Page last updated: 2024-08-21

dihydrotestosterone and Innate Inflammatory Response

dihydrotestosterone has been researched along with Innate Inflammatory Response in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.88)18.7374
1990's5 (14.71)18.2507
2000's6 (17.65)29.6817
2010's11 (32.35)24.3611
2020's10 (29.41)2.80

Authors

AuthorsStudies
Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J1
Bachmann, M; Gonther, S; Mühl, H; Stülb, H1
Ganesh, SK; Hunker, KL; Kanthi, Y; Knight, JS; Kumar, N; Obi, AT; Yalavarthi, S; Zuo, Y1
Clifton, VL; Gough, M; Meakin, AS; Saif, Z1
Barreto, GE; González, J; McGovern, AJ; Ramírez, D1
Abe, S; Cui, G; Ejima, A; Hirai, T; Ikuta, K; Kato, S; Munakata, S; Sato, S; Shimba, A; Takeuchi, O; Tani-Ichi, S; Uehata, T1
Chen, X; Liang, Y; Liu, S; Liu, X; Sun, W; Wang, X; Xiao, L; Yao, H; Yin, J1
Pham, Q; Wang, TTY; Yu, L; Yu, LL1
Chen, PF; Miao, S; Tong, Y; Yang, L; Zhou, RY1
Chen, P; Liu, X; Miao, S; Shen, Y; Tong, Y; Yang, L; Zhou, R1
Amoriello, R; Ballerini, C; Cellai, I; Cipriani, S; Comeglio, P; Fambrini, M; Filippi, S; Guarnieri, G; Lombardelli, L; Maggi, M; Maseroli, E; Morelli, A; Petraglia, F; Piccinni, MP; Rastrelli, G; Rosi, M; Sarchielli, E; Sorbi, F; Vignozzi, L1
Antić, IB; Bursać, B; Djordjevic, A; Macut, D; Macut, JB; Matić, G; Milutinović, DV; Nestorov, J; Nikolić, M; Teofilović, A; Veličković, N; Zidane, AS1
English, RS1
Culig, Z; Madersbacher, S; Sampson, N1
Corbo, GM; Di Marco Berardino, A; Inchingolo, R; Mancini, A; Raimondo, S; Smargiassi, A; Valente, S1
Agostini, D; Annibalini, G; Calcabrini, C; Colombo, E; Guescini, M; Martinelli, C; Sestili, P; Stocchi, V; Tibollo, P1
Soory, M; Tilakaratne, A1
An, HJ; Cheon, SY; Chung, KS; Kwon, KR; Lee, KH1
An, HJ; Cheon, SY; Chung, KS; Kim, CY; Lee, JH; Park, YB1
Duckles, SP; Gonzales, RJ; Krause, DN1
Spence, RD; Voskuhl, RR1
Gonzales, RJ; Handa, RJ; Swift, SN; Wu, TJ; Zuloaga, KL1
Celermajer, DS; Handelsman, DJ; Liu, PY; Ly, LP; Nakhla, S; Ng, MK; Williams, AJ1
Catapano, AL; Norata, GD; Poletti, A; Seccomandi, PM; Tibolla, G1
Ashcroft, GS; Ashworth, JJ; Gilliver, SC; Hardman, MJ; Mills, SJ1
Huhtaniemi, I; Mäkelä, S; Pakarainen, T; Poutanen, M; Savolainen, S1
Bonner, JC; Card, JW; Carey, MA; Degraff, LM; Ferguson, CD; Flake, GP; Korach, KS; Voltz, JW; Zeldin, DC1
Colville-Nash, P; da Silva, JA; Scott, DL; Spector, TD; Willoughby, DA1
Da Silva, JA; Peers, SH; Perretti, M; Willoughby, DA1
Bender, K; Cato, AC; Göttlicher, M; Heck, S; Herrlich, P; Kullmann, M1
Dahlqvist, SR; Green, PG; Isenberg, WM; Levine, JD; Miao, FJ; Strausbaugh, HJ1
Lin, YC; Talley, DJ; Villee, CA1
Gower, DB; Soory, M1
Robinette, CL1

Reviews

2 review(s) available for dihydrotestosterone and Innate Inflammatory Response

ArticleYear
Pathophysiology of Benign Prostatic Hyperplasia and Benign Prostatic Enlargement: A Mini-Review.
    Gerontology, 2019, Volume: 65, Issue:5

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Aging; Diabetes Mellitus; Dihydrotestosterone; Dutasteride; Dyslipidemias; Finasteride; Humans; Inflammation; Lower Urinary Tract Symptoms; Male; Metabolic Syndrome; Prostatic Hyperplasia; Receptors, Androgen

2019
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration.
    Frontiers in neuroendocrinology, 2012, Volume: 33, Issue:1

    Topics: Animals; Central Nervous System Diseases; Dihydrotestosterone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Estradiol; Estriol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Humans; Inflammation; Male; Mice; Multiple Sclerosis; Neuroprotective Agents; Pregnancy; Selective Estrogen Receptor Modulators; Species Specificity; Testosterone

2012

Trials

1 trial(s) available for dihydrotestosterone and Innate Inflammatory Response

ArticleYear
Prospective study of effect of androgens on serum inflammatory markers in men.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Jul-01, Volume: 22, Issue:7

    Topics: Aged; Androgens; Biomarkers; C-Reactive Protein; Chorionic Gonadotropin; Dihydrotestosterone; Double-Blind Method; Humans; Inflammation; Intercellular Adhesion Molecule-1; Male; Prospective Studies; Recombinant Proteins; Solubility; Testosterone; Vascular Cell Adhesion Molecule-1

2002

Other Studies

31 other study(ies) available for dihydrotestosterone and Innate Inflammatory Response

ArticleYear
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
    Current protocols in cytometry, 2010, Volume: Chapter 13

    Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature

2010
Acetaminophen-Induced Liver Injury Exposes Murine IL-22 as Sex-Related Gene Product.
    International journal of molecular sciences, 2021, Sep-30, Volume: 22, Issue:19

    Topics: Acetaminophen; Adaptive Immunity; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Dihydrotestosterone; Disease Models, Animal; Female; Gene Expression; Immunity, Innate; Inflammation; Interleukin-22; Interleukins; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Receptors, Aryl Hydrocarbon; Sex Factors; Signal Transduction; Spleen; T-Lymphocytes; Testosterone

2021
SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism.
    Viruses, 2021, 11-03, Volume: 13, Issue:11

    Topics: Angiotensin Receptor Antagonists; Cell Adhesion Molecules; Cells, Cultured; COVID-19; Dihydrotestosterone; Endothelium, Vascular; Female; Humans; Inflammation; Male; SARS-CoV-2; Sex Characteristics; Spike Glycoprotein, Coronavirus; Spironolactone; Tumor Necrosis Factor-alpha; Valsartan

2021
An ex vivo approach to understanding sex-specific differences in placental androgen signalling in the presence and absence of inflammation.
    Placenta, 2022, 03-24, Volume: 120

    Topics: Androgens; Asthma; Dihydrotestosterone; Female; Humans; Inflammation; Lipopolysaccharides; Male; Placenta; Pregnancy; Protein Isoforms; Receptors, Androgen

2022
Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology.
    International immunopharmacology, 2022, Volume: 108

    Topics: Androgens; Brain Injuries, Traumatic; Dihydrotestosterone; Humans; Hydroxymethylglutaryl CoA Reductases; Inflammation; Mitochondrial Proteins; PPAR gamma; Prohibitins

2022
Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells.
    Journal of immunology (Baltimore, Md. : 1950), 2022, 09-15, Volume: 209, Issue:6

    Topics: 5' Untranslated Regions; Androgens; Animals; Asthma; Dihydrotestosterone; Disease Models, Animal; Dual-Specificity Phosphatases; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Hypersensitivity; Inflammation; Interleukin-4; Male; Mice; Mice, Knockout; Receptors, Androgen; Receptors, Estrogen; Th17 Cells; Th2 Cells

2022
Dihydrotestosterone mediates the inflammation effect under lipopolysaccharides in bovine endometrial epithelial cells via AR blockading TLR4/MyD88 signaling pathway.
    Animal reproduction science, 2023, Volume: 255

    Topics: Animals; Cattle; Cattle Diseases; Dihydrotestosterone; Endometritis; Epithelial Cells; Female; Inflammation; Lipopolysaccharides; Myeloid Differentiation Factor 88; Receptors, Androgen; Signal Transduction; Toll-Like Receptor 4

2023
Modulation of CXC-motif chemokine receptor 7, but not 4, expression is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020, Volume: 69, Issue:2

    Topics: Androgens; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Computer Simulation; Dihydrotestosterone; Flagellin; Humans; Inflammation; Male; Prostatic Neoplasms; Receptors, Androgen; Receptors, CXCR; Receptors, CXCR4; RNA, Messenger; RNA, Neoplasm; Tumor Microenvironment

2020
Neuroprotection of dihydrotestosterone via suppression of the toll-like receptor 4/nuclear factor-kappa B signaling pathway in high glucose-induced BV-2 microglia inflammatory responses.
    Neuroreport, 2020, 01-27, Volume: 31, Issue:2

    Topics: Anti-Inflammatory Agents; Dihydrotestosterone; Glucose; Humans; Inflammation; Microglia; Neuroprotection; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Signal Transduction; Toll-Like Receptor 4

2020
Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation.
    Neurobiology of disease, 2020, Volume: 140

    Topics: Androgens; Animals; Anti-Inflammatory Agents; Brain; Cyclooxygenase 2; Cytokines; Dihydrotestosterone; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; Neurons; Neuroprotection; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2020
Anti-inflammatory effects of androgens in the human vagina.
    Journal of molecular endocrinology, 2020, Volume: 65, Issue:3

    Topics: Androgens; Animals; Anti-Inflammatory Agents; Cells, Cultured; Dihydrotestosterone; Female; Gene Expression; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Myocytes, Smooth Muscle; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Toll-Like Receptors; Vagina

2020
Enhanced Inflammation without Impairment of Insulin Signaling in the Visceral Adipose Tissue of 5α-Dihydrotestosterone-Induced Animal Model of Polycystic Ovary Syndrome.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2017, Volume: 125, Issue:8

    Topics: Animals; Dihydrotestosterone; Disease Models, Animal; Female; Inflammation; Insulin; Interleukin-1beta; Interleukin-6; Intra-Abdominal Fat; Obesity, Abdominal; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Signal Transduction

2017
A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors.
    Medical hypotheses, 2018, Volume: 111

    Topics: Alopecia; Androgens; Biomarkers; Dihydrotestosterone; Disease Progression; Estrogens; Female; Fibrosis; Hair; Hormone Replacement Therapy; Humans; Inflammation; Male; Models, Theoretical; Scalp; Transforming Growth Factor beta1

2018
Serum level of testosterone, dihydrotestosterone and IGF-1 during an acute exacerbation of COPD and their relationships with inflammatory and prognostic indices: a pilot study.
    Minerva medica, 2014, Volume: 105, Issue:4

    Topics: Aged; APACHE; Biomarkers; Dihydrotestosterone; Disease Progression; Female; Humans; Hypogonadism; Inflammation; Insulin-Like Growth Factor I; Male; Pilot Projects; Prognosis; Pulmonary Disease, Chronic Obstructive; Reference Values; Serum Amyloid A Protein; Testosterone

2014
Effects of sex hormones on inflammatory response in male and female vascular endothelial cells.
    Journal of endocrinological investigation, 2014, Volume: 37, Issue:9

    Topics: Cells, Cultured; Dihydrotestosterone; Estradiol; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Male; Testosterone

2014
Antioxidant response of osteoblasts to doxycycline in an inflammatory model induced by C-reactive protein and interleukin-6.
    Infectious disorders drug targets, 2014, Volume: 14, Issue:1

    Topics: Androstenedione; Anti-Inflammatory Agents; Antioxidants; Biomarkers; C-Reactive Protein; Cell Line; Dihydrotestosterone; Dose-Response Relationship, Drug; Doxycycline; Humans; Inflammation; Interleukin-6; Osteoblasts; Oxidative Stress

2014
Bee venom suppresses testosterone-induced benign prostatic hyperplasia by regulating the inflammatory response and apoptosis.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:12

    Topics: Animals; Apoptosis; Bee Venoms; Blotting, Western; Dihydrotestosterone; Inflammation; Male; Organ Size; Proliferating Cell Nuclear Antigen; Prostate; Prostatic Hyperplasia; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Testosterone

2015
Rice Hull Extract Suppresses Benign Prostate Hyperplasia by Decreasing Inflammation and Regulating Cell Proliferation in Rats.
    Journal of medicinal food, 2016, Volume: 19, Issue:8

    Topics: 5-alpha Reductase Inhibitors; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Dihydrotestosterone; Hyperplasia; Inflammation; Male; Nitric Oxide Synthase Type II; Oryza; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Prostate; Prostatic Hyperplasia; Rats, Sprague-Dawley; Seeds

2016
Dihydrotestosterone stimulates cerebrovascular inflammation through NFkappaB, modulating contractile function.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:2

    Topics: Animals; Body Weight; Cerebral Arterial Diseases; Cerebrovascular Circulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dihydrotestosterone; Inflammation; Male; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Prostate; Rats; Rats, Wistar; Tissue Culture Techniques; Vasoconstriction

2009
The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 expression, and P-glycoprotein expression in male human brain microvascular endothelial cells.
    Endocrinology, 2012, Volume: 153, Issue:12

    Topics: Androstane-3,17-diol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cells, Cultured; Cyclooxygenase 2; Dihydrotestosterone; Estrogen Receptor beta; Gene Expression Regulation; Humans; Inflammation; Male; RNA, Messenger; Vascular Cell Adhesion Molecule-1

2012
Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:2

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Cell Line, Tumor; Cyclooxygenase 2; Dihydrotestosterone; Drug Interactions; E-Selectin; Endothelial Cells; Humans; Immunoblotting; Inflammation; Intercellular Adhesion Molecule-1; Lipopolysaccharides; NF-kappa B; Nitriles; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tosyl Compounds; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2006
Androgens modulate the inflammatory response during acute wound healing.
    Journal of cell science, 2006, Feb-15, Volume: 119, Issue:Pt 4

    Topics: Aged; Aging; Androgens; Animals; Cholestenone 5 alpha-Reductase; Cytokines; Dihydrotestosterone; Fibroblasts; Gene Expression Regulation; Humans; Inflammation; Macrophage Activation; Macrophages; Male; Mice; Organ Specificity; Rats; Smad3 Protein; Smad7 Protein; Testosterone; Wound Healing

2006
Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta.
    The American journal of pathology, 2007, Volume: 171, Issue:3

    Topics: Animals; Aromatase Inhibitors; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Fulvestrant; Humans; Hyperplasia; Inflammation; Ki-67 Antigen; Male; Mice; Mice, Knockout; Nitriles; Phosphoproteins; Prolactin; Prostate; Receptors, Androgen; Receptors, LH; Receptors, Progesterone; Testosterone; Trans-Activators; Triazoles

2007
Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis.
    American journal of respiratory cell and molecular biology, 2008, Volume: 39, Issue:1

    Topics: Animals; Bleomycin; Collagen; Dihydrotestosterone; Estradiol; Female; Inflammation; Lung Compliance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orchiectomy; Ovariectomy; Polymerase Chain Reaction; Pulmonary Fibrosis; Respiratory Function Tests; RNA; Sex Characteristics

2008
Inflammation-induced cartilage degradation in female rodents. Protective role of sex hormones.
    Arthritis and rheumatism, 1993, Volume: 36, Issue:7

    Topics: Animals; Cartilage Diseases; Cartilage, Articular; Dihydrotestosterone; Estradiol; Female; Gonadal Steroid Hormones; Granuloma; Inflammation; Interleukin-1; Mice; Mice, Inbred BALB C; Ovariectomy; Progesterone; Proteoglycans; Rats; Rats, Wistar

1993
Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1.
    The Journal of endocrinology, 1993, Volume: 136, Issue:3

    Topics: Animals; Corticosterone; Dihydrotestosterone; Female; Gonadal Steroid Hormones; Hypothalamo-Hypophyseal System; Inflammation; Interleukin-1; Male; Mice; Mice, Inbred BALB C; Orchiectomy; Ovariectomy; Pituitary-Adrenal System; Progesterone; Sex Characteristics

1993
I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.
    The EMBO journal, 1997, Aug-01, Volume: 16, Issue:15

    Topics: Animals; Base Sequence; Cell Line; Dihydrotestosterone; Dimerization; DNA Primers; DNA-Binding Proteins; Down-Regulation; Estradiol; Glucocorticoids; HeLa Cells; Humans; I-kappa B Proteins; Inflammation; Mice; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Glucocorticoid; Transfection

1997
Sex steroid regulation of the inflammatory response: sympathoadrenal dependence in the female rat.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, May-15, Volume: 19, Issue:10

    Topics: Adrenal Glands; Animals; Dihydrotestosterone; Estradiol; Female; Hypothalamo-Hypophyseal System; Immunohistochemistry; Inflammation; Male; Ovary; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Sympathetic Nervous System; Testis; Testosterone

1999
Increased progesterone receptor concentrations in bladder lesions of estrogen-treated Syrian hamsters.
    Cancer research, 1979, Volume: 39, Issue:7 Pt 1

    Topics: Aldosterone; Animals; Binding, Competitive; Cricetinae; Cytosol; Dihydrotestosterone; Estradiol; Estrogens; Hyperplasia; Inflammation; Male; Mesocricetus; Metaplasia; Receptors, Progesterone; Urinary Bladder Diseases

1979
The influence of inflammatory mediators on the effects of phenytoin on steroidogenesis by human gingival fibroblasts (HGF).
    Biochemical Society transactions, 1991, Volume: 19, Issue:2

    Topics: Alprostadil; Androgens; Cells, Cultured; Dihydrotestosterone; Fibroblasts; Gingiva; Humans; Inflammation; Kinetics; Phenytoin; Testosterone

1991
Sex-hormone-induced inflammation and fibromuscular proliferation in the rat lateral prostate.
    The Prostate, 1988, Volume: 12, Issue:3

    Topics: Animals; Collagen; Dihydrotestosterone; Disease Models, Animal; Drug Implants; Estradiol; Fibroblasts; Fibrosis; Inflammation; Male; Muscle, Smooth; Orchiectomy; Organ Size; Prostate; Prostatic Diseases; Prostatic Hyperplasia; Rats; Rats, Inbred Strains

1988