cells.
Topics: Antineoplastic Agents; Benzamides; Cell Hypoxia; Cell Line, Tumor; Cobalt; Dihydrotestosterone; Disulfides; Drug Synergism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indole Alkaloids; Male; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Transcription, Genetic | 2015 |
Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androgen Receptor Antagonists; Androgens; Androstenes; Animals; Benzamides; Biosynthetic Pathways; Biotransformation; Cell Division; Chromatin; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Steroid 17-alpha-Hydroxylase; Survival Analysis; Xenograft Model Antitumor Assays | 2015 |
[(14)C]Fluciclovine (alias anti-[(14)C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells.
Topics: Amino Acid Transport System ASC; Androgens; Animals; Binding, Competitive; Biological Transport; Carboxylic Acids; Cell Line, Tumor; Cyclobutanes; Dihydrotestosterone; Feasibility Studies; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Minor Histocompatibility Antigens; Prostatic Neoplasms, Castration-Resistant | 2015 |
FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer.
Topics: Androgen Antagonists; Androgens; Anilides; Antineoplastic Agents; Benzamides; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hepatocyte Nuclear Factor 3-alpha; Humans; Kallikreins; Male; Mutation; Nitriles; Phenylthiohydantoin; Prostate-Specific Antigen; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tosyl Compounds | 2015 |
[Regulatory effect of Skp2 on the expression and transactivation of the androgen receptor in the progression of castration-resistant prostate cancer].
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; Disease Progression; Gene Knockdown Techniques; Humans; Male; Neoplasm Proteins; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; S-Phase Kinase-Associated Proteins; Transcriptional Activation; Up-Regulation | 2016 |
Evaluation of Castration-Resistant Prostate Cancer with Androgen Receptor-Axis Imaging.
Topics: Biomarkers, Tumor; Dihydrotestosterone; Evidence-Based Medicine; Humans; Image Enhancement; Male; Molecular Imaging; Neoplasm Staging; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Radiopharmaceuticals; Receptors, Androgen | 2016 |
Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075.
Topics: Androgen Antagonists; Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Proliferation; Chromatin; Dihydrotestosterone; Drug Resistance, Neoplasm; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Ligands; Male; Mice; Nitriles; Phenotype; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Protein Domains; Pyridones; Receptors, Androgen; Signal Transduction; Sulfonamides; Transcription Factors; Transcription, Genetic | 2017 |
Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.
Topics: Androgen Antagonists; Binding Sites; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Disease Progression; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Phosphorylation; Promoter Regions, Genetic; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Signal Transduction; src-Family Kinases; Time Factors; Transcription, Genetic; Transcriptome; Transfection | 2017 |
Intracrine androgen biosynthesis in renal cell carcinoma.
Topics: Abiraterone Acetate; Androgens; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Carcinoma, Renal Cell; Cell Proliferation; Dihydrotestosterone; Female; Humans; Immunoenzyme Techniques; Kidney Neoplasms; Male; Mice; Mice, Nude; Nitriles; Orchiectomy; Phenylthiohydantoin; Prognosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |