Page last updated: 2024-08-21

dihydrotestosterone and Osteoporosis

dihydrotestosterone has been researched along with Osteoporosis in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.64)18.7374
1990's2 (9.09)18.2507
2000's11 (50.00)29.6817
2010's4 (18.18)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Bell, CE; Bohl, CE; Chen, J; Dalton, JT; Hwang, DJ; Miller, DD; Mohler, ML; Mustafa, S; Wu, Z; Yang, J1
Amano, S; Furuya, K; Inoguchi, K; Miyakawa, M; Nagata, N; Nejishima, H; Yamamoto, N1
Bian, J; Chen, R; Li, M; Li, Z; Tang, J; Tian, Y; Xie, Y; Xu, X; Zhang, Y; Zhang, Z1
Dick, D; Lee, J; Maupin, KA; Williams, BO1
Hsieh, YW; Kao, CH; Lin, CL; Lin, WL; Sung, FC; Wu, CH1
De Toni, L; Di Nisio, A; Ferlin, A; Foresta, C; Rocca, MS; Speltra, E; Taglialavoro, G1
Hussain, Z; Mohamed, IN; Shuid, AN; Thu, HE1
Altman, MK; Bhakta, AM; Borst, SE; Conover, CF; Conrad, B; Franz, SE; Purandare, AV; Wronski, TJ; Yarrow, JF; Zheng, N1
Adler, G; Boehm, B; Klaus, J; Reinshagen, M; von Tirpitz, C1
Boonen, S; Bouillon, R; Callewaert, F; Ophoff, J; Vanderschueren, D; Venken, K1
Balaganesh, M; Balasubramanian, K; Ilangovan, R; Queimado, L; Ravi Sankar, B; Sittadjody, S; Sivakumar, R; Srinivasan, N; Srinivasan, S; Subramanian, C; Thompson, DM1
Ali, AA; Bellido, T; Chen, JR; Ebert, R; Fu, Q; Han, L; Jilka, RL; Kousteni, S; Mancino, AT; Manolagas, SC; O'Brien, CA; Parfitt, AM; Plotkin, L; Powers, CC; Stewart, SA; Vertino, AM; Weinstein, RS; Wen, Y1
Boonen, S; Bouillon, R; Swinnen, JV; Van Herck, E; Vandenput, L; Vanderschueren, D1
Bullmann, C; Jockenhövel, F; Krone, W; Minnemann, T; Reiners, C; Schubert, M1
GLOGOWSKI, G1
Andersson, N; Bouillon, R; Eriksson, AL; Gustafsson, JA; Mohan, S; Movérare, S; Ohlsson, C; Salmon, P; Skrtic, S; Vanderschueren, D; Venken, K; Wergedal, J1
Amano, S; Furuya, K; Hanada, K; Ichikawa, K; Miyakawa, M; Nakamura, T; Nejishima, H; Oguro, N; Sumita, Y; Yamamoto, N1
de Winter-Modzelewski, J; Handelsman, DJ; Jimenez, M; Liu, PY; Ly, LP; Meier, C; Seibel, MJ1
Cafiero, F; Foresta, C; Guarneri, G; Meneghello, A; Ruzza, G; Sidran, MP1
Keck, E; Krück, F; Niederle, N; Rulf, W; Schäfer, HE; Schweikert, HU1
Gruber, DM; Huber, JC1
Harell, A; Kaye, AM; Mor, Z; Sömjen, D; Weisman, Y1

Reviews

2 review(s) available for dihydrotestosterone and Osteoporosis

ArticleYear
Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998-2021).
    European journal of medicinal chemistry, 2022, Feb-15, Volume: 230

    Topics: Androgen Antagonists; Androgens; Humans; Osteoporosis; Receptors, Androgen; Structure-Activity Relationship

2022
Conjugated estrogens--the natural SERMs.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13 Suppl 6

    Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Cardiovascular Diseases; Dihydrotestosterone; Equilin; Estradiol; Estradiol Congeners; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hydroxyestrones; Osteoporosis; Progesterone; Selective Estrogen Receptor Modulators; Testosterone; Thyroxine; Triiodothyronine

1999

Trials

2 trial(s) available for dihydrotestosterone and Osteoporosis

ArticleYear
Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism.
    Hormone research, 2003, Volume: 60, Issue:1

    Topics: Adult; Aged; Androgens; Bone Density; Dihydrotestosterone; Double-Blind Method; Drug Implants; Estradiol; Hormone Replacement Therapy; Humans; Hypogonadism; Male; Mesterolone; Middle Aged; Osteoporosis; Prospective Studies; Steroids; Testosterone

2003
Recombinant human chorionic gonadotropin but not dihydrotestosterone alone stimulates osteoblastic collagen synthesis in older men with partial age-related androgen deficiency.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:6

    Topics: Aged; Androgens; Biomarkers; Bone Remodeling; Chorionic Gonadotropin; Collagen; Dihydrotestosterone; Humans; Male; Middle Aged; Osteoblasts; Osteoporosis; Recombinant Proteins

2004

Other Studies

18 other study(ies) available for dihydrotestosterone and Osteoporosis

ArticleYear
Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.
    Bioorganic & medicinal chemistry letters, 2008, Oct-15, Volume: 18, Issue:20

    Topics: Amides; Cachexia; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Humans; Ligands; Male; Models, Chemical; Molecular Conformation; Muscles; Osteoporosis; Protein Structure, Tertiary; Receptors, Androgen

2008
Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.
    Bioorganic & medicinal chemistry letters, 2011, Nov-01, Volume: 21, Issue:21

    Topics: Animals; Bone Density; Female; Osteoporosis; Ovariectomy; Quinolines; Rats; Receptors, Androgen

2011
Loss of Lgals3 Protects Against Gonadectomy-Induced Cortical Bone Loss in Mice.
    Calcified tissue international, 2020, Volume: 106, Issue:3

    Topics: Androgens; Animals; Body Composition; Cancellous Bone; Castration; Cortical Bone; Dihydrotestosterone; Estrogens; Female; Galectin 3; Male; Mice; Mice, Knockout; Osteoporosis

2020
A population-based nested case-control study: the use of 5-alpha-reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia.
    Clinical endocrinology, 2015, Volume: 82, Issue:4

    Topics: 5-alpha Reductase Inhibitors; Aged; Aged, 80 and over; Case-Control Studies; Comorbidity; Databases, Factual; Dihydrotestosterone; Female; Finasteride; Humans; Longitudinal Studies; Male; Odds Ratio; Osteoporosis; Prostate; Prostatic Hyperplasia; Risk Factors; Testosterone

2015
Regulation of Sclerostin Production in Human Male Osteocytes by Androgens: Experimental and Clinical Evidence.
    Endocrinology, 2015, Volume: 156, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Adult; Androgens; Blotting, Western; Bone Morphogenetic Proteins; Case-Control Studies; Cells, Cultured; Dihydrotestosterone; Fluorescent Antibody Technique; Follicle Stimulating Hormone; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Markers; Humans; Hypogonadism; In Vitro Techniques; Luteinizing Hormone; Male; Osteocytes; Osteoporosis; Parathyroid Hormone; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone; Young Adult

2015
Eurycoma longifolia as a potential alternative to testosterone for the treatment of osteoporosis: Exploring time-mannered proliferative, differentiative and morphogenic modulation in osteoblasts.
    Journal of ethnopharmacology, 2017, Jan-04, Volume: 195

    Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone Density Conservation Agents; Calcification, Physiologic; Cell Differentiation; Cell Line; Cell Proliferation; Collagen; Dihydrotestosterone; Dose-Response Relationship, Drug; Eurycoma; Extracellular Matrix; Mice; Osteoblasts; Osteogenesis; Osteoporosis; Phytotherapy; Plant Extracts; Plants, Medicinal; Time Factors; Tumor Protein, Translationally-Controlled 1

2017
Supraphysiological testosterone enanthate administration prevents bone loss and augments bone strength in gonadectomized male and female rats.
    American journal of physiology. Endocrinology and metabolism, 2008, Volume: 295, Issue:5

    Topics: Amino Acids; Androgens; Animals; Body Weight; Bone and Bones; Creatinine; Dihydrotestosterone; Estradiol; Female; Femur; Kidney; Male; Muscle, Skeletal; Orchiectomy; Organ Size; Osteocalcin; Osteoporosis; Ovariectomy; Rats; Rats, Inbred F344; Tensile Strength; Testosterone; Tibia

2008
Bones and Crohn's: estradiol deficiency in men with Crohn's disease is not associated with reduced bone mineral density.
    BMC gastroenterology, 2008, Oct-23, Volume: 8

    Topics: Adult; Aged; Biomarkers; Bone and Bones; Bone Density; Case-Control Studies; Collagen Type I; Crohn Disease; Dihydrotestosterone; Estradiol; Humans; Male; Middle Aged; Osteocalcin; Osteoporosis; Peptide Fragments; Peptides; Procollagen; Sex Hormone-Binding Globulin; Testosterone; Young Adult

2008
Sex steroids during bone growth: a comparative study between mouse models for hypogonadal and senile osteoporosis.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009, Volume: 20, Issue:10

    Topics: Absorptiometry, Photon; Aging; Amino Acids; Animals; Bone Development; Dihydrotestosterone; Disease Models, Animal; Estradiol; Gonadal Steroid Hormones; Hormone Replacement Therapy; Hypogonadism; Male; Mice; Orchiectomy; Osteocalcin; Osteoporosis; Phenotype; Tomography, X-Ray Computed

2009
Dihydrotestosterone is a determinant of calcaneal bone mineral density in men.
    The Journal of steroid biochemistry and molecular biology, 2009, Volume: 117, Issue:4-5

    Topics: Absorptiometry, Photon; Adult; Aged; Body Mass Index; Bone Density; Calcaneus; Case-Control Studies; Dihydrotestosterone; Humans; Male; Middle Aged; Osteoporosis

2009
Reversal of bone loss in mice by nongenotropic signaling of sex steroids.
    Science (New York, N.Y.), 2002, Oct-25, Volume: 298, Issue:5594

    Topics: Animals; Apoptosis; Body Weight; Bone and Bones; Bone Density; Breast Neoplasms; Cell Division; Cells, Cultured; Compressive Strength; Dihydrotestosterone; Estradiol; Estrenes; Female; Humans; Male; Mice; Orchiectomy; Organ Size; Osteoblasts; Osteocalcin; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; Pyrazoles; Receptors, Estrogen; Seminal Vesicles; Transcription, Genetic; Tumor Cells, Cultured; Uterus

2002
Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2002, Volume: 17, Issue:11

    Topics: Aging; Anabolic Agents; Animals; Body Composition; Bone Density; Dihydrotestosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Female; Male; Orchiectomy; Osteoporosis; Rats

2002
[Osteoporosis and anabolic therapy].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1963, Volume: 97

    Topics: Dihydrotestosterone; Humans; Osteoporosis

1963
Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-11, Volume: 100, Issue:23

    Topics: Animals; Bone and Bones; Dihydrotestosterone; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogen Receptor alpha; Female; Heterozygote; Insulin-Like Growth Factor I; Male; Mice; Osteocalcin; Osteoporosis; Prostate; Receptors, Androgen; Receptors, Estrogen; Time Factors; Tomography, X-Ray Computed

2003
Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:11

    Topics: Anabolic Agents; Animals; Bone and Bones; Bone Density; Dihydrotestosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Osteoporosis; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Androgen

2003
[Hormone studies in human senile osteoporosis].
    Minerva medica, 1981, Sep-08, Volume: 72, Issue:32

    Topics: Aged; Dihydrotestosterone; Humans; Male; Middle Aged; Osteoporosis; Parathyroid Hormone; Testosterone

1981
Testosterone metabolism in human bone.
    Acta endocrinologica, 1980, Volume: 95, Issue:2

    Topics: Adult; Androstenedione; Bone and Bones; Child; Dihydrotestosterone; DNA; Female; Humans; Male; Osteoporosis; Testosterone

1980
Regulation of proliferation of rat cartilage and bone by sex steroid hormones.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 40, Issue:4-6

    Topics: Animals; Bone and Bones; Cell Division; Cells, Cultured; Creatine Kinase; Dihydrotestosterone; Estradiol; Estrus; Female; Growth Plate; In Vitro Techniques; Male; Osteoblasts; Osteoporosis; Ovariectomy; Rats; Rats, Inbred Strains; Tamoxifen; Testosterone

1991