dihydrotestosterone has been researched along with Cancer of Prostate in 979 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 221 (22.57) | 18.7374 |
| 1990's | 193 (19.71) | 18.2507 |
| 2000's | 309 (31.56) | 29.6817 |
| 2010's | 227 (23.19) | 24.3611 |
| 2020's | 29 (2.96) | 2.80 |
| Authors | Studies |
|---|---|
| Carlson, KE; Katzenellenbogen, JA; Liu, A | 1 |
| Bonasera, TA; Chi, DY; Choe, YS; Katzenellenbogen, JA; Lidström, PJ; Welch, MJ | 1 |
| Fedoruk, MN; Giménez-Bonafé, P; Guns, ES; Mayer, LD; Nelson, CC | 1 |
| Bastow, KF; Lee, KH; Lin, L; Nyarko, AK; Shi, Q; Shih, CC; Su, CY; Wu, CC | 1 |
| Dalton, JT; Hwang, DJ; Miller, DD; Mohler, ML; Rakov, IM; Xu, H; Yang, J | 1 |
| Badalassi, F; Bertozzi, F; Bradley, SR; Fejzic, A; Gardell, LR; Lewinsky, R; Lund, BW; Olsson, R; Pawlas, J; Piu, F; Schlienger, N; Tabatabaei, A; Thygesen, MB | 1 |
| Bohl, CE; Dalton, JT; Duke, CB; Jones, A; Miller, DD | 1 |
| Fournier, MA; Maltais, R; Poirier, D | 1 |
| Furuya, S; Hamamura, K; Hara, T; Hitaka, T; Ito, M; Kanzaki, N; Kusaka, M; Matsunaga, N; Miyazaki, J; Santou, T; Tasaka, A; Yamada, M; Yamamoto, S; Yamaoka, M | 1 |
| Aikawa, K; Baba, A; Hara, T; Hasuoka, A; Ito, M; Kaku, T; Kanzaki, N; Kobayashi, H; Yamamoto, S; Yamaoka, M | 1 |
| Cho, WJ; Gong, EY; Khadka, DB; Lee, K; Park, E; Song, CH; Van, HT; Yang, SH | 1 |
| Djigoué, GB; Kenmogne, LC; Maltais, R; Poirier, D; Roy, J | 1 |
| He, Y; Hwang, DJ; Miller, DD; Mohler, ML; Narayanan, R; Ponnusamy, S; Thiyagarajan, T | 1 |
| Chai, X; Chen, C; Cui, S; Hou, T; Hu, X; Li, D; Lou, S | 1 |
| Albert, JM; Gorityala, S; Montano, MM; Mozar, F; Sharma, V; Xu, Y | 1 |
| Chu, L; Chu, T; Ge, M; Huang, Y; Lu, Q; Shu, X | 1 |
| Amano, R; Hayakawa, A; Kanemoto, Y; Kato, S; Kurokawa, T; Mori, J; Sawada, T | 1 |
| Lorenzetti, S; Mantovani, A; Marcoccia, D; Smeriglio, A; Trombetta, D | 1 |
| Caron, P; Guillemette, C; Lacombe, L; Lévesque, É; Morin, F; Neveu, B; Pouliot, F; Rouleau, M; Toren, P; Turcotte, V | 1 |
| Claessens, F; Eerlings, R; Helsen, C; Lee, XY; Louros, N; Nguyen, TT; Rousseau, F; Schymkowitz, J; Voet, A | 1 |
| Cardoso, HJ; Carvalho, TMA; Figueira, MI; Madureira, PA; Serra, CDM; Socorro, S; Vaz, CV | 1 |
| Blas, L; Endo, S; Eto, M; Fujimoto, N; Shiota, M | 1 |
| Brown, K; Michael, P; Roversi, G; Sharifi, N | 1 |
| Bouchal, J; Eliáš, M; Frank, É; Jorda, R; Kiss, MA; Kovalová, M; Kurfürstová, D; Mada, L; Mótyán, G; Peřina, M; Študent, V; Szczyrbová, E | 1 |
| Bérubé, G; Fortin, L; Girouard, J; Paquin, A; Reyes-Moreno, C; Sevrioukova, IF | 1 |
| Barone, B; Crocetto, F; Dentice, M; Imbimbo, C; Miro, C; Torabinejad, S | 1 |
| Baji, Á; Bělíček, J; Bereczki, L; Frank, É; Jorda, R; Kiss, MA; Peřina, M | 1 |
| Hodolic, M; Kairemo, K | 1 |
| Negishi, M; Pedersen, L; Perera, L; Shizu, R; Yokobori, K | 1 |
| Boutin, S; Maltais, R; Poirier, D; Roy, J | 1 |
| Pham, Q; Wang, TTY; Yu, L; Yu, LL | 1 |
| Da, J; Li, W; Lu, M; Wang, Y; Wang, Z; Xu, M | 1 |
| Espinoza, C; Fernández-Pomares, C; Hernández-Aguilar, ME; Muñoz-Fonseca, MB; Rojas-Durán, F; Suárez-Medellín, J; Trigos, A; Vidal-Limon, A | 1 |
| Gustafsson, O; Kjellman, A; Lundgren, PO; Norming, U | 1 |
| Wadman, M | 1 |
| Begemann, D; Kyprianou, N; Wang, Y; Yang, W | 1 |
| Kvítek, L; Panáček, A; Vrzal, R; Ženata, O | 1 |
| Afshari, A; Azarpira, N; Janfeshan, S; Roozbeh, J; Yaghobi, R | 1 |
| Brás, LA; Cardoso, HJ; Carvalho, TMA; Figueira, MI; Madureira, PA; Oliveira, PJ; Sardão, VA; Socorro, S; Vaz, CV | 1 |
| Baji, Á; Bazgier, V; Frank, É; Jorda, R; Kiss, MA; May, NV; Peřina, M | 1 |
| Ang, LS; Bose, A; Brady, L; Christiani, AJ; Coleman, IM; Corella, A; Corey, E; Dalton, JT; De Sarkar, N; Dumpit, RF; Frank, SB; Haffner, MC; Howard, T; Janssens, DH; Meade, HE; Meers, MP; Mostaghel, EA; Nelson, PS; Nyquist, MD; Pierce, C; Plymate, SR | 1 |
| Ando, K; Anzai, N; Fujimoto, A; Hirota, T; Ichikawa, T; Ikehara, Y; Imamura, Y; Kanai, Y; Kaneda, A; Kanesaka, M; Maimaiti, M; Rii, J; Sakamoto, S; Shindo, N; Sugiura, M; Wakai, K; Xu, M; Yamada, Y | 1 |
| Azad, A; Boyle, GM; Cooper, C; Crucitta, S; Del Re, M; Jenster, GW; Kusuma, GD; Lim, HK; Lim, R; Martens-Uzunova, ES; Ochiya, T; Ramm, GA; Riches, JE; Soekmadji, C; Southey, MC | 1 |
| Xiao, WJ; Ye, DW; Zhang, GM | 1 |
| Honma, S; Hung, NN; Kido, T; Koh, E; Manh, HD; Maruzeni, S; Nakagawa, H; Nakano, T; Nhu, DD; Nishijo, M; Okamoto, R; Son, LK; Sun, XL; Takasuga, T | 1 |
| Dudley, RE; Page, ST; Salameh, WA; Swerdloff, RS; Wang, C | 1 |
| Göös, H; Lampinen, RE; Lempiäinen, JK; Niskanen, EA; Palvimo, JJ; Varjosalo, M; Vuoti, KM | 1 |
| Alvarez, E; Colombero, C; Mormandi, E; Nowicki, S; Papademetrio, D; Sacca, P | 1 |
| Carney, ST; Chen, Z; De Hoedt, A; Freedland, SJ; Grant, DJ; Howard, LE; Huang, J; Magyar, CE; Squires, J; Vidal, AC; Wiggins, E | 1 |
| Chung, YM; Dai, C; Klein, EA; Kovac, E; Li, J; Magi-Galluzzi, C; Sharifi, N; Stephenson, AJ; Zhu, Z | 1 |
| Cha, S; Myung, JK; Seok, JR; Shin, DH | 1 |
| Huang, J; Kong, Z; Li, Y; Qi, X; Wan, X; Wu, H; Zhang, P; Zhang, X; Zhang, Y | 1 |
| Fu, F; Kong, Z; Li, Y; Su, X; Wan, X; Wang, D; Wu, H; Zhang, P; Zhang, Y | 1 |
| Stone, L | 1 |
| Liss, MA; Thompson, IM | 1 |
| Kang, JS; Park, JW | 1 |
| Chen, J; Han, B; Ide, H; Inoue, S; Izumi, K; Kashiwagi, E; Li, P; Miyamoto, H; Mizushima, T | 1 |
| Choi, Y; Jung, YJ; Kang, K; Kim, JY; Kim, SM; Lee, EH; Lee, HJ; Pan, CH; Peng, L; Sung, SH | 1 |
| Horie, S; Ide, H; Kawato, S; Lu, Y; Muto, S; Noguchi, T; Okada, H | 1 |
| Guo, LX; Lin, J; Liu, LL; Ma, TF; Otecko, NO; Sun, WJ; Wang, SQ; Zhang, YP; Zhao, H | 1 |
| Han, S; Hong, JH; Hwang, MS; Jung, DW; Kang, HS; Koo, YE; Lee, HS; Moon, G; Oh, HS; Park, Y; Suh, JH | 1 |
| Abedinpour, P; Borgstrom, P; Chrastina, A; Pelayo, J; Rondeau, G; Welsh, J | 1 |
| Assinger, A; Basílio, J; Dikorman, B; Hell, L; Hoesel, B; Mackman, N; Moser, B; Mussbacher, M; Paar, H; Resch, U; Salzmann, M; Schmid, JA; Thaler, J | 1 |
| Chan, YX; Yeap, BB | 1 |
| Armstrong, BK; Chrzanowska, A; Cumming, R; Egger, S; Handelsman, DJ; Le Couteur, D; Mason, R; Nair-Shalliker, V; Seibel, MJ; Smith, DP; Waite, L | 1 |
| Ishikawa, K; Kogame, A; Matsui, H; Tagawa, Y; Tanaka, A; Watanabe, T | 1 |
| Fan, Y; Jarosek, SL; Konety, BR; Lawrentschuk, NL; Sathianathen, NJ | 1 |
| Boström, PJ; Elo, LL; Ettala, O; Knaapila, J; Knuuttila, M; Laiho, A; Mäkelä, SI; Mäki-Jouppila, J; Mehmood, A; Ohlsson, C; Poutanen, M; Ryberg, H; Sipilä, P; Taimen, P; Venäläinen, MS | 1 |
| Gorityala, S; Montano, MM; Xu, Y; Yang, S | 1 |
| Büyükalpelli, R; Diri, B; Diri, MA; Yildiz, L | 1 |
| Duan, HL; He, J; Lan, X; Luo, H; Zhou, XD | 1 |
| Hamid, ARAH; Mochtar, CA; Schalken, JA; Sesari, SS; Tendi, W; Umbas, R; Verhaegh, G | 1 |
| Baylina, P; Duarte, MF; Faria, MI; Fernandes, R; La Fuente, JM; Luis, C | 1 |
| Botto, H; Dreyfus, JF; Fiet, J; Ghoneim, T; Giton, F; Lebret, T; Meunier, ME; Neuzillet, Y; Radulescu, C; Raynaud, JP; Rouanne, M | 1 |
| Choi, YJ; Deng, Y; Fan, M; Kim, EK; Moon, SH; Tang, Y; Yao, G; Yu, Y | 1 |
| Beitel, LK; Chowdhury, S; Lumbroso, R; Paliouras, M; Purisima, EO; Trifiro, M | 1 |
| Dai, X; Guo, K; Liang, Z; Liu, L; Wang, H; Xu, S | 1 |
| Bellucci, A; Berruti, A; Fragni, M; Galli, D; Longhena, F; Memo, M; Nardini, M; Roca, E; Rossini, E; Sigala, S; Vezzoli, S; Zametta, M | 1 |
| Rössler, OG; Thiel, G; Welck, J; Wissenbach, U | 1 |
| Bhattacharyya, S; Feferman, L; Tobacman, JK | 1 |
| Azabdaftari, G; Pop, E; Smith, GJ; Tang, L; Wu, Y | 1 |
| Dervan, PB; Kurmis, AA | 1 |
| Bosland, MC; Cavalieri, EL; Horton, L; Huang, X; Liehr, J; Ozten, N; Rogan, EG; Vega, K | 1 |
| Hämäläinen, E; Knuuttila, M; Poutanen, M | 1 |
| Hammes, SR; Levin, ER | 1 |
| Frank, É; Gopisetty, MK; Kiricsi, M; Kiss-Faludy, RE; Kulmány, Á; Mótyán, G; Zupkó, I | 1 |
| Billakanti, S; Hong, JH; Kim, IY; Kim, JH; Kim, MM; Kim, WJ; Kwon, SJ; Lee, GT; Nagaya, N; Stein, MN | 1 |
| Choi, KC; Go, RE; Hwang, KA; Jang, YG | 1 |
| Cai, J; Imperato-McGinley, J; Li, J; Wen, J; Weng, C; Yang, K; Yuan, H; Zhao, Y; Zhu, YS | 1 |
| Alessi, P; Belleri, M; Bonomi, E; Coltrini, D; Corsini, M; Di Salle, E; Garlanda, C; Giacomini, A; Leali, D; Presta, M; Ronca, R; Tardanico, R; Tobia, C; Vermi, W | 1 |
| Balk, SP; Brown, M; Cai, C; Chen, S; Fiore, C; He, HH; He, L; Liu, XS; Loda, M; Ma, F; Mucci, L; Sowalsky, AG; Wang, H; Wang, Q; Yuan, X | 1 |
| Kikuchi, E; Kosaka, T; Maeda, T; Miyajima, A; Nagata, H; Oya, M | 1 |
| Chen, WC; Cheng, TS; Hsiao, PW; Huang, CY; Ko, CJ; Lee, MS; Liao, CI; Lin, YY; Shyu, HY; Tsai, CH; Tzeng, SF; Yang, PC | 1 |
| Azen, CG; Pike, MC; Stanczyk, FZ | 1 |
| Argellati, F; Boccardo, F; Mangerini, R; Nuzzo, PV; Ricci, F; Rubagotti, A | 1 |
| Hara, N; Ishizaki, F; Kawasaki, T; Miyashiro, Y; Naito, M; Nishiyama, T; Takahashi, K; Takizawa, I | 1 |
| Chen, HL; Du, JJ; Li, YC | 1 |
| Ahmad, H; Alam, SM; Chou, YW; Kumar, S; Lin, MF; Muniyan, S; Zhang, L | 1 |
| Chen, MH; Chen, YL; Chiu, HW; Fang, WH; Hung, CM; Wang, YJ; Wu, MD; Wu, MJ; Yuan, GF | 1 |
| Chen, D; Chen, XM; Gong, AY; Solelo Leon, D; Young, CY; Yu, C | 1 |
| Abdelbaqi, K; Beach, A; Goldberg, AA; Safe, S; Sanderson, JT; Titorenko, VI | 1 |
| Buchanan, G; Butler, LM; Chopra, S; Coetzee, GA; Leach, DA; Need, EF; Pinnock, CB; Selth, LA; Tilley, WD; Trotta, AP | 1 |
| Azzouni, F; Godoy, A; Ip, C; Mohler, JL; Wilton, JH; Wu, Y | 1 |
| Cheng, J; Chhipa, RR; Halim, D; Ip, C; Mohler, JL; Wu, Y; Zhang, HY | 1 |
| Jeong, BC; Kim, HJ; Kim, JH; Kim, SH; Kwon, GY; Lee, HM; Lim, JE; Seo, WY; Yu, EJ | 1 |
| Amaral, C; Carvalho, RA; Correia-da-Silva, G; Costa, SC; Cunha, SC; Fernandes, JO; Roleira, FM; Tavares da Silva, E; Teixeira, N; Varela, C | 1 |
| Axcrona, K; Axcrona, U; Kvalheim, G; Liang, D; Liu, J; Ma, Y; Nesland, JM; Paus, E; Servoll, E; Suo, Z; Sæter, T; Vlatkovic, L; Waaler, G; Wen, JG; Yang, Y; Zhang, Z | 1 |
| Gao, L; He, M; Ni, X; Sun, Y; Tang, G; Wang, L; Xu, B; Yu, Y | 1 |
| Auchus, RJ; Chang, KH; Guo, X; Kapur, P; Kuri, B; Li, R; Liu, J; Lotan, Y; Mirzaei, H; Nelson, PS; Roehrborn, CG; Sharifi, N; Vessella, R | 1 |
| Payton, S | 1 |
| Chuang, CK; Lenka, G; Ng, KF; Pang, ST; Weng, WH | 1 |
| Bai, S; French, FS; Grossman, G; Harris Ford, O; Mohler, JL; Pop, EA; Smith, GJ; Tan, JA; Titus, MA; Wilson, EM | 1 |
| Bloem, LM; Schloms, L; Storbeck, KH; Swart, AC | 1 |
| Armbrüster, A; Bogeski, I; Holzmann, C; Jung, V; Kappel, S; Kilch, T; Peinelt, C; Schwarz, EC; Stöckle, M | 1 |
| Amin, KS; Baishya, G; Banerjee, PP; Barua, NC; Bhattacharya, S; Jagadeesh, S; Rao, PG | 1 |
| Balk, S; Ellis, W; Gulati, R; Hunter Merrill, R; Kantoff, P; Lange, P; Lin, DW; Marck, B; Matsumoto, AM; Montgomery, B; Mostaghel, EA; Nelson, PS; Penning, T; Tamae, D; Taplin, ME; True, LD; Vessella, R | 1 |
| Fox, JJ; Goldman, DA; Gonen, M; Hricak, H; Kuk, D; Larson, SM; Morris, MJ; Scher, HI; Vargas, HA; Wassberg, C; Wibmer, A | 1 |
| Bhargava, S | 1 |
| Adomat, H; Beheshti, EH; Chin, MY; Deb, S; Guns, ET; Kharmate, G; Locke, J; Ming, DS; Pham, S | 1 |
| Adisetiyo, H; Baniwal, SK; Chimge, NO; Frenkel, B; Groshen, S; Hawes, D; Jones, JO; Khalid, O; Kim, SY; Little, GH; Pinski, J; Schones, DE | 1 |
| Hayashi, H; Igawa, T; Izumida, M; Kakoki, K; Kamiyama, H; Kubo, Y; Matsuyama, T; Sakai, H; Yamamoto, N; Yashima, Y | 1 |
| Chen, S; Wang, Y; Zhou, D | 1 |
| Barai, RS; Chaudhari, UK; Fernandes, G; Jacob, S; Kholkute, SD; Menon, S; Nayak, S; Sachdeva, G | 1 |
| Kacker, R; Morgentaler, A; Traish, A | 1 |
| Efstathiou, E; Fetterly, GJ; Mohler, JL; Titus, MA; Wilton, JH | 1 |
| Hollier, B; Jeet, V; Lehman, M; Nelson, C; Tevz, G | 1 |
| Conney, AH; Cui, XX; Ding, N; Du, ZY; Wang, H; Wei, XC; Zhang, K; Zheng, X; Zhou, DY | 1 |
| Baniahmad, A; Bartsch, S; Esmaeili, M; Foller, S; Grimm, MO; Hessenkemper, W; Huettner, SS; Liehr, T; Manvelyan, M; Petersen, I; Roediger, J | 1 |
| Harada, M; Honma, S; Ichikawa, T; Kubota, Y; Masumori, N; Miyoshi, Y; Mizokami, A; Morita, S; Nonomura, N; Sakai, H; Sakamaki, K; Shibata, Y; Sugimura, Y; Suzuki, K; Uemura, H; Umemoto, S | 1 |
| Andrew, R; Faqehi, AM; Homer, NZ; Hughes, KA; Naredo, G; Stewart, LH; Upreti, R; Walker, BR | 1 |
| Rivest, P; Robitaille, CN; Sanderson, JT | 1 |
| Behnsawy, HM; Fujisawa, M; Hanioka, K; Huang, WC; Kawabata, M; Li, X; Meligy, FY; Miyake, H; Shigemura, K; Shirakawa, T; Tanaka, K; Yamamichi, F; Yamanaka, K | 1 |
| Appella, E; Auricchio, F; Bernal, F; Castoria, G; Ciociola, A; Di Donato, M; Giovannelli, P; Hayashi, R; Migliaccio, A | 1 |
| Chhabra, M; Dalela, D; Goel, A; Goel, MM; Natu, SM; Rajender, S; Tewari, R | 1 |
| Iizuka, M; Ikaga, R; Kajitani, T; Okazaki, T; Okinaga, H; Susa, T; Tamamori-Adachi, M | 1 |
| Aburatani, H; Fujimura, T; Homma, Y; Inoue, S; Suzuki, T; Takahashi, S; Takayama, K; Tsutsumi, S; Urano, T | 1 |
| Goodman, OB; Mitra, R | 1 |
| Cheong, HS; Choi, SY; Kim, HJ; Myung, SC | 1 |
| AbuBakar, S; Chan, KL; Low, BS; Ma, HQ; Tong, KL; Wong, PF | 1 |
| Gooderham, NJ; Koufaris, C; Powell, C; Segal, CV | 1 |
| Cohen, AS; Hougaard, DM; Jørgensen, JO; Kjaer, TN; Neghabat, S; Ornstrup, MJ; Pedersen, SB; Poulsen, MM; Richelsen, B | 1 |
| Alyamani, M; Auchus, RJ; Bishop, AC; Bunch, D; Dreicer, R; Garcia, JA; Li, Z; Liu, J; Sharifi, N; Upadhyay, SK | 1 |
| Jänne, OA; Pihlajamaa, P; Sahu, B | 1 |
| Reznikov, AG; Salivonyk, OA; Shuba, YM; Sotkis, AG | 1 |
| Belledant, A; Brisson, H; Caron, P; Fradet, Y; Garcia, L; Guillemette, C; Hovington, H; Lacombe, L; Lévesque, E; Simonyan, D; Têtu, B; Villeneuve, L | 1 |
| Bjartell, A; Fabre, A; Gallagher, WM; Kay, EW; Morrissey, C; Nguyen, LK; O'Hurley, G; O'Neill, A; Prencipe, M; Watson, RW | 1 |
| Chattopadhyay, A; Cox, MB; Sieglaff, DH; Storer Samaniego, C; Suh, JH; Webb, P | 1 |
| Inouye, Y; Kanno, Y; Nemoto, K; Yamashita, N; Yanai, K; Zhao, S | 1 |
| Casimiro, MC; Chen, K; Crosariol, M; Di Sante, G; Gormley, M; Ju, X; Li, Z; Lisanti, MP; Meng, H; Pestell, RG; Yaman, I | 1 |
| Fradet, Y; Jain, P; Neveu, B; Pouliot, F; Têtu, B; Wu, L | 1 |
| Berthuy, OI; Blum, LJ; Marquette, CA | 1 |
| Bane, KL; Corum, SL; Danielpour, D; Kao, HY; Shankar, E; Song, K; Wang, H | 1 |
| Mostaghel, EA; Plymate, S; Zhang, A; Zhang, J | 1 |
| Bratoeff, E; Cabeza, M; Garrido, M; Sánchez-Márquez, A; Silva, A | 1 |
| Bolden, A; Olokpa, E; Stewart, LV | 1 |
| Eto, M; Inokuchi, J; Itsumi, M; Kajioka, S; Kashiwagi, E; Naito, S; Shiota, M; Takeuchi, A; Tatsugami, K; Uchiumi, T; Yokomizo, A | 1 |
| Chen, Y; Cheng, Y; Duan, X; Liao, Z; Liu, C; Liu, W; Pan, X; Tao, Z; Wang, X; Yin, B; Yu, P | 1 |
| Gupta, G; Kumar, L; Maikhuri, JP; Mohanty, SK; Rajender, S; Sharma, V | 1 |
| Bristow, RG; Chua, ML | 1 |
| Bogner, J; Hickson, I; Romer, T; Yurlova, L; Zolghadr, K | 1 |
| Kaplan, SA | 1 |
| Hara, N; Ishizaki, F; Nishiyama, T; Takeda, K; Tasaki, M; Tomita, Y | 1 |
| Abaffy, P; Bäcker, A; Baumbach, T; Cato, AC; Cecilia, A; Göppert, B; Gruhl, FJ; Heckmann, J; Neeb, A; Sollich, T | 1 |
| Fu, F; Huang, W; Huang, Y; Li, T; Li, Y; Pu, H; Wan, X; Wu, H; Yang, S; Zhang, Y | 1 |
| Ando, T; Hara, N; Ishizaki, F; Miyashiro, Y; Nishiyama, T; Takeda, K; Takizawa, I; Tomita, Y | 1 |
| Fox, JJ; Larson, SM; Morris, MJ; Pandit-Taskar, N; Scher, HI; Veach, DR | 1 |
| Harada, M; Honma, S; Kubota, Y; Miyoshi, Y; Shibata, Y; Suzuki, K; Uemura, H | 1 |
| Kenmogne, LC; Maltais, R; Neveu, B; Poirier, D; Pouliot, F; Rouleau, M; Roy, J | 1 |
| Alfonso, H; Chan, YX; Chubb, SA; Fegan, PG; Flicker, L; Golledge, J; Handelsman, DJ; Hankey, GJ; Yeap, BB | 1 |
| Ahn, HJ; Faiena, I; Han, CS; Kim, IY; Kim, WJ; Kwon, SJ; Kwon, YS; Lee, GT; Modi, PK; Patel, N; Patel, R; Singer, EA | 1 |
| Bilski, P; Rice, AB; Risek, B; Schrader, WT | 1 |
| Cuevas, ME; Seilheimer, K | 1 |
| Allen, JD; Grygiel, JG; Handelsman, DJ; Henshall, SM; Ho, LL; Horvath, LG; Kench, JG; Scheffer, GL; Stricker, PD; Sutherland, RL | 1 |
| Acevedo, C; Cabezas, J; Castellón, EA; Contreras, HR; Huidobro, C; Mendoza, P; Noé, G; Sánchez, C; Vergara, J | 1 |
| Helenius, MA; Suikki, HE; Urbanucci, A; Visakorpi, T; Waltering, KK | 1 |
| Mayer, D; Mukherjee, B | 1 |
| Hahn, RG; Ray, P; Rittmaster, R; Shannon, JB; Wurzel, R | 1 |
| Crews, CM; Cyrus, K; Deshaies, RJ; Kim, K; Rodriguez-Gonzalez, A; Sakamoto, KM; Salcius, M | 1 |
| Danby, FW | 1 |
| Danielpour, D; Kim, SJ; Krebs, TL; Song, K; Wang, H | 1 |
| Bahl, A; Holly, JM; Patel, S; Perks, CM; Persad, R; Thomas, F | 1 |
| Boivin, A; Gan, L; Labrie, F; Ma, C; St-Amand, J; Takase, Y; Yoshioka, M | 1 |
| Han, BM; Hong, Y; Sun, XW; Tang, YQ; Wang, Y; Xia, SJ; Yao, XQ; Yu, SQ; Zhao, FJ | 1 |
| Bagalà, C; Barone, C; Bianchetti, S; Cassano, A; Fabiano, A; Landriscina, M; Piscazzi, A; Quirino, M; Schinzari, G; Sica, G | 1 |
| Ji, J; Sun, Y; Tang, G; Wang, L; Xu, B; Xu, C; Zhang, Y | 1 |
| Cerny, RL; Galbenus, R; Raza, A; Simpson, MA; Wei, Q | 1 |
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| Becker, H; Kurniawan, E; Tamm, J; Volkwein, U | 1 |
| Andriole, GL; Kish, ML; Linehan, WM; Loriaux, DL; Rittmaster, RS | 1 |
| Luckert, PH; Pollard, M; Snyder, DL | 1 |
| Bongini, M; Ledenko, N; Legrand, JC; Mestayer, C; Wright, F | 1 |
| Mauvais-Jarvis, P; Mowszowicz, I; Portois, MC; Santen, RJ | 1 |
| Labrie, F; Veilleux, R | 1 |
| Keefer, DA; Lippert, MC | 1 |
| Boucher, WS; Leav, I; Ofner, P; Vena, RL | 1 |
| Labrie, F; Luthy, I | 1 |
| Kadohama, N; Karr, JP; Kim, U; Murphy, GP; Sandberg, AA; Wakisaka, M | 1 |
| Lerner, S; Nag, A; Norris, JS; Smith, RG; Syms, AJ | 1 |
| Bauer, HW; Fittler, F; Schulz, P | 1 |
| Schroeder, FH | 1 |
| Sagalowsky, AI | 1 |
| Anbar, D; Glass, AG; Glode, LM; Jagst, CL; Max, DT; Murphy, GP; Smith, JA; Stein, BS; Wettlaufer, JN | 1 |
| Santen, RJ; Warner, B | 1 |
| Guinan, P; Lee, M; Ojeda, L; Ray, P; Sharifi, R; Stobnicki, M | 1 |
| English, HF; Kloszewski, ED; Santen, RJ; Valentine, EG | 1 |
| Meikle, AW; Smith, JA; West, DW | 1 |
| Beckman, WC; Fried, FA; Mickey, DD | 1 |
| Howie, BJ; Shultz, TD | 1 |
| Isaacs, JT | 1 |
| Ellis, WJ; Isaacs, JT | 1 |
| Pavone-Macaluso, M | 1 |
| Farnsworth, WE | 1 |
| Becker, H; Horst, HJ; Voigt, KD | 1 |
| Ito, Y; Kurihara, H; Shida, K; Shimazaki, J | 1 |
| Mann, T | 1 |
| Dunning, WF; Voigt, W | 1 |
| Altwein, JE; Hohenfellner, R; Orestano, F | 1 |
| Giorgi, EP; Grant, JK; Moses, T | 1 |
| Bird, CE; Clark, AF | 1 |
| Griffiths, K; Peeling, WB | 1 |
77 review(s) available for dihydrotestosterone and Cancer of Prostate
| Article | Year |
|---|---|
Steroidogenesis in castration-resistant prostate cancer.
Topics: Androgen Antagonists; Androgens; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Testosterone | 2023 |
Adrenal Steroids and Resistance to Hormonal Blockade of Prostate and Breast Cancer.
Topics: Androgens; Breast Neoplasms; Dihydrotestosterone; Estrogen Receptor alpha; Estrogens; Female; Humans; Male; Prostate; Prostatic Neoplasms; Steroids | 2023 |
The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications.
Topics: Androgens; Animals; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Thyroid Hormones | 2023 |
Androgen Receptor Imaging in the Management of Hormone-Dependent Cancers with Emphasis on Prostate Cancer.
Topics: Dihydrotestosterone; Humans; Male; Positron-Emission Tomography; Prostate; Prostatic Neoplasms; Receptors, Androgen | 2023 |
Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
Topics: Aged; Angiotensin-Converting Enzyme 2; COVID-19; Dihydrotestosterone; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Male; Oncogene Proteins, Fusion; Prostatic Neoplasms; Receptors, Androgen; SARS-CoV-2; Serine Endopeptidases; Signal Transduction; Spike Glycoprotein, Coronavirus; Transcription, Genetic; Virus Internalization | 2021 |
Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.
Topics: 5-alpha Reductase Inhibitors; Animals; Dihydrotestosterone; Female; Humans; Male; Prostate; Prostatic Neoplasms; Sex Characteristics; Testosterone | 2017 |
Prostate cancer prevention with 5-alpha reductase inhibitors: concepts and controversies.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Dihydrotestosterone; Dutasteride; Early Detection of Cancer; Finasteride; Humans; Male; Organ Size; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Receptors, Androgen; Risk Factors | 2018 |
Dihydrotestosterone and cancer risk.
Topics: Androgens; Animals; Breast Neoplasms; Colorectal Neoplasms; Dihydrotestosterone; Endometrial Neoplasms; Estrogens; Female; Humans; Lung Neoplasms; Male; Prostatic Neoplasms; Risk Factors | 2018 |
The importance of targeting intracrinology in prostate cancer management.
Topics: Abiraterone Acetate; Androgen Antagonists; Androgens; Antineoplastic Agents; Benzamides; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Testosterone | 2019 |
Applying mass spectrometric methods to study androgen biosynthesis and metabolism in prostate cancer.
Topics: Animals; Dihydrotestosterone; Humans; Immunoassay; Male; Mass Spectrometry; Prostatic Neoplasms; Testosterone | 2019 |
Impact of estrogens in males and androgens in females.
Topics: Androgens; Animals; Bone and Bones; Breast Neoplasms; Central Nervous System; Dihydrotestosterone; Disease Progression; Estradiol; Estrogens; Female; Genitalia; Humans; Male; Mice; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Sex Factors; Testosterone | 2019 |
[Advances in the study of steroidal inhibitors of cytochrome P45017alpha].
Topics: Androstenedione; Androstenes; Androstenols; Animals; Antineoplastic Agents; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Molecular Structure; Pregnenolone; Progesterone; Prostatic Neoplasms; Steroid 17-alpha-Hydroxylase; Testosterone | 2013 |
11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androstenedione; Dihydrotestosterone; Humans; Hydroxysteroid Dehydrogenases; Male; Prostatic Neoplasms; Steroid 11-beta-Hydroxylase | 2013 |
Medical hypothesis: loss of the endocrine function of the prostate is important to the pathophysiology of postprostatectomy erectile dysfunction.
Topics: Androgens; Animals; Dihydrotestosterone; Erectile Dysfunction; Humans; Male; Organ Sparing Treatments; Penile Erection; Penis; Postoperative Complications; Prostate; Prostatectomy; Prostatic Neoplasms; Recovery of Function | 2014 |
Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling.
Topics: Androgen Antagonists; Androgens; Cells, Cultured; Chromatin; Dihydrotestosterone; DNA; Humans; Male; Organ Specificity; Progestins; Prostatic Neoplasms; Receptors, Androgen; Receptors, Glucocorticoid; Response Elements; Signal Transduction; Testosterone | 2015 |
Classical and Non-Classical Roles for Pre-Receptor Control of DHT Metabolism in Prostate Cancer Progression.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Dihydrotestosterone; Disease Progression; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase; Humans; Hydroxysteroid Dehydrogenases; Male; Minor Histocompatibility Antigens; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Racemases and Epimerases; Receptors, Androgen | 2016 |
Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androgens; Dihydrotestosterone; Drug Discovery; Humans; Male; Molecular Conformation; Prostatic Hyperplasia; Prostatic Neoplasms; Structure-Activity Relationship | 2016 |
A broader role for 5ARIs in prostate disease? Existing evidence and emerging benefits.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Aged; Aging; Azasteroids; Dihydrotestosterone; Dutasteride; Enzyme Inhibitors; Finasteride; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Sulfonamides; Tamsulosin; Testosterone; Urinary Tract Infections | 2009 |
Molecular imaging of prostate cancer.
Topics: Animals; Antigens, Neoplasm; Bombesin; Cell Line, Tumor; Choline; Dideoxynucleosides; Dihydrotestosterone; Fluorodeoxyglucose F18; GPI-Linked Proteins; Humans; Male; Membrane Glycoproteins; Molecular Diagnostic Techniques; Neoplasm Proteins; Positron-Emission Tomography; Prostate; Prostatic Neoplasms; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon | 2009 |
Understanding the epidemiology, natural history, and key pathways involved in prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Dihydrotestosterone; Ethnicity; Humans; Male; Prostatic Neoplasms; Testosterone | 2009 |
Molecular profiles of finasteride effects on prostate carcinogenesis.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Androgens; Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Azasteroids; Dihydrotestosterone; Disease Progression; Dutasteride; Epithelial Cells; Finasteride; Humans; Isoenzymes; Male; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Patient Selection; Prostate; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Stromal Cells | 2009 |
SRD5A2 gene mutations--a population-based review.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Alleles; Dihydrotestosterone; Disorders of Sex Development; Genetic Variation; Genitalia, Male; Humans; Hypospadias; Male; Membrane Proteins; Mutation; Population Groups; Prostatic Neoplasms; Testosterone | 2010 |
Dutasteride: novel milestones in prostate cancer chemoprevention.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticarcinogenic Agents; Azasteroids; Dihydrotestosterone; Dutasteride; Humans; Male; Prostatic Neoplasms; Treatment Outcome | 2011 |
Targeting 5α-reductase for prostate cancer prevention and treatment.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Dihydrotestosterone; Drug Delivery Systems; Humans; Male; Prostatic Neoplasms; Signal Transduction; Testosterone; Treatment Outcome | 2011 |
Differing levels of testosterone and the prostate: a physiological interplay.
Topics: Animals; Dihydrotestosterone; Hormone Replacement Therapy; Humans; Hypogonadism; Male; Prostate; Prostatic Neoplasms; Testosterone | 2011 |
Recent developments in antiandrogens and selective androgen receptor modulators.
Topics: Androgen Antagonists; Dihydrotestosterone; Drug Discovery; Gonadal Disorders; Humans; Male; Prostatic Neoplasms; Receptors, Androgen | 2012 |
Intraprostatic testosterone and dihydrotestosterone. Part I: concentrations and methods of determination in men with benign prostatic hyperplasia and prostate cancer.
Topics: Adult; Dihydrotestosterone; Humans; Immunoassay; Male; Mass Spectrometry; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 2012 |
Intraprostatic testosterone and dihydrotestosterone. Part II: concentrations after androgen hormonal manipulation in men with benign prostatic hyperplasia and prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Adult; Androgen Antagonists; Contraindications; Dihydrotestosterone; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 2012 |
The 5α-androstanedione pathway to dihydrotestosterone in castration-resistant prostate cancer.
Topics: Abiraterone Acetate; Androstadienes; Biosynthetic Pathways; Dihydrotestosterone; Etiocholanolone; Humans; Male; Orchiectomy; Prostatic Neoplasms | 2012 |
[The alternative androgen synthesis pathway in humans].
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenal Hyperplasia, Congenital; Androgens; Androstenedione; Animals; Child; Child, Preschool; Dehydroepiandrosterone; Dihydrotestosterone; Female; Humans; Infant; Infant, Newborn; Male; Neoplasms, Hormone-Dependent; Orchiectomy; Pregnancy; Prostatic Neoplasms; Sex Differentiation; Steroid 21-Hydroxylase; Testis; Testosterone | 2013 |
Molecular therapeutics in prostate cancer.
Topics: Androgens; Apoptosis; Dihydrotestosterone; DNA Methylation; Genetic Therapy; Growth Substances; Humans; Male; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Prostatic Neoplasms; Signal Transduction; Tumor Suppressor Protein p53 | 2003 |
Effect of finasteride on risk of prostate cancer: how little we really know.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Clinical Trials as Topic; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Humans; Male; Prostate; Prostatic Neoplasms; Testosterone | 2004 |
Monotherapy in advanced prostate cancer: an overview.
Topics: Adenocarcinoma; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Cyproterone Acetate; Dihydrotestosterone; Estrogens; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazolidines; Male; Nitriles; Orchiectomy; Palliative Care; Progesterone Congeners; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Testosterone; Tosyl Compounds | 2004 |
Sex steroid hormone metabolism and prostate cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Androgens; Cell Line, Tumor; Cell Transformation, Neoplastic; Dihydrotestosterone; Estrogens; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Male; Prostatic Neoplasms; Testosterone | 2004 |
Stepping-stones to the further advancement of androgen-deprivation therapy for prostate cancer.
Topics: Androgen Antagonists; Androgens; Castration; Dihydrotestosterone; Humans; Male; Prognosis; Prostatic Neoplasms; Quality of Life; Receptors, Androgen; Survival Analysis | 2006 |
Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies.
Topics: Aged; Androgens; Androstenediols; Androstenedione; Case-Control Studies; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Glucuronides; Gonadal Steroid Hormones; Humans; Logistic Models; Male; Middle Aged; Prostatic Neoplasms; Research Design; Risk Assessment; Risk Factors; Sex Hormone-Binding Globulin; Testosterone | 2008 |
The rationale for inhibiting 5alpha-reductase isoenzymes in the prevention and treatment of prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androgen Receptor Antagonists; Azasteroids; Dihydrotestosterone; Disease Progression; Dutasteride; Enzyme Inhibitors; Finasteride; Humans; Isoenzymes; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen | 2008 |
Prostate tissue androgens: history and current clinical relevance.
Topics: Biopsy; Dihydrotestosterone; Hormone Replacement Therapy; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 2008 |
Regulation of prostate growth in organ culture.
Topics: Animals; Cell Differentiation; Cell Division; Culture Media; Dihydrotestosterone; Dogs; Hormones; Humans; Male; Mice; Neoplasms, Experimental; Organ Culture Techniques; Polyamines; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Testosterone; Vitamin A | 1980 |
Control of prostate growth.
Topics: Adrenal Glands; Adult; Aged; Dihydrotestosterone; Estradiol; Estrone; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Pituitary Gland; Progesterone-Binding Globulin; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Testis; Testosterone; Transcortin | 1981 |
[Recent findings on androgen receptors].
Topics: Animals; Cell Nucleus; Cytosol; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid; RNA | 1981 |
Histochemical studies of epithelial cell glycoconjugates in atrophic, metaplastic, hyperplastic, and neoplastic canine prostate.
Topics: Androstane-3,17-diol; Animals; Binding, Competitive; Carbohydrates; Castration; Cell Differentiation; Dihydrotestosterone; Dog Diseases; Dogs; Epithelium; Estradiol; Histocytochemistry; Male; Prostate; Prostatic Diseases; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Mitogen | 1984 |
Androgen receptor assays in advanced prostatic cancer.
Topics: Binding Sites; Dihydrotestosterone; Estrenes; Estrogens; Humans; Male; Metribolone; Prostatic Neoplasms; Radioligand Assay; Receptors, Androgen; Receptors, Steroid; Testosterone Congeners | 1984 |
Clinical applications and value of receptor levels in treatment of prostate cancer.
Topics: Androgens; Biopsy; Dihydrotestosterone; Estrenes; Histocytochemistry; Humans; Ligands; Male; Methods; Metribolone; Prostate; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Receptors, Steroid; Sex Hormone-Binding Globulin; Testosterone Congeners | 1984 |
Endocrine therapy: predictors of response to prostatic cancer.
Topics: Androgen Antagonists; Cell Nucleus; Cytosol; Dihydrotestosterone; Humans; Male; Neoplasm Staging; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen | 1983 |
The clinical relevance of in vitro markers.
Topics: Acid Phosphatase; Antigens, Neoplasm; Cell Division; Chromosome Aberrations; Dihydrotestosterone; Humans; Hybridomas; Karyotyping; Male; Neoplasm Staging; Prostate; Prostatic Neoplasms; Testosterone | 1981 |
5-Alpha-reductase inhibition and prostate cancer prevention.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Cell Transformation, Neoplastic; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostate; Prostatic Neoplasms; Risk Factors; Survival Rate | 1994 |
Mechanism of action and pure antiandrogenic properties of flutamide.
Topics: Androgen Antagonists; Androgen-Binding Protein; Animals; Antineoplastic Combined Chemotherapy Protocols; Dihydrotestosterone; Flutamide; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormone; Male; Orchiectomy; Ornithine Decarboxylase; Phosphatidylethanolamine Binding Protein; Prostate; Prostatein; Prostatic Neoplasms; RNA, Messenger; Secretoglobins; Tumor Cells, Cultured; Uteroglobin | 1993 |
Prostate cancer. Primary hormonal treatment.
Topics: Combined Modality Therapy; Cyproterone Acetate; Diethylstilbestrol; Dihydrotestosterone; Estrogens; Flutamide; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormone; Male; Orchiectomy; Patient Participation; Prostate; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 1993 |
Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy.
Topics: Adrenal Cortex Hormones; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Combined Modality Therapy; Dihydrotestosterone; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Neoplasm Staging; Orchiectomy; Prostate; Prostatic Neoplasms; Tumor Cells, Cultured; Ultrasonography | 1993 |
Androgens, androgen receptors, antiandrogens and the treatment of prostate cancer.
Topics: Androgen Antagonists; Androgens; Animals; Antineoplastic Agents; Binding Sites; Cell Division; Combined Modality Therapy; Dihydrotestosterone; Down-Regulation; Genes, Tumor Suppressor; Growth Substances; Humans; Male; Orchiectomy; Palliative Care; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Androgen; Signal Transduction; Tumor Cells, Cultured | 1997 |
Innovative approaches to the hormonal treatment of advanced prostate cancer.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Antineoplastic Agents; Biomarkers, Tumor; Combined Modality Therapy; Controlled Clinical Trials as Topic; Dihydrotestosterone; Humans; Male; Palliative Care; Prostate-Specific Antigen; Prostatic Neoplasms; Quality of Life; Risk Assessment; Testosterone | 1997 |
Selections from current literature: androgenetic alopecia: the science behind a new oral treatment.
Topics: 5-alpha Reductase Inhibitors; Alopecia; Biomarkers, Tumor; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 1998 |
The androgen receptor: genetic considerations in the development and treatment of prostate cancer.
Topics: Androgen Antagonists; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Receptors, Androgen | 1999 |
Hormonal predictors of prostate cancer: a meta-analysis.
Topics: Age Factors; Androgens; Body Mass Index; Case-Control Studies; Cohort Studies; Confidence Intervals; Dihydrotestosterone; Estradiol; Forecasting; Gonadal Steroid Hormones; Hormones; Humans; Insulin-Like Growth Factor I; Male; Multivariate Analysis; Odds Ratio; Prospective Studies; Prostatic Neoplasms; Risk Factors; Sex Hormone-Binding Globulin; Steroids; Testosterone | 2000 |
Androgens: biphasic dose responses.
Topics: Androgens; Animals; Cell Division; Chondrocytes; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Male; Prolactin; Prostatic Neoplasms; Sertoli Cells; Testis; Testosterone; Tumor Cells, Cultured | 2001 |
5alpha-reductase activity in the prostate.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Cryptorchidism; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Forecasting; Humans; Infertility, Male; Isoenzymes; Male; Mice; Mice, Knockout; Mutation; Penile Erection; Penis; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Testis; Tumor Cells, Cultured | 2001 |
Androgen binding and metabolism in the human prostate.
Topics: Androgens; Androstanes; Androstenedione; Animals; Cytosol; Dihydrotestosterone; Humans; Male; Muscles; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Protein Binding; Rats; Receptors, Cell Surface; Testosterone | 1975 |
[Clinical aspects of the anti-androgens].
Topics: 17-Ketosteroids; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Androgen Antagonists; Androgens; Androsterone; Contraceptives, Oral, Hormonal; Cyclopentanes; Cyproterone; Dermatitis, Seborrheic; Dihydrotestosterone; Estradiol Congeners; Female; Follicle Stimulating Hormone; Glucocorticoids; Hirsutism; Humans; Hydroxysteroids; Luteinizing Hormone; Male; Medroxyprogesterone; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; Sex Hormone-Binding Globulin; Steroids; Testosterone | 1979 |
EB 33, an epithelial cell line from human prostate carcinoma: a review.
Topics: Acid Phosphatase; Animals; Cell Line; Chromosome Aberrations; Dihydrotestosterone; Epithelium; Glucosephosphate Dehydrogenase; Humans; Immunity; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Transplantation, Heterologous | 1978 |
The relevance of studies on androgen action to prostatic cancer.
Topics: Aging; Androgen Antagonists; Androgens; Cell Membrane; Cells, Cultured; Dihydrotestosterone; Estrogens; Humans; Hyperplasia; Male; Neoplasms, Experimental; Precancerous Conditions; Prostate; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 1976 |
Potential test systems for chemotherapeutic agents against prostatic cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Animals; Antineoplastic Agents; Arginase; Dihydrotestosterone; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Estradiol; Estramustine; Estriol; Estrogens; Flutamide; Haplorhini; Humans; Male; Mice; Neoplasms, Experimental; Prostate; Prostatic Neoplasms; Rats; Testosterone | 1975 |
Benign prostatic hyperplasia: antecedents and natural history.
Topics: Adult; Aged; Dihydrotestosterone; Estrogens; Growth Substances; Humans; Male; Middle Aged; Prevalence; Prostate; Prostatectomy; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Adrenergic; Risk Factors; Testosterone | 1992 |
Plasma steroid transport in subjects with tumors of hormonal target organs: a review.
Topics: Breast Neoplasms; Dihydrotestosterone; Endometrial Neoplasms; Estradiol; Female; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Sex Hormone-Binding Globulin | 1992 |
Dual control by androgens and peptide growth factors of prostatic growth in human benign prostatic hyperplasia.
Topics: 5-alpha Reductase Inhibitors; Androgens; Androstenes; Azasteroids; Carcinoma; Cell Division; Cells, Cultured; Dihydrotestosterone; Epidermal Growth Factor; Finasteride; Gonadotropin-Releasing Hormone; Growth Substances; Humans; Insulin-Like Growth Factor I; Male; Peptides; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Tumor Cells, Cultured | 1991 |
Review of assessment of total androgen blockade as treatment of metastatic prostate cancer.
Topics: Adrenal Glands; Androgen Antagonists; Androgens; Animals; Dihydrotestosterone; Humans; Male; Orchiectomy; Prostatic Neoplasms; Rats; Receptors, Androgen; Survival Analysis | 1991 |
Prostatic polyamines and polyamine targeting as a new approach to therapy of prostatic cancer.
Topics: Aziridines; Biological Transport; Cell Division; Dihydrotestosterone; Eflornithine; Guanidines; Humans; Male; Mitoguazone; Ornithine Decarboxylase; Polyamines; Prostate; Prostatic Neoplasms; Putrescine | 1991 |
Adrenal androgen blockade in relapsed prostate cancer.
Topics: Adrenalectomy; Aminoglutethimide; Androgen Antagonists; Castration; Combined Modality Therapy; Cyproterone; Cyproterone Acetate; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Megestrol; Megestrol Acetate; Neoplasm Metastasis; Prognosis; Prostate; Prostatic Neoplasms | 1985 |
Advantages of total androgen blockade in the treatment of advanced prostate cancer.
Topics: Adrenal Cortex; Androgen Antagonists; Androgens; Clinical Trials as Topic; Dihydrotestosterone; Humans; Male; Orchiectomy; Prostate; Prostatic Neoplasms | 1988 |
Combination therapy with flutamide and [D-Trp6, des-Gly-NH2(10)]LHRH ethylamide in stage C and D prostate cancer: today's therapy of choice--rationale and 5-year clinical experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Delayed-Action Preparations; Dihydrotestosterone; Flutamide; Follow-Up Studies; Gonadotropin-Releasing Hormone; Humans; Male; Orchiectomy; Prostate; Prostatic Neoplasms; Triptorelin Pamoate | 1988 |
New concepts on the androgen sensitivity of prostate cancer.
Topics: Adrenalectomy; Androgens; Antineoplastic Combined Chemotherapy Protocols; Dihydrotestosterone; Drug Resistance; Estrogens; Humans; Male; Orchiectomy; Prostate; Prostatic Neoplasms | 1987 |
Steroid receptor and biochemical profiles in prostatic cancer: correlation with response to hormonal treatment.
Topics: Cell Nucleus; Cytosol; Dihydrotestosterone; Estrogens; Humans; Male; Orchiectomy; Prostate; Prostatic Neoplasms; Receptors, Androgen | 1987 |
Treatment of prostate cancer with gonadotropin-releasing hormone agonists.
Topics: Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Dihydrotestosterone; Estrogens; Flutamide; Humans; Luteinizing Hormone; Male; Orchiectomy; Pituitary Hormone-Releasing Hormones; Prostatic Neoplasms; Radioimmunoassay; Testosterone | 1986 |
The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adenocarcinoma; Animals; Dihydrotestosterone; Humans; Male; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Progesterone; Prostate; Prostatic Neoplasms; Rats; Testosterone | 1986 |
Total androgen suppression in the management of prostatic cancer. A critical review.
Topics: Adrenalectomy; Aminoglutethimide; Androgen Antagonists; Castration; Diethylstilbestrol; Dihydrotestosterone; Glucocorticoids; Humans; Male; Prostate; Prostatic Neoplasms; Testosterone | 1985 |
Endocrine therapy for prostate cancer.
Topics: Adrenal Glands; Adrenalectomy; Androgens; Dihydrotestosterone; Estramustine; Estrogens; Gonadotropin-Releasing Hormone; Humans; Hypophysectomy; Hypothalamo-Hypophyseal System; Male; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Testis | 1985 |
Secretory function of the prostate, seminal vesicle and other male accessory organs of reproduction.
Topics: Acid Phosphatase; Animals; Body Fluids; Bulbourethral Glands; Cattle; Citrates; Dihydrotestosterone; Dogs; Fructose; Humans; Inositol; Male; Potassium; Prostaglandins; Prostate; Prostatic Neoplasms; Proteins; Putrescine; Rats; Secretory Rate; Semen; Seminal Vesicles; Species Specificity; Spermatozoa; Spermine; Swine; Testicular Diseases; Testosterone | 1974 |
33 trial(s) available for dihydrotestosterone and Cancer of Prostate
| Article | Year |
|---|---|
Finasteride does not prevent bladder cancer: A secondary analysis of the Medical Therapy for Prostatic Symptoms Study.
Topics: 5-alpha Reductase Inhibitors; Androgens; Dihydrotestosterone; Finasteride; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Prostatic Neoplasms; Urinary Bladder Neoplasms | 2018 |
Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Aged; Androstane-3,17-diol; Androstenedione; Dihydrotestosterone; Finasteride; Humans; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 2013 |
Targeted androgen pathway suppression in localized prostate cancer: a pilot study.
Topics: 5-alpha Reductase Inhibitors; Aged; Aged, 80 and over; Androgen Antagonists; Androgen Receptor Antagonists; Androsterone; Anilides; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Azasteroids; Biomarkers, Tumor; Chemotherapy, Adjuvant; Dihydrotestosterone; Dutasteride; Goserelin; Humans; Ketoconazole; Male; Middle Aged; Molecular Targeted Therapy; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Pilot Projects; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Steroid 17-alpha-Hydroxylase; Testosterone; Tosyl Compounds; Treatment Outcome | 2014 |
Resveratrol reduces the levels of circulating androgen precursors but has no effect on, testosterone, dihydrotestosterone, PSA levels or prostate volume. A 4-month randomised trial in middle-aged men.
Topics: Aged; Androgens; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Dihydrotestosterone; Double-Blind Method; Humans; Male; Metabolic Syndrome; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Regression Analysis; Resveratrol; Stilbenes; Testosterone; Testosterone Congeners | 2015 |
Effect of dutasteride on intraprostatic androgen levels in men with benign prostatic hyperplasia or prostate cancer.
Topics: Aged; Azasteroids; Dihydrotestosterone; Dutasteride; Enzyme Inhibitors; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Time Factors | 2008 |
Preliminary evaluation of the effect of dutasteride on PCA3 in post-DRE urine sediments: a randomized, open-label, parallel-group pilot study.
Topics: 5-alpha Reductase Inhibitors; Antigens, Neoplasm; Azasteroids; Biomarkers, Tumor; Dihydrotestosterone; Dose-Response Relationship, Drug; Dutasteride; Enzyme Inhibitors; Humans; Longitudinal Studies; Male; Middle Aged; Pilot Projects; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone | 2009 |
Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial.
Topics: 5-alpha Reductase Inhibitors; Aged; Antineoplastic Agents, Hormonal; Azasteroids; Biopsy; Dihydrotestosterone; Double-Blind Method; Dutasteride; Humans; Kallikreins; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; Neoplasms, Hormone-Dependent; Odds Ratio; Placebos; Prospective Studies; Prostate-Specific Antigen; Prostatic Neoplasms; Research Design; Testosterone; Time Factors; Treatment Outcome; Up-Regulation | 2012 |
Prostatic response to supranutritional selenium supplementation: comparison of the target tissue potency of selenomethionine vs. selenium-yeast on markers of prostatic homeostasis.
Topics: Aging; Animals; Apoptosis; Cell Proliferation; Dietary Supplements; Dihydrotestosterone; DNA Damage; Dogs; Homeostasis; Male; Models, Animal; Prostate; Prostatic Neoplasms; Selenium; Selenomethionine; Testosterone; Yeasts | 2012 |
Biomarker-based methods for determining noncompliance in a prevention trial.
Topics: Aged; Algorithms; Biomarkers; Dihydrotestosterone; Drug Monitoring; Enzyme Inhibitors; Finasteride; Humans; Male; Middle Aged; Patient Compliance; Prostatic Neoplasms; Randomized Controlled Trials as Topic; ROC Curve; Sensitivity and Specificity | 2002 |
Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible mechanism of action.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Androgen Antagonists; Androstenediols; Benzoquinones; Biomarkers, Tumor; Chemical and Drug Induced Liver Injury; Dihydrotestosterone; Disease-Free Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Humans; Isoenzymes; Life Tables; Male; Neoplasm Proteins; Orchiectomy; Prostate-Specific Antigen; Prostatic Neoplasms; Safety; Substrate Specificity; Testosterone; Treatment Outcome | 2004 |
Tumor localization of 16beta-18F-fluoro-5alpha-dihydrotestosterone versus 18F-FDG in patients with progressive, metastatic prostate cancer.
Topics: Aged; Bone Neoplasms; Dihydrotestosterone; Fluorodeoxyglucose F18; Humans; Male; Metabolic Clearance Rate; Middle Aged; Prostatic Neoplasms; Radiopharmaceuticals; Receptors, Androgen; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Tomography, Emission-Computed; Whole-Body Counting | 2004 |
Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Aged; Androgens; Antigens, CD34; Apoptosis; Atrophy; Azasteroids; Dihydrotestosterone; Double-Blind Method; Dutasteride; Epithelium; Humans; Male; Microcirculation; Middle Aged; Neovascularization, Pathologic; Prostate; Prostatic Neoplasms; Testosterone | 2004 |
Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer.
Topics: Adenocarcinoma; Aged; Androgens; Biomarkers, Tumor; Bread; Dihydrotestosterone; Double-Blind Method; Flax; Genistein; Gonadal Steroid Hormones; Humans; Isoflavones; Male; Middle Aged; Neoplasm Proteins; Phytoestrogens; Phytotherapy; Prostate-Specific Antigen; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Soy Foods; Testosterone | 2004 |
PET-based radiation dosimetry in man of 18F-fluorodihydrotestosterone, a new radiotracer for imaging prostate cancer.
Topics: Body Burden; Dihydrotestosterone; Humans; Image Interpretation, Computer-Assisted; Male; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Prostatic Neoplasms; Radiation Dosage; Radiation Protection; Radiometry; Relative Biological Effectiveness; Risk Assessment; Risk Factors; Tissue Distribution; Whole-Body Counting | 2004 |
Positron tomographic assessment of androgen receptors in prostatic carcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Dihydrotestosterone; Feasibility Studies; Fluorine Radioisotopes; Humans; Male; Middle Aged; Positron-Emission Tomography; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen | 2005 |
The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer--results from a 4-month pre-radical prostatectomy study.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Aged; Aged, 80 and over; Apoptosis; Azasteroids; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Double-Blind Method; Dutasteride; Enzyme Inhibitors; Humans; Male; Middle Aged; Pilot Projects; Prostate; Prostatectomy; Prostatic Neoplasms; Treatment Outcome | 2006 |
Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial.
Topics: Adult; Age of Onset; Aged; Biopsy, Needle; Dihydrotestosterone; Double-Blind Method; Epithelial Cells; Gene Expression Profiling; Hormone Replacement Therapy; Humans; Hypogonadism; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Prostate; Prostatic Neoplasms; RNA; Testosterone | 2006 |
Effect of very high dose D-leucine6-gonadotropin-releasing hormone proethylamide on the hypothalamic-pituitary testicular axis in patients with prostatic cancer.
Topics: Adenocarcinoma; Adult; Animals; Castration; Clinical Trials as Topic; Dihydrotestosterone; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Hypothalamo-Hypophyseal System; Leuprolide; Luteinizing Hormone; Male; Prostatic Neoplasms; Rats; Testis; Testosterone | 1983 |
Three-year safety and efficacy data on the use of finasteride in the treatment of benign prostatic hyperplasia.
Topics: Adult; Aged; Aged, 80 and over; Dihydrotestosterone; Double-Blind Method; Finasteride; Humans; Male; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Severity of Illness Index; Urodynamics | 1994 |
[Phase I study of flutamide, a nonsteroidal antiandrogen, in patients with prostatic cancer].
Topics: Administration, Oral; Aged; Aged, 80 and over; Dihydrotestosterone; Drug Administration Schedule; Flutamide; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Prolactin; Prostatic Neoplasms; Testosterone | 1993 |
Dihydrotestosterone and testosterone levels in men screened for prostate cancer: a study of a randomized population.
Topics: Aged; Dihydrotestosterone; Humans; Male; Mass Screening; Middle Aged; Multivariate Analysis; Neoplasm Staging; Ploidies; Prostate-Specific Antigen; Prostatic Neoplasms; Regression Analysis; Sex Hormone-Binding Globulin; Testosterone | 1996 |
An evaluation of pharmacokinetics and pharmacodynamics of leuprorelin acetate 3M-depot in patients with advanced and metastatic carcinoma of the prostate.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Carcinoma; Delayed-Action Preparations; Dihydrotestosterone; Evaluation Studies as Topic; Follicle Stimulating Hormone; Humans; Injections, Subcutaneous; Leuprolide; Linear Models; Luteinizing Hormone; Male; Middle Aged; Neoplasm Metastasis; Prostate-Specific Antigen; Prostatic Neoplasms; Severity of Illness Index; Statistics, Nonparametric; Testosterone; Treatment Outcome | 1998 |
Comparison of LH-RH analogue 1-month depot and 3-month depot by their hormone levels and pharmacokinetic profile in patients with advanced prostate cancer.
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents, Hormonal; Delayed-Action Preparations; Dihydrotestosterone; Gonadotropin-Releasing Hormone; Humans; Injections, Subcutaneous; Leuprolide; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone; Time Factors | 1998 |
Finasteride in association with either flutamide or goserelin as combination hormonal therapy in patients with stage M1 carcinoma of the prostate gland. International Prostate Health Council (IPHC) Trial Study Group.
Topics: 5-alpha Reductase Inhibitors; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Flutamide; Follicle Stimulating Hormone; Goserelin; Humans; Luteinizing Hormone; Male; Middle Aged; Neoplasm Staging; Prostate-Specific Antigen; Prostatic Neoplasms | 1999 |
Effects of replacing meat with soyabean in the diet on sex hormone concentrations in healthy adult males.
Topics: Adult; Androstane-3,17-diol; Cross-Over Studies; Dietary Proteins; Dihydrotestosterone; Estradiol; Glycine max; Gonadal Steroid Hormones; Humans; Male; Meat; Middle Aged; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Testosterone | 2000 |
The gonadotropin-releasing hormone antagonist abarelix depot versus luteinizing hormone releasing hormone agonists leuprolide or goserelin: initial results of endocrinological and biochemical efficacies in patients with prostate cancer.
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents, Hormonal; Delayed-Action Preparations; Dihydrotestosterone; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Goserelin; Humans; Injections, Intramuscular; Leuprolide; Luteinizing Hormone; Male; Middle Aged; Oligopeptides; Prospective Studies; Prostate-Specific Antigen; Prostatic Neoplasms; Testis; Testosterone | 2001 |
Sex hormone binding globulin binding capacity, testosterone, 5alpha-dihydrotestosterone, oestradiol and prolactin in plasma of patients with prostatic carcinoma under various types of hormonal treatment.
Topics: Chorionic Gonadotropin; Clinical Trials as Topic; Cyproterone; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Humans; Male; Mefruside; Prednisone; Prolactin; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Testosterone | 1977 |
Castration-like effects on the human prostate of a 5 alpha-reductase inhibitor, finasteride.
Topics: 5-alpha Reductase Inhibitors; Androstenes; Azasteroids; Dihydrotestosterone; Finasteride; Humans; Male; Orchiectomy; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1992 |
Aromatase inhibition: 4-hydroxyandrostenedione (4-OHA, CGP 32349) in advanced prostatic cancer.
Topics: Aged; Androstenedione; Aromatase Inhibitors; Dihydrotestosterone; Estradiol; Humans; Male; Neoplasm Staging; Prostatic Neoplasms; Testosterone; Time Factors | 1992 |
3.75 and 7.5 mg leuprorelin acetate depot in the treatment of advanced prostatic cancer: preliminary report. German Leuprorelin Study Group.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Clinical Trials as Topic; Delayed-Action Preparations; Dihydrotestosterone; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Injections, Intramuscular; Injections, Subcutaneous; Leuprolide; Luteinizing Hormone; Male; Middle Aged; Prostatic Neoplasms; Testosterone | 1990 |
Advantages of total androgen blockade in the treatment of advanced prostate cancer.
Topics: Adrenal Cortex; Androgen Antagonists; Androgens; Clinical Trials as Topic; Dihydrotestosterone; Humans; Male; Orchiectomy; Prostate; Prostatic Neoplasms | 1988 |
Clinical effects of gonadotropin-releasing hormone analogue in metastatic carcinoma of prostate.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Castration; Clinical Trials as Topic; Diethylstilbestrol; Dihydrotestosterone; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hormones; Humans; Leuprolide; Luteinizing Hormone; Male; Middle Aged; Neoplasm Metastasis; Prostatic Neoplasms; Testosterone | 1985 |
Comparison of leuprolide and diethylstilbestrol for stage D2 adenocarcinoma of prostate.
Topics: Acid Phosphatase; Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Diethylstilbestrol; Dihydrotestosterone; Gonadotropin-Releasing Hormone; Humans; Leuprolide; Male; Middle Aged; Neoplasm Staging; Prostate; Prostatic Neoplasms; Random Allocation; Testosterone; Time Factors | 1985 |
870 other study(ies) available for dihydrotestosterone and Cancer of Prostate
| Article | Year |
|---|---|
Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography.
Topics: Androgens; Animals; Dihydrotestosterone; Estrenes; Fluorine; Male; Metribolone; Molecular Conformation; Molecular Structure; Nandrolone; Prostate; Prostatic Neoplasms; Rats; Receptors, Androgen; Structure-Activity Relationship; Testosterone; Tomography, Emission-Computed | 1992 |
Synthesis of 11 beta-[18F]fluoro-5 alpha-dihydrotestosterone and 11 beta-[18F]fluoro-19-nor-5 alpha-dihydrotestosterone: preparation via halofluorination-reduction, receptor binding, and tissue distribution.
Topics: Animals; Dihydrotestosterone; Fluorine Radioisotopes; Isotope Labeling; Male; Oxidation-Reduction; Prostatic Neoplasms; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Solubility; Testosterone Congeners; Tissue Distribution | 1995 |
P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Northern; Blotting, Western; Cyclosporins; Dihydrotestosterone; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Neoplasms, Hormone-Dependent; Precipitin Tests; Prostatic Neoplasms; Receptors, Androgen; RNA, Neoplasm; Verapamil | 2004 |
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
Topics: Androgen Antagonists; Antineoplastic Agents; Cell Line, Tumor; Curcumin; Drug Design; Drug Screening Assays, Antitumor; Genes, Reporter; Humans; Luciferases; Male; Mutation; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Structure-Activity Relationship; Transcriptional Activation; Transfection | 2006 |
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemical Phenomena; Chemistry, Physical; Haplorhini; Humans; Isothiocyanates; Ligands; Magnetic Resonance Spectroscopy; Male; Prostatic Neoplasms; Receptors, Androgen; Rhodamines; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2006 |
Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
Topics: Administration, Oral; Androgen Receptor Antagonists; Androgens; Animals; Azabicyclo Compounds; Dogs; Drug Design; Humans; Ligands; Male; Mice; Microsomes, Liver; Mutation; NIH 3T3 Cells; Orchiectomy; Prostatic Neoplasms; Rats; Receptors, Androgen; Structure-Activity Relationship; Substrate Specificity; Testosterone Propionate | 2009 |
Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Crystallography, X-Ray; Drug Design; Drug Resistance, Neoplasm; Humans; Male; Molecular Structure; Molecular Targeted Therapy; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Structure-Activity Relationship | 2011 |
Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3.
Topics: 17-Hydroxysteroid Dehydrogenases; Androsterone; Enzyme Inhibitors; HEK293 Cells; Humans; Inhibitory Concentration 50; Male; Prostatic Neoplasms; Structure-Activity Relationship | 2011 |
Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists.
Topics: Amino Acid Substitution; Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Resistance, Neoplasm; Humans; Male; Mice; Mice, Inbred ICR; Mice, Nude; Mutation; Prostatic Neoplasms; Pyrroles; Receptors, Androgen; Transplantation, Heterologous | 2012 |
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Castration; Cell Line, Tumor; Drug Design; Humans; Male; Mice; Models, Molecular; Prostate; Prostatic Neoplasms; Pyrrolidines; Receptors, Androgen; Xenograft Model Antitumor Assays | 2013 |
SAR based design of nicotinamides as a novel class of androgen receptor antagonists for prostate cancer.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Cell Line, Tumor; Drug Design; Humans; Isoquinolines; Male; Niacinamide; Prostatic Neoplasms; Receptors, Androgen; Structure-Activity Relationship | 2013 |
Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3.
Topics: 17-Hydroxysteroid Dehydrogenases; Androgens; Animals; Carbamates; Cell Line, Tumor; Drug Design; Enzyme Inhibitors; Humans; Male; Morpholines; Prostate; Prostatic Neoplasms; Rats; Spiro Compounds | 2015 |
Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Half-Life; Humans; Male; Mice; Microsomes, Liver; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2020 |
Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1
Topics: Acetamides; Androgen Antagonists; Androgen Receptor Antagonists; Cell Line, Tumor; Cell Proliferation; Humans; Ligands; Male; Prostatic Neoplasms; Pyrazoles; Receptors, Androgen | 2022 |
Downregulation of Dihydrotestosterone and Estradiol Levels by HEXIM1.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Down-Regulation; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation; Humans; Ligands; Male; MCF-7 Cells; Prostatic Neoplasms; Receptors, Androgen; RNA-Binding Proteins; RNA, Small Interfering; Transcription Factors | 2022 |
Sex steroid hormones in urinary exosomes as biomarkers for the prediction of prostate cancer.
Topics: Androstenedione; Biomarkers; Dehydroepiandrosterone; Dihydrotestosterone; Exosomes; Humans; Male; Prostatic Neoplasms; Tandem Mass Spectrometry; Testosterone | 2022 |
Antagonistic action of a synthetic androgen ligand mediated by chromatin remodeling in a human prostate cancer cell line.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Cell Line, Tumor; Chromatin; Chromatin Assembly and Disassembly; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Ligands; Male; Prostatic Neoplasms; Receptors, Androgen | 2022 |
Intracellular distribution of vinclozolin and its metabolites differently affects 5α-dihydrotestosterone (DHT)-induced PSA secretion in LNCaP cells.
Topics: Androgen Antagonists; Androgens; Cell Line, Tumor; Dihydrotestosterone; Flutamide; Humans; Male; Oxazoles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen | 2022 |
Extensive Alteration of Androgen Precursor Levels After Castration in Prostate Cancer Patients and Their Association With Active Androgen Level.
Topics: Androgen Antagonists; Androgens; Androstenedione; Androsterone; Dehydroepiandrosterone; Dihydrotestosterone; Estrone; Humans; Male; Orchiectomy; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sulfates; Testosterone | 2022 |
Exploiting Ligand-binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Cell Line, Tumor; Dihydrotestosterone; Dimerization; HEK293 Cells; Humans; Ligands; Male; Prostatic Neoplasms; Receptors, Androgen | 2022 |
Androgens and low density lipoprotein-cholesterol interplay in modulating prostate cancer cell fate and metabolism.
Topics: Androgens; Cholesterol, LDL; Dihydrotestosterone; Humans; Male; Obesity; Prostatic Neoplasms; Receptors, Androgen | 2022 |
A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor.
Topics: Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Humans; Male; Prostatic Neoplasms; Pyrazoles; Receptors, Androgen; Steroids | 2023 |
Investigating a new C2-symmetric testosterone dimer and its dihydrotestosterone analog: Synthesis, antiproliferative activity on prostate cancer cell lines and interaction with CYP3A4.
Topics: Androgens; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP3A; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Testosterone | 2023 |
Dihydrotestosterone-based A-ring-fused pyridines: Microwave-assisted synthesis and biological evaluation in prostate cancer cells compared to structurally related quinolines.
Topics: Androgen Receptor Antagonists; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Microwaves; Prostatic Neoplasms; Pyridines; Receptors, Androgen | 2023 |
Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus.
Topics: Androgens; Animals; Cell Nucleus; Chlorocebus aethiops; COS Cells; Cytoplasm; Dihydrotestosterone; Humans; Ligands; Male; Mutation; Prostatic Neoplasms; Protein Conformation; Protein Multimerization; Protein Transport; Receptors, Androgen; Signal Transduction; Tumor Cells, Cultured | 2019 |
Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen.
Topics: Androgens; Androstane-3,17-diol; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Structure-Activity Relationship | 2020 |
Modulation of CXC-motif chemokine receptor 7, but not 4, expression is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli.
Topics: Androgens; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Computer Simulation; Dihydrotestosterone; Flagellin; Humans; Inflammation; Male; Prostatic Neoplasms; Receptors, Androgen; Receptors, CXCR; Receptors, CXCR4; RNA, Messenger; RNA, Neoplasm; Tumor Microenvironment | 2020 |
Kaempferol Promotes Apoptosis While Inhibiting Cell Proliferation via Androgen-Dependent Pathway and Suppressing Vasculogenic Mimicry and Invasion in Prostate Cancer.
Topics: Androgens; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Inhibitory Concentration 50; Kaempferols; Male; Neoplasm Invasiveness; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger | 2019 |
Ergosterol exerts a differential effect on AR-dependent LNCaP and AR-independent DU-145 cancer cells.
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; Ergosterol; Humans; Male; Prostatic Neoplasms | 2021 |
Association between dihydrotestosterone and long-term risk for prostate cancer mortality: A prospective cohort study.
Topics: Aged; Cohort Studies; Dihydrotestosterone; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prospective Studies; Prostatic Neoplasms; Risk; Survival Analysis; Sweden | 2020 |
Sex hormones signal why virus hits men harder.
Topics: Androgen Antagonists; Coronavirus Infections; COVID-19; Dihydrotestosterone; Humans; Male; Pandemics; Pneumonia, Viral; Prostatic Neoplasms; Sex Factors; Testosterone; Treatment Outcome | 2020 |
Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer.
Topics: Androgen Antagonists; Animals; Antineoplastic Agents; Cell Line, Tumor; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Orchiectomy; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Random Allocation; Receptors, Androgen; Taxoids; Xenograft Model Antitumor Assays | 2020 |
The impact of graphene oxide on androgen receptor signalling in prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; Graphite; Humans; Male; Prostatic Neoplasms; Receptors, Androgen | 2021 |
Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation.
Topics: Amino Acid Transport System ASC; Androgens; Anilides; Animals; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Lactic Acid; Lipid Metabolism; Male; Minor Histocompatibility Antigens; Models, Biological; Neoplasm Proteins; Nitriles; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rats; Sulfides; Thiadiazoles; Tosyl Compounds | 2021 |
Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero)arylidene, pyrazolo[1,5-a]pyrimidine and triazolo[1,5-a]pyrimidine moieties and their targeting of the androgen receptor in prostate cancer.
Topics: Androgen Receptor Antagonists; Cell Survival; Dihydrotestosterone; Humans; Male; Molecular Conformation; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2021 |
Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth.
Topics: Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction | 2021 |
Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor.
Topics: Aged; Amino Acid Transport System y+L; Amino Acid Transport Systems, Basic; Cell Movement; Cell Proliferation; Cell Survival; Cohort Studies; Dihydrotestosterone; Disease Progression; Gene Knockdown Techniques; Humans; Male; Middle Aged; Neoplasm Proteins; PC-3 Cells; Prognosis; Prostatectomy; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Separase; Signal Transduction; TOR Serine-Threonine Kinases; Transfection | 2021 |
Androgens alter the heterogeneity of small extracellular vesicles and the small RNA cargo in prostate cancer.
Topics: Androgens; Antigens, Neoplasm; Antigens, Surface; Benzamides; Biomarkers, Tumor; Cell Line, Tumor; Dihydrotestosterone; Extracellular Vesicles; Humans; Kallikreins; Male; MicroRNAs; Nitriles; Phenylthiohydantoin; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tetraspanin 29; Tetraspanin 30 | 2021 |
Functional interaction of fibroblast growth factor 8b and androgen in prostate cancer cell proliferation.
Topics: CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Dihydrotestosterone; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 8; G2 Phase; Humans; JNK Mitogen-Activated Protein Kinases; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Smad Proteins | 2017 |
The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in Vietnamese men.
Topics: 3-Hydroxysteroid Dehydrogenases; Age Factors; Aged; Aged, 80 and over; Dihydrotestosterone; Dioxins; Estradiol; Gonadal Steroid Hormones; Humans; Male; Middle Aged; Prostatic Neoplasms; Testosterone; Vietnam | 2017 |
Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.
Topics: A549 Cells; Benzamides; Co-Repressor Proteins; Dexamethasone; Dihydrotestosterone; DNA-Binding Proteins; Humans; Male; Mifepristone; Nitriles; Nuclear Proteins; Phenylthiohydantoin; Prostatic Neoplasms; Protein Interaction Mapping; Receptors, Androgen; Receptors, Glucocorticoid; Transcription, Genetic | 2017 |
Role of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Androgen-Mediated Cell Viability in Prostate Cancer Cells.
Topics: Androgens; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochrome P450 Family 4; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Hydroxyeicosatetraenoic Acids; Male; Prostatic Neoplasms; Receptors, Androgen | 2017 |
UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression.
Topics: Aged; Biomarkers; Dihydrotestosterone; Disease Progression; Follow-Up Studies; Gene Expression; Glucuronosyltransferase; Humans; Immunohistochemistry; Isoenzymes; Male; Middle Aged; Proportional Hazards Models; Prostatic Neoplasms; Recurrence; Retrospective Studies | 2017 |
Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Aged; Animals; Cell Line, Tumor; Chromatography, Liquid; Dihydrotestosterone; Disease Models, Animal; Heterografts; Humans; Male; Metabolic Networks and Pathways; Mice; Middle Aged; Neoplasm Grading; Neoplasm Staging; Prostate; Prostatectomy; Prostatic Neoplasms; Steroids; Substrate Specificity; Tandem Mass Spectrometry; Testosterone | 2017 |
Differential proteome expression analysis of androgen-dependent and -independent pathways in LNCaP prostate cancer cells.
Topics: Androgens; Animals; Benzhydryl Compounds; Cell Line, Tumor; Chlorohydrins; Colforsin; Dihydrotestosterone; Electrophoresis, Gel, Two-Dimensional; Humans; Immunohistochemistry; Male; Mice; Peptide Elongation Factor Tu; Phosphoenolpyruvate Carboxykinase (ATP); Prostatic Neoplasms; Proteome; Proteomics; Signal Transduction; Tandem Mass Spectrometry; Tubulin; Xenograft Model Antitumor Assays | 2017 |
Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer.
Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Genetic Markers; Humans; Male; Prostatic Neoplasms; RNA; RNA, Circular; Up-Regulation | 2017 |
An androgen reduced transcript of LncRNA GAS5 promoted prostate cancer proliferation.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Down-Regulation; Gene Regulatory Networks; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; RNA Interference; RNA, Long Noncoding; RNA, Messenger; RNA, Small Interfering | 2017 |
Prostate cancer: The pathway to progression: DHT biosynthesis.
Topics: Dihydrotestosterone; Disease Progression; Humans; Male; Prostatectomy; Prostatic Neoplasms | 2017 |
Insight on cytotoxic effects of silver nanoparticles: Alternative androgenic transactivation by adsorption with DHT.
Topics: Adsorption; Androgens; Biological Availability; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Metal Nanoparticles; Prostatic Neoplasms; Silver; Transcriptional Activation | 2018 |
The interaction between androgen receptor and semenogelin I: a synthetic LxxLL peptide antagonist inhibits the growth of prostate cancer cells.
Topics: Alanine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chlorides; Dihydrotestosterone; Humans; Leucine; Male; Mutation; Peptides; Prostatic Neoplasms; Receptors, Androgen; Seminal Vesicle Secretory Proteins; Transcription, Genetic; Zinc Compounds | 2018 |
High-throughput and direct measurement of androgen levels using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS) to discover chemicals that modulate dihydrotestosterone production in human prostate canc
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chromatography, Liquid; Dihydrotestosterone; Drug Discovery; Flavanones; High-Throughput Screening Assays; Humans; Male; Mass Spectrometry; Plant Extracts; Prostatic Neoplasms; Testosterone; Xanthophylls | 2018 |
Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer.
Topics: Androgens; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cholesterol Side-Chain Cleavage Enzyme; Curcumin; Dihydrotestosterone; Female; Humans; Hydroxysteroid Dehydrogenases; Male; Mice; Mice, Inbred C57BL; Progesterone Reductase; Prostate; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 2018 |
Identification of valid reference genes for mRNA and microRNA normalisation in prostate cancer cell lines.
Topics: Algorithms; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; MicroRNAs; Prostate-Specific Antigen; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Reference Standards; Reproducibility of Results; RNA, Messenger; Software | 2018 |
Veterinary drug, 17β-trenbolone promotes the proliferation of human prostate cancer cell line through the Akt/AR signaling pathway.
Topics: Anabolic Agents; Androgens; Animals; Cattle; Cell Line, Tumor; Cell Proliferation; Cyclin D2; Dihydrotestosterone; Down-Regulation; Humans; Male; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Signal Transduction; Trenbolone Acetate; Veterinary Drugs | 2018 |
Differential gene expression induced by anti-cancer agent plumbagin is mediated by androgen receptor in prostate cancer cells.
Topics: Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Male; Mice; Naphthoquinones; Prostate; Prostatic Neoplasms; Receptors, Androgen; Testis; Transcriptome | 2018 |
Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1.
Topics: Androgen Antagonists; Androgens; Animals; Binding Sites; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Early Growth Response Protein 1; Epithelial Cells; Humans; Male; Mice, Inbred C57BL; NF-kappa B; Orchiectomy; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Signal Transduction; Thromboplastin; Venous Thromboembolism | 2018 |
Associations between sun sensitive pigmentary genes and serum prostate specific antigen levels.
Topics: Aged; Aged, 80 and over; Androgens; Australia; Dihydrotestosterone; Europe; Genes, Neoplasm; Genetic Predisposition to Disease; Humans; Male; Melanoma; Models, Genetic; Neoplasms, Hormone-Dependent; Neoplasms, Radiation-Induced; New Zealand; Prostate-Specific Antigen; Prostatic Neoplasms; Radiation Tolerance; Reference Values; Skin Neoplasms; Skin Pigmentation; Sunlight; Testosterone | 2018 |
Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Disease Models, Animal; Kisspeptins; Male; Prostatic Neoplasms; Rats; Xenograft Model Antitumor Assays | 2018 |
Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer.
Topics: Androgens; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Oncogene Proteins, Fusion; Prostate; Prostatic Neoplasms; Serine Endopeptidases; Testosterone; Transcriptional Regulator ERG | 2018 |
Simultaneous determination of dihydrotestosterone and its metabolites in mouse sera by LC-MS/MS with chemical derivatization.
Topics: Animals; Chromatography, Liquid; Dihydrotestosterone; Linear Models; Male; Mice; Picolinic Acids; Prostatic Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2018 |
The effect of dutasteride on microscopic and macroscopic changes of testosterone replacement treatment on prostate tissue.
Topics: 5-alpha Reductase Inhibitors; Animals; Dihydrotestosterone; Disease Models, Animal; Dutasteride; Hormone Replacement Therapy; Humans; Male; Orchiectomy; Precancerous Conditions; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Testosterone; Treatment Outcome | 2018 |
CA916798 affects growth and metastasis of androgen-dependent prostate cancer cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dihydrotestosterone; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Male; Minor Histocompatibility Antigens; Promoter Regions, Genetic; Prostatic Neoplasms; Proteins; Receptors, Androgen; RNA, Small Interfering | 2018 |
Clinical and metabolic implications of obesity in prostate cancer: is testosterone a missing link?
Topics: Adipose Tissue; Age Factors; Aged; Body Mass Index; Correlation of Data; Dihydrotestosterone; Early Detection of Cancer; Estradiol; Humans; Leptin; Luteinizing Hormone; Male; Middle Aged; Neoplasm Grading; Obesity; Portugal; Prolactin; Prostatic Neoplasms; Risk Factors; Testosterone | 2019 |
Sex steroids in serum and prostatic tissue of human cancerous prostate (STERKPROSER trial).
Topics: Aged; Cystectomy; Dihydrotestosterone; Estradiol; Gonadal Steroid Hormones; Humans; Male; Middle Aged; Prostatectomy; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Urinary Bladder Neoplasms | 2019 |
Sika deer (Cervus nippon) velvet antler extract attenuates prostate cancer in xenograft model.
Topics: Animals; Antlers; Deer; Dihydrotestosterone; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Heterografts; Humans; Kallikreins; Male; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Neoplasm Proteins; Neovascularization, Pathologic; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 2019 |
A Targeted Bivalent Androgen Receptor Binding Compound for Prostate Cancer Therapy.
Topics: Amino Acid Motifs; Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Membrane; Chlorocebus aethiops; COS Cells; Crystallography, X-Ray; Dihydrotestosterone; Drug Resistance, Neoplasm; Glycine; Humans; Inhibitory Concentration 50; Male; Molecular Dynamics Simulation; Mutation; Peptides; Prostate; Prostatic Neoplasms; Protein Binding; Receptors, Androgen | 2019 |
Silencing of lncRNA MALAT1 inhibits cell cycle progression via androgen receptor signaling in prostate cancer cells.
Topics: Androgens; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Gene Silencing; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; RNA, Long Noncoding; Signal Transduction | 2019 |
Abiraterone acetate exerts a cytotoxic effect in human prostate cancer cell lines.
Topics: Abiraterone Acetate; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Survival; Dihydrotestosterone; Humans; Male; Molecular Docking Simulation; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Receptors, Androgen | 2019 |
Dihydrotestosterone activates AP-1 in LNCaP prostate cancer cells.
Topics: Androgen-Binding Protein; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Mutation; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transcription Factor AP-1; Transcription, Genetic; TRPM Cation Channels; Tumor Necrosis Factor-alpha | 2019 |
Dihydrotestosterone inhibits arylsulfatase B and Dickkopf Wnt signaling pathway inhibitor (DKK)-3 leading to enhanced Wnt signaling in prostate epithelium in response to stromal Wnt3A.
Topics: Adaptor Proteins, Signal Transducing; Androgens; Cell Line; Dihydrotestosterone; Epithelial Cells; Epithelium; Humans; Laser Capture Microdissection; Male; N-Acetylgalactosamine-4-Sulfatase; Neoplasm Recurrence, Local; Prostate; Prostatic Neoplasms; Stromal Cells; Wnt Signaling Pathway; Wnt3A Protein | 2019 |
Adrenal androgens rescue prostatic dihydrotestosterone production and growth of prostate cancer cells after castration.
Topics: Adrenal Glands; Androgens; Animals; Cell Line, Tumor; Cell Proliferation; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Humans; Male; Mice, Nude; Mice, SCID; Orchiectomy; Prostate; Prostatic Neoplasms; Receptors, Androgen; Steryl-Sulfatase; Xenograft Model Antitumor Assays | 2019 |
Sequence specific suppression of androgen receptor-DNA binding in vivo by a Py-Im polyamide.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Base Sequence; Binding Sites; Cell Line, Tumor; Dihydrotestosterone; Gene Expression; Humans; Imidazoles; Male; Mice; Mice, SCID; Nylons; Prostatic Neoplasms; Pyrroles; Receptors, Androgen; Response Elements; Tumor Burden; Xenograft Model Antitumor Assays | 2019 |
Role of Estrogen in Androgen-Induced Prostate Carcinogenesis in NBL Rats.
Topics: Androgens; Animals; Carcinogenesis; Carcinoma; Dihydrotestosterone; DNA Adducts; DNA Damage; Estradiol; Estrogens; Estrogens, Catechol; Guanosine; Humans; Incidence; Male; Prostate; Prostatic Neoplasms; Rats; Receptors, Estrogen; Testosterone | 2019 |
Anti-Cancer Activity of Novel Dihydrotestosterone-Derived Ring A-Condensed Pyrazoles on Androgen Non-Responsive Prostate Cancer Cell Lines.
Topics: Androgens; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Humans; Male; Models, Molecular; Prostatic Neoplasms; Pyrazoles | 2019 |
Dihydrotestosterone Increases Cytotoxic Activity of Macrophages on Prostate Cancer Cells via TRAIL.
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Dihydrotestosterone; Humans; Immunotherapy; Macrophages; Male; Mice; Mice, Inbred C57BL; Prostatic Neoplasms; Receptors, Androgen; TNF-Related Apoptosis-Inducing Ligand | 2019 |
Resveratrol inhibits DHT-induced progression of prostate cancer cell line through interfering with the AR and CXCR4 pathway.
Topics: Androgen Receptor Antagonists; Androgens; Antioxidants; Apoptosis; Cell Movement; Cell Proliferation; Dihydrotestosterone; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Receptors, CXCR4; Resveratrol; Signal Transduction; Tumor Cells, Cultured | 2019 |
Suppression of DHT-induced paracrine stimulation of endothelial cell growth by estrogens via prostate cancer cells.
Topics: Androgens; Animals; Cell Line; Cell Line, Tumor; Cell Size; Dihydrotestosterone; Endothelial Cells; Estradiol; Estrogens; Humans; Indoles; Male; Mice; Prostate; Prostatic Neoplasms; Pyrroles; Receptors, Vascular Endothelial Growth Factor | 2013 |
Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; C-Reactive Protein; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Dihydrotestosterone; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Mitogens; Neovascularization, Physiologic; Prostate; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Recombinant Proteins; Serum Amyloid P-Component | 2013 |
ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.
Topics: Androgens; Animals; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, SCID; Mice, Transgenic; Neoplasm Invasiveness; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Oncogene Proteins, Fusion; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; SOX9 Transcription Factor; Trans-Activators; Transcriptional Regulator ERG; Transcriptome | 2013 |
Human castration resistant prostate cancer rather prefer to decreased 5α-reductase activity.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androstenedione; Carbon Isotopes; Castration; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Coculture Techniques; Dihydrotestosterone; Humans; Male; Membrane Proteins; Prostatic Neoplasms; RNA, Messenger; Tandem Mass Spectrometry; Testosterone | 2013 |
Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis.
Topics: Androgens; Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Movement; Cell Proliferation; Curcumin; Dihydrotestosterone; Epidermal Growth Factor; Heterografts; Humans; Lymphatic Metastasis; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Tumor Cells, Cultured | 2013 |
Dihydrotestosterone and bicalutamide do not affect periostin expression in androgen-dependent LNCaP prostate cancer cell lines.
Topics: Androgens; Anilides; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; RNA, Messenger; Tosyl Compounds | 2013 |
Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Aged; Androgens; Androstane-3,17-diol; Cell Line, Tumor; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Middle Aged; Prostatic Neoplasms; RNA Interference; RNA, Small Interfering | 2013 |
Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways.
Topics: Androgens; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Dihydrotestosterone; Humans; Leucine; Leupeptins; Lysosomes; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Androgen; Transcriptome; Up-Regulation | 2013 |
Preventive effects of Monascus on androgen-related diseases: androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer.
Topics: Administration, Oral; Aging; Alopecia; Animals; Dihydrotestosterone; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Monascus; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Testosterone | 2013 |
Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF.
Topics: Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Humans; Isothiocyanates; Male; MicroRNAs; p300-CBP Transcription Factors; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Up-Regulation | 2013 |
Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells.
Topics: Androgens; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Extracellular Space; Gene Expression Regulation, Neoplastic; Humans; Indoles; Intracellular Space; Male; Necrosis; Prostatic Neoplasms; Receptors, Death Domain; Signal Transduction; Up-Regulation | 2014 |
Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation.
Topics: Animals; Carrier Proteins; Cell Proliferation; Dihydrotestosterone; Humans; Male; Mice; Molecular Chaperones; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Signal Transduction; Transcriptome; Tumor Suppressor Protein p53 | 2013 |
Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α-reductase inhibitors.
Topics: 5-alpha Reductase Inhibitors; Azasteroids; Cell Line, Tumor; Dihydrotestosterone; Dutasteride; Finasteride; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tandem Mass Spectrometry; Testosterone | 2013 |
The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific.
Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Cattle; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dutasteride; Finasteride; Gene Expression Regulation; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transfection | 2013 |
CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2.
Topics: Apoptosis Regulatory Proteins; Carcinogenesis; Cell Cycle Proteins; Cell Line, Tumor; Cells, Cultured; Chromatin; Dihydrotestosterone; Enhancer Elements, Genetic; GATA2 Transcription Factor; Humans; Male; Nuclear Receptor Coactivators; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transcription, Genetic | 2013 |
New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line.
Topics: Cell Line, Tumor; Cell Proliferation; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Prostate; Prostatic Neoplasms; Testosterone | 2013 |
SHBG is an important factor in stemness induction of cells by DHT in vitro and associated with poor clinical features of prostate carcinomas.
Topics: Adult; Aged; Biomarkers; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Disease Progression; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Middle Aged; Nanog Homeobox Protein; Neoplasm Grading; Neoplasm Staging; Neoplastic Stem Cells; Octamer Transcription Factor-3; Phenotype; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Sex Hormone-Binding Globulin; Spheroids, Cellular; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2013 |
Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Androgen Receptor Antagonists; Androgens; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclofenil; Dihydrotestosterone; Disease Progression; Estradiol; Hormone Antagonists; Humans; Imidazoles; Indoles; Male; Mifepristone; Platelet Activating Factor; Prostatic Neoplasms; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Wnt Proteins | 2013 |
A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgens; Animals; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Prostatic Neoplasms; Proteolysis; Ubiquitination | 2013 |
Prostate cancer: Steroid enzyme mutated in CRPC.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms | 2013 |
Aberrant expression of the PRAC gene in prostate cancer.
Topics: Androgen Antagonists; Androgens; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Decitabine; Dihydrotestosterone; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Nuclear Proteins; Prostatic Neoplasms | 2013 |
Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer.
Topics: Animals; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell-Free System; Chlorocebus aethiops; Chromatin; Co-Repressor Proteins; COS Cells; Dihydrotestosterone; Epithelium; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Ligands; Male; Nuclear Proteins; Nuclear Receptor Coactivator 2; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; RNA, Small Interfering; Saccharomyces cerevisiae; STAT3 Transcription Factor; Stromal Cells; Transcription, Genetic; Transcriptional Activation | 2014 |
ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer.
Topics: Calcium; Calcium Channels; Calcium Signaling; Cell Line; Cell Line, Tumor; Dihydrotestosterone; Epithelial Cells; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction | 2013 |
A naturally derived small molecule disrupts ligand-dependent and ligand-independent androgen receptor signaling in human prostate cancer cells.
Topics: Androgens; Blotting, Western; Carbazoles; CDC2 Protein Kinase; Cytoplasm; Dihydrotestosterone; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Ligands; Male; Microscopy, Fluorescence; Molecular Structure; Murraya; Phosphorylation; Plant Leaves; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Transport; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Transcriptional Activation | 2014 |
Bone metastases in castration-resistant prostate cancer: associations between morphologic CT patterns, glycolytic activity, and androgen receptor expression on PET and overall survival.
Topics: Aged; Aged, 80 and over; Bone Neoplasms; Cross-Sectional Studies; Diatrizoate; Diatrizoate Meglumine; Dihydrotestosterone; Fluorodeoxyglucose F18; Glycolysis; Humans; Male; Multimodal Imaging; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Receptors, Androgen; Retrospective Studies; Survival Rate; Tomography, X-Ray Computed | 2014 |
Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer.
Topics: Adult; Alopecia; Androgens; Cell Proliferation; Dihydrotestosterone; Finasteride; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Models, Theoretical; Prostaglandin D2; Prostatic Neoplasms | 2014 |
Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo.
Topics: Androgens; Androstenedione; Animals; Blotting, Western; Cell Proliferation; Dihydrotestosterone; Humans; In Vitro Techniques; Lythraceae; Male; Mice; Mice, Knockout; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; PTEN Phosphohydrolase; Receptors, Androgen; Testosterone; Tumor Cells, Cultured | 2014 |
Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness.
Topics: Animals; Biopsy; Cell Line, Tumor; Chlorocebus aethiops; Core Binding Factor Alpha 1 Subunit; COS Cells; Dihydrotestosterone; Doxycycline; Gene Expression; Humans; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Receptors, Androgen; Snail Family Transcription Factors; Transcription Factors | 2014 |
Androgen-independent proliferation of LNCaP prostate cancer cells infected by xenotropic murine leukemia virus-related virus.
Topics: Androgen Receptor Antagonists; Androgens; Anilides; Animals; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Humans; Male; Mice; Nitriles; Prostatic Neoplasms; Rats; Receptors, Androgen; Tosyl Compounds; Xenotropic murine leukemia virus-related virus | 2014 |
SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1.
Topics: Androgens; Base Sequence; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Dihydrotestosterone; Enzyme Activation; G1 Phase Cell Cycle Checkpoints; Humans; Male; Molecular Sequence Data; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptors, Androgen; Ribosomal Protein S6 Kinases, 70-kDa; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2014 |
Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer.
Topics: Androgens; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Dihydrotestosterone; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Immunoenzyme Techniques; Male; MicroRNAs; Neoplasms, Hormone-Dependent; Prostatic Hyperplasia; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured; Wound Healing; Zinc Finger E-box Binding Homeobox 2 | 2014 |
Androgenic biomarker prof|ling in human matrices and cell culture samples using high throughput, electrospray tandem mass spectrometry.
Topics: Androgens; Biomarkers; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Tandem Mass Spectrometry; Testosterone | 2014 |
Elevated YKL40 is associated with advanced prostate cancer (PCa) and positively regulates invasion and migration of PCa cells.
Topics: Adipokines; Aged; Aged, 80 and over; Androgen Antagonists; Androgens; Benzamides; Cell Line; Cell Line, Tumor; Cell Movement; Chitinase-3-Like Protein 1; Dihydrotestosterone; Disease Progression; Humans; Lectins; Male; Metribolone; Middle Aged; Neoplasm Invasiveness; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms | 2014 |
Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Curcumin; Dihydrotestosterone; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Testosterone | 2014 |
Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Dihydrotestosterone; E2F1 Transcription Factor; Humans; Imaging, Three-Dimensional; In Situ Hybridization, Fluorescence; Male; MAP Kinase Signaling System; Metribolone; Prostatic Neoplasms | 2014 |
High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients.
Topics: Aged; Biopsy, Needle; Dihydrotestosterone; Humans; Kallikreins; Male; Middle Aged; Neoplasm Grading; Prognosis; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 2014 |
Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry.
Topics: 5-alpha Reductase Inhibitors; Androgens; Androstenedione; Azasteroids; Chromatography, Liquid; Dihydrotestosterone; Dutasteride; Finasteride; Humans; Male; Prostatic Neoplasms; Solid Phase Extraction; Tandem Mass Spectrometry; Testosterone; Tissue Distribution | 2015 |
Antiandrogenic mechanisms of pesticides in human LNCaP prostate and H295R adrenocortical carcinoma cells.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Benomyl; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme Inhibitors; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Imidazoles; Kallikreins; Male; Membrane Proteins; Oxazoles; Pesticides; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Steroid 17-alpha-Hydroxylase | 2015 |
Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial-mesenchymal transition in prostate cancer.
Topics: Cadherins; Cell Line, Tumor; Cell Proliferation; Culture Media, Conditioned; Dihydrotestosterone; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Gene Expression; Hedgehog Proteins; Humans; Male; Osteonectin; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Stromal Cells; Transcription Factors; Veratrum Alkaloids; Vimentin; Zinc Finger Protein GLI1 | 2014 |
Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells.
Topics: Animals; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Dihydrotestosterone; Dyrk Kinases; Fibroblasts; Fibrosarcoma; Filamins; Gene Expression Regulation; Humans; Male; Mesenchymal Stem Cells; Metribolone; Mice; NIH 3T3 Cells; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; rac1 GTP-Binding Protein; ras Proteins; Receptors, Androgen; Serine; Signal Transduction; Testosterone Congeners; Tumor Cells, Cultured | 2014 |
Significant association of metabolic indices, lipid profile, and androgen levels with prostate cancer.
Topics: Aged; Body Mass Index; Case-Control Studies; Dihydrotestosterone; Follow-Up Studies; Humans; Insulin; Lipids; Male; Neoplasm Grading; Neoplasm Staging; Prognosis; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 2014 |
Wild-type and specific mutant androgen receptor mediates transcription via 17β-estradiol in sex hormone-sensitive cancer cells.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Dihydrotestosterone; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mutation; Parathyroid Hormone-Related Protein; Promegestone; Prostatic Neoplasms; Receptors, Androgen | 2015 |
RUNX1, an androgen- and EZH2-regulated gene, has differential roles in AR-dependent and -independent prostate cancer.
Topics: Aged; Androgens; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Core Binding Factor Alpha 2 Subunit; Dihydrotestosterone; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histones; Humans; Immunohistochemistry; Male; Methylation; Middle Aged; Polycomb Repressive Complex 2; Prognosis; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Survival Analysis | 2015 |
CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR.
Topics: Blotting, Western; Bridged-Ring Compounds; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dihydrotestosterone; Fluorescent Antibody Technique; Humans; Male; Metribolone; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Triazoles | 2015 |
The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean population.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aged; Case-Control Studies; Dihydrotestosterone; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Logistic Models; Male; Membrane Proteins; Middle Aged; Neoplasm Grading; Neoplasm Staging; Odds Ratio; Polymorphism, Single Nucleotide; Prostate-Specific Antigen; Prostatic Neoplasms; Republic of Korea; Risk Factors; Testosterone | 2015 |
The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Eurycoma; Humans; In Vitro Techniques; Male; Mice; Mice, Nude; Prostatic Neoplasms; Quassins; Xenograft Model Antitumor Assays | 2015 |
Effects of treatment with androgen receptor ligands on microRNA expression of prostate cancer cells.
Topics: Androgen Antagonists; Androgens; Anilides; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kallikreins; Ligands; Male; MicroRNAs; Nandrolone; Neoplasms, Hormone-Dependent; Nitriles; Oligonucleotide Array Sequence Analysis; Prostate-Specific Antigen; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Time Factors; Tosyl Compounds | 2015 |
Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androgen Receptor Antagonists; Androgens; Androstenes; Animals; Benzamides; Biosynthetic Pathways; Biotransformation; Cell Division; Chromatin; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Steroid 17-alpha-Hydroxylase; Survival Analysis; Xenograft Model Antitumor Assays | 2015 |
Assessment of gold nanoparticle effect on prostate cancer LNCaP cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Shape; Dihydrotestosterone; Drug Screening Assays, Antitumor; Gold; Humans; Male; Metal Nanoparticles; Particle Size; Prostatic Neoplasms | 2015 |
The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.
Topics: Adult; Aged; Biomarkers, Tumor; Biopsy; Dihydrotestosterone; Disease Progression; Gas Chromatography-Mass Spectrometry; Genetic Predisposition to Disease; Glucuronides; Glucuronosyltransferase; Humans; Kallikreins; Linear Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; Phenotype; Predictive Value of Tests; Proportional Hazards Models; Prostate-Specific Antigen; Prostatic Neoplasms; Risk Assessment; Risk Factors; Tandem Mass Spectrometry; Testosterone | 2016 |
Relationship between serum response factor and androgen receptor in prostate cancer.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Down-Regulation; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; RNA, Small Interfering; Serum Response Factor | 2015 |
Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists.
Topics: Androgen Antagonists; beta Catenin; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Flutamide; Genes, Reporter; HEK293 Cells; Humans; Male; Prostatic Neoplasms; Receptors, Androgen | 2015 |
Androgen receptor functions as a negative transcriptional regulator of DEPTOR, mTOR inhibitor.
Topics: Androgen Antagonists; Anilides; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Dihydrotestosterone; Histones; Humans; Intracellular Signaling Peptides and Proteins; Male; Nitriles; Phosphorylation; Prostatic Neoplasms; Receptor Cross-Talk; Receptors, Androgen; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Tosyl Compounds; Transcription, Genetic; Tumor Cells, Cultured | 2015 |
Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells.
Topics: Animals; Cell Line, Tumor; Cyclin D1; Dihydrotestosterone; DNA Damage; DNA Repair; Histones; Humans; Male; Mice; Mice, Knockout; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Transfection | 2016 |
A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer.
Topics: Aged; Aged, 80 and over; Androgens; Animals; Antigens, Neoplasm; Cell Line; Cell Line, Tumor; Dihydrotestosterone; Gene Amplification; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Male; Mice, SCID; Middle Aged; Models, Genetic; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; Sensitivity and Specificity; Transcriptional Activation; Transplantation, Heterologous | 2016 |
Cancer-Cells on Chip for Label-Free Detection of Secreted Molecules.
Topics: beta 2-Microglobulin; Biosensing Techniques; Cell Adhesion; Cell Line, Tumor; Dihydrotestosterone; Gold; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Tissue Array Analysis | 2016 |
A Signaling Network Controlling Androgenic Repression of c-Fos Protein in Prostate Adenocarcinoma Cells.
Topics: Adenocarcinoma; Androgens; Cell Death; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Metribolone; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostate; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-fos; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2016 |
The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells.
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; PPAR gamma; Prostatic Neoplasms; Proteasome Inhibitors; Receptors, Androgen; RNA, Messenger; Transcription, Genetic | 2016 |
Equol inhibits prostate cancer growth through degradation of androgen receptor by S-phase kinase-associated protein 2.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Equol; Humans; Male; Phytoestrogens; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; S-Phase Kinase-Associated Proteins | 2016 |
[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].
Topics: Androgens; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Fibronectins; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Male; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Receptors, Androgen; Repressor Proteins; RNA, Messenger | 2015 |
Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin.
Topics: Androgen Antagonists; Androgens; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Curcumin; Dihydrotestosterone; DNA Methylation; Down-Regulation; Drug Synergism; Epigenetic Repression; Humans; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Quercetin; Receptors, Androgen; RNA, Messenger | 2016 |
Testosterone in Androgen Receptor Signaling and DNA Repair: Enemy or Frenemy?
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Combined Modality Therapy; Dihydrotestosterone; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Humans; Male; Orchiectomy; Poly-ADP-Ribose Binding Proteins; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Testosterone | 2016 |
The fluorescent two-hybrid assay for live-cell profiling of androgen receptor modulators.
Topics: Androgen Antagonists; Androgens; Androstadienes; Androstenes; Anilides; Animals; Benzamides; Benzimidazoles; Biological Assay; Cell Line; Cricetinae; Dihydrotestosterone; Flutamide; HEK293 Cells; Humans; Male; Microscopy, Fluorescence; Mutation; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Receptors, Androgen; Tosyl Compounds; Transcription Factors; Two-Hybrid System Techniques | 2017 |
Re: Resveratrol Reduces the Levels of Circulating Androgen Precursors but has No Effect on Testosterone, Dihydrotestosterone, PSA Levels or Prostate Volume. A 4-Month Randomised Trial in Middle-Aged Men.
Topics: Androgens; Dihydrotestosterone; Humans; Male; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Resveratrol; Stilbenes; Testosterone | 2016 |
Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen.
Topics: Androgen Antagonists; Anilides; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Mutation; Nitriles; Nuclear Receptor Coactivators; Prostatic Neoplasms; Receptors, Androgen; Tosyl Compounds | 2016 |
Superporous Poly(ethylene glycol) Diacrylate Cryogel with a Defined Elastic Modulus for Prostate Cancer Cell Research.
Topics: Cell Line, Tumor; Cell Proliferation; Cryogels; Dihydrotestosterone; Elastic Modulus; Humans; Male; Microscopy, Electron, Scanning; Polyethylene Glycols; Prostatic Neoplasms | 2016 |
Identification of androgen-responsive lncRNAs as diagnostic and prognostic markers for prostate cancer.
Topics: Androgens; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cohort Studies; Computational Biology; Databases, Genetic; Dihydrotestosterone; Genome-Wide Association Study; Humans; Male; Prognosis; Prostatic Neoplasms; RNA, Long Noncoding; Seminal Vesicle Secretory Proteins; Tissue Array Analysis; Transcriptional Activation | 2016 |
Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.
Topics: 3-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstenes; Cell Line, Tumor; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Neoplasm Proteins; Prostatic Neoplasms | 2016 |
Evaluation of Castration-Resistant Prostate Cancer with Androgen Receptor-Axis Imaging.
Topics: Biomarkers, Tumor; Dihydrotestosterone; Evidence-Based Medicine; Humans; Image Enhancement; Male; Molecular Imaging; Neoplasm Staging; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Radiopharmaceuticals; Receptors, Androgen | 2016 |
High serum dihydrotestosterone examined by ultrasensitive LC-MS/MS as a predictor of benign prostatic hyperplasia or Gleason score 6 cancer in men with prostate-specific antigen levels of 3-10 ng/mL.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Chromatography, Liquid; Dihydrotestosterone; Humans; Male; Middle Aged; Neoplasm Grading; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Tandem Mass Spectrometry; Testosterone | 2017 |
Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstanes; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Sulfonamides | 2017 |
Higher Dihydrotestosterone Is Associated with the Incidence of Lung Cancer in Older Men.
Topics: Age Factors; Aged; Aged, 80 and over; Colorectal Neoplasms; Dihydrotestosterone; Estradiol; Humans; Incidence; Lung Neoplasms; Male; Prostatic Neoplasms; Risk Factors; Testosterone | 2017 |
Intracrine androgen biosynthesis in renal cell carcinoma.
Topics: Abiraterone Acetate; Androgens; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Carcinoma, Renal Cell; Cell Proliferation; Dihydrotestosterone; Female; Humans; Immunoenzyme Techniques; Kidney Neoplasms; Male; Mice; Mice, Nude; Nitriles; Orchiectomy; Phenylthiohydantoin; Prognosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Androgen receptor-mediated apoptosis is regulated by photoactivatable androgen receptor ligands.
Topics: Active Transport, Cell Nucleus; Androgen Receptor Antagonists; Apoptosis; Base Sequence; Cell Line, Tumor; Dihydrotestosterone; DNA Damage; Humans; Ligands; Male; Metribolone; Models, Biological; Oxidative Stress; Photobiology; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Pyridines; Quinolones; Receptors, Androgen; Recombinant Proteins; RNA, Small Interfering; Transfection | 2008 |
In vitro cytotoxic activity of anthrapyrazole analogues in human prostate DU-145 and testicular NTERA-2 carcinoma cells.
Topics: Anthracyclines; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Testicular Neoplasms; Testosterone | 2008 |
Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer.
Topics: Adenocarcinoma; Aged; Androgen Antagonists; Androgens; Case-Control Studies; Cell Line, Tumor; Cohort Studies; Dihydrotestosterone; Down-Regulation; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Prostatic Neoplasms; RNA, Messenger; Testosterone; Up-Regulation | 2008 |
Evaluation of MENT on primary cell cultures from benign prostatic hyperplasia and prostate carcinoma.
Topics: Androgens; Dihydrotestosterone; Finasteride; Humans; Male; Nandrolone; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Testosterone; Testosterone Congeners | 2009 |
Androgen regulation of the androgen receptor coregulators.
Topics: Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; Disease Progression; Gene Expression Regulation; Genetic Vectors; Humans; Male; Mice; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors | 2008 |
Dihydrotestosterone interacts with EGFR/MAPK signalling and modulates EGFR levels in androgen receptor-positive LNCaP prostate cancer cells.
Topics: Androgens; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoprecipitation; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transfection; Ubiquitination | 2008 |
Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Drug Delivery Systems; Estradiol; Estrogen Receptor alpha; Female; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Receptors, Androgen; Receptors, Steroid; Recombinant Fusion Proteins; Ubiquitination | 2008 |
Re: Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies.
Topics: Androgens; Dairy Products; Dihydrotestosterone; Feedback, Physiological; Gonadal Steroid Hormones; Humans; Male; Meta-Analysis as Topic; Prospective Studies; Prostatic Neoplasms; Testosterone | 2008 |
Androgenic control of transforming growth factor-beta signaling in prostate epithelial cells through transcriptional suppression of transforming growth factor-beta receptor II.
Topics: Androgens; Apoptosis; bcl-X Protein; Caspase 3; Cells, Cultured; Cyclin D; Cyclins; Cytoprotection; Dihydrotestosterone; Down-Regulation; Epithelial Cells; Humans; Male; Plasminogen Activator Inhibitor 1; Prostate; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta | 2008 |
Dihydrotestosterone sensitises LNCaP cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor.
Topics: Blotting, Western; Catechin; Cell Death; Cell Line, Tumor; Dihydrotestosterone; DNA Replication; DNA, Neoplasm; Humans; Male; Neoplasm Proteins; Prostatic Neoplasms; Receptor, IGF Type 1; Thymidine | 2009 |
Atlas of dihydrotestosterone actions on the transcriptome of prostate in vivo.
Topics: Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Prostate; Prostatic Neoplasms | 2009 |
Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Receptors, Androgen; Recombinant Fusion Proteins; Signal Transduction; Ubiquitin | 2009 |
Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Animals; Cell Differentiation; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Dihydrotestosterone; Docetaxel; Drug Synergism; Humans; Male; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Nevirapine; Nitriles; Prostatic Neoplasms; Random Allocation; Receptors, Androgen; Reverse Transcriptase Inhibitors; RNA, Neoplasm; Signal Transduction; Taxoids; Tosyl Compounds; Xenograft Model Antitumor Assays | 2009 |
Id-1 expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen receptor.
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; Humans; Inhibitor of Differentiation Protein 1; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger | 2009 |
Androgen-stimulated UDP-glucose dehydrogenase expression limits prostate androgen availability without impacting hyaluronan levels.
Topics: Androgens; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Humans; Hyaluronic Acid; Male; Metribolone; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid | 2009 |
Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genistein; Glycine max; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Male; Molecular Structure; Prostate-Specific Antigen; Prostatic Neoplasms; Pterocarpans; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors | 2009 |
Repression of activated aryl hydrocarbon receptor-induced transcriptional activation by 5alpha-dihydrotestosterone in human prostate cancer LNCaP and human breast cancer T47D cells.
Topics: Androgens; Aryl Hydrocarbon Hydroxylases; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Dihydrotestosterone; Female; Gene Expression Regulation; Humans; Immunoprecipitation; Luciferases; Male; Methylcholanthrene; Polymerase Chain Reaction; Prostatic Neoplasms; Repressor Proteins; RNA, Messenger; Transcription, Genetic | 2009 |
Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer.
Topics: Adenosine Triphosphatases; Cell Growth Processes; Cell Survival; Dihydrotestosterone; Disease Progression; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Male; Metribolone; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transcription, Genetic | 2009 |
Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.
Topics: Breast Neoplasms; Calcium-Binding Proteins; Cell Line, Tumor; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Female; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Intracellular Signaling Peptides and Proteins; Male; Prostatic Neoplasms | 2009 |
The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines.
Topics: Androgens; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Gene Expression; Humans; Male; MicroRNAs; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Transcription, Genetic; Transfection | 2009 |
The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth.
Topics: Acetylation; Androgen Receptor Antagonists; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Eye Proteins; Histone Deacetylases; Humans; Immunohistochemistry; Male; Prostatic Neoplasms; Protein Structure, Tertiary; Receptors, Androgen; Repressor Proteins; RNA, Messenger; Signal Transduction; Sirtuin 1; Sirtuins; Transcription Factors; Transcription, Genetic; Transfection | 2009 |
Suppression of mutant androgen receptors by flutamide.
Topics: Androgen Antagonists; Androgens; Binding, Competitive; Cell Line, Tumor; Dihydrotestosterone; Flutamide; Humans; Luciferases; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation | 2009 |
GnRH receptor expression in human prostate cancer cells is affected by hormones and growth factors.
Topics: Androgen Antagonists; Androgens; Antineoplastic Agents, Hormonal; Blotting, Western; Cell Line, Tumor; Cyproterone Acetate; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Leuprolide; Male; Prostatic Neoplasms; Receptors, LHRH; RNA, Messenger; Up-Regulation | 2009 |
Regarding "Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling".
Topics: Animals; Aromatase; Dihydrotestosterone; Estradiol; Estrogens; Humans; Male; Prostate; Prostatic Neoplasms | 2009 |
Combined effect of the finasteride and doxazosin on rat ventral prostate morphology and physiology.
Topics: Androgens; Animals; Cell Proliferation; Dihydrotestosterone; Doxazosin; Epithelial Cells; Extracellular Matrix; Finasteride; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Rats, Wistar; RNA, Messenger; Testosterone; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1 | 2010 |
Isoflavone supplements stimulated the production of serum equol and decreased the serum dihydrotestosterone levels in healthy male volunteers.
Topics: Adult; Cholesterol; Dietary Supplements; Dihydrotestosterone; Equol; Genistein; Humans; Isoflavones; Male; Middle Aged; Prostatic Neoplasms; Sex Hormone-Binding Globulin | 2009 |
Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone.
Topics: Blotting, Western; Bone and Bones; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Coculture Techniques; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Luciferases; Male; Middle Aged; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Electrospray Ionization; Stromal Cells; Testosterone; Transfection | 2009 |
Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination.
Topics: Animals; Blotting, Western; Carcinogens; Chromatography, Liquid; Dihydrotestosterone; Electrophoresis, Gel, Two-Dimensional; Gene Expression; Image Processing, Computer-Assisted; Imidazoles; Male; Prostate; Prostatic Neoplasms; Proteomics; Rats; Rats, Inbred F344; Tandem Mass Spectrometry | 2009 |
Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone.
Topics: Animals; Castration; Cattle; Cell Division; Cell Line; Charcoal; Culture Media; Dextrans; Dihydrotestosterone; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Homeostasis; Humans; Male; Osmolar Concentration; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 2009 |
Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone.
Topics: Cell Growth Processes; Cell Line, Tumor; Cyclin D1; Dihydrotestosterone; Dimerization; Gene Knockdown Techniques; Humans; Male; Peroxiredoxins; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; RNA Interference; RNA, Small Interfering; Tissue Kallikreins | 2009 |
Prolongation of off-cycle interval by finasteride is not associated with survival improvement in intermittent androgen deprivation therapy in LNCaP tumor model.
Topics: Androgen Antagonists; Androgens; Animals; Cell Cycle; Cell Line, Tumor; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Finasteride; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orchiectomy; Prostatic Neoplasms; Survival Analysis; Testosterone; Time Factors; Xenograft Model Antitumor Assays | 2010 |
Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2.
Topics: Adult; Aged; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cells, Cultured; Cytoplasm; Dihydrotestosterone; DNA-Binding Proteins; Epithelial Cells; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression; Histone-Lysine N-Methyltransferase; Humans; Male; Middle Aged; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Prostate; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; Transcription Factors; Tumor Cells, Cultured | 2009 |
Radical prostatectomy: influence on serum and urinary androgen levels.
Topics: Aged; Androgens; Androstane-3,17-diol; Androsterone; Cross-Sectional Studies; Dihydrotestosterone; Follicle Stimulating Hormone; Glucuronides; Humans; Inhibins; Luteinizing Hormone; Male; Middle Aged; Prostate; Prostatectomy; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Testosterone | 2010 |
HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.
Topics: Acetylation; Animals; Blotting, Western; Castration; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Gene Expression; Histone Deacetylase 6; Histone Deacetylases; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Immunoprecipitation; Male; Mice; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Xenograft Model Antitumor Assays | 2009 |
HE3235 inhibits growth of castration-resistant prostate cancer.
Topics: Androstanols; Animals; Antineoplastic Agents; Bone Neoplasms; Castration; Dihydrotestosterone; Gene Expression; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Testosterone; Xenograft Model Antitumor Assays | 2009 |
Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells.
Topics: Androgen Receptor Antagonists; Blotting, Western; Cell Dedifferentiation; Cell Line, Tumor; Cell Movement; Dihydrotestosterone; Epithelial Cells; Flow Cytometry; Humans; Male; Mesoderm; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta | 2010 |
TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.
Topics: Androgens; Animals; Cell Line, Tumor; Chlorocebus aethiops; Chromosomal Proteins, Non-Histone; COS Cells; Dihydrotestosterone; Histone Acetyltransferases; Humans; Ligands; Lysine Acetyltransferase 5; Male; Mice; Neoplasm Proteins; Nuclear Proteins; Prostatic Neoplasms; Receptors, Androgen; Repressor Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic | 2009 |
Induced chromosomal proximity and gene fusions in prostate cancer.
Topics: Cell Line, Tumor; Chromosome Aberrations; Chromosomes, Human, Pair 21; Dihydrotestosterone; DNA Breaks, Double-Stranded; Humans; In Situ Hybridization, Fluorescence; Male; Oncogene Fusion; Oncogene Proteins, Fusion; Prostatic Neoplasms; Receptors, Androgen; Serine Endopeptidases; Signal Transduction; Trans-Activators; Transcriptional Regulator ERG | 2009 |
Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H.
Topics: Androgen Antagonists; Anilides; Blotting, Western; Cell Line, Tumor; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Humans; Hydrocortisone; Hydrophobic and Hydrophilic Interactions; Male; Mutation; Nitriles; Progesterone; Prostatic Neoplasms; Protein Structure, Secondary; Receptors, Androgen; Steroids; Structure-Activity Relationship; Tosyl Compounds | 2010 |
Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Aged; Biomarkers, Tumor; Dihydrotestosterone; DNA-Binding Proteins; Gene Dosage; Genetic Predisposition to Disease; Genotype; Glucuronosyltransferase; Humans; Hydroxysteroid Dehydrogenases; Male; Middle Aged; Minor Histocompatibility Antigens; Polymorphism, Single Nucleotide; Prostate-Specific Antigen; Prostatic Neoplasms; Risk Factors; Testosterone | 2010 |
Pharmacokinetic assessment of the uptake of 16beta-18F-fluoro-5alpha-dihydrotestosterone (FDHT) in prostate tumors as measured by PET.
Topics: Aged; Cohort Studies; Dihydrotestosterone; Fluorine Radioisotopes; Heart; Humans; Male; Middle Aged; Models, Biological; Positron-Emission Tomography; Prospective Studies; Prostatic Neoplasms; Radiopharmaceuticals; Receptors, Androgen | 2010 |
The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Core Binding Factor Alpha 1 Subunit; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Proteins; Prostatic Neoplasms; Proteomics; Transforming Growth Factor beta | 2010 |
Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aged; Aged, 80 and over; Aldo-Keto Reductase Family 1 Member C3; Androgens; Androstenedione; Animals; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyprostaglandin Dehydrogenases; Male; Mice; Middle Aged; Neoplasms, Experimental; Orchiectomy; Pregnenolone; Progesterone Reductase; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Testosterone; Transplantation, Heterologous | 2010 |
Growth inhibition of androgen-responsive prostate cancer cells with brefeldin A targeting cell cycle and androgen receptor.
Topics: Antineoplastic Agents; Brefeldin A; Cell Cycle; Cyclin D; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Dihydrotestosterone; G1 Phase; Growth Inhibitors; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2010 |
Inhibition of glycogen synthase kinase-3beta promotes nuclear export of the androgen receptor through a CRM1-dependent mechanism in prostate cancer cell lines.
Topics: Active Transport, Cell Nucleus; Binding Sites; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoprecipitation; Karyopherins; Male; Microscopy, Fluorescence; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Receptors, Cytoplasmic and Nuclear | 2010 |
Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene.
Topics: Androgen Antagonists; Androgens; Azacitidine; Blotting, Western; CpG Islands; Decitabine; Dihydrotestosterone; Disease Progression; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Receptor, IGF Type 1; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 2010 |
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
Topics: Androgens; Animals; Carcinoma; Cell Line; Dihydrotestosterone; Epithelial Cells; Humans; Hyperplasia; Hypoxia; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Orchiectomy; Phenotype; Prostate; Prostatic Neoplasms; Stromal Cells; Thrombospondin 1; Transforming Growth Factor beta | 2010 |
Saturable binding of finasteride to steroid 5alpha-reductase as determinant of nonlinear pharmacokinetics.
Topics: 5-alpha Reductase Inhibitors; Animals; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Male; Nonlinear Dynamics; Prostatic Hyperplasia; Prostatic Neoplasms; Rats | 2010 |
Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Fulvestrant; Humans; Male; Mass Spectrometry; Mice; Mice, SCID; Orchiectomy; Prostatic Neoplasms; Receptors, Estrogen; Testosterone; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cell Nucleus; Dehydroepiandrosterone; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Male; Models, Biological; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Treatment Failure | 2010 |
Atmospheric pressure photoionization tandem mass spectrometry of androgens in prostate cancer.
Topics: Androgens; Atmospheric Pressure; Chromatography, High Pressure Liquid; Dihydrotestosterone; Etiocholanolone; Humans; Male; Prostatic Neoplasms; Tandem Mass Spectrometry | 2010 |
Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice.
Topics: Androgens; Animals; Azasteroids; Cell Division; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Dutasteride; Enzyme Inhibitors; Finasteride; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nuclear Proteins; Orchiectomy; Prostate-Specific Antigen; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Testosterone; Trans-Activators; Transplantation, Heterologous; Tumor Suppressor Proteins | 2010 |
AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model.
Topics: Androgen Antagonists; Androgens; Anilides; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Drug Synergism; Gossypol; Humans; Immunoblotting; Male; Nitriles; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; Tosyl Compounds | 2010 |
Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
Topics: ADAM Proteins; ADAMTS Proteins; ADAMTS1 Protein; Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; Disease Progression; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Nude; Prostatic Neoplasms | 2010 |
The synthetic estrogen diethylstilbestrol (DES) inhibits the telomerase activity and gene expression of prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Diethylstilbestrol; Dihydrotestosterone; DNA Primers; Estrogens, Non-Steroidal; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Male; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Telomerase; Testosterone | 2010 |
Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Paxillin; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic | 2010 |
Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines.
Topics: Binding Sites; Cell Line, Tumor; Chromatin Immunoprecipitation; Dihydrotestosterone; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasms, Hormone-Dependent; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger | 2010 |
Testosterone may speed up the growth of prostate cancer due to aromatase activity.
Topics: Androgens; Dihydrotestosterone; Humans; Hypogonadism; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 2010 |
Statins reduce the androgen sensitivity and cell proliferation by decreasing the androgen receptor protein in prostate cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Receptors, Androgen | 2011 |
Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgens; Cell Line, Tumor; Chromatography, Liquid; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Mass Spectrometry; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 2010 |
Integration of cap analysis of gene expression and chromatin immunoprecipitation analysis on array reveals genome-wide androgen receptor signaling in prostate cancer cells.
Topics: Acetylation; Androgens; Binding Sites; Cell Line, Tumor; Chromatin Immunoprecipitation; Dihydrotestosterone; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Genomics; Histones; Humans; Male; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transcription Initiation Site | 2011 |
The PPARγ ligand ciglitazone regulates androgen receptor activation differently in androgen-dependent versus androgen-independent human prostate cancer cells.
Topics: Androgen-Binding Protein; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Dihydrotestosterone; Gene Expression; Genes, Reporter; Humans; Hypoglycemic Agents; Male; Mutation; Neoplasms, Hormone-Dependent; PPAR gamma; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Small Interfering; Rosiglitazone; Thiazolidinediones; Transfection | 2010 |
Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor α and β.
Topics: Antineoplastic Agents, Hormonal; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression Regulation, Neoplastic; Humans; Male; Metallothionein; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Raloxifene Hydrochloride; Receptors, Thrombin; RNA, Messenger; Selective Estrogen Receptor Modulators; Signal Transduction; Time Factors; Transcription, Genetic | 2011 |
Androgen regulation of micro-RNAs in prostate cancer.
Topics: Androgens; Animals; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; MicroRNAs; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Transfection; Transplantation, Heterologous | 2011 |
Androgen-induced TMPRSS2:ERG fusion in nonmalignant prostate epithelial cells.
Topics: Androgens; Argonaute Proteins; Cell Line, Transformed; Cell Line, Tumor; Dihydrotestosterone; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Regulation, Neoplastic; Gene Fusion; Humans; In Situ Hybridization, Fluorescence; Male; Oncogene Proteins, Fusion; Prostate; Prostatic Neoplasms; Proteins; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2010 |
Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression.
Topics: 3-Hydroxysteroid Dehydrogenases; Blotting, Western; Cell Line, Tumor; Cell Survival; Computational Biology; Dihydrotestosterone; Disease Progression; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Estradiol; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Hydroxyprostaglandin Dehydrogenases; Insulin-Like Growth Factor I; Male; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Calcitriol; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Tumor Suppressor Protein p53; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
Effect of castration monotherapy on the levels of adrenal androgens in cancerous prostatic tissues.
Topics: Adrenal Glands; Androgens; Androstenediol; Androstenedione; Castration; Chromatography, Liquid; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Neoplasms | 2011 |
The culinary-medicinal mushroom Coprinus comatus as a natural antiandrogenic modulator.
Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Androgens; Aniline Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coprinus; Dexamethasone; Dihydrotestosterone; Down-Regulation; Female; Flutamide; Gene Expression; Genes, Reporter; Humans; Inhibitory Concentration 50; Luciferases; Male; Mifepristone; Nitriles; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Quinolines; Receptors, Androgen; Receptors, Glucocorticoid; Tumor Stem Cell Assay; Up-Regulation | 2011 |
Beyond FDG: Many Molecular Imaging Agents Are in Development.
Topics: Biomarkers, Tumor; Breast Neoplasms; Dihydrotestosterone; Drug Design; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose; Humans; Male; Neoplasms; Nuclear Medicine; Positron-Emission Tomography; Prostatic Neoplasms; Radiology; Radiopharmaceuticals; Receptor, ErbB-2; Receptors, Androgen; Sensitivity and Specificity; Tomography, X-Ray Computed | 2011 |
Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence.
Topics: Animals; Cell Line, Tumor; Dihydrotestosterone; Equol; Humans; Isoflavones; Male; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Rats | 2011 |
Abiraterone and MVD3100 take androgen deprivation to a new level.
Topics: Androgen Antagonists; Androstenes; Androstenols; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Diabetes Mellitus; Dihydrotestosterone; Drug Approval; Gonadotropin-Releasing Hormone; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Testosterone; Time Factors; United States; United States Food and Drug Administration | 2011 |
Effects of androgen receptor and androgen on gene expression in prostate stromal fibroblasts and paracrine signaling to prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; Fibroblasts; Gene Expression Regulation; Humans; Male; Paracrine Communication; Prostate; Prostatic Neoplasms; Receptors, Androgen; Stromal Cells | 2011 |
Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer.
Topics: Androgens; Androstane-3,17-diol; Animals; Carcinoma; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation; Transplantation, Heterologous; Tumor Cells, Cultured | 2011 |
Changes of androgen receptor and insulin-like growth factor-1 in LNCaP prostate cancer cells treated with sex hormones and flutamide.
Topics: Androgen Antagonists; Androgens; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; Estrogens; Estrone; Flutamide; Humans; Immunoenzyme Techniques; Insulin-Like Growth Factor I; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2010 |
Leuprorelin acetate affects adhesion molecule expression in human prostate cancer cells.
Topics: Antineoplastic Agents, Hormonal; Cell Adhesion Molecules; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Leuprolide; Male; Prostatic Neoplasms | 2011 |
TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status.
Topics: Acetyl-CoA Carboxylase; Androgen Receptor Antagonists; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Death; Cell Line, Tumor; Cytochromes c; Dihydrotestosterone; Fatty Acids; Furans; Genes, p53; Humans; Introns; Lipids; Male; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neuropilin-1; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen | 2011 |
Influence of short polyglutamine tracts and p160 coactivators on the transactivation of the androgen receptor.
Topics: Androgen Antagonists; Anilides; Dihydrotestosterone; Humans; Luciferases; Male; Mutation; Nitriles; Nuclear Receptor Coactivator 2; Nuclear Receptor Coactivators; Peptides; Prostatic Neoplasms; Receptors, Androgen; Saccharomyces cerevisiae; Tosyl Compounds; Transcriptional Activation; Up-Regulation | 2011 |
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA.
Topics: Base Sequence; Cell Line, Tumor; Cell Lineage; Dihydrotestosterone; Down-Regulation; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genome, Human; HEK293 Cells; Hepatocyte Nuclear Factor 3-alpha; Histones; Humans; Kallikreins; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Small Interfering; RNA, Untranslated; Transcription, Genetic | 2011 |
Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen.
Topics: Androgen Antagonists; Androgens; Animals; Antibodies, Monoclonal; Antigens, Surface; Benzamides; Cell Line, Tumor; Copper Radioisotopes; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Glutamate Carboxypeptidase II; Heterocyclic Compounds, 1-Ring; Humans; Immunoblotting; Male; Mice; Mice, SCID; Neoplasms, Experimental; Nitriles; Orchiectomy; Phenylthiohydantoin; Positron-Emission Tomography; Prostate-Specific Antigen; Prostatic Neoplasms; Radiopharmaceuticals; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transplantation, Heterologous | 2011 |
Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone.
Topics: Androstenediol; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms; Signal Transduction; Steroid 17-alpha-Hydroxylase | 2011 |
Androgen receptor W741C and T877A mutations in AIDL cells, an androgen-independent subline of prostate cancer LNCaP cells.
Topics: Androgens; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; DNA Mutational Analysis; Gene Expression Regulation, Neoplastic; Humans; Male; Metribolone; Mutation, Missense; Point Mutation; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Attenuation of androgenic regulation by brefeldin A in androgen-responsive prostate cancer cells.
Topics: Androgens; Antineoplastic Combined Chemotherapy Protocols; Brefeldin A; Cell Proliferation; Dihydrotestosterone; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Synthesis Inhibitors; Receptors, Androgen; Tumor Cells, Cultured | 2013 |
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Castration; Dihydrotestosterone; Disease Progression; Humans; Male; Membrane Proteins; Metabolic Networks and Pathways; Mice; Prostatic Neoplasms; Testosterone; Transplantation, Heterologous | 2011 |
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants.
Topics: Alternative Splicing; Androgens; Androstenes; Androstenols; Animals; Biosynthetic Pathways; Cell Proliferation; Dihydrotestosterone; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, SCID; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Steroid 17-alpha-Hydroxylase; Xenograft Model Antitumor Assays | 2011 |
A novel steroidal antiandrogen targeting wild type and mutant androgen receptors.
Topics: Androgen Antagonists; Animals; Binding, Competitive; Carbamates; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; Dihydrotestosterone; Drug Screening Assays, Antitumor; Flutamide; Humans; Male; Models, Molecular; Mutation; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Transport; Receptors, Androgen; Structure-Activity Relationship; Transcriptional Activation | 2011 |
Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells.
Topics: Androgen Antagonists; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cycloheximide; Dihydrotestosterone; Down-Regulation; Drug Synergism; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Receptors, Androgen; Resveratrol; RNA, Messenger; Stilbenes; Transcriptional Activation | 2011 |
Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells.
Topics: Acetylation; Acetyltransferases; Androgens; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Dihydrotestosterone; Enhancer Elements, Genetic; GATA2 Transcription Factor; Gene Expression; Gene Expression Regulation, Neoplastic; Histones; Humans; Ligands; Male; Methylation; Methyltransferases; Nucleosomes; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Sequence Analysis, DNA; Serine Endopeptidases; Tissue Kallikreins | 2011 |
Practical approach for comparative analysis of multilesion molecular imaging using a semiautomated program for PET/CT.
Topics: Automation; Biomarkers, Tumor; Dihydrotestosterone; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Male; Molecular Imaging; Multimodal Imaging; Orchiectomy; Positron-Emission Tomography; Prostatic Neoplasms; Reference Standards; Retrospective Studies; Tomography, X-Ray Computed | 2011 |
Differential cytotoxicity of triphala and its phenolic constituent gallic acid on human prostate cancer LNCap and normal cells.
Topics: Apoptosis; Cells, Cultured; Dihydrotestosterone; Gallic Acid; Humans; Male; Plant Extracts; Prostate; Prostatic Neoplasms | 2011 |
Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer.
Topics: Androstane-3,17-diol; Cell Proliferation; Dihydrotestosterone; Epithelium; Estrogen Receptor beta; HEK293 Cells; Humans; Hyperplasia; Immunohistochemistry; Male; Models, Biological; Prostate; Prostatic Neoplasms; Racemases and Epimerases; Signal Transduction; Transcriptional Activation | 2011 |
Androgens regulate Hedgehog signalling and proliferation in androgen-dependent prostate cells.
Topics: Adult; Anilides; Cell Line, Tumor; Cell Proliferation; Cinnamates; Dihydrotestosterone; Hedgehog Proteins; Humans; Male; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tosyl Compounds; Veratrum Alkaloids | 2012 |
Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells.
Topics: Androgen Receptor Antagonists; Androgens; Animals; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Dimerization; Drugs, Chinese Herbal; Gene Expression; HEK293 Cells; Humans; Male; Mice; Mice, Nude; Orchiectomy; Phenanthrenes; Prostatic Neoplasms; Receptors, Androgen; Salvia miltiorrhiza; Transcriptional Activation; Xenograft Model Antitumor Assays | 2012 |
Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Animals; Cell Line, Tumor; Cholestenone 5 alpha-Reductase; Dactinomycin; Dihydrotestosterone; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Male; Membrane Proteins; Organ Specificity; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Response Elements; RNA, Messenger; Transcription, Genetic; Xenograft Model Antitumor Assays | 2011 |
The effect of finasteride and dutasteride on the growth of WPE1-NA22 prostate cancer xenografts in nude mice.
Topics: Animals; Azasteroids; Body Weight; Cell Line, Tumor; Cell Survival; Dihydrotestosterone; Dutasteride; Finasteride; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Rats; Testosterone; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Hypoxia enhances ligand-occupied androgen receptor activity.
Topics: Androgens; Cell Hypoxia; Cell Line, Tumor; Dihydrotestosterone; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ligands; Luciferases; Male; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transcriptional Activation | 2012 |
Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer.
Topics: Androgens; Animals; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Genes, Dominant; Humans; Immunoblotting; Male; Mice; Mice, Nude; Mice, Transgenic; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Testosterone; Transcriptional Activation; Transplantation, Heterologous; Tumor Burden | 2012 |
Characterization of hydrogen sulfide and its synthases, cystathionine β-synthase and cystathionine γ-lyase, in human prostatic tissue and cells.
Topics: Adenocarcinoma; Androgens; Cell Line; Cell Line, Tumor; Culture Media; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Dihydrotestosterone; Down-Regulation; Enzyme Induction; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Sulfide; Male; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Prostate; Prostatic Neoplasms; Receptors, Androgen; Stromal Cells | 2012 |
Dihydrotestosterone synthesis from adrenal precursors does not involve testosterone in castration-resistant prostate cancer.
Topics: Dihydrotestosterone; Disease Progression; Humans; Male; Molecular Targeted Therapy; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 2012 |
Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins; Dihydrotestosterone; Estradiol; Estrogen Receptor beta; Estrogens; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Luciferases; Male; Multiprotein Complexes; Neoplasm Grading; Prostatic Neoplasms; Protein Structure, Tertiary; Receptors, Androgen; Response Elements; Tissue Array Analysis; Transcription Factors | 2012 |
Fluorinated and pegylated polyaspartamide derivatives to increase solubility and efficacy of Flutamide.
Topics: Adenocarcinoma; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Chromatography, Gel; Dihydrotestosterone; Drug Carriers; Drug Delivery Systems; Ethylenediamines; Flutamide; Humans; Hydrophobic and Hydrophilic Interactions; Male; Micelles; Microscopy, Electron, Scanning; Oxadiazoles; Peptides; Polyethylene Glycols; Polymers; Prostatic Neoplasms; Solubility | 2012 |
Down-regulation of calcium/calmodulin-dependent protein kinase kinase 2 by androgen deprivation induces castration-resistant prostate cancer.
Topics: Aged; Aged, 80 and over; Androgens; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Dihydrotestosterone; Down-Regulation; Humans; Male; Mice; Mice, SCID; Middle Aged; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen | 2012 |
Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation.
Topics: Active Transport, Cell Nucleus; Animals; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dihydrotestosterone; ets-Domain Protein Elk-1; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation; Granulosa Cells; Homeodomain Proteins; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Paxillin; Phosphoproteins; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-fos; Receptors, Androgen; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2012 |
Goodbye androgen hypothesis, hello saturation model.
Topics: 5-alpha Reductase Inhibitors; Antineoplastic Agents, Hormonal; Azasteroids; Dihydrotestosterone; Dutasteride; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Testosterone | 2012 |
NGF/γ-IFN inhibits androgen-independent prostate cancer and reverses androgen receptor function through downregulation of FGFR2 and decrease in cancer stem cells.
Topics: Animals; Apoptosis; Cell Count; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Down-Regulation; Humans; Interferon-gamma; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Nerve Growth Factor; Prostatic Neoplasms; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Androgen; Transplantation, Heterologous; Wnt1 Protein; Wnt2 Protein | 2012 |
Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; Abiraterone Acetate; Active Transport, Cell Nucleus; Androstadienes; Androstenedione; Animals; Antineoplastic Agents; Cell Line, Tumor; Dehydroepiandrosterone; Dihydrotestosterone; Drug Resistance, Neoplasm; Humans; Isoenzymes; Male; Mice; Mice, Inbred NOD; Mice, SCID; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Testosterone; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Physical exercise on the rat ventral prostate: steroid hormone receptors, apoptosis and cell proliferation.
Topics: Animals; Apoptosis; Cell Proliferation; Corticosterone; Dihydrotestosterone; Disease Models, Animal; Estradiol; Gonadal Steroid Hormones; Male; Physical Conditioning, Animal; Prostate; Prostatic Diseases; Prostatic Neoplasms; Rats; Rats, Wistar; Testosterone | 2012 |
Androgen-modulated p21 and p53 gene expression in human non-transformed epithelial prostatic cells in primary cultures.
Topics: Aged; Androgens; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Dihydrotestosterone; Epithelial Cells; Gene Expression Regulation; Humans; Male; Middle Aged; Prostate; Prostatic Neoplasms; Tumor Suppressor Protein p53 | 2012 |
Expression changes and regulation of AR and IGF-1 in PC3 prostate cancer cells treated with sexual hormones and flutamide.
Topics: Androgen Antagonists; Androgens; Blotting, Western; Dihydrotestosterone; Estrogens; Estrone; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Insulin-Like Growth Factor I; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Protein Kinase Inhibitors; Receptors, Androgen; Signal Transduction; Tumor Cells, Cultured | 2012 |
Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells.
Topics: Adenocarcinoma; Androgens; Animals; Antigens, Neoplasm; Antigens, Surface; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Epithelial Cells; Estradiol; Estrogens; Humans; Intercellular Junctions; Male; Neoplasm Proteins; Orchiectomy; Oxidoreductases; Prostate; Prostatic Neoplasms; Rats; Rats, Wistar | 2013 |
miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells.
Topics: Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Humans; Immunohistochemistry; Male; MicroRNAs; p300-CBP Transcription Factors; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Up-Regulation | 2012 |
Differential effects of estrogen receptor ligands on regulation of dihydrotestosterone-induced cell proliferation in endothelial and prostate cancer cells.
Topics: Androgens; Aorta; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclin A; Dihydrotestosterone; Endothelium, Vascular; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering | 2013 |
Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Male; Molecular Targeted Therapy; Orchiectomy; Prostatic Neoplasms; Testosterone | 2013 |
Modeling truncated AR expression in a natural androgen responsive environment and identification of RHOB as a direct transcriptional target.
Topics: Androgens; Cell Line, Tumor; Cell Movement; Cell Nucleus; Chromatin; Dihydrotestosterone; Doxycycline; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Prostatic Neoplasms; Protein Binding; Protein Multimerization; Protein Transport; Receptors, Androgen; Reproducibility of Results; Response Elements; rhoB GTP-Binding Protein; RNA, Messenger; Transcription, Genetic | 2012 |
Development of prostate cancer in a patient with primary hypogonadism: intratumoural steroidogenesis in prostate cancer tissues.
Topics: Aged; Androstenedione; Dihydrotestosterone; Disease Progression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Hypogonadism; Immunohistochemistry; Male; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone | 2013 |
Decrease in lean body mass in men with prostate cancer receiving androgen deprivation therapy: mechanism and biomarkers.
Topics: Aged; Androgen Antagonists; Androstane-3,17-diol; Biomarkers; Body Composition; Body Mass Index; Calcitriol; Dihydrotestosterone; Electric Impedance; Humans; Insulin-Like Growth Factor I; Male; Middle Aged; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Statistics, Nonparametric; Testosterone; Thinness | 2013 |
Synergistic activation of the androgen receptor by bombesin and low-dose androgen.
Topics: Bombesin; Dihydrotestosterone; Drug Synergism; Electrophoretic Mobility Shift Assay; Gene Expression; Humans; Luciferases; Male; Phosphorylation; Precipitin Tests; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Bombesin; Response Elements; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2002 |
Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Androgens; Cycloheximide; Dihydrotestosterone; DNA, Complementary; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Proteins; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Prostate; Prostatic Neoplasms; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2002 |
The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton.
Topics: Actin Cytoskeleton; Binding Sites; Biological Transport; Cell Membrane; Dihydrotestosterone; Humans; Male; Models, Biological; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Cell Surface; Testosterone; Tumor Cells, Cultured | 2002 |
Nerve growth factor induces the re-expression of functional androgen receptors and p75(NGFR) in the androgen-insensitive prostate cancer cell line DU145.
Topics: Androgen Antagonists; Androgens; Apoptosis; Cell Division; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Gene Expression; Humans; Male; Nerve Growth Factor; Prostatic Neoplasms; Receptor, Nerve Growth Factor; Receptors, Androgen; RNA, Messenger; Telomerase; Tumor Cells, Cultured | 2002 |
Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4.
Topics: Blotting, Northern; Blotting, Western; Chloramphenicol O-Acetyltransferase; Dihydrotestosterone; DNA Primers; DNA-Binding Proteins; Genes, Tumor Suppressor; Glutathione Transferase; Humans; Ligands; Male; Models, Biological; Precipitin Tests; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad3 Protein; Smad4 Protein; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2002 |
Effect of parathyroid hormone related protein, and dihydrotestosterone on proliferation and ornithine decarboxylase mRNA in human prostate cancer cell lines.
Topics: Adenocarcinoma; Blotting, Northern; Dihydrotestosterone; DNA; Gene Expression; Humans; Male; Ornithine Decarboxylase; Parathyroid Hormone-Related Protein; Peptide Hormones; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 2001 |
Androgen modulation of adhesion and antiadhesion molecules in PC-3 prostate cancer cells expressing androgen receptor.
Topics: Cell Adhesion; Cell Adhesion Molecules; Collagen Type I; Dihydrotestosterone; Down-Regulation; Humans; Integrins; Male; Mucin-1; Prostatic Neoplasms; Receptors, Androgen; Receptors, Collagen; RNA, Messenger; Up-Regulation | 2002 |
Bcl-2 antagonizes the combined apoptotic effect of transforming growth factor-beta and dihydrotestosterone in prostate cancer cells.
Topics: Apoptosis; Blotting, Western; Caspase 1; Dihydrotestosterone; Genes, bcl-2; Humans; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2002 |
Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dihydrotestosterone; Glycine max; Humans; Isoflavones; Lung Neoplasms; Lymph Nodes; Male; Mice; Mice, SCID; Neoplasms, Hormone-Dependent; Neovascularization, Pathologic; Plant Extracts; Prostatic Neoplasms; Random Allocation; Receptors, Androgen; Soybean Proteins; Specific Pathogen-Free Organisms; Testosterone; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2002 |
Genistein alters growth but is not toxic to the rat prostate.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen-Binding Protein; Animals; Anticarcinogenic Agents; Diethylstilbestrol; Dihydrotestosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal; Genistein; Glycine max; Growth Inhibitors; Humans; Isoflavones; Male; Organ Size; Phytoestrogens; Plant Preparations; Prostate; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Testosterone | 2002 |
Androgen-mediated resistance to apoptosis.
Topics: Apoptosis; Caspases; Dihydrotestosterone; Humans; Male; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2002 |
Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells.
Topics: Adenocarcinoma; Cell Division; Dihydrotestosterone; Eicosanoic Acids; Flow Cytometry; gamma-Linolenic Acid; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2003 |
Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function.
Topics: Androgen Receptor Antagonists; Androgens; Animals; Cell Division; Culture Media, Conditioned; Dihydrotestosterone; Epidermal Growth Factor; Gene Expression; Heparin-binding EGF-like Growth Factor; Immunoblotting; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, SCID; Neoplasm Transplantation; Phosphopyruvate Hydratase; Prostatic Neoplasms; Receptors, Androgen; Solubility; Transfection; Tumor Cells, Cultured | 2002 |
MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor model.
Topics: Acetates; Androgen Antagonists; Androgens; Animals; Carbon; Diethylstilbestrol; Dihydrotestosterone; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Nude; Neoplasm Transplantation; Organ Specificity; Prostate; Prostatic Neoplasms; Radiopharmaceuticals; Rats; Tissue Distribution; Tomography, Emission-Computed | 2002 |
A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity.
Topics: Alanine; Animals; Binding Sites; Biological Transport; Cell Nucleus; COS Cells; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Stability; Gene Expression; Heat-Shock Proteins; Humans; Male; Metribolone; Models, Molecular; Mutation; Prostatic Neoplasms; Protein Conformation; Receptors, Androgen; Structure-Activity Relationship; Testosterone; Threonine; Transcription, Genetic; Transfection | 2002 |
The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells.
Topics: Adenocarcinoma; Benzhydryl Compounds; Bromodeoxyuridine; Cell Division; Cell Nucleus; Dihydrotestosterone; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal; Flow Cytometry; Genes, Reporter; Humans; Immunoblotting; Kinetics; Male; Phenols; Plasmids; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Cells, Cultured | 2002 |
Monogene and polygene therapy for the treatment of experimental prostate cancers by use of apoptotic genes bax and bad driven by the prostate-specific promoter ARR(2)PB.
Topics: Adenoviridae; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Carrier Proteins; Cell Line; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Genetic Therapy; Humans; Male; Mice; Mice, Nude; Promoter Regions, Genetic; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; Tumor Cells, Cultured | 2002 |
Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells.
Topics: Antigens, Differentiation; Blotting, Western; Bone Morphogenetic Proteins; Cell Differentiation; Dihydrotestosterone; Epithelial Cells; Growth Differentiation Factor 15; Humans; Male; Membrane Proteins; Proprotein Convertases; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Subtilisins; Tumor Cells, Cultured | 2003 |
Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism.
Topics: 20-Hydroxysteroid Dehydrogenases; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Androgens; Carcinoma, Hepatocellular; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxysteroid Dehydrogenases; Male; Oxidoreductases; Polymerase Chain Reaction; Prostate; Prostatic Neoplasms; Transfection; Tumor Cells, Cultured | 2003 |
A novel human prostate-specific gene-1 (HPG-1): molecular cloning, sequencing, and its potential involvement in prostate carcinogenesis.
Topics: Amino Acid Sequence; Base Sequence; Cell Adhesion Molecules; Cell Division; Cloning, Molecular; Dihydrotestosterone; DNA, Complementary; Humans; Male; Molecular Sequence Data; Neoplasms, Hormone-Dependent; Oligonucleotides, Antisense; Polymerase Chain Reaction; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation | 2003 |
A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors.
Topics: Actins; Androstadienes; cdc42 GTP-Binding Protein; Cell Membrane; Cytoskeleton; Dihydrotestosterone; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Neuropeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Protein-Tyrosine Kinases; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Receptors, Androgen; Serum Albumin, Bovine; Signal Transduction; Testosterone; Tumor Cells, Cultured; Wortmannin | 2003 |
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.
Topics: Acetylcysteine; Benzoquinones; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Gene Expression; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Leupeptins; Ligases; Male; Molecular Chaperones; Multienzyme Complexes; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Quinones; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Tumor Cells, Cultured; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells.
Topics: Anticarcinogenic Agents; Dihydrotestosterone; Down-Regulation; Estrogens, Non-Steroidal; Gene Expression Regulation, Neoplastic; Genistein; Humans; Isoflavones; Male; Membrane Proteins; Neoplasm Proteins; Prostatic Neoplasms; Tumor Cells, Cultured | 2003 |
Androgen regulation of parathyroid hormone-related peptide production in human prostate cancer cells.
Topics: Androgens; Animals; Cell Division; Dihydrotestosterone; Gene Expression; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Orchiectomy; Parathyroid Hormone-Related Protein; Peptide Hormones; Promoter Regions, Genetic; Prostatic Neoplasms; Rats; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Cells, Cultured | 2003 |
Alterations of expression and regulation of transforming growth factor beta in human cancer prostate cell lines.
Topics: Blotting, Northern; Culture Media, Conditioned; Dihydrotestosterone; Enzyme-Linked Immunosorbent Assay; Estradiol; Fibroblasts; Gene Expression Regulation; Humans; Male; Prostatic Neoplasms; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Tumor Cells, Cultured | 2002 |
5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids.
Topics: Adenocarcinoma; Animals; Arachidonate 15-Lipoxygenase; Cells, Cultured; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Eicosapentaenoic Acid; gamma-Linolenic Acid; Male; Oxidoreductases; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Rats, Wistar; Testosterone; Tumor Cells, Cultured | 2002 |
Regulation of Bcl-2 expression by dihydrotestosterone in hormone sensitive LNCaP-FGC prostate cancer cells.
Topics: Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasms, Hormone-Dependent; Prostate; Prostatic Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Up-Regulation | 2003 |
Androgen receptor activity at the prostate specific antigen locus: steroidal and non-steroidal mechanisms.
Topics: Acetylation; Adenylyl Cyclases; Cell Division; Colforsin; Dihydrotestosterone; Genes, Reporter; Histones; Humans; Interleukin-6; Ligands; Luciferases; Male; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2003 |
Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells.
Topics: Adenocarcinoma; Androgen Antagonists; Anilides; Animals; Anticarcinogenic Agents; Binding, Competitive; Cell Division; Cell Nucleus; Cytoplasm; Dihydrotestosterone; DNA; Gene Expression Regulation, Neoplastic; Indoles; Male; Metribolone; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Signal Transduction; Testosterone Congeners; Tosyl Compounds; Transcription, Genetic; Tumor Cells, Cultured; Vegetables | 2003 |
The response of extracellular signal-regulated kinase (ERK) to androgen-induced proliferation in the androgen-sensitive prostate cancer cell line, LNCaP.
Topics: Androgens; Cell Count; Cell Division; Cell Line, Tumor; Dihydrotestosterone; eIF-2 Kinase; Enzyme Activation; Epidermal Growth Factor; Humans; Ki-67 Antigen; Male; Mitogen-Activated Protein Kinases; Prostatic Neoplasms | 2003 |
Secretion of endogenous kallikreins 2 and 3 by androgen receptor-transfected PC-3 prostate cancer cells.
Topics: Androgens; Dihydrotestosterone; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Time Factors; Tissue Kallikreins; Transfection; Tumor Cells, Cultured | 2003 |
Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis.
Topics: 2-Methoxyestradiol; Apoptosis; Dihydrotestosterone; Estradiol; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
Androgen-independent prostate cancer DU145 cells suppress androgen-dependent growth of prostate stromal cells through production of inhibitory factors for androgen responsiveness.
Topics: Carcinoma; Coculture Techniques; Culture Media, Conditioned; Dihydrotestosterone; Epidermal Growth Factor; Fibroblast Growth Factor 2; Humans; Male; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Sepharose; Stromal Cells; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.
Topics: 17-Hydroxysteroid Dehydrogenases; Adenocarcinoma; Androstane-3,17-diol; Animals; Bone Neoplasms; COS Cells; Dihydrotestosterone; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Isoenzymes; Male; Prostate; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 2003 |
Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells.
Topics: Androgens; Blotting, Western; Cell Line, Tumor; Chromones; Culture Media, Conditioned; Dihydrotestosterone; DNA-Binding Proteins; Enzyme Inhibitors; Flutamide; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Ligands; Male; Models, Biological; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; RNA; Signal Transduction; Time Factors; Transcription Factors; Transcriptional Activation; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A | 2003 |
Prostate cancer prevention trial yields positive results, but with a few cautions.
Topics: Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemoprevention; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Humans; Incidence; Male; Middle Aged; Multicenter Studies as Topic; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Severity of Illness Index; Testosterone | 2003 |
Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator.
Topics: Animals; Cloning, Molecular; COS Cells; Dihydrotestosterone; Flutamide; Gelsolin; Humans; Male; Mice; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation | 2003 |
Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells.
Topics: Apoptosis; Caspases; Cell Adhesion; Cell Division; Cytokines; Dihydrotestosterone; Epithelial Cells; Estradiol; Gene Expression Profiling; Growth Differentiation Factor 15; Humans; Male; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Transforming Growth Factor beta; Tumor Cells, Cultured | 2003 |
Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis.
Topics: Anilides; beta Catenin; Binding, Competitive; Cell Nucleus; Colonic Neoplasms; Cytoskeletal Proteins; Dihydrotestosterone; DNA-Directed RNA Polymerases; Humans; Male; Nitriles; Phosphorylation; Prostatic Neoplasms; Receptors, Androgen; TCF Transcription Factors; Tosyl Compounds; Trans-Activators; Transcription Factor 7-Like 2 Protein; Transcription Factors; Tumor Cells, Cultured | 2003 |
Androgen and the blocking of radiation-induced sensitization to Fas-mediated apoptosis through c-jun induction in prostate cancer cells.
Topics: Androgens; Apoptosis; Cell Survival; Chromatin; Cosmids; Dihydrotestosterone; DNA Fragmentation; Dose-Response Relationship, Radiation; Enzyme Inhibitors; fas Receptor; Flavonoids; Flow Cytometry; Humans; Immunoblotting; Luciferases; Male; Mitogen-Activated Protein Kinases; Models, Biological; Models, Genetic; Oligonucleotides, Antisense; Plasmids; Precipitin Tests; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-jun; Time Factors; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2003 |
Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells.
Topics: Adenocarcinoma; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Benzoflavones; beta-Galactosidase; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Luciferases; Male; Nitriles; Polycyclic Aromatic Hydrocarbons; Proadifen; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Aryl Hydrocarbon; Saccharomyces cerevisiae; Tosyl Compounds; Vehicle Emissions | 2003 |
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Topics: ADAM Proteins; ADAM10 Protein; ADAM17 Protein; Adenocarcinoma; Amyloid Precursor Protein Secretases; Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Disintegrins; Humans; Male; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Prostatic Hyperplasia; Prostatic Neoplasms; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases; Up-Regulation | 2003 |
Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth.
Topics: Acetylation; Amino Acid Substitution; Animals; Apoptosis; Binding Sites; Cell Division; Cell Line, Tumor; Dihydrotestosterone; E1A-Associated p300 Protein; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; In Vitro Techniques; Ligands; Male; Mice; Mice, Nude; Nuclear Proteins; Prostatic Neoplasms; Receptors, Androgen; Trans-Activators | 2003 |
Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells.
Topics: Androgens; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Dihydrotestosterone; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; NF-kappa B; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transfection | 2003 |
Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxyacyl CoA Dehydrogenases; Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acid Substitution; Cell Line; Dihydrotestosterone; Epithelial Cells; Humans; Male; Molecular Sequence Data; Oxidation-Reduction; Prostate; Prostatic Neoplasms; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection | 2003 |
p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomas.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Breast Neoplasms; Cell Division; Dihydrotestosterone; Estrogens; Humans; Male; Neoplasms, Hormone-Dependent; Phosphorylation; Prostate; Prostatic Neoplasms; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Testicular Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2004 |
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Androgens; Blotting, Western; Cell Membrane; Cell Nucleus; Dihydrotestosterone; Epidermal Growth Factor; Gene Expression Regulation; Humans; Immunoenzyme Techniques; In Situ Hybridization; Insulin-Like Growth Factor I; Male; Membrane Proteins; Metalloendopeptidases; Prostatic Hyperplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2004 |
The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptor.
Topics: Androgen Antagonists; Androgens; Androstenediol; Cell Division; Cell Line, Tumor; Dihydrotestosterone; DNA Primers; Genes, Reporter; Humans; Male; Mutation; Polymerase Chain Reaction; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Transfection | 2004 |
Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells.
Topics: Androgen Antagonists; Anilides; Blotting, Western; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dihydrotestosterone; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Interleukin-6; Isoquinolines; Kinetics; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; STAT3 Transcription Factor; Sulfonamides; Tosyl Compounds; Trans-Activators; Tumor Cells, Cultured | 2004 |
The androgen axis in recurrent prostate cancer.
Topics: Aged; Aged, 80 and over; Androgens; Androstenedione; Antibodies, Monoclonal; Cell Nucleus; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Microscopy, Video; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Radioimmunoassay; Receptors, Androgen; Recurrence | 2004 |
Regulation of prostate-specific antigen by activin A in prostate cancer LNCaP cells.
Topics: Activins; Androgens; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Drug Interactions; Gene Expression; Humans; Inhibin-beta Subunits; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Up-Regulation | 2004 |
Androgens target prohibitin to regulate proliferation of prostate cancer cells.
Topics: Amino Acid Sequence; Androgens; Base Sequence; Cell Division; Cell Line, Tumor; Cloning, Molecular; Dihydrotestosterone; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Humans; Male; Molecular Sequence Data; Neoplasm Proteins; Peptide Fragments; Prohibitins; Prostatic Neoplasms; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection | 2004 |
The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Culture Media; Dihydrotestosterone; Farnesol; Humans; Male; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Salicylates | 2004 |
Expression of bone morphogenetic protein-7 (BMP-7) in human prostate.
Topics: Aged; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Line, Tumor; Dihydrotestosterone; Disease Progression; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2004 |
Relationship between upregulated oestrogen receptors and expression of growth factors in cultured, human, prostatic stromal cells exposed to estradiol or dihydrotestosterone.
Topics: Dihydrotestosterone; Estradiol; Flow Cytometry; Growth Substances; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Estrogen; Stromal Cells; Tumor Cells, Cultured; Up-Regulation | 2004 |
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
Topics: Benzofurans; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Dihydrotestosterone; Estradiol; Female; Genes, Reporter; Humans; Male; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Receptors, Aryl Hydrocarbon; Time Factors; Transcriptional Activation | 2004 |
Androgen receptor signaling: mechanism of interleukin-6 inhibition.
Topics: Cell Line, Tumor; Cell Nucleus; Dihydrotestosterone; DNA-Binding Proteins; Gene Expression; Histone Deacetylase 1; Histone Deacetylases; Humans; Interleukin-6; Male; Nuclear Proteins; Nuclear Receptor Co-Repressor 2; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Repressor Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation | 2004 |
Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells.
Topics: Androgen Antagonists; Androgens; Anilides; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Estrogen Receptor beta; Fulvestrant; Genes, Reporter; Humans; Male; Nitriles; Oligonucleotides, Antisense; Prostatic Neoplasms; Receptors, Androgen; Response Elements; Tosyl Compounds | 2004 |
Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Arachidonic Acid; Cyclooxygenase 2; Dihydrotestosterone; Dinoprostone; Disease Models, Animal; Disease Progression; Eicosanoic Acids; gamma-Linolenic Acid; Humans; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Tumor Cells, Cultured | 2004 |
Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells.
Topics: beta Catenin; Cell Cycle; Cell Division; Cell Line, Tumor; Cytoskeletal Proteins; Dihydrotestosterone; Humans; Male; Polymerase Chain Reaction; Prostatic Neoplasms; Receptors, Androgen; RNA, Small Interfering; Trans-Activators; Transfection | 2004 |
Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation.
Topics: Androstane-3,17-diol; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Profiling; Humans; Male; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Receptors, Androgen | 2004 |
Proteomic identification of 14-3-3 sigma as a common component of the androgen receptor and the epidermal growth factor receptor signaling pathways of the human prostate epithelial cell line M12.
Topics: 14-3-3 Proteins; Active Transport, Cell Nucleus; Amino Acid Sequence; Biomarkers, Tumor; Cell Line, Tumor; Dihydrotestosterone; Epidermal Growth Factor; ErbB Receptors; Exonucleases; Exoribonucleases; Humans; Male; Molecular Sequence Data; Neoplasm Proteins; Promoter Regions, Genetic; Prostatic Neoplasms; Proteome; Receptors, Androgen; Signal Transduction | 2004 |
Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol.
Topics: Adaptor Proteins, Signal Transducing; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Androstenediol; Androstenedione; Anilides; Animals; Breast Neoplasms; Carrier Proteins; Cell Division; Chlorocebus aethiops; COS Cells; Cyproterone Acetate; Dihydrotestosterone; Humans; Ligands; Macaca mulatta; Male; Mammary Tumor Virus, Mouse; Mice; Nerve Tissue Proteins; Nitriles; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, AMPA; Receptors, Androgen; Tosyl Compounds; Transcription, Genetic; Tumor Cells, Cultured | 2004 |
Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors.
Topics: Androgens; Animals; Cell Division; Cell Line, Transformed; Cell Survival; Dihydrotestosterone; Enzyme Inhibitors; Humans; Insulin-Like Growth Factor I; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Androgen; RNA, Messenger; Signal Transduction; Transcription, Genetic | 2004 |
Differential expression of integrin subunits in DU-145/AR prostate cancer cells.
Topics: Androgens; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Collagen Type I; Collagen Type IV; Dihydrotestosterone; DNA, Complementary; Extracellular Matrix; Fibronectins; Humans; Integrin alpha2; Integrin alpha5; Integrin alpha6; Integrin beta4; Kalinin; Laminin; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Protein Subunits; Receptors, Androgen; Transfection | 2004 |
A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes.
Topics: Animals; Blotting, Western; Cell Division; Cell Line, Tumor; Chromosome Aberrations; Dihydrotestosterone; DNA-Binding Proteins; Humans; Male; Mice; Mice, SCID; Middle Aged; Phenotype; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Telomerase | 2004 |
Testosterone, prostate cancer, and balding: is there a link?
Topics: Alopecia; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Testosterone | 2004 |
Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth.
Topics: Antineoplastic Agents; Benzothiazoles; Bone Morphogenetic Proteins; Calcitriol; Calcium Channel Agonists; Cell Line, Tumor; Cell Proliferation; Dactinomycin; Dihydrotestosterone; DNA, Complementary; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; Humans; Male; Membrane Proteins; Prostatic Neoplasms; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Thiazoles; Toluene; Vanadates | 2004 |
Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Androgens; Apoptosis; Clusterin; Deoxyguanosine; Dihydrotestosterone; DNA Damage; DNA, Complementary; Gene Expression; Glycoproteins; Humans; Hydrogen Peroxide; Lipid Peroxidation; Male; Molecular Chaperones; Neoplasms, Hormone-Dependent; Oxidative Stress; Prostatic Neoplasms; Transfection; Tumor Cells, Cultured | 2004 |
Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.
Topics: Activating Transcription Factor 1; Anilides; Animals; Cell Line, Tumor; Co-Repressor Proteins; Dihydrotestosterone; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; Nitriles; Phosphorylation; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; src-Family Kinases; Tosyl Compounds; Trans-Activators; Transcription Factors | 2004 |
Genes differentially expressed in prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Testosterone | 2004 |
MUC1 expression in human prostate cancer cell lines and primary tumors.
Topics: Blotting, Western; Cytokines; Dihydrotestosterone; Gene Expression Profiling; Humans; Immunohistochemistry; Male; Mucin-1; Neoplasm Staging; Prostatic Neoplasms; Tumor Cells, Cultured | 2005 |
Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth.
Topics: Amino Acid Motifs; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; COS Cells; Dihydrotestosterone; Gelsolin; Genes, Reporter; Histone Acetyltransferases; Humans; Ligands; Male; Microscopy, Fluorescence; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivators; Oncogene Proteins; Peptides; Plasmids; Prostatic Neoplasms; Protein Binding; Protein Structure, Tertiary; Receptors, Androgen; Time Factors; Transcription Factors; Transcriptional Activation; Transfection; Two-Hybrid System Techniques | 2005 |
Hormonal regulation of H19 gene expression in prostate epithelial cells.
Topics: Animals; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Dihydrotestosterone; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation, Neoplastic; In Situ Hybridization; Janus Kinase 2; Male; Milk Proteins; Prolactin; Prostate; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Wistar; RNA, Long Noncoding; RNA, Untranslated; Signal Transduction; STAT5 Transcription Factor; Stromal Cells; Trans-Activators | 2004 |
The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Aged; Aged, 80 and over; Androgen Antagonists; Androgens; Chromatography, Liquid; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Middle Aged; Prostate; Prostatic Neoplasms; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2004 |
Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells.
Topics: Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dehydroepiandrosterone; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogen Receptor beta; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Polymerase Chain Reaction; Prostate-Specific Antigen; Prostatic Neoplasms; Receptor, IGF Type 1; Receptors, Androgen; Testosterone; Testosterone Congeners | 2005 |
5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells.
Topics: Androgen Receptor Antagonists; Androgens; Anilides; Calcitriol; Cycloheximide; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Drug Interactions; Flutamide; Gene Expression Regulation, Enzymologic; Humans; Male; Nitriles; Prostatic Neoplasms; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Steroid Hydroxylases; Tosyl Compounds; Tumor Cells, Cultured; Vitamin D3 24-Hydroxylase | 2005 |
Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Dihydrotestosterone; Finasteride; Humans; Male; Phytotherapy; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Serenoa; Testosterone | 2005 |
Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells.
Topics: Androgens; Animals; Cell Line; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Dihydrotestosterone; DNA-Binding Proteins; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Growth Substances; Humans; Janus Kinase 2; Male; Mutation; Phenotype; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Retinoic Acid; RNA, Messenger; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrphostins | 2005 |
Bone morphogenetic protein-2 induces hypophosphorylation of Rb protein and repression of E2F in androgen-treated LNCaP human prostate cancer cells.
Topics: Androgens; Blotting, Northern; Blotting, Western; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase Inhibitor p21; Dihydrotestosterone; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Gentian Violet; Humans; Male; Phosphorylation; Prostatic Neoplasms; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Time Factors; Transcription Factors; Transforming Growth Factor beta; Up-Regulation | 2005 |
Androgen receptor activation by G(s) signaling in prostate cancer cells.
Topics: Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dihydrotestosterone; GTP-Binding Protein alpha Subunits, Gs; Humans; Isoproterenol; Male; Prostatic Neoplasms; Receptors, Adrenergic, beta-2; Receptors, Androgen; Signal Transduction | 2005 |
Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status.
Topics: Benzhydryl Compounds; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Estrogens, Non-Steroidal; Genes, Reporter; Humans; Luciferases; Male; Phenols; Prostatic Neoplasms; Radioligand Assay; Receptors, Androgen; Transfection | 2005 |
Additive antitumor effects of the epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib (Iressa), and the nonsteroidal antiandrogen, bicalutamide (Casodex), in prostate cancer cells in vitro.
Topics: Androgen Antagonists; Anilides; Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Male; Nitriles; Prostatic Neoplasms; Quinazolines; Tosyl Compounds; Transplantation, Heterologous | 2005 |
RE: Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Apoptosis; Azasteroids; Biomarkers, Tumor; Dihydrotestosterone; Dutasteride; Finasteride; Humans; Male; Prostatic Neoplasms; Testosterone | 2005 |
The Estradiol-Dihydrotestosterone model of prostate cancer.
Topics: Animals; Dihydrotestosterone; Estradiol; Female; Humans; Male; Mice; Models, Biological; Prostatic Neoplasms | 2005 |
Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer.
Topics: Acetylation; Androgen Receptor Antagonists; Androgens; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; Dihydrotestosterone; ErbB Receptors; Gefitinib; Histones; Humans; Immunoglobulin Fragments; Lapatinib; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Quinazolines; Receptor, ErbB-2; Receptors, Androgen; Response Elements; Transcription, Genetic | 2005 |
The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype.
Topics: Anabolic Agents; Androstane-3,17-diol; Cadherins; Cell Line, Tumor; Cell Migration Inhibition; Cell Movement; Dihydrotestosterone; Estrogen Receptor beta; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Transfection | 2005 |
Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor.
Topics: Androgens; Cell Death; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; HSP90 Heat-Shock Proteins; Humans; Lactones; Macrolides; Male; Molecular Chaperones; Prostatic Neoplasms; Protein Kinase Inhibitors; Radiation Tolerance; Radiation-Sensitizing Agents; Receptors, Androgen | 2005 |
Clinical trials point to complexities of chemoprevention for cancer.
Topics: Aspirin; Breast Neoplasms; Clinical Trials as Topic; Diet; Dihydrotestosterone; Female; Finasteride; Humans; Male; Neoplasms; Prostatic Neoplasms; Selective Estrogen Receptor Modulators; Tamoxifen; Vitamin E | 2005 |
Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer.
Topics: Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dihydrotestosterone; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prostatic Neoplasms; Radioimmunoassay; Spectrometry, Mass, Electrospray Ionization; Survival Analysis; Testosterone | 2005 |
The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aged; Alanine; Alleles; Arginine; Biomarkers, Tumor; Case-Control Studies; Dihydrotestosterone; Disease Progression; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Glutamine; Humans; Leucine; Luteinizing Hormone; Male; Middle Aged; Point Mutation; Polymorphism, Genetic; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Risk Factors; Sex Hormone-Binding Globulin; Sweden; Terminal Repeat Sequences; Testosterone; Threonine; Valine | 2005 |
Effects of 2,4-D and DCP on the DHT-induced androgenic action in human prostate cancer cells.
Topics: 2,4-Dichlorophenoxyacetic Acid; Androgens; Cell Line, Tumor; Cell Proliferation; Chlorophenols; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Transcriptional Activation | 2005 |
Effect of increasing ratio of estrogen: androgen on proliferation of normal human prostate stromal and epithelial cells, and the malignant cell line LNCaP.
Topics: Cell Division; Cell Line, Tumor; Dihydrotestosterone; DNA Primers; Epithelial Cells; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Male; Polymerase Chain Reaction; Prostate; Prostatic Neoplasms; Receptors, Androgen; Stromal Cells | 2006 |
Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.
Topics: Activins; Animals; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Chlorocebus aethiops; COS Cells; Dihydrotestosterone; Dose-Response Relationship, Drug; Forkhead Transcription Factors; Green Fluorescent Proteins; Humans; Image Processing, Computer-Assisted; Immunoprecipitation; Inhibin-beta Subunits; Ligands; Male; Microscopy, Confocal; Plasmids; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Smad2 Protein; Smad4 Protein; Transcriptional Activation; Transfection; Two-Hybrid System Techniques | 2005 |
Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation.
Topics: Androgen Antagonists; Androgens; Animals; Arsenic; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Dihydrotestosterone; Epidermal Growth Factor; Epithelial Cells; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Flutamide; Gene Expression Regulation; Humans; Male; Mice; Pituitary Gland; Prostate; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger | 2005 |
Androgen receptor-dependent PSA expression in androgen-independent prostate cancer cells does not involve androgen receptor occupancy of the PSA locus.
Topics: Cell Line, Tumor; Chromatin Immunoprecipitation; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Kinases; Protein Serine-Threonine Kinases; Receptors, Androgen; RNA, Messenger; Transfection | 2005 |
Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways.
Topics: Androgens; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dihydrotestosterone; Endoribonucleases; Enzyme Activation; Female; Gene Expression; Genes, Reporter; Humans; Interferon-gamma; Interferons; Ligands; Male; Models, Biological; Mutation; Prostatic Neoplasms; Receptor Cross-Talk; Receptors, Androgen; Recombinant Proteins; Signal Transduction | 2005 |
Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells.
Topics: Acid Phosphatase; Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cell Proliferation; Clone Cells; Dihydrotestosterone; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Male; Phosphorylation; Prostatic Neoplasms; Protein Isoforms; Protein Tyrosine Phosphatases; RNA Interference; S Phase; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Up-Regulation | 2005 |
Overexpression of PKCepsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1.
Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Immunoblotting; Macrolides; Male; Phosphorylation; Prostatic Neoplasms; Protein Kinase C-epsilon; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Transfection | 2006 |
Reductase activity of 17beta-hydroxysteroid oxidoreductase in prostatic tumors of different histological structure.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Biopsy; Dihydrotestosterone; Humans; Male; Prostatic Hyperplasia; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Testosterone | 2005 |
Androgen receptor and TGFbeta1/Smad signaling are mutually inhibitory in prostate cancer.
Topics: Apoptosis; Dihydrotestosterone; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured; Up-Regulation | 2005 |
The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androgen Receptor Antagonists; Apoptosis Regulatory Proteins; Binding, Competitive; Cell Growth Processes; CSK Tyrosine-Protein Kinase; Dihydrotestosterone; Epithelium; Genes, Tumor Suppressor; Humans; Male; Phosphotransferases; Prostate; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Androgen; RNA Interference; Signal Transduction; src-Family Kinases; Transfection; Tumor Suppressor Proteins | 2005 |
Phenotypic characterization of telomerase-immortalized primary non-malignant and malignant tumor-derived human prostate epithelial cell lines.
Topics: Adult; Aged; Animals; Cell Aggregation; Cell Proliferation; Chromosomes, Human; Cytogenetic Analysis; Dihydrotestosterone; DNA-Binding Proteins; Gene Expression Profiling; Humans; Immunohistochemistry; Male; Mice; Mice, SCID; Middle Aged; Neoplasm Transplantation; Neoplasms, Experimental; Phenotype; Prostatic Neoplasms; Racemases and Epimerases; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Telomerase; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2006 |
Androgen receptor activity is inhibited in response to genotoxic agents in a p53-independent manner.
Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Chromatin Immunoprecipitation; Cisplatin; Dihydrotestosterone; Etoposide; Humans; Ligands; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Subcellular Fractions; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2006 |
Peroxisome proliferator-activated receptor gamma-independent repression of prostate-specific antigen expression by thiazolidinediones in prostate cancer cells.
Topics: Animals; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Pioglitazone; PPAR gamma; Prostate-Specific Antigen; Prostatic Neoplasms; Thiazolidinediones; Transfection | 2006 |
Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells.
Topics: Breast Neoplasms; Dihydrotestosterone; Enzyme Activation; Enzyme Induction; Estradiol; Female; Humans; Hydrolysis; Male; Membrane Glycoproteins; Prostatic Neoplasms; Proteinase Inhibitory Proteins, Secretory; Serine Endopeptidases; Tumor Cells, Cultured | 2006 |
Renin-angiotensin system is an important factor in hormone refractory prostate cancer.
Topics: Androgen Antagonists; Angiotensin I; Angiotensin II; Antineoplastic Agents, Hormonal; Blotting, Western; Cell Line, Tumor; Dexamethasone; Dihydrotestosterone; Drug Resistance, Neoplasm; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Male; Peptidyl-Dipeptidase A; Prostate; Prostatic Neoplasms; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Induction of neutral endopeptidase activity in PC-3 cells by an aqueous extract of Epilobium angustifolium L. and oenothein B.
Topics: Cell Line, Tumor; Cell Proliferation; Cytarabine; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Epilobium; Humans; Hydrolyzable Tannins; Male; Medicine, Traditional; Neprilysin; Peptidyl-Dipeptidase A; Phytotherapy; Plant Extracts; Prostatic Neoplasms; Water | 2006 |
Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.
Topics: Androgens; Cell Line; Cell Line, Tumor; Dihydrotestosterone; Disease Progression; DNA, Complementary; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Snail Family Transcription Factors; Sterol Regulatory Element Binding Protein 2; Sterol Regulatory Element Binding Proteins; Transcription Factors; Transfection | 2006 |
[Effect of dihydrotestosterone on the transcriptions and expressions of Smad3 and Smad4 in LNCaP cell line].
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; Flutamide; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad4 Protein; Transcription, Genetic | 2006 |
Comparison of prostate cancer cell lines for androgen receptor-mediated reporter gene assays.
Topics: Androgen Antagonists; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dexamethasone; Dihydrotestosterone; Dose-Response Relationship, Drug; Fungicides, Industrial; Gene Expression; Humans; Immunoblotting; Insecticides; Luciferases; Male; Oxazoles; Prostatic Neoplasms; Pyrethrins; Receptors, Androgen; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation | 2006 |
Androgen-dependent regulation of Her-2/neu in prostate cancer cells.
Topics: Androgen Receptor Antagonists; Androgens; Animals; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Mice; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Receptor, ErbB-2; Receptors, Androgen; RNA, Messenger; RNA, Small Interfering; Transfection | 2006 |
Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells.
Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Leuprolide; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Time Factors; Tyrphostins | 2006 |
Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Administration, Oral; Animals; Azasteroids; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Dihydrotestosterone; Disease Models, Animal; Dutasteride; Enzyme Activation; Enzyme Inhibitors; Finasteride; Gene Expression Profiling; Humans; Male; Mass Spectrometry; Mice; Mice, Nude; Molecular Conformation; Prostatic Neoplasms; Protein Isoforms; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2006 |
Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins.
Topics: AMP-Activated Protein Kinases; Cell Growth Processes; Cell Line, Tumor; Cyclin D; Cyclins; Dihydrotestosterone; Enzyme Activation; Humans; Male; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Ribosomal Protein S6 Kinases; RNA, Messenger; TOR Serine-Threonine Kinases | 2006 |
Hormonal control of androgen receptor function through SIRT1.
Topics: Acetylation; Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Line; Cell Proliferation; Dihydrotestosterone; Gene Expression Regulation; Genes, Reporter; Histone Acetyltransferases; Humans; Lysine; Male; Models, Molecular; Molecular Sequence Data; p300-CBP Transcription Factors; Peptides; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Sirtuin 1; Sirtuins; Transcription Factors; Transcription, Genetic | 2006 |
Reduced isoflavone metabolites formed by the human gut microflora suppress growth but do not affect DNA integrity of human prostate cancer cells.
Topics: Androgens; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Comet Assay; Dihydrotestosterone; DNA Damage; DNA, Neoplasm; Estradiol; Genistein; Humans; Intestines; Isoflavones; Male; Phytoestrogens; Prostatic Neoplasms | 2006 |
Increased expression of the metastasis-associated gene Ehm2 in prostate cancer.
Topics: Adenocarcinoma; Cell Adhesion; Cell Line, Transformed; Cell Line, Tumor; Cytoskeletal Proteins; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Lymphatic Metastasis; Male; Neoplasm Recurrence, Local; Prostate; Prostatectomy; Prostatic Neoplasms; Receptor, Fibroblast Growth Factor, Type 4; Reverse Transcriptase Polymerase Chain Reaction; Tissue Array Analysis; Up-Regulation | 2006 |
Prohibitin and cofilin are intracellular effectors of transforming growth factor beta signaling in human prostate cancer cells.
Topics: Cell Line, Tumor; Cell Survival; Cofilin 1; Cytochromes c; Dihydrotestosterone; Humans; Hydrogen-Ion Concentration; Male; Prohibitins; Prostatic Neoplasms; Proteome; Repressor Proteins; Signal Transduction; Transforming Growth Factor beta | 2006 |
Association between the dihydrotestosterone level in the prostate and prostate cancer aggressiveness using the Gleason score.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Dihydrotestosterone; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone Congeners | 2006 |
Androgen regulation of soluble guanylyl cyclasealpha1 mediates prostate cancer cell proliferation.
Topics: Base Sequence; Cell Line, Tumor; Cell Proliferation; Cyclic GMP; Dihydrotestosterone; DNA Primers; Guanylate Cyclase; Humans; Male; Nitric Oxide; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Soluble Guanylyl Cyclase | 2007 |
Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells.
Topics: Acetylation; Androgens; Animals; Chromatin; Chromatin Assembly and Disassembly; Dihydrotestosterone; Genes, Reporter; Histones; Humans; Ligands; Luciferases; Male; Methylation; Mice; Mice, Nude; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Response Elements; Transcription, Genetic; Tumor Cells, Cultured | 2006 |
Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Dihydrotestosterone; Drug Resistance, Neoplasm; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Male; Methotrexate; Multidrug Resistance-Associated Proteins; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2007 |
Regulation of androgen receptor activity by tyrosine phosphorylation.
Topics: Androgens; Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Dihydrotestosterone; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Indoles; Interleukin-6; Kinetics; Male; Mice; Mice, SCID; Neuregulin-1; Phosphorylation; Prostatic Neoplasms; Pyrimidines; Receptors, Androgen; src-Family Kinases; Sulfonamides; Tyrosine; Xenograft Model Antitumor Assays | 2006 |
Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells.
Topics: Androgen Antagonists; Androgens; Cadmium; Cell Line, Transformed; Cell Proliferation; Cell Transformation, Neoplastic; Dihydrotestosterone; Disease Progression; Epithelial Cells; Estradiol; Estrogens; Flutamide; Gene Expression Regulation; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; RNA, Messenger; Signal Transduction | 2007 |
Effect of hypoxia on the uptake of [methyl-3H]choline, [1-14C] acetate and [18F]FDG in cultured prostate cancer cells.
Topics: Acetates; Adenosine Triphosphate; Carbon Radioisotopes; Cell Count; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Choline; Dihydrotestosterone; Fluorodeoxyglucose F18; Humans; Male; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Tritium | 2006 |
Prosaposin is a novel androgen-regulated gene in prostate cancer cell line LNCaP.
Topics: Androgens; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Interleukin-6; Luciferases; Male; Plasmids; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Saposins; Signal Transduction; Transfection | 2007 |
Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; COS Cells; Dihydrotestosterone; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin; Insulin-Like Growth Factor I; Male; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; PTEN Phosphohydrolase; Receptors, Androgen; Repressor Proteins; Signal Transduction; Transcriptional Activation | 2007 |
By modulating androgen receptor coactivators, daidzein may act as a phytoandrogen.
Topics: Cell Line, Tumor; Dihydrotestosterone; Estradiol; Humans; Intracellular Signaling Peptides and Proteins; Isoflavones; LIM Domain Proteins; Male; Nuclear Receptor Coactivators; Oncogene Proteins; Phytoestrogens; Prostatic Neoplasms; Receptors, Androgen; Transcription Factors; Transcription, Genetic; Transfection | 2007 |
Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling.
Topics: 20-Hydroxysteroid Dehydrogenases; Aged; Androgen Receptor Antagonists; Dihydrotestosterone; Humans; Hydroxysteroid Dehydrogenases; Male; Middle Aged; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction | 2007 |
Expression of human AR cDNA driven by its own promoter results in mild promotion, but not suppression, of growth in human prostate cancer PC-3 cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; DNA, Complementary; Humans; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transfection | 2007 |
Effects of dietary saw palmetto on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP).
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adenocarcinoma; Androgen Antagonists; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diet; Dihydrotestosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Size; Plant Extracts; Prostate; Prostatic Neoplasms; Serenoa; Testosterone | 2007 |
Non-steroidal antiandrogens act as AF-1 agonists under conditions of high androgen-receptor expression.
Topics: Androgens; Anilides; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Flutamide; HeLa Cells; Humans; Male; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Receptors, Interferon; Tosyl Compounds; Transcriptional Activation | 2007 |
Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells.
Topics: ADAM Proteins; Androgen Antagonists; Androgens; Anilides; Catalase; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Male; Membrane Proteins; Nitriles; Prostatic Neoplasms; Reactive Oxygen Species; Receptors, Androgen; Serum; Signal Transduction; Tosyl Compounds; Transfection | 2007 |
Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adrenal Glands; Androgens; Cell Line, Tumor; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Humans; Male; Neoplasms, Hormone-Dependent; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells.
Topics: Adenoviridae; Androgen Receptor Antagonists; Androgens; Animals; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Down-Regulation; Gene Expression Regulation; Male; Mice; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation; Xenograft Model Antitumor Assays | 2007 |
Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia.
Topics: Adult; Aged; Androgens; Anilides; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Dihydrotestosterone; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Aged; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Repressor Proteins; Signal Transduction; Tosyl Compounds; Vascular Endothelial Growth Factor A | 2007 |
Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells.
Topics: Androgens; Base Sequence; Cell Line, Tumor; Cholecalciferol; Cholestanetriol 26-Monooxygenase; Dihydrotestosterone; Estrogens; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Data; Prostatic Neoplasms; Receptors, Androgen | 2007 |
Dihydrotestosterone levels and survival in screening-detected prostate cancer: a 15-yr follow-up study.
Topics: Aged; Biomarkers, Tumor; Dihydrotestosterone; Follow-Up Studies; Humans; Male; Mass Screening; Middle Aged; Prostatic Neoplasms; Radioimmunoassay; Risk Factors; Survival Rate; Sweden; Time Factors | 2008 |
ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
Topics: Androgens; Cell Line, Tumor; Dihydrotestosterone; DNA-Binding Proteins; Humans; Male; Neoplasm Invasiveness; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transcription Factors | 2007 |
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP.
Topics: Aldehyde Dehydrogenase; Androgens; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Estradiol; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Male; Metribolone; Prostatic Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Retinaldehyde; Retinoic Acid 4-Hydroxylase; RNA, Messenger; RNA, Small Interfering; src-Family Kinases; Tretinoin | 2007 |
Identification of novel androgen receptor target genes in prostate cancer.
Topics: Adenocarcinoma; Androgens; Binding Sites; Cell Adhesion Molecules; Cell Line, Tumor; Chromosomes, Human; delta-1-Pyrroline-5-Carboxylate Reductase; Dihydrotestosterone; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Intracellular Signaling Peptides and Proteins; Male; Mucin-6; Mucins; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Ornithine-Oxo-Acid Transaminase; Prostatic Neoplasms; Protein Kinase C-delta; Pyrroline Carboxylate Reductases; Receptors, Androgen; Transcription, Genetic; TRPV Cation Channels | 2007 |
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide.
Topics: Androgen Antagonists; Androgens; Anilides; Base Pair Mismatch; Base Pairing; Base Sequence; Cell Line, Tumor; Dihydrotestosterone; DNA; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Data; Nitriles; Nylons; Phthalic Acids; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Response Elements; RNA, Messenger; Tosyl Compounds | 2007 |
Androgen-induced Wnt signaling in preosteoblasts promotes the growth of MDA-PCa-2b human prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Dihydrotestosterone; Fluorescent Antibody Technique; Humans; Immunoblotting; Male; Neoplasm Invasiveness; Osteoblasts; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transfection; Wnt Proteins | 2007 |
Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.
Topics: Amino Acid Motifs; Androgens; Animals; Antigens, Neoplasm; Binding Sites; Crystallography, X-Ray; Dihydrotestosterone; Genitalia, Male; Haplorhini; HeLa Cells; Humans; Hydrogen Bonding; Male; Mutation; Neoplasm Proteins; Peptides; Prostatic Neoplasms; Protein Binding; Protein Structure, Tertiary; Receptors, Androgen; Testosterone | 2007 |
In vitro and in vivo effects of bicalutamide on the expression of TrkA and P75 neurotrophin receptors in prostate carcinoma.
Topics: Adult; Aged; Androgen Antagonists; Anilides; Antineoplastic Agents; Blotting, Western; Carbazoles; Carcinoma; Cell Line, Tumor; Cohort Studies; Dihydrotestosterone; Furans; Humans; Immunohistochemistry; Indoles; Male; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Protein Kinase Inhibitors; Receptor, Nerve Growth Factor; Receptor, trkA; Receptor, trkC; Tosyl Compounds | 2007 |
The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms.
Topics: Androgens; Biological Transport; Cell Division; Cell Line, Tumor; Cell Nucleus; Cyclophilins; Cyclosporine; Dihydrotestosterone; Humans; Immunophilins; Ligands; Male; Nuclear Proteins; Peptidyl-Prolyl Isomerase F; Phosphoprotein Phosphatases; Prostatic Neoplasms; Receptors, Androgen; Tacrolimus; Tacrolimus Binding Proteins; Transcription, Genetic | 2007 |
A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells.
Topics: Androgen Receptor Antagonists; Androgens; Anilides; Antineoplastic Agents; Cell Proliferation; Dihydrotestosterone; Drug Resistance, Neoplasm; Drug Synergism; Flutamide; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Imidazolidines; Male; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tosyl Compounds; Transcription, Genetic | 2007 |
Androgen receptor-mediated repression of novel target genes.
Topics: Androgen Antagonists; Anilides; Cell Line, Tumor; Cycloheximide; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Nitriles; Prostatic Neoplasms; Protein Synthesis Inhibitors; Receptor, Muscarinic M1; Receptors, Androgen; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tosyl Compounds; Transfection | 2007 |
The change in the dihydrotestosterone level in the prostate before and after androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score.
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Biomarkers, Tumor; Dihydrotestosterone; Disease Progression; Flutamide; Goserelin; Humans; Leuprolide; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Orchiectomy; Prognosis; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 2007 |
Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androgen-Binding Protein; Animals; Antigens, Viral, Tumor; Apoptosis; Azasteroids; Cell Division; Cell Transformation, Neoplastic; Dihydrotestosterone; Disease Models, Animal; Dutasteride; Enzyme Inhibitors; Female; Male; Membrane Proteins; Mice; Mice, Transgenic; Neoplasms, Hormone-Dependent; Orchiectomy; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Seminal Vesicles; Transgenes | 2007 |
Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA.
Topics: Androgens; Cells, Cultured; Coat Protein Complex I; Coatomer Protein; Dihydrotestosterone; HeLa Cells; Humans; Male; Models, Biological; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Tissue Distribution; Ubiquitin-Protein Ligases; Ubiquitination | 2008 |
Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.
Topics: ADAM Proteins; ADAM10 Protein; Aged; Aged, 80 and over; Amyloid Precursor Protein Secretases; Biopsy; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Dihydrotestosterone; Disease Progression; DNA Primers; Humans; Immunohistochemistry; Male; Membrane Proteins; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering | 2007 |
Androgen receptor regulation of the versican gene through an androgen response element in the proximal promoter.
Topics: Base Sequence; Cell Line, Tumor; Dihydrotestosterone; HeLa Cells; Humans; Luciferases; Male; Metribolone; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Recombinant Proteins; Response Elements; RNA Interference; Transcriptional Activation; Versicans | 2007 |
Androgen receptor-dependent and -independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells.
Topics: Annexin A5; Apoptosis; Caspase 3; Caspase 8; Cell Proliferation; Cyclin D; Cyclins; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasms, Hormone-Dependent; Plant Extracts; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Receptors, Androgen; Reishi; Tumor Cells, Cultured | 2007 |
Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells.
Topics: Adenocarcinoma; Androgens; Catalysis; Cell Line, Tumor; Cell Survival; Cystathionine beta-Synthase; Dihydrotestosterone; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glutathione; Homocysteine; Humans; Luciferases; Male; Oxidation-Reduction; Oxidative Stress; Prostatic Neoplasms; Protein Processing, Post-Translational; Sulfur; Temperature | 2007 |
17alpha-estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals.
Topics: Animals; Blotting, Western; Cell Growth Processes; Cell Line, Tumor; Cyclin A; Cyclin D1; Dihydrotestosterone; Estradiol; Gene Expression; Humans; Male; Mice; Mice, SCID; Neoplasms, Hormone-Dependent; Prostate-Specific Antigen; Prostatic Neoplasms; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stereoisomerism; Xenograft Model Antitumor Assays | 2007 |
Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription, Genetic; Transfection | 2007 |
An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer.
Topics: Androgens; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cytosol; Dihydrotestosterone; Humans; Male; Mice; Mice, SCID; Neoplasm Transplantation; Prostatic Neoplasms; Receptor, IGF Type 1; Receptors, Androgen; Signal Transduction; Testosterone | 2007 |
Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Cell Growth Processes; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; RNA, Small Interfering; Testosterone; Transfection | 2008 |
Autophagy protects LNCaP cells under androgen deprivation conditions.
Topics: Androgens; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Shape; Cell Survival; Culture Media, Serum-Free; Dihydrotestosterone; Humans; Male; Membrane Proteins; Microtubule-Associated Proteins; Phagosomes; Prostatic Neoplasms; Recombinant Fusion Proteins; RNA, Small Interfering; Tumor Cells, Cultured | 2008 |
Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status.
Topics: Adenocarcinoma; Benzhydryl Compounds; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Estrogen Receptor beta; Estrogens, Non-Steroidal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Mutation; Oligonucleotide Array Sequence Analysis; Phenols; Prostatic Neoplasms; Receptors, Androgen | 2007 |
Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.
Topics: Androgens; Animals; Cell Line, Tumor; Dihydrotestosterone; DNA Adducts; DNA Damage; Flutamide; Humans; Male; Mice; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Reactive Oxygen Species | 2008 |
Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Kaplan-Meier Estimate; Male; Membrane Proteins; Middle Aged; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Tosyl Compounds | 2008 |
TGF-beta signaling and androgen receptor status determine apoptotic cross-talk in human prostate cancer cells.
Topics: Androgen-Binding Protein; Apoptosis; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; Drug Synergism; Humans; Luciferases; Male; Microscopy, Fluorescence; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Androgen; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad4 Protein; Transcriptional Activation; Transfection; Transforming Growth Factor beta | 2008 |
Androgen receptor regulates CD168 expression and signaling in prostate cancer.
Topics: Animals; Bone Marrow Cells; Cell Line, Tumor; Dihydrotestosterone; Extracellular Matrix Proteins; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Male; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction | 2008 |
Getting over testosterone: postulating a fresh start for etiologic studies of prostate cancer.
Topics: Androgens; Androstenediols; Androstenedione; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Glucuronides; Gonadal Steroid Hormones; Humans; Male; Meta-Analysis as Topic; Prostatic Neoplasms; Research Design; Risk Factors; Testosterone | 2008 |
Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.
Topics: Androgen Receptor Antagonists; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Gene Expression; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Humans; Male; Minor Histocompatibility Antigens; Neoplasms, Hormone-Dependent; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; RNA Interference | 2008 |
5alpha-androstane-3alpha,17beta-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: implication of androgen-independent prostate cancer progression.
Topics: Androstane-3,17-diol; Apoptosis; beta Catenin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytoplasm; Dihydrotestosterone; Disease Progression; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Male; Models, Biological; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Time Factors | 2008 |
Steroid 5-alpha reductase type 2 activity in biopsies from malignant and normal prostatic tissues.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aged; Aged, 80 and over; Biopsy; Dihydrotestosterone; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 2008 |
[Time-course of plasma testosterone in patients with prostate cancer treated by endocrine therapy].
Topics: Androgen Antagonists; Dihydrotestosterone; Humans; Kinetics; Male; Orchiectomy; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone | 2008 |
Overexpression of JKTBP1 induces androgen-independent LNCaP cell proliferation through activation of epidermal growth factor-receptor (EGF-R).
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Enzyme Activation; ErbB Receptors; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Ribonucleoproteins | 2008 |
Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor.
Topics: Androgens; Apoptosis; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Estradiol; Flavonoids; Humans; Insulin-Like Growth Factor I; Lythraceae; Male; Phenols; Plant Extracts; Polymerase Chain Reaction; Polyphenols; Prostatic Neoplasms; Receptors, Androgen | 2008 |
Prosaposin is an AR-target gene and its neurotrophic domain upregulates AR expression and activity in prostate stromal cells.
Topics: Androgens; Animals; Bone and Bones; Cell Line; Cell Nucleus; Culture Media, Conditioned; Dihydrotestosterone; Fibroblasts; Humans; Male; Mice; Nerve Growth Factors; Phosphotyrosine; Prostate; Prostatic Neoplasms; Protein Structure, Tertiary; Receptors, Androgen; Response Elements; Saposins; Serum; Stromal Cells; Transcription, Genetic; Up-Regulation | 2008 |
Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.
Topics: Antioxidants; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation, Neoplastic; Humans; Male; Masoprocol; Phosphorylation; Prostatic Neoplasms; Protein Conformation; Receptor, IGF Type 1; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Characterization of androgen regulation of ZEB-1 and PSA in 22RV1 prostate cancer cells.
Topics: Androgen Antagonists; Dihydrotestosterone; Flutamide; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Tumor Cells, Cultured; Zinc Finger E-box-Binding Homeobox 1 | 2008 |
Valproic acid activity in androgen-sensitive and -insensitive human prostate cancer cells.
Topics: Blotting, Western; Cadherins; Cell Proliferation; Dihydrotestosterone; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Immunoblotting; Male; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured; Valproic Acid | 2008 |
Endocrine dependence of prostatic cancer upon dihydrotestosterone and not upon testosterone.
Topics: Adenocarcinoma; Animals; Cells, Cultured; Dihydrotestosterone; Male; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Progesterone; Prostatic Neoplasms; Rats; Testosterone | 1984 |
Measurements of prolactin and androgens in patients with prostatic diseases.
Topics: Adult; Aged; Antineoplastic Agents; Castration; Dihydrotestosterone; Estradiol Congeners; Female; Humans; Male; Middle Aged; Prolactin; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1980 |
Methodologic basis for the radioimmunoassay of endogenous steroids in human prostatic tissue.
Topics: Adenocarcinoma; Adult; Aged; Dihydrotestosterone; Estradiol; Estrone; Humans; Male; Middle Aged; Progesterone; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Radioimmunoassay; Steroids; Testosterone | 1980 |
Correlation between clinical response to antiandrogenic therapy and occurrence of receptors in human prostatic cancer.
Topics: Aged; Androgen Antagonists; Cyproterone; Dihydrotestosterone; Estradiol; Humans; Hydrocortisone; Male; Middle Aged; Progesterone; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Steroid | 1980 |
Evaluation of androgen metabolism studies in human prostate cancer--correlation with zinc levels.
Topics: Aged; Androgens; Androstenedione; Carcinoma; Dihydrotestosterone; Humans; Male; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Zinc | 1980 |
Dihydrotestosterone receptors in the human prostate. I. Nuclear concentration in normal, benign, and malignant tissues.
Topics: Binding, Competitive; Cell Nucleus; Chromatography; Dihydrotestosterone; Histological Techniques; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Temperature; Time Factors | 1980 |
Altered androgen metabolism in carcinoma of the prostate.
Topics: Androstenediols; Androstenedione; Culture Techniques; Dihydrotestosterone; Male; Oxidation-Reduction; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1981 |
Relationships between oestradiol-17 beta, testosterone, dihydrotestosterone and 5 alpha-androstane-3 alpha, 27 beta-diol in human benign hypertrophy and carcinoma of the prostate.
Topics: Adult; Aged; Androgens; Androstane-3,17-diol; Dihydrotestosterone; Estradiol; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1981 |
Interaction of prolactin and testosterone in the human prostate.
Topics: Dihydrotestosterone; Humans; Male; Prolactin; Prostatic Hyperplasia; Prostatic Neoplasms; Stimulation, Chemical; Testosterone; Thyrotropin-Releasing Hormone | 1981 |
The effect of therapy on the concentration and occupancy of androgen receptors in human prostatic cytosol.
Topics: Castration; Cytosol; Dihydrotestosterone; DNA; Estrogens; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Testosterone | 1980 |
Binding of dihydrotestosterone, R 1881 and R 5020 in cytosols from normal, benign hypertrophic and cancerous human prostates.
Topics: Cytosol; Dihydrotestosterone; Estrenes; Humans; In Vitro Techniques; Male; Metribolone; Norpregnadienes; Promegestone; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone Congeners | 1981 |
Testosterone metabolism of fibroblasts grown from prostatic carcinoma, benign prostatic hyperplasia and skin fibroblasts.
Topics: Androstanes; Androsterone; Carcinoma; Cells, Cultured; Chromatography, Thin Layer; Dihydrotestosterone; Fibroblasts; Humans; In Vitro Techniques; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Skin; Stereoisomerism; Testosterone; Tritium | 1982 |
Partial characterization of stromal and epithelial forms of 5 alpha-reductase in human prostate.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adolescent; Adult; Aged; Dihydrotestosterone; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; NADP; Oxidoreductases; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1981 |
Polyamines and prostatic function.
Topics: Adult; Aged; Castration; Cyclic AMP; Dihydrotestosterone; Humans; Male; Middle Aged; Ornithine Decarboxylase; Polyamines; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Protein Kinases; Seminal Vesicles | 1981 |
Responses of serum levels of testicular steroid hormones to hCG stimulation in patients with prostatic cancer and benign prostatic hypertrophy.
Topics: Aged; Androsterone; Chorionic Gonadotropin; Dihydrotestosterone; Estradiol; Humans; Male; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms; Testicular Hormones; Testosterone | 1981 |
Androphilic proteins in the human prostate.
Topics: Androgen-Binding Protein; Carrier Proteins; Cell Nucleus; Cytosol; Dihydrotestosterone; Estrenes; Humans; Male; Metribolone; Promegestone; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms | 1981 |
Studies of the cytosol 3 alpha-hydroxysteroid dehydrogenase of human prostatic tissue: comparison of enzyme activities in hyperplastic, malignant and normal tissues.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Adult; Androstanols; Cytosol; Dihydrotestosterone; Humans; Hydrogen-Ion Concentration; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Subcellular Fractions | 1982 |
Measurement of androgen receptor in cytosols from normal, benign hypertrophic and cancerous human prostates.
Topics: Cytosol; Dihydrotestosterone; Estrenes; Humans; Kinetics; Male; Metribolone; Molybdenum; Progesterone Congeners; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Triamcinolone Acetonide | 1981 |
[Endogenous androgen levels of human prostatic tissues].
Topics: Aged; Androgens; Androsterone; Dihydrotestosterone; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Radioimmunoassay; Testosterone | 1982 |
Plasma steroids in benign prostatic hypertrophy and carcinoma of the prostate.
Topics: 17-alpha-Hydroxyprogesterone; Age Factors; Aged; Dihydrotestosterone; Estradiol; Estrone; Humans; Hydrocortisone; Hydroxyprogesterones; Male; Middle Aged; Progesterone; Prostatic Hyperplasia; Prostatic Neoplasms; Reference Values; Testosterone | 1982 |
Nuclear androgen receptors of human prostatic tissue--a quantitative histological study.
Topics: Adenocarcinoma; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid | 1983 |
[Comparison of natural and synthetic ligands for determining androgen receptors in prostatic tumors and prostatic nodular hyperplasia].
Topics: Dihydrotestosterone; Estrenes; Humans; Male; Metribolone; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Testosterone Congeners | 1983 |
Circulating unconjugated 5 alpha-androstane-3 alpha, 17 beta-diol in elderly men and patients with prostatic tumours.
Topics: Aged; Androstane-3,17-diol; Androstanols; Dihydrotestosterone; Humans; Male; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms | 1983 |
Studies of the nuclear 5 alpha-reductase of human prostatic tissue: comparison of enzyme activities in hyperplastic, malignant, and normal tissues.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Acid Phosphatase; Dihydrotestosterone; Humans; Male; NADP; Oxidoreductases; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Tissue Distribution | 1983 |
Subcellular distribution of zinc in the benign and malignant human prostate: evidence for a direct zinc androgen interaction.
Topics: Cell Nucleus; Cytosol; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Subcellular Fractions; Testosterone; Zinc | 1984 |
Comparison of various hormonal therapies for prostatic carcinoma.
Topics: Androgen Antagonists; Androgens; Antineoplastic Combined Chemotherapy Protocols; Binding, Competitive; Castration; Dihydrotestosterone; Estradiol; Humans; Male; Megestrol; Megestrol Acetate; Palliative Care; Prolactin; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 1983 |
Correlation of estrogen and androgen receptor status in prostatic disease measured by high pressure liquid chromatography.
Topics: Adenocarcinoma; Chromatography, High Pressure Liquid; Dihydrotestosterone; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Steroid | 1984 |
Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Cortisone; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Middle Aged; Prostatic Neoplasms; Sleep Stages; Testosterone | 1984 |
[Dosage of hormonal receptors for DHT in programming therapy for prostatic cancer].
Topics: Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Cell Surface | 1980 |
Uptake and retention of androgens by the rat ventral prostate and consideration of their use as site directing agents.
Topics: Androgens; Animals; Castration; Dihydrotestosterone; Estradiol; Male; Organ Specificity; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Testosterone; Time Factors | 1982 |
Exchange assay for androgen receptors in the presence of molybdate.
Topics: Animals; Binding, Competitive; Castration; Cytosol; Dihydrotestosterone; Estrenes; Kinetics; Male; Metribolone; Molybdenum; Prostatic Neoplasms; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Steroid; Testosterone; Testosterone Congeners; Tissue Distribution; Tritium | 1984 |
Suppression of testicular steroidogenesis by the GnRH agonistic analogue Buserelin (HOE-766) in patients with prostatic cancer: studies in relation to dose and route of administration.
Topics: Aged; Androgens; Buserelin; Dihydrotestosterone; Gonadotropin-Releasing Hormone; Hormones; Humans; Luteinizing Hormone; Male; Middle Aged; Prostatic Neoplasms; Testis; Testosterone | 1983 |
New hormonal treatment in cancer of the prostate: combined administration of an LHRH agonist and an antiandrogen.
Topics: Androgen Antagonists; Animals; Buserelin; Castration; Dihydrotestosterone; Drug Therapy, Combination; Gonadotropin-Releasing Hormone; Hormones; Humans; Imidazoles; Imidazolidines; Male; Prostate; Prostatic Neoplasms; Rats; Seminal Vesicles; Testosterone | 1983 |
Long term effects of administration of a gonadotropin-releasing hormone superagonist analog in men with prostatic carcinoma.
Topics: Aged; Dihydrotestosterone; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Leuprolide; Luteinizing Hormone; Male; Middle Aged; Prostatic Neoplasms; Testosterone; Time Factors | 1984 |
Long-term effects of endocrine treatment on serum steroids in advanced prostatic carcinoma patients.
Topics: Aged; Androstenedione; Androsterone; Castration; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; Humans; Hydroxyprogesterones; Male; Middle Aged; Organophosphorus Compounds; Pregnenolone; Progesterone; Prostatic Neoplasms; Steroids; Testosterone | 1980 |
Zinc potentiation of androgen receptor binding to nuclei in vitro.
Topics: Animals; Cations, Divalent; Cell Line; Cell Nucleus; Chlorides; Dihydrotestosterone; Kinetics; Male; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid; Zinc; Zinc Compounds | 1984 |
Androgen receptor binding to nuclear matrix in vitro and its inhibition by 8S androgen receptor promoting factor.
Topics: Animals; Cell Line; Cell Nucleus; Dihydrotestosterone; Kinetics; Male; Osmolar Concentration; Prostatic Neoplasms; Proteins; Pyridoxal Phosphate; Rats; Receptors, Androgen; Receptors, Steroid; Thermodynamics; Zinc | 1984 |
Comparison of prostatic cancer tissue dihydrotestosterone levels at the time of relapse following orchiectomy or estrogen therapy.
Topics: Castration; Diethylstilbestrol; Dihydrotestosterone; Humans; Male; Neoplasm Recurrence, Local; Prostate; Prostatic Neoplasms; Testosterone | 1984 |
Selective inhibition of prostatic tumor 5 alpha-reductase by a 4-methyl-4-azasteroid.
Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Cell Nucleus; Cytosol; Dihydrotestosterone; Humans; Kinetics; Male; Organ Culture Techniques; Oxidoreductases; Pregnanes; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred WF; Steroids, Heterocyclic; Testosterone | 1984 |
Ultrafiltrable plasma testosterone and 5 alpha-dihydrotestosterone as measured across the human testes.
Topics: Aged; Castration; Dihydrotestosterone; Humans; Male; Middle Aged; Prostatic Neoplasms; Testis; Testosterone; Ultrafiltration | 1984 |
[Detection of androgen receptor in human prostatic carcinomas by the autoradiography].
Topics: Androgen Antagonists; Autoradiography; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Tritium | 1984 |
R3327 prostate adenocarcinoma clonogenic cells: epithelial properties and hormone response.
Topics: Acid Phosphatase; Adenocarcinoma; Animals; Castration; Cell Line; Dihydrotestosterone; Epithelium; Estradiol; Female; Histocytochemistry; Hormones; In Vitro Techniques; Male; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Testosterone | 1983 |
Androgen stimulated elevation in androgen receptor levels is inhibited by the synthetic glucocorticoid triamcinolone acetonide.
Topics: Androgens; Animals; Cell Line; Clone Cells; Cricetinae; Dihydrotestosterone; Estrenes; Kinetics; Male; Metribolone; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid; Testosterone Congeners; Triamcinolone Acetonide | 1983 |
Androgen receptor binding characteristics in the cytosol of the rat dorsolateral prostate gland and the Dunning R-3327 prostatic adenocarcinoma.
Topics: Adenocarcinoma; Aging; Animals; Binding, Competitive; Cytosol; Dihydrotestosterone; Estrenes; Male; Metribolone; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Steroid; Testosterone; Testosterone Congeners | 1984 |
Steroid receptors in prostate neoplasms.
Topics: Dihydrotestosterone; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estradiol; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid | 1983 |
[Interdependence between hormonal disorders, stage of development and degree of malignancy of prostatic cancer. 1].
Topics: Acid Phosphatase; Aged; Dihydrotestosterone; Hormones; Humans; Luteinizing Hormone; Male; Middle Aged; Neoplasm Staging; Prostatic Neoplasms; Testosterone | 1983 |
Androgen metabolism by human prostatic tumours in organ culture.
Topics: Androstenedione; Dihydrotestosterone; Humans; Male; NADPH Dehydrogenase; Organ Culture Techniques; Oxidation-Reduction; Prostatic Neoplasms; Testosterone | 1983 |
Tissue dihydrotestosterone levels and clinical response to hormonal therapy in patients with advanced prostate cancer.
Topics: Androgen Antagonists; Cell Nucleus; Cytosol; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen | 1984 |
Effects of sodium molybdate on the androgen receptor from the R3327 prostatic tumor.
Topics: Animals; Cell Line; Dihydrotestosterone; DNA; Male; Molybdenum; Osmolar Concentration; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid | 1984 |
Inhibition of serum androgen levels by chronic intranasal and subcutaneous administration of a potent luteinizing hormone-releasing hormone (LH-RH) agonist in adult men.
Topics: Administration, Intranasal; Aged; Buserelin; Dihydrotestosterone; Estradiol; Gonadotropin-Releasing Hormone; Humans; Hydroxyprogesterones; Injections, Subcutaneous; Luteinizing Hormone; Male; Middle Aged; Prostatic Neoplasms; Testosterone; Time Factors | 1982 |
Clinical and biochemical effect of aminoglutethimide in the treatment of advanced prostatic carcinoma.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Bone Neoplasms; Dihydrotestosterone; Drug Therapy, Combination; Humans; Hydrocortisone; Male; Middle Aged; Prostatic Neoplasms; Testosterone | 1983 |
Leiomyosarcoma of prostate.
Topics: Dihydrotestosterone; Humans; Leiomyosarcoma; Male; Middle Aged; Prostatic Neoplasms; Receptors, Androgen | 1983 |
Hormonal regulation of zinc metabolism in a human prostatic carcinoma cell line (PC-3).
Topics: Adenocarcinoma; Cell Line; Cycloheximide; Cystine; Dexamethasone; Dihydrotestosterone; Hormones; Humans; Insulin; Kinetics; Male; Metallothionein; Prostaglandins E; Prostatic Neoplasms; Zinc | 1982 |
Abnormal levels of plasma hormones in men with prostate cancer: evidence toward a "two-disease" theory.
Topics: Age Factors; Aged; Dihydrotestosterone; Estrone; Hormones; Humans; Hydrocortisone; Male; Middle Aged; Prostatic Neoplasms; Testosterone | 1982 |
Studies of the human testis. XV. Androgen-binding protein and function of Leydig cells and tubules in aged men with prostatic carcinoma.
Topics: Aged; Androgen-Binding Protein; Carrier Proteins; Concanavalin A; Dihydrotestosterone; Humans; Kinetics; Leydig Cells; Male; Middle Aged; Prostatic Neoplasms; Seminiferous Tubules; Testis | 1980 |
Androgen receptors in prostate cancer.
Topics: Cytosol; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Sex Hormone-Binding Globulin | 1981 |
Familial prostatic cancer risk and low testosterone.
Topics: Dihydrotestosterone; Estradiol; Estrone; Humans; Male; Middle Aged; Prostatic Neoplasms; Risk; Sex Hormone-Binding Globulin; Testosterone; Utah | 1982 |
Effect of LS 1727, a nitrosocarbamate of 19-nortestosterone, on the R-3327 rat prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Dihydrotestosterone; Male; Nandrolone; Neoplasms, Experimental; Prostatic Neoplasms; Rats | 1981 |
Identification of an 8S androgen receptor-promoting factor that converts the 4.5S form of the androgen receptor to 8S.
Topics: Adenocarcinoma; Animals; Cytosol; Dihydrotestosterone; Kinetics; Male; Molecular Weight; Neoplasms, Experimental; Prostatic Neoplasms; Proteins; Rats; Receptors, Androgen; Receptors, Steroid; Tissue Distribution | 1981 |
Androgen and glucocorticoid receptors in the Pollard prostate adenocarcinoma cell lines.
Topics: Adenocarcinoma; Cell Line; Centrifugation, Density Gradient; Dexamethasone; Dihydrotestosterone; DNA Replication; Male; Prostatic Neoplasms; Protein Biosynthesis; Receptors, Androgen; Receptors, Glucocorticoid; Receptors, Steroid | 1980 |
Radioimmunoassay of tissue steroids in adenocarcinoma of the prostate.
Topics: Adenocarcinoma; Biopsy, Needle; Dihydrotestosterone; Estradiol; Estrone; Hormones; Humans; Male; Progesterone; Prostatic Neoplasms; Radioimmunoassay; Testosterone | 1981 |
Testosterone, dihydrotestosterone, and zinc concentrations in human testis and epididymis.
Topics: Aged; Dihydrotestosterone; Epididymis; Estrogens; Humans; Male; Middle Aged; Penile Neoplasms; Prostatic Neoplasms; Testis; Testosterone; Zinc | 1981 |
[Histological and endocrinological studies on prostatic carcinoma (author's transl)].
Topics: Aged; Biotransformation; Dihydrotestosterone; Histocytochemistry; Humans; Male; Middle Aged; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Testosterone | 1981 |
Comparison of the characteristics of androgen receptors from normal prostate and prostatic adenocarcinoma of A x C rats.
Topics: Adenocarcinoma; Animals; Cytosol; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Kinetics; Male; Molecular Weight; Neoplasms, Experimental; Prostate; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid | 1980 |
Testosterone and some of its precursors and metabolites in the human epididymis.
Topics: Aged; Androstane-3,17-diol; Androstenedione; Androsterone; Dihydrotestosterone; Epididymis; Estrogens; Humans; Hydroxyprogesterones; Male; Middle Aged; Pregnenolone; Progesterone; Prostatic Neoplasms; Testis; Testosterone; Vas Deferens | 1980 |
Androgen receptor protein in the androgen-dependent Dunning R-3327 prostate carcinoma.
Topics: Animals; Castration; Cytosol; Dihydrotestosterone; Kinetics; Male; Molecular Weight; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid; Testosterone | 1981 |
Comparative effects and mechanisms of castration, estrogen anti-androgen, and anti-estrogen-induced regression of accessory sex organ epithelium and muscle.
Topics: Androgen Antagonists; Animals; Castration; Cyproterone; Dihydrotestosterone; Epithelium; Estradiol; Estrogen Antagonists; Guinea Pigs; Male; Muscles; Prostatic Neoplasms; Seminal Vesicles | 1981 |
Influence of dihydrotestosterone, epidermal growth factor, and basic fibroblast growth factor on the cell kinetics of the PC3, DU145, and LNCaP prostatic cancer cell lines: relationship with DNA ploidy level.
Topics: Cell Division; Cell Nucleus; Dihydrotestosterone; DNA, Neoplasm; Drug Interactions; Epidermal Growth Factor; Fibroblast Growth Factor 2; Humans; Image Processing, Computer-Assisted; Male; Ploidies; Prostatic Neoplasms; Tumor Cells, Cultured | 1995 |
Regulation of prostate-specific antigen gene expression in LNCaP human prostatic carcinoma cells by growth, dihydrotestosterone, and extracellular matrix.
Topics: Adenocarcinoma; Cell Adhesion; Cell Division; Dihydrotestosterone; DNA, Neoplasm; Down-Regulation; Extracellular Matrix; Gene Expression Regulation, Neoplastic; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Expression of the prostate-specific membrane antigen.
Topics: Adrenal Cortex Hormones; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Blotting, Western; Cell Line; Cell Membrane; Dihydrotestosterone; Gene Expression; Glutamate Carboxypeptidase II; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Molecular Weight; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Protein Biosynthesis; RNA, Messenger; Testosterone; Transcription, Genetic; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 1994 |
Comparison of testosterone metabolism in benign prostatic hyperplasia and human prostate cancer cell lines in vitro.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Cell Division; Dihydrotestosterone; Humans; In Vitro Techniques; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1994 |
An inhibitory effect of TZP-4238 on the growth of androgen-sensitive rat prostatic tumor (Dunning R3327).
Topics: Administration, Oral; Androgen Antagonists; Androgens; Animals; Chlormadinone Acetate; Dihydrotestosterone; Male; Neoplasms, Hormone-Dependent; Orchiectomy; Organ Size; Prostate; Prostatic Neoplasms; Rats; Testis; Testosterone | 1993 |
Inverse relationships between cell proliferation and basal or androgen-stimulated apolipoprotein D secretion in LNCaP human prostate cancer cells.
Topics: Apolipoproteins; Apolipoproteins D; Cell Division; Dihydrotestosterone; Humans; Male; Nifedipine; Prostate-Specific Antigen; Prostatic Neoplasms; Tumor Cells, Cultured | 1994 |
Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP.
Topics: Adenocarcinoma; Androgens; Blotting, Northern; Carrier Proteins; Cloning, Molecular; Cycloheximide; Diazepam Binding Inhibitor; Dihydrotestosterone; DNA, Complementary; Humans; Immune Sera; Male; Metribolone; Nandrolone; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Testosterone; Tumor Cells, Cultured | 1994 |
Regulation of proliferation and production of prostate-specific antigen in androgen-sensitive prostatic cancer cells, LNCaP, by dihydrotestosterone.
Topics: Androgens; Blotting, Western; Cell Division; Culture Media; Dihydrotestosterone; Humans; Immunohistochemistry; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Sensitivity and Specificity; Tumor Cells, Cultured | 1995 |
Altered growth and insulin-like growth factor-binding protein-3 production in PC3 prostate carcinoma cells stably transfected with a constitutively active androgen receptor complementary deoxyribonucleic acid.
Topics: Androgens; Carcinoma; Carrier Proteins; Cell Division; Culture Media, Conditioned; Dihydrotestosterone; DNA, Complementary; Humans; Insulin-Like Growth Factor Binding Proteins; Male; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Somatomedins; Transfection | 1995 |
Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor.
Topics: Androgen Antagonists; Base Sequence; Breast Neoplasms; Cell Division; Cell Line; Cell Nucleus; Cytosol; Dihydrotestosterone; DNA Primers; DNA, Neoplasm; Estradiol; Female; Flutamide; Gene Expression; Humans; Kinetics; Male; Molecular Sequence Data; Polymerase Chain Reaction; Prostate-Specific Antigen; Prostatic Neoplasms; Radioligand Assay; Receptors, Estradiol; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
[Organ culture of human tissue as study model of hormonal and pharmacological regulation of benign prostatic hyperplasia and of prostatic cancer].
Topics: Aged; Aged, 80 and over; Autoradiography; Cell Division; Dihydrotestosterone; Epidermal Growth Factor; Humans; Male; Middle Aged; Models, Biological; Organ Culture Techniques; Prolactin; Prostatic Hyperplasia; Prostatic Neoplasms | 1995 |
Binding of estradiol to whole prostatic DU-145 cells in the presence and absence of tamoxifen and acetylsalicylic acid.
Topics: Aspirin; Binding, Competitive; Cytoplasm; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Estrogens, Non-Steroidal; Humans; Immunohistochemistry; Male; Prostatic Neoplasms; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured | 1995 |
Androgens inhibit the proliferation of a variant of the human prostate cancer cell line LNCaP.
Topics: Amino Acid Sequence; Androgens; Base Sequence; Cell Division; Coloring Agents; Dihydrotestosterone; DNA, Neoplasm; Epidermal Growth Factor; Exons; Fibroblast Growth Factor 2; Humans; Male; Metribolone; Molecular Sequence Data; Molecular Weight; Neoplasm Proteins; Point Mutation; Prostatic Neoplasms; Receptors, Androgen; Testosterone Congeners; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1995 |
Androgen up-regulates epidermal growth factor receptor expression and binding affinity in PC3 cell lines expressing the human androgen receptor.
Topics: Adenocarcinoma; Androgens; Animals; Bone Neoplasms; Cell Division; Dihydrotestosterone; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; Mice; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Stimulation, Chemical; Transforming Growth Factor alpha; Tumor Cells, Cultured; Up-Regulation | 1995 |
Effects of sex steroids on cell growth and C-myc oncogene expression in LN-CaP and DU-145 prostatic carcinoma cell lines.
Topics: Adenocarcinoma; Blotting, Southern; Cell Division; Dihydrotestosterone; Estradiol; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; In Situ Hybridization; In Vitro Techniques; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured | 1995 |
Sex steroids up-regulate E-cadherin expression in hormone-responsive LNCaP human prostate cancer cells.
Topics: Androgen Antagonists; Cadherins; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Gonadal Steroid Hormones; Humans; Immunoblotting; Immunohistochemistry; Male; Prostatic Neoplasms | 1995 |
Growth modulation of human prostatic cancer cells by interleukin-1 and interleukin-1 receptor antagonist.
Topics: Cell Division; Dihydrotestosterone; Humans; In Vitro Techniques; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Prostatic Neoplasms; Receptors, Interleukin-1; Sialoglycoproteins; Tumor Cells, Cultured | 1995 |
Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels.
Topics: Androgens; Dihydrotestosterone; Epidermal Growth Factor; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Transforming Growth Factor alpha | 1993 |
Basis for hormonal management of advanced prostate cancer.
Topics: Androstenedione; Animals; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Orchiectomy; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Protein Biosynthesis; Rats; Testosterone | 1993 |
Effect of retinoic acid on the proliferation and secretory activity of androgen-responsive prostatic carcinoma cells.
Topics: Androgens; Cell Division; Dihydrotestosterone; Flow Cytometry; Humans; Male; Metribolone; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Testosterone; Tretinoin; Tumor Cells, Cultured | 1993 |
Androgen induction of a human prostate-specific kallikrein, hKLK2: characterization of an androgen response element in the 5' promoter region of the gene.
Topics: Androgens; Base Sequence; Chloramphenicol O-Acetyltransferase; Dihydrotestosterone; DNA-Binding Proteins; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Kallikreins; Kinetics; Male; Molecular Sequence Data; Nandrolone; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Sequence Deletion; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1993 |
Hormone regulation of human prostate in organ culture.
Topics: Aged; Cell Division; Dexamethasone; Dihydrotestosterone; DNA; DNA, Neoplasm; Estradiol; Humans; Immunohistochemistry; Insulin; Male; Middle Aged; Organ Culture Techniques; Prostate; Prostatectomy; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen | 1993 |
Glucuronosyltransferase activity in human cancer cell line LNCaP.
Topics: Androstane-3,17-diol; Androsterone; Cell Line; Dihydrotestosterone; Glucuronates; Glucuronosyltransferase; Humans; Male; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured; Uridine Diphosphate Glucuronic Acid | 1995 |
No effect of kinins on DNA synthesis in LNCaP prostate cancer cells.
Topics: Adenocarcinoma; Bradykinin Receptor Antagonists; Dihydrotestosterone; DNA, Neoplasm; Drug Interactions; Humans; Indomethacin; Kallidin; Male; Metribolone; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1994 |
Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells.
Topics: Apoptosis; Base Sequence; Cell Survival; Dihydrotestosterone; Drug Interactions; Etoposide; Humans; Immunohistochemistry; Male; Molecular Sequence Data; Oligonucleotides, Antisense; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 1995 |
Finasteride dose-dependently reduces the proliferation rate of the LnCap human prostatic cancer cell line in vitro.
Topics: Androgen Antagonists; Cell Division; Cyproterone Acetate; Dihydrotestosterone; Dose-Response Relationship, Drug; Finasteride; Flutamide; Humans; Linear Models; Male; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1995 |
Rapid induction of keratinocyte growth factor (FGF-7) and beta-actin after exposure of prostate stromal cells to androgen.
Topics: Actins; Animals; Dihydrotestosterone; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Gene Expression Regulation, Neoplastic; Growth Substances; Male; Prostate; Prostatic Neoplasms; Rats; RNA, Messenger; Stromal Cells; Tumor Cells, Cultured | 1994 |
Clinical review: 67: Approach to chemoprevention of prostate cancer.
Topics: Dihydrotestosterone; Finasteride; Humans; Male; Prostate; Prostatic Neoplasms | 1995 |
Regulation of the expression of prostatic acid phosphatase in LNCaP human prostate carcinoma cells.
Topics: Acid Phosphatase; Biomarkers, Tumor; Cell Count; Cell Division; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Male; Prostate; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Development and characterization of nontumorigenic and tumorigenic epithelial cell lines from rat dorsal-lateral prostate.
Topics: Acid Phosphatase; Animals; Calcitriol; Cell Division; Cell Line; Dihydrotestosterone; Epithelium; Karyotyping; Male; Methylnitrosourea; Mice; Mice, Nude; Prostate; Prostatic Neoplasms; Rats; Rats, Wistar; Receptors, Androgen; Transforming Growth Factor beta; Tretinoin; Tumor Cells, Cultured | 1994 |
Study of estramustine binding protein: its relationship to androgen dependency and histological differentiation in human prostatic carcinoma tissue.
Topics: Aged; Carrier Proteins; Combined Modality Therapy; Dihydrotestosterone; Estramustine; Humans; Male; Prostate; Prostatectomy; Prostatic Neoplasms; Prostatic Secretory Proteins; Radioimmunoassay | 1994 |
Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon.
Topics: Androgen Antagonists; Androgens; Cell Cycle; Cell Division; Dihydrotestosterone; Drug Resistance; Flutamide; Humans; Immunohistochemistry; Interferon-beta; Male; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 1994 |
Inhibition of the activity of 'basic' 5 alpha-reductase (type 1) detected in DU 145 cells and expressed in insect cells.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Azasteroids; Baculoviridae; Brain Neoplasms; Chromatography, High Pressure Liquid; Dihydrotestosterone; Finasteride; Gene Expression; Humans; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Male; Moths; Prostatic Neoplasms; Recombinant Proteins; Testosterone; Tumor Cells, Cultured | 1994 |
Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
Topics: Adrenal Glands; Aged; Amino Acid Sequence; Androgen Antagonists; Androstenedione; Animals; Base Sequence; Carcinoma; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Dehydroepiandrosterone; Dihydrotestosterone; DNA, Complementary; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Male; Molecular Sequence Data; Neoplasm Proteins; Point Mutation; Polymerase Chain Reaction; Progesterone; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Steroids; Transcriptional Activation | 1993 |
Antiandrogens inhibit human androgen receptor-dependent gene transcription activation in the human prostate cancer cells LNCaP.
Topics: Amino Acid Sequence; Androgen Antagonists; Binding, Competitive; Blotting, Western; Chloramphenicol O-Acetyltransferase; Cyproterone Acetate; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Gene Expression Regulation, Viral; Humans; Imidazoles; Imidazolidines; Male; Mammary Tumor Virus, Mouse; Molecular Sequence Data; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1994 |
Influence of culture media on the morphological differentiation of the PC-3 and DU145 prostatic neoplastic cell lines.
Topics: Animals; Cattle; Cell Transformation, Neoplastic; Clone Cells; Culture Media; Dihydrotestosterone; Fetal Blood; Humans; Image Processing, Computer-Assisted; Male; Platelet-Derived Growth Factor; Ploidies; Prostatic Neoplasms; Software; Tumor Cells, Cultured | 1994 |
Effect of early exposure of flutamide on subsequent growth of transplantable rat prostatic tumor (dunning R-3327).
Topics: Animals; Cell Division; Dihydrotestosterone; Estradiol; Female; Flutamide; Male; Neoplasm Transplantation; Organ Size; Prostate; Prostatic Neoplasms; Rats; Seminal Vesicles; Testis; Testosterone; Time Factors | 1994 |
Effects of testosterone, dihydrotestosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Dihydrotestosterone; Ethinyl Estradiol; Male; Organ Size; Prostatic Neoplasms; Rats; Rats, Inbred F344; Testosterone | 1994 |
Effect of 5-alpha-reductase inhibition and dexamethasone administration on the growth characteristics and intratumor androgen levels of the human prostate cancer cell line PC-3.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgens; Animals; Azasteroids; Dexamethasone; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Random Allocation; Testosterone; Tumor Cells, Cultured | 1994 |
Effect of cell density on androgen regulation of the mRNA level of human prostatic acid phosphatase.
Topics: Acid Phosphatase; Androgens; Cell Count; Dihydrotestosterone; Gene Expression Regulation; Humans; Male; Prostate; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 1994 |
Enhanced androgen sensitivity in serum-free medium of a subline of the LNCaP human prostate cancer cell line.
Topics: Blood; Cell Division; Culture Media; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Hormonal regulation of transforming growth factor beta-2 expression in human prostate cancer.
Topics: Androgens; Cell Nucleus; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Ribonucleases; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured | 1993 |
Castration-induced changes in morphology, androgen levels, and proliferative activity of human prostate cancer tissue grown in athymic nude mice.
Topics: Animals; Dihydrotestosterone; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Orchiectomy; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1993 |
Regulation of prostatic acid phosphatase expression and secretion by androgen in LNCaP human prostate carcinoma cells.
Topics: Acid Phosphatase; Blotting, Northern; Cloning, Molecular; Dihydrotestosterone; DNA Probes; Humans; Isoenzymes; Kinetics; Male; Methionine; Prostate; Prostatic Neoplasms; Restriction Mapping; RNA, Messenger; RNA, Neoplasm; Time Factors; Tumor Cells, Cultured | 1993 |
Ki-67 expression and BrdUrd incorporation as markers of proliferative activity in human prostate tumour models.
Topics: Animals; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; Male; Mice; Models, Biological; Neoplasm Proteins; Nuclear Proteins; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1993 |
Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.
Topics: Animals; Apoptosis; Cell Division; Dihydrotestosterone; DNA; Epidermal Growth Factor; Humans; Male; Metribolone; Prostatic Neoplasms; Rabbits; Receptors, Androgen; Transfection; Tumor Cells, Cultured | 1993 |
Insulin-like growth factor I: action and receptor characterization in human prostate cancer cell lines.
Topics: Binding, Competitive; Cell Division; Culture Media, Serum-Free; Dihydrotestosterone; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Humans; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptor, IGF Type 1; Tumor Cells, Cultured | 1993 |
Specificity of glucuronosyltransferase activity in the human cancer cell line LNCaP, evidence for the presence of at least two glucuronosyltransferase enzymes.
Topics: Adenocarcinoma; Androstane-3,17-diol; Androsterone; Binding, Competitive; Dihydrotestosterone; Estradiol; Estriol; Estrone; Glucuronosyltransferase; Humans; Kinetics; Male; Prostatic Neoplasms; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 1995 |
Testosterone metabolism in primary cultures of human prostate epithelial cells and fibroblasts.
Topics: 17-Hydroxysteroid Dehydrogenases; Adenosarcoma; Androstenedione; Azasteroids; Blotting, Northern; Cells, Cultured; Cholestenone 5 alpha-Reductase; Chromatography, High Pressure Liquid; Dihydrotestosterone; Enzyme Inhibitors; Epithelium; Etiocholanolone; Fibroblasts; Finasteride; Humans; Male; Meningioma; Oxidoreductases; Placenta; Prostatic Neoplasms; RNA; RNA, Messenger; Testosterone; Tumor Cells, Cultured | 1995 |
Modulation of sensitivity to transforming growth factor-beta 1 (TGF-beta 1) and the level of type II TGF-beta receptor in LNCaP cells by dihydrotestosterone.
Topics: Binding, Competitive; Cell Count; Cell Division; Dihydrotestosterone; DNA, Neoplasm; Humans; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Transcriptional Activation; Transforming Growth Factor beta; Tumor Cells, Cultured | 1996 |
Responses of LNCaP prostatic adenocarcinoma cell cultures to LY300502, a benzoquinolinone human type I 5alpha-reductase inhibitor.
Topics: Adenocarcinoma; Cell Division; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Oxidoreductases; Prostate-Specific Antigen; Prostatic Neoplasms; Quinolones; Tumor Cells, Cultured | 1996 |
Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; Dihydrotestosterone; DNA-Binding Proteins; Flutamide; Humans; Male; Molecular Sequence Data; Nuclear Receptor Coactivators; Oncogene Proteins; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Recombinant Proteins; RNA, Messenger; Testosterone; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Evidence for a role of glucuronosyltransferase in the regulation of androgen action in the human prostatic cancer cell line LNCaP.
Topics: Adenocarcinoma; Cell Division; Dihydrotestosterone; Glucuronosyltransferase; Humans; Hydroxysteroid Dehydrogenases; Male; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Divergent effect of TGFbeta1 on growth and proteolytic modulation of human prostatic-cancer cell lines.
Topics: Bone Marrow; Brain Neoplasms; Carcinoma; Cell Division; Culture Media; Dihydrotestosterone; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Metastasis; Neoplasm Proteins; Plasminogen Activator Inhibitor 1; Prostatic Neoplasms; RNA, Messenger; RNA, Neoplasm; Transforming Growth Factor beta; Tretinoin; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1996 |
Estramustine-binding protein to dihydrotestosterone ratio in human prostatic carcinoma: a new marker for predicting disease progression.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Carrier Proteins; Dihydrotestosterone; Disease Progression; Humans; Male; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatic Secretory Proteins | 1996 |
Role of prostatic basal cells in the regulation and suppression of human prostate cancer cells.
Topics: Base Sequence; Cell Division; Dihydrotestosterone; Epithelium; Humans; Male; Molecular Sequence Data; Polymerase Chain Reaction; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured | 1996 |
Expression of transcripts encoding steroid UDP-glucuronosyltransferases in human prostate hyperplastic tissue and the LNCaP cell line.
Topics: Androsterone; Base Sequence; Blotting, Northern; Cell Line; Dihydrotestosterone; DNA Probes; Gene Expression; Glucuronosyltransferase; Humans; Liver; Male; Molecular Sequence Data; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; RNA, Messenger; Steroids; Substrate Specificity; Testosterone | 1995 |
Preclinical evaluation of fluorine-18-labeled androgen receptor ligands in baboons.
Topics: Animals; Dihydrotestosterone; Drug Evaluation, Preclinical; Fluorine Radioisotopes; Male; Nandrolone; Papio; Prostate; Prostatic Neoplasms; Receptors, Androgen; Testosterone Congeners; Tomography, Emission-Computed | 1996 |
Prospective study of sex hormone levels and risk of prostate cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstane-3,17-diol; Case-Control Studies; Dihydrotestosterone; Estradiol; Gonadal Steroid Hormones; Humans; Male; Middle Aged; Odds Ratio; Prolactin; Prospective Studies; Prostatic Neoplasms; Risk; Sex Hormone-Binding Globulin; Testosterone | 1996 |
Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats.
Topics: Aminobiphenyl Compounds; Animals; Carcinogens; Dihydrotestosterone; Ethinyl Estradiol; Genital Neoplasms, Male; Male; Orchiectomy; Prostatic Neoplasms; Rats; Rats, Inbred F344; Seminal Vesicles; Testosterone | 1996 |
Regulation of steroid glucuronosyltransferase activities and transcripts by androgen in the human prostatic cancer LNCaP cell line.
Topics: Androgen Antagonists; Androgens; Cell Division; Cell Line; Dihydrotestosterone; Estrogens; Gene Expression Regulation, Neoplastic; Glucuronates; Glucuronosyltransferase; Humans; Kinetics; Least-Squares Analysis; Male; Metribolone; Prostatic Neoplasms; Substrate Specificity; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Estramustine-binding protein in carcinoma and benign hyperplasia of the human prostate.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Carrier Proteins; Dihydrotestosterone; Estramustine; Humans; Male; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatic Secretory Proteins; Radioimmunoassay | 1996 |
Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter.
Topics: Cell Line; Dihydrotestosterone; DNA Footprinting; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression Regulation; HeLa Cells; Humans; I-kappa B Proteins; Interleukin-6; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Transcription, Genetic | 1996 |
Stimulation of prostate cancer growth by androgens and estrogens through the intermediacy of sex hormone-binding globulin.
Topics: Cell Division; Cyclic AMP; Dihydrotestosterone; Estradiol; Humans; Male; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Thionucleotides; Tumor Cells, Cultured | 1996 |
Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride.
Topics: Androgen-Binding Protein; Animals; Cell Division; Cell Line; Dihydrotestosterone; DNA Primers; Drug Implants; Enzyme Inhibitors; Estradiol; Finasteride; Humans; Male; Medroxyprogesterone Acetate; Mice; Mice, Nude; Orchiectomy; Polymerase Chain Reaction; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone; Time Factors; Transplantation, Heterologous | 1996 |
Androgen independence of primary epithelial cultures of the prostate is associated with a down-regulation of androgen receptor gene expression.
Topics: Androgen Antagonists; Androgens; Base Sequence; Blotting, Northern; Cell Division; Dihydrotestosterone; DNA, Neoplasm; Dose-Response Relationship, Drug; Down-Regulation; Epithelium; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Data; Polymerase Chain Reaction; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1996 |
Bone extracellular matrix induces homeobox proteins independent of androgens: possible mechanism for androgen-independent growth in human prostate cancer cells.
Topics: Adenine; Androgens; Animals; Base Sequence; Binding Sites; Bone and Bones; Cell Division; Dihydrotestosterone; DNA, Neoplasm; Extracellular Matrix; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Homeodomain Proteins; Humans; Male; Mice; Molecular Sequence Data; Polymerase Chain Reaction; Prostatic Neoplasms; RNA, Messenger; Thymine; Tumor Cells, Cultured | 1996 |
Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells.
Topics: Androgens; Ascorbic Acid; Catalase; Cell Division; Dihydrotestosterone; Free Radicals; gamma-Glutamyltransferase; Glutathione; Humans; Hydrogen Peroxide; Lipid Peroxidation; Male; Metribolone; Mitochondria; Oxidation-Reduction; Oxygen; Oxygen Consumption; Prostatic Neoplasms; Testosterone Congeners; Time Factors; Tumor Cells, Cultured | 1997 |
Androgen-repressed phenotype in human prostate cancer.
Topics: Aged; Aged, 80 and over; Androgens; Animals; Ascites; Cell Division; Cell Line; Dihydrotestosterone; Estradiol; Estrogens; Genetic Markers; Humans; Karyotyping; Lymphatic Metastasis; Male; Mice; Mice, Nude; Mutagenesis, Site-Directed; Neoplasm Metastasis; Phenotype; Prostatic Neoplasms; Receptors, Androgen; Recombinant Proteins; Transplantation, Heterologous; Tumor Cells, Cultured | 1996 |
Characterization of 5alpha-reductase gene expression in stroma and epithelium of human prostate.
Topics: Aged; Androgen Antagonists; Azasteroids; Blotting, Northern; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Epithelium; Gene Expression Regulation, Enzymologic; Humans; Hyperplasia; Isoenzymes; Kinetics; Male; Middle Aged; Oxidoreductases; Polymerase Chain Reaction; Prostate; Prostatic Neoplasms; RNA, Messenger; Stromal Cells; Tumor Cells, Cultured | 1996 |
Androgen regulation of ribosomal RNA synthesis in LNCaP cells and rat prostate.
Topics: Animals; Blotting, Western; Cell Division; Dihydrotestosterone; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Male; Orchiectomy; Pol1 Transcription Initiation Complex Proteins; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; RNA Polymerase I; RNA, Ribosomal; Testosterone; Transcription Factors; Tumor Cells, Cultured | 1996 |
The effects of dihydrotestosterone on the expression of p185(erbB-2) and c-erbB-2 mRNA in the prostatic cell line LNCaP.
Topics: Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Proto-Oncogene Mas; Receptor, ErbB-2; RNA, Messenger; Thymidine; Tritium; Tumor Cells, Cultured | 1996 |
Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen.
Topics: Base Sequence; Dihydrotestosterone; DNA, Complementary; Gene Expression Regulation; Genetic Therapy; Humans; Male; Molecular Sequence Data; Organ Specificity; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Tumor Cells, Cultured | 1997 |
Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor.
Topics: Androgens; Apoptosis; Cell Cycle; Cell Division; Cell Nucleus; Dihydrotestosterone; Gene Expression; Humans; Luciferases; Male; Mammary Tumor Virus, Mouse; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured | 1997 |
Effect of turosteride, a 5 alpha-reductase inhibitor, on the Dunning R3327 rat prostatic carcinoma.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Flutamide; Leuprolide; Luteinizing Hormone; Male; Organ Size; Pituitary Gland, Anterior; Prostate; Prostatic Neoplasms; Random Allocation; Rats; Seminal Vesicles; Testis; Testosterone | 1997 |
A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Alleles; Codon; Cohort Studies; Dihydrotestosterone; Disease Susceptibility; Gene Frequency; Humans; Male; Point Mutation; Polymorphism, Genetic; Prostatic Neoplasms; Racial Groups | 1997 |
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.
Topics: Adenocarcinoma; Androgen Antagonists; Androgens; Anilides; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Induction; Fatty Acid Synthases; Gene Expression Regulation, Neoplastic; Humans; Lipids; Male; Metribolone; Nandrolone; Neoplasm Proteins; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Testosterone; Testosterone Congeners; Tosyl Compounds; Tumor Cells, Cultured | 1997 |
LNCaP-OM, a new androgen-resistant prostate cancer subline.
Topics: Androgens; Blotting, Northern; Cell Division; Dihydrotestosterone; Drug Tolerance; Humans; Male; Prostatic Neoplasms; Tumor Cells, Cultured | 1997 |
A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Aged; Aged, 80 and over; Alleles; Androgens; Black People; Case-Control Studies; Cohort Studies; Dihydrotestosterone; Disease Progression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Frequency; Genotype; Homozygote; Humans; Incidence; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Prevalence; Prostate; Prostatic Neoplasms; Repetitive Sequences, Nucleic Acid; Risk Factors; Testosterone; White People | 1997 |
Transcriptional up-regulation of the human androgen receptor by androgen in bone cells.
Topics: Bone Neoplasms; Chloramphenicol O-Acetyltransferase; Dexamethasone; Dihydrotestosterone; Estradiol; Genes, Reporter; Humans; Kinetics; Male; Osteoblasts; Osteosarcoma; Plasmids; Progesterone; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation | 1997 |
Steroid hormone induction and expression patterns of L-plastin in normal and carcinomatous prostate tissues.
Topics: Blotting, Western; Dihydrotestosterone; Estradiol; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Membrane Glycoproteins; Microfilament Proteins; Molecular Sequence Data; Phosphoproteins; Prostate; Prostatic Neoplasms; Signal Transduction; Time Factors; Tumor Cells, Cultured | 1997 |
Establishment of a three-dimensional human prostate organoid coculture under microgravity-simulated conditions: evaluation of androgen-induced growth and PSA expression.
Topics: Bioreactors; Cell Culture Techniques; Cell Division; Cells, Cultured; Coculture Techniques; Culture Media; Dihydrotestosterone; Epithelial Cells; Fibroblasts; Humans; Male; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Space Simulation; Tumor Cells, Cultured; Weightlessness | 1997 |
1alpha,25-dihydroxyvitamin D3 actions in LNCaP human prostate cancer cells are androgen-dependent.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Anilides; Blotting, Northern; Blotting, Western; Calcitriol; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Neoplasms, Hormone-Dependent; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Tosyl Compounds; Tritium; Tumor Cells, Cultured; Up-Regulation | 1997 |
Serum steroids in relation to prostate cancer risk in a case-control study (Greece).
Topics: Aged; Case-Control Studies; Dihydrotestosterone; Estradiol; Humans; Logistic Models; Male; Odds Ratio; Prostatic Neoplasms; Residence Characteristics; Risk Factors; Sex Hormone-Binding Globulin; Testosterone; Urban Health | 1997 |
A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans.
Topics: Animals; Dihydrotestosterone; Epithelium; Female; Gene Expression Regulation, Developmental; Humans; Kallikreins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Orchiectomy; Promoter Regions, Genetic; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Salivary Glands; Tissue Distribution; Tumor Cells, Cultured | 1997 |
Anthropometric risk factors for prostate cancer.
Topics: Aged; Anthropometry; Body Composition; Body Height; Body Weight; Bone Density; Case-Control Studies; Dihydrotestosterone; Female; Humans; Male; Middle Aged; Prostatic Neoplasms; Risk Factors; Sex Hormone-Binding Globulin; Skinfold Thickness; Testosterone | 1997 |
Autocrine effect of androgen on proliferation of an androgen responsive prostatic carcinoma cell line, LNCAP: role of interleukin-6.
Topics: Androgens; Antibodies; Carcinoma; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Interleukin-6; Male; Prostatic Neoplasms; Tumor Cells, Cultured | 1997 |
Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia.
Topics: Aged; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Enzyme-Linked Immunosorbent Assay; Estradiol; Greece; Humans; Insulin-Like Growth Factor I; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Radioimmunoassay; Risk Factors; Sex Hormone-Binding Globulin; Testosterone | 1997 |
Androgens in serum and the risk of prostate cancer: a nested case-control study from the Janus serum bank in Norway.
Topics: Adult; Aged; Androgens; Androstane-3,17-diol; Biomarkers; Blood Specimen Collection; Case-Control Studies; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Humans; Male; Middle Aged; Norway; Oxidoreductases; Prostatic Neoplasms; Risk Factors; Time Factors | 1997 |
Hormonal modulation of the accumulation of 5-aminolevulinic acid-induced protoporphyrin and phototoxicity in prostate cancer cells.
Topics: Aminolevulinic Acid; Animals; Blood; Cattle; Cell Division; Cell Survival; Culture Media; Dihydrotestosterone; Estradiol; Humans; Kinetics; Male; Photochemotherapy; Prostatic Neoplasms; Protoporphyrins; Tumor Cells, Cultured | 1997 |
Androgens are not a direct requirement for the proliferation of human prostatic epithelium in vitro.
Topics: Acid Phosphatase; Androgens; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Synergism; Epithelial Cells; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Immunoblotting; Male; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 1997 |
Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression.
Topics: Biomarkers, Tumor; Biopsy; Cell Division; Cell Nucleus; Dihydrotestosterone; Disease Progression; Gene Transfer Techniques; Humans; Kinetics; Male; Neoplasm Metastasis; Neprilysin; Polymerase Chain Reaction; Prostatic Neoplasms; Recombinant Proteins; Tetracycline; Time Factors; Transfection; Tumor Cells, Cultured | 1998 |
Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells.
Topics: Adult; Antibodies, Monoclonal; Cell Division; Cell Line, Transformed; Cells, Cultured; Dihydrotestosterone; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Male; Phosphates; Prostate; Prostatic Neoplasms; Tumor Cells, Cultured | 1998 |
Effect of interleukins on UGT2B15 and UGT2B17 steroid uridine diphosphate-glucuronosyltransferase expression and activity in the LNCaP cell line.
Topics: Cell Division; Dihydrotestosterone; Gene Expression Regulation, Enzymologic; Glucuronates; Glucuronosyltransferase; Humans; Interleukin-1; Interleukin-4; Interleukin-6; Interleukins; Male; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1998 |
Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells.
Topics: Adenocarcinoma; Androgen Antagonists; Androgens; Animals; Chloramphenicol O-Acetyltransferase; Dihydrotestosterone; Humans; Luciferases; Male; Mammary Tumor Virus, Mouse; Plasmids; Prostatic Neoplasms; Rats; Repetitive Sequences, Nucleic Acid; Sulfotransferases; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1998 |
Effect of fibroblastic growth factors (FGF) on steroid UDP-glucuronosyltransferase expression and activity in the LNCaP cell line.
Topics: Androgens; Cell Division; Dihydrotestosterone; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Gene Expression; Glucuronates; Glucuronosyltransferase; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; RNA, Messenger; RNA, Neoplasm; Steroids; Tumor Cells, Cultured | 1998 |
Effect of the dual 5alpha-reductase inhibitor PNU 157706 on the growth of dunning R3327 prostatic carcinoma in the rat.
Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Antineoplastic Agents; Castration; Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epididymis; Male; Molecular Structure; Organ Size; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Seminal Vesicles; Testis | 1998 |
The conventional transforming growth factor-beta (TGF-beta) receptor type I is not required for TGF-beta 1 signaling in a human prostate cancer cell line, LNCaP.
Topics: Activin Receptors, Type I; Dihydrotestosterone; Gene Expression; Humans; Male; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Sensitivity and Specificity; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Regarding Zagars and Pollack.
Topics: Dihydrotestosterone; Humans; Luteinizing Hormone; Male; Prostatic Neoplasms; Testis; Testosterone; Time Factors | 1998 |
Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells.
Topics: Cell Cycle; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Recombinant Fusion Proteins; Repressor Proteins; Retinoblastoma Protein; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1998 |
Influence of radical prostatectomy on serum hormone levels.
Topics: Adult; Age Factors; Aged; Androgens; Dihydrotestosterone; Estradiol; Feedback; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hypothalamo-Hypophyseal System; Libido; Luteinizing Hormone; Male; Middle Aged; Prolactin; Prospective Studies; Prostate; Prostatectomy; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Sexual Behavior; Sexual Dysfunction, Physiological; Testis; Testosterone | 1998 |
Transforming growth factor-beta1 induces nuclear to cytoplasmic distribution of androgen receptor and inhibits androgen response in prostate smooth muscle cells.
Topics: Androgens; Animals; Cell Line; Cell Nucleus; Cytoplasm; Dihydrotestosterone; Epithelial Cells; Male; Muscle, Smooth; Prostate; Prostatic Neoplasms; Rats; Receptors, Androgen; RNA, Messenger; Stromal Cells; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Dihydrotestosterone prevents spontaneous adenocarcinomas in the prostate-seminal vesicle in aging L-W rats.
Topics: Adenocarcinoma; Aging; Animals; Delayed-Action Preparations; Dihydrotestosterone; Male; Prostatic Neoplasms; Rats; Rats, Wistar; Seminal Vesicles | 1998 |
Effects of some novel inhibitors of C17,20-lyase and 5alpha-reductase in vitro and in vivo and their potential role in the treatment of prostate cancer.
Topics: Androgens; Animals; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Humans; Ketoconazole; Male; Organ Size; Oxidoreductases; Prostate; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Steroid 17-alpha-Hydroxylase; Testosterone | 1998 |
Androgen induction of urokinase gene expression in LNCaP cells is dependent on their interaction with the extracellular matrix.
Topics: Dihydrotestosterone; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Gene Expression; Humans; Male; Neoplasm Invasiveness; Neoplasm Proteins; Prostatic Neoplasms; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1998 |
Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue.
Topics: Androgens; Animals; Apoptosis; Dihydrotestosterone; Endothelial Growth Factors; Humans; Lymphokines; Male; Mice; Mice, SCID; Orchiectomy; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Rats; Time Factors; Transplantation, Heterologous; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Functional characterization of mutant androgen receptors from androgen-independent prostate cancer.
Topics: Amino Acid Substitution; Androgen Antagonists; Androgens; Androstenedione; Animals; beta-Galactosidase; Cell Line; Dihydrotestosterone; Estradiol; Flutamide; Genes, Reporter; Imidazoles; Imidazolidines; Luciferases; Male; Point Mutation; Progesterone; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Transfection | 1997 |
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.
Topics: Animals; Bone Neoplasms; Cell Division; Culture Media; Dihydrotestosterone; Genetic Variation; Humans; Karyotyping; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Orchiectomy; Prostate-Specific Antigen; Prostatic Neoplasms; Tumor Cells, Cultured | 1996 |
Nuclear matrix targeting of the protein kinase CK2 signal as a common downstream response to androgen or growth factor stimulation of prostate cancer cells.
Topics: Adenocarcinoma; Animals; Casein Kinase II; Cell Division; Chromatin; Cytosol; Dihydrotestosterone; DNA-Binding Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances; Humans; Kinetics; Male; Nuclear Matrix; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1999 |
Effect of leuprorelin acetate on cell growth and prostate-specific antigen gene expression in human prostatic cancer cells.
Topics: Antineoplastic Agents, Hormonal; Cell Division; Culture Media; Dihydrotestosterone; Epidermal Growth Factor; Gene Expression Regulation; Humans; Leuprolide; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 1999 |
Activation of Rb and decline in androgen receptor protein precede retinoic acid-induced apoptosis in androgen-dependent LNCaP cells and their androgen-independent derivative.
Topics: Antigens, Surface; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Carboxypeptidases; Cell Differentiation; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glutamate Carboxypeptidase II; Growth Inhibitors; Humans; Keratins; Male; Paclitaxel; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Retinoblastoma Protein; Tretinoin; Tumor Cells, Cultured | 1999 |
Phosphorylation/dephosphorylation of androgen receptor as a determinant of androgen agonistic or antagonistic activity.
Topics: Androgen Antagonists; Androgens; Anilides; Animals; Base Sequence; Dihydrotestosterone; Estradiol; Estramustine; Flutamide; Humans; Ligands; Male; Molecular Sequence Data; Nitriles; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Tosyl Compounds; Tumor Cells, Cultured | 1999 |
Growth of HPV-18 immortalized human prostatic intraepithelial neoplasia cell lines. Influence of IL-10, follistatin, activin-A, and DHT.
Topics: Activins; Adjuvants, Immunologic; Androgens; Animals; Blotting, Western; Cell Adhesion; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Colony-Forming Units Assay; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme-Linked Immunosorbent Assay; Follistatin; Glycoproteins; Growth Substances; Humans; Inhibins; Interleukin-10; Light; Male; Mice; Mice, SCID; Microscopy; Papillomaviridae; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Tumor Cells, Cultured | 1999 |
Elevated expression of FGF-2 does not cause prostate cancer progression in LNCaP cells.
Topics: Animals; Cell Division; Dihydrotestosterone; Disease Progression; Female; Fibroblast Growth Factor 2; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Prostatic Neoplasms; Testosterone; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Characteristics of nonmalignant and malignant human prostate in organ culture.
Topics: Cell Division; Dihydrotestosterone; Epidermal Growth Factor; Epithelial Cells; Humans; Insulin; Ki-67 Antigen; Male; Organ Culture Techniques; Pituitary Gland; Prostate; Prostatectomy; Prostatic Neoplasms; Tissue Extracts | 1999 |
The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells.
Topics: Androgens; Apoptosis; Cell Survival; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; Protective Agents; Signal Transduction; Tumor Cells, Cultured | 1999 |
Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Dihydrotestosterone; Drug Stability; Female; Gene Expression Regulation; Homeostasis; Humans; Male; Prostatic Neoplasms; Protein Processing, Post-Translational; Receptors, Androgen; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Cloning and characterization of the prostate-specific membrane antigen promoter.
Topics: Base Sequence; Dihydrotestosterone; Dose-Response Relationship, Drug; Gene Library; HeLa Cells; Humans; Luciferases; Male; Models, Genetic; Molecular Sequence Data; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Pseudogenes; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines.
Topics: Animals; Blotting, Western; Castration; Caveolin 1; Caveolins; Dihydrotestosterone; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Nude; Prostate; Prostatic Neoplasms; Random Allocation; Tumor Cells, Cultured | 1999 |
Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Androgens; Biomarkers; Bombesin; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Lineage; Chromogranin A; Chromogranins; Colforsin; Cyclic AMP; Cytoplasmic Granules; Dihydrotestosterone; Disease Progression; Epinephrine; Humans; Isoproterenol; Male; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Neoplastic Stem Cells; Neuroendocrine Tumors; Neurotensin; Parathyroid Hormone-Related Protein; Phenotype; Phosphopyruvate Hydratase; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proteins; Second Messenger Systems; Serotonin; Tumor Cells, Cultured | 1999 |
Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2).
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adenocarcinoma; Asian People; Black People; Case-Control Studies; Dihydrotestosterone; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Isoenzymes; Male; Neoplasms, Hormone-Dependent; North Carolina; Odds Ratio; Polymorphism, Genetic; Prostatic Neoplasms; Risk; Steroid 17-alpha-Hydroxylase; Taiwan; Testosterone; White People | 1999 |
Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells.
Topics: Androgen Antagonists; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cycloheximide; Dihydrotestosterone; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flutamide; Humans; Male; Metribolone; Microtubule-Associated Proteins; Prostatic Neoplasms; Protein Synthesis Inhibitors; Receptors, Androgen; Testosterone Congeners; Trastuzumab; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1999 |
Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells.
Topics: Androstenediol; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation; Tumor Cells, Cultured | 1999 |
Combined treatment with the 5 alpha-reductase inhibitor PNU 157706 and the antiandrogen flutamide on the Dunning R3327 prostatic carcinoma in rats.
Topics: Androstenes; Animals; Antineoplastic Combined Chemotherapy Protocols; Dihydrotestosterone; Enzyme Inhibitors; Flutamide; Male; Organ Size; Prostate; Prostatic Neoplasms; Rats; Testosterone | 1999 |
Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.
Topics: Androgens; Animals; Cell Division; Clone Cells; Dihydrotestosterone; Drug Implants; Female; Humans; Male; Mice; Mice, SCID; Orchiectomy; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anastrozole; Androgens; Androstenedione; Aromatase; Aromatase Inhibitors; Blotting, Southern; Dihydrotestosterone; Enzyme Inhibitors; Etiocholanolone; Humans; Hydrogen-Ion Concentration; Isoenzymes; Male; Microsomes; Nitriles; Prostatic Hyperplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone; Triazoles; Tumor Cells, Cultured | 1999 |
Rapid signalling by androgen receptor in prostate cancer cells.
Topics: Adenocarcinoma; Androgen Antagonists; Cell Nucleus; Cytoplasm; Dihydrotestosterone; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Indoles; Ligands; Male; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptors, Androgen; Recombinant Fusion Proteins; Testosterone; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured | 1999 |
Mitogenic effect of nerve growth factor (NGF) in LNCaP prostate adenocarcinoma cells: role of the high- and low-affinity NGF receptors.
Topics: Adenocarcinoma; Blotting, Western; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Mitogens; Nerve Growth Factor; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Nerve Growth Factor; Time Factors; Transfection; Tumor Cells, Cultured | 2000 |
Androgen receptor protein is down-regulated by basic fibroblast growth factor in prostate cancer cells.
Topics: Calcium; Dihydrotestosterone; Dose-Response Relationship, Drug; Down-Regulation; Fibroblast Growth Factor 2; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Time Factors; Tumor Cells, Cultured | 2000 |
Combined treatment of Dunning R3327 rat prostatic tumor with the 5alpha-reductase inhibitor PNU 157706 and the antiandrogen bicalutamide.
Topics: Androgen Antagonists; Androstenes; Anilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Enzyme Inhibitors; Male; Nitriles; Organ Size; Oxidoreductases; Prostatic Neoplasms; Rats; Testosterone; Tosyl Compounds | 2000 |
Androgen and taxol cause cell type-specific alterations of centrosome and DNA organization in androgen-responsive LNCaP and androgen-independent DU145 prostate cancer cells.
Topics: Androgens; Antineoplastic Agents, Phytogenic; Cell Division; Centrosome; Dihydrotestosterone; DNA, Neoplasm; Humans; Male; Metribolone; Microscopy, Electron; Microscopy, Fluorescence; Neoplasms, Hormone-Dependent; Paclitaxel; Prostatic Neoplasms; Testosterone Congeners | 2000 |
Effects of novel 17-azolyl compounds on androgen synthesis in vitro and in vivo.
Topics: Androgens; Animals; Antineoplastic Agents; Azoles; Dihydrotestosterone; Enzyme Inhibitors; Genitalia, Male; Humans; In Vitro Techniques; Kinetics; Male; Prostate; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Steroid 17-alpha-Hydroxylase; Steroids; Testis; Testosterone | 1999 |
Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
Topics: Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2000 |
Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro.
Topics: Adenocarcinoma; Androgens; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Survival; Chlordecone; Dichlorodiphenyl Dichloroethylene; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Food Additives; Food Contamination; Hexachlorocyclohexane; Hormone Antagonists; Humans; Insecticides; Luciferases; Male; Pesticide Residues; Polychlorinated Dibenzodioxins; Prostatic Neoplasms; Receptors, Androgen; Toxaphene; Transfection; Tumor Cells, Cultured | 2000 |
Involvement of p27Kip1 in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells.
Topics: CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin D; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Dihydrotestosterone; Dose-Response Relationship, Drug; G1 Phase; Growth Inhibitors; Humans; Male; Microtubule-Associated Proteins; Oligonucleotides, Antisense; Prostatic Neoplasms; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells.
Topics: Antisense Elements (Genetics); Biological Transport; Cell Division; Cell Nucleus; Cell Survival; Cytoplasm; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Genes, myc; Genetic Therapy; Humans; Male; Microscopy, Fluorescence; Nuclear Localization Signals; Peptide Nucleic Acids; Prostatic Neoplasms; Receptors, Androgen; Substrate Specificity; Tumor Cells, Cultured | 2000 |
Effects of androgens on telomerase activity in normal and malignant prostate cells in vitro.
Topics: Androgens; Cell Cycle; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Neoplasms; Telomerase; Tumor Cells, Cultured | 2000 |
Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase.
Topics: Androgens; Animals; Blotting, Western; Cell Division; Dihydrotestosterone; Male; Neprilysin; Prostatic Neoplasms; Rats; Receptors, Androgen; Transfection; Tumor Cells, Cultured | 2000 |
Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3'-kinase pathway.
Topics: Androgens; Apoptosis; Cell Division; Cyclin D1; Dihydrotestosterone; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Male; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Transfection; Tumor Cells, Cultured | 2000 |
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
Topics: Aldosterone; Androgens; Animals; Cell Division; Cell Line; Chlorocebus aethiops; Cortisone; COS Cells; Dihydrotestosterone; Estradiol; Glucocorticoids; Humans; Hydrocortisone; Male; Mutagenesis; Progesterone; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2000 |
Insulin-like growth factor binding protein-3 is regulated by dihydrotestosterone and stimulates deoxyribonucleic acid synthesis and cell proliferation in LNCaP prostate carcinoma cells.
Topics: Cell Division; Dihydrotestosterone; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Combinations; Humans; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Prostatic Neoplasms; Thymidine; Tumor Cells, Cultured; Vitamin D | 2000 |
LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis.
Topics: Animals; Blotting, Northern; Bone Neoplasms; Cell Line; Dihydrotestosterone; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Gentian Violet; Histocytochemistry; Humans; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Karyotyping; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orchiectomy; Osteosarcoma; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Neoplasm; Specific Pathogen-Free Organisms; Tumor Cells, Cultured | 2000 |
Autocrine effect of DHT on FGF signaling and cell proliferation in LNCaP cells: role of heparin/heparan-degrading enzymes.
Topics: Cell Division; Culture Media, Serum-Free; Dihydrotestosterone; DNA Primers; Electrophoresis, Agar Gel; Fibroblast Growth Factor 2; Gene Expression Regulation, Neoplastic; Heparin Lyase; Humans; Male; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Tumor Cells, Cultured | 2000 |
Re: Back to future-the role of complementary medicine in urology.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Dietary Fats; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Rats | 2000 |
Targeting and eradicating cancer cells by a prostate-specific vector carrying the diphtheria toxin A gene.
Topics: Dihydrotestosterone; Diphtheria Toxin; Genetic Therapy; Genetic Vectors; Humans; Immunotoxins; Liposomes; Luminescent Proteins; Male; Peptide Fragments; Plasmids; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Transfection; Tumor Cells, Cultured | 2000 |
Expression of receptor protein tyrosine phosphatase alpha mRNA in human prostate cancer cell lines.
Topics: Acid Phosphatase; Animals; Blotting, Northern; Butyrates; Carcinogens; Cattle; Dihydrotestosterone; Fetal Proteins; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; RNA, Messenger; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Rapid androgen actions on calcium signaling in rat sertoli cells and two human prostatic cell lines: similar biphasic responses between 1 picomolar and 100 nanomolar concentrations.
Topics: Androgen Antagonists; Androgens; Animals; Calcium Signaling; Cell Line; Cyproterone Acetate; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Gap Junctions; Humans; Kinetics; Male; Metribolone; Prostate; Prostatic Neoplasms; Rats; Rats, Wistar; Sertoli Cells; Testosterone; Tumor Cells, Cultured | 2000 |
Tumor necrosis factor-alpha represses androgen sensitivity in the LNCaP prostate cancer cell line.
Topics: Antibiotics, Antineoplastic; Blotting, Northern; Blotting, Western; Carcinogens; Cell Division; Dactinomycin; Dihydrotestosterone; Disease Progression; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Luciferases; Male; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
[Perhaps an explanation for the therapeutic escape of prostate cancer treated with antiandrogens].
Topics: Androgen Antagonists; Dihydrotestosterone; Drug Resistance, Neoplasm; Humans; Hydrocortisone; Male; Neoplasms, Hormone-Dependent; Point Mutation; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured; X Chromosome | 2000 |
Re: "parental age at child's birth and son's risk of prostate cancer: the Framingham Study".
Topics: Adult; Age Factors; Coitus; Dihydrotestosterone; Female; Fertility; Humans; Male; Paternal Exposure; Prostatic Neoplasms; Risk Assessment | 2000 |
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone.
Topics: Blotting, Northern; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Formazans; Humans; Male; Membrane Glycoproteins; Metalloendopeptidases; Prostate-Specific Antigen; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Tumor Cells, Cultured | 2000 |
Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells.
Topics: Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Hydroxyprostaglandin Dehydrogenases; Male; Prostaglandins; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 2000 |
Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Chromosomes, Human, Pair 19; Cloning, Molecular; Dihydrotestosterone; Exons; Gene Expression Profiling; Humans; Introns; Kallikreins; Male; Molecular Sequence Data; Neoplasm Proteins; Phylogeny; Physical Chromosome Mapping; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Sequence Alignment; Tumor Cells, Cultured; Up-Regulation | 2001 |
Differential responsiveness of prostatic acid phosphatase and prostate-specific antigen mRNA to androgen in prostate cancer cells.
Topics: Acid Phosphatase; Androgens; Carcinogens; Cell Division; Dihydrotestosterone; Humans; Male; Phenolsulfonphthalein; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer.
Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents; Blotting, Western; Chromans; Dihydrotestosterone; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Ligands; Male; Middle Aged; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Cytoplasmic and Nuclear; Response Elements; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2000 |
Potential involvement of mt1 receptor and attenuated sex steroid-induced calcium influx in the direct anti-proliferative action of melatonin on androgen-responsive LNCaP human prostate cancer cells.
Topics: Adenocarcinoma; Blotting, Western; Calcium; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Humans; Immunoenzyme Techniques; Male; Melatonin; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2000 |
Prostate-specific antigen and androgens in African-American and white normal subjects and prostate cancer patients.
Topics: Aged; Biomarkers, Tumor; Black or African American; Black People; Case-Control Studies; Dihydrotestosterone; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Testosterone; White People | 2000 |
Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells.
Topics: Blotting, Northern; Blotting, Western; Carrier Proteins; Cell Line; Dihydrotestosterone; DNA; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; Humans; Luciferases; Male; Precipitin Tests; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 2000 |
Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.
Topics: Adenocarcinoma; Androgen Antagonists; Androgens; Animals; Binding Sites; Cell Line; COS Cells; Dihydrotestosterone; DNA; Estradiol; Flutamide; Humans; Male; Mice; Mice, Transgenic; Models, Molecular; Mutagenesis; Mutation; Progesterone; Prostatic Neoplasms; Protein Structure, Secondary; Receptors, Androgen; Structure-Activity Relationship; Transcriptional Activation; Transfection | 2001 |
In vivo model mimicking natural history of dog prostate cancer using DPC-1, a new canine prostate carcinoma cell line.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Dihydrotestosterone; Disease Models, Animal; Dogs; Humans; Immunohistochemistry; Iodine Radioisotopes; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Prostatic Neoplasms; Radionuclide Imaging; Tumor Cells, Cultured | 2001 |
Pregnenolone stimulates LNCaP prostate cancer cell growth via the mutated androgen receptor.
Topics: Animals; Binding, Competitive; Cell Division; Cell Line; Dexamethasone; Dihydrotestosterone; Gene Expression Regulation; Humans; Male; Mice; Mice, SCID; Mutation; Neoplasm Transplantation; Pregnenolone; Prostatic Neoplasms; Receptors, Androgen; Steroids; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
[7alpha-18F]fluoro-17alpha-methyl-5alpha-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer.
Topics: Animals; Dihydrotestosterone; Male; Prostatic Neoplasms; Radionuclide Imaging; Rats; Receptors, Androgen; Tissue Distribution | 2001 |
Testosterone: its role in development of prostate cancer and potential risk from use as hormone replacement therapy.
Topics: Animals; Dihydrotestosterone; Hormone Replacement Therapy; Humans; Male; Prostate; Prostatic Neoplasms; Risk Factors; Testosterone | 2000 |
[Clinical role of cell cycle regulators in androgen-dependent cancer cell growth].
Topics: Androgens; Animals; Cell Cycle Proteins; Cell Division; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Long-term exposure of tumor necrosis factor alpha causes hypersensitivity to androgen and anti-androgen withdrawal phenomenon in LNCaP prostate cancer cells.
Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Dihydrotestosterone; Humans; Luciferases; Male; Nitriles; Prostatic Neoplasms; Time Factors; Tosyl Compounds; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Covariate measurement error adjustment for matched case-control studies.
Topics: Bias; Biometry; Case-Control Studies; Computer Simulation; Dihydrotestosterone; Humans; Logistic Models; Male; Monte Carlo Method; Odds Ratio; Prostatic Neoplasms; Risk Factors; Testosterone | 2001 |
Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation.
Topics: Animals; Caveolin 1; Caveolins; Cell Line; Cell Membrane; Dihydrotestosterone; Humans; Male; Mammals; Prostatic Neoplasms; Receptors, Androgen; Recombinant Proteins; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2001 |
Effects of cyclic adenosine-monophosphate on growth and PSA secretion of human prostate cancer cell line.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cell Division; Colforsin; Cyclic AMP; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 2001 |
Antitumor effect of an HER2-specific antibody-toxin fusion protein on human prostate cancer cells.
Topics: ADP Ribose Transferases; Animals; Antibodies, Monoclonal; Apoptosis; Bacterial Toxins; Dihydrotestosterone; Exotoxins; Immunotoxins; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Pseudomonas aeruginosa Exotoxin A; Receptor, ErbB-2; Recombinant Fusion Proteins; Tumor Cells, Cultured; Virulence Factors | 2001 |
Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone.
Topics: Amino Acid Sequence; Amino Acid Substitution; Androgens; Animals; Binding Sites; Crystallography, X-Ray; Dihydrotestosterone; Dimerization; Humans; Ligands; Male; Models, Molecular; Molecular Sequence Data; Mutation; Progesterone; Prostatic Neoplasms; Protein Structure, Tertiary; Rats; Receptors, Androgen; Receptors, Progesterone; Sequence Alignment; Substrate Specificity; Threonine; Tumor Cells, Cultured | 2001 |
Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells.
Topics: Androgen Receptor Antagonists; Antineoplastic Agents, Hormonal; Carcinoma; Dihydrotestosterone; DNA-Binding Proteins; Drug Synergism; Flutamide; Gene Expression; Humans; Interleukin-6; Kidney Neoplasms; Male; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2001 |
Hypogonadism following prostate-bed radiation therapy for prostate carcinoma.
Topics: Aged; Aged, 80 and over; Dihydrotestosterone; Estradiol; Fertility Agents, Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; Luteinizing Hormone; Male; Middle Aged; Orchiectomy; Prostatic Neoplasms; Radiation Injuries; Testis; Testosterone | 2001 |
Role of canine basal cells in prostatic post natal development, induction of hyperplasia, sex hormone-stimulated growth; and the ductal origin of carcinoma.
Topics: Adenocarcinoma; Androstane-3,17-diol; Animals; Cell Division; Dihydrotestosterone; Disease Models, Animal; Dog Diseases; Dogs; Estradiol; Gonadal Steroid Hormones; Immunohistochemistry; Keratins; Ki-67 Antigen; Male; Orchiectomy; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen | 2001 |
Dihydrotestosterone enhances transforming growth factor-beta-induced apoptosis in hormone-sensitive prostate cancer cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Dihydrotestosterone; Drug Interactions; Enzyme Inhibitors; Humans; Male; Microtubule-Associated Proteins; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland.
Topics: Androgens; Animals; Aromatase; Body Weight; Diet; Diethylstilbestrol; Dihydrotestosterone; Glycine max; Immunohistochemistry; Isoflavones; Male; Mice; Mice, Knockout; Organ Size; Prolactin; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 2001 |
Identification of differentially expressed genes by serial analysis of gene expression in human prostate cancer.
Topics: Dihydrotestosterone; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Prostate; Prostatic Neoplasms; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.
Topics: Aged; Androgen Antagonists; Animals; Dihydrotestosterone; Histone Acetyltransferases; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivator 2; Orchiectomy; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Testosterone; Transcription Factors; Transcriptional Activation; Transplantation, Heterologous | 2001 |
Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Aged; Base Pair Mismatch; Carrier Proteins; Case-Control Studies; Dihydrotestosterone; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Lymphocytes; Male; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Pilot Projects; Prostatic Neoplasms; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; Statistics, Nonparametric; Testosterone | 2001 |
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
Topics: Amino Acid Substitution; Androgen Receptor Antagonists; Apoptosis; Chromones; Dihydrotestosterone; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Morpholines; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Recombinant Proteins; Serine; Signal Transduction; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2001 |
Role of canine basal cells in postnatal prostatic development, induction of hyperplasia, and sex hormone-stimulated growth; and the ductal origin of carcinoma.
Topics: Adenocarcinoma; Androstane-3,17-diol; Animals; Cell Division; Dihydrotestosterone; Disease Models, Animal; Dog Diseases; Dogs; Estradiol; Gonadal Steroid Hormones; Immunohistochemistry; Keratins; Ki-67 Antigen; Male; Orchiectomy; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen | 2001 |
Androgen receptor isoforms in human prostatic cancer tissue and LNCaP cell line.
Topics: Dihydrotestosterone; Humans; Isoelectric Focusing; Isomerism; Male; Prostatic Neoplasms; Radioligand Assay; Receptors, Androgen; Tritium; Tumor Cells, Cultured | 2001 |
The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3.
Topics: Adenocarcinoma; Cycloheximide; Dactinomycin; Dihydrotestosterone; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, Reporter; Humans; Immediate-Early Proteins; Ligands; Male; Metribolone; Prostatic Neoplasms; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-fos; Receptors, Androgen; Signal Transduction; Smad3 Protein; Testosterone Congeners; Trans-Activators; Transcription Factors; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2002 |
Identification of androgen-regulated genes in the prostate cancer cell line LNCaP by serial analysis of gene expression and proteomic analysis.
Topics: Androgens; Dihydrotestosterone; Electrophoresis, Gel, Two-Dimensional; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Proteins; Prostatic Neoplasms; Proteome; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Tumor Cells, Cultured | 2001 |
[Measurement of T and DHT contents in normal and diseased human prostate tissues].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Dihydrotestosterone; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Radioimmunoassay; Testosterone | 2000 |
Protein kinase C pathway is involved in regulating the secretion of prostatic acid phosphatase in human prostate cancer cells.
Topics: Acid Phosphatase; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
The regulation of prostate cancer cell adhesion to human bone marrow endothelial cell monolayers by androgen dihydrotestosterone and cytokines.
Topics: Adenocarcinoma; Bone Marrow; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Dihydrotestosterone; E-Selectin; Endothelium, Vascular; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Integrins; Male; Neoplasm Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Prostatic Neoplasms; Receptors, Collagen; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
The effects of natural ligands of hormone receptors and their antagonists on telomerase activity in the androgen sensitive prostatic cancer cell line LNCaP.
Topics: Androgens; Antineoplastic Agents, Hormonal; Dihydrotestosterone; Estradiol; Humans; Immunoblotting; Ligands; Male; Prostatic Neoplasms; Receptors, Pancreatic Hormone; Tamoxifen; Telomerase; Tumor Cells, Cultured | 2002 |
Dihydrotestosterone (DHT) modulates the ability of NSAIDs to induce apoptosis of prostate cancer cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dihydrotestosterone; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Microscopy, Electron; Microscopy, Electron, Scanning; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Sulfonamides; Tumor Cells, Cultured | 2002 |
A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer.
Topics: Androgen Antagonists; Androgens; Anilides; Binding, Competitive; Cell Line; Dihydrotestosterone; Fludrocortisone; Genes, Reporter; Glucocorticoids; Humans; Hydrocortisone; Kinetics; Ligands; Male; Mifepristone; Models, Molecular; Mutation; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Radioligand Assay; Receptors, Androgen; Tosyl Compounds; Triamcinolone | 2002 |
Differentiation and stromal-induced growth promotion of murine prostatic tumors.
Topics: Agar; Animals; Cell Differentiation; Cell Division; Cell Line, Transformed; Cell Transplantation; Culture Media; Dihydrotestosterone; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth; Neoplasm Transplantation; Phenotype; Prostate; Prostatic Neoplasms; Stromal Cells; Transforming Growth Factor beta; Tumor Cells, Cultured | 2002 |
Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer.
Topics: Androgens; Antigens, Surface; Carboxypeptidases; Dihydrotestosterone; Dose-Response Relationship, Drug; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Glutamate Carboxypeptidase II; HeLa Cells; Humans; Male; Plasmids; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation | 2002 |
Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Catalytic Domain; Cloning, Molecular; Dihydrotestosterone; DNA, Complementary; Enzyme Activation; Enzyme Induction; Humans; Male; Molecular Sequence Data; Open Reading Frames; Phosphorylation; Phylogeny; Prostatic Neoplasms; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Subcellular Fractions; Tumor Cells, Cultured | 2002 |
Sexual activity and the risk of prostate cancer.
Topics: Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Risk Factors; Sexual Behavior; Sexually Transmitted Diseases | 2002 |
TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells.
Topics: Animals; Calcitriol; Cell Division; Dihydrotestosterone; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Proteins; Mice; Prostate; Prostatic Neoplasms; RNA, Neoplasm; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Physiologic basis for hormonal theapy in carcinoma of the prostate.
Topics: Adrenalectomy; Androgen Antagonists; Androgens; Animals; Castration; Chemical Phenomena; Chemistry; Chlormadinone Acetate; Cyproterone; Depression, Chemical; Dihydrotestosterone; Estrogens; Hormones; Humans; Hypophysectomy; Luteinizing Hormone; Male; Prostate; Prostatic Neoplasms; Testosterone | 1975 |
Letter: Hormones, elderly testes, and carcinoma of the prostate.
Topics: Androgens; Androstenedione; Dihydrotestosterone; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1975 |
[Androgens].
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen Antagonists; Androgen-Insensitivity Syndrome; Androgens; Animals; Dihydrotestosterone; Female; Male; Medroxyprogesterone; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Receptors, Cell Surface; Testosterone | 1975 |
Androgen of the human prostate.
Topics: Androgens; Androstane-3,17-diol; Desoxycorticosterone; Dihydrotestosterone; Female; Humans; Male; Organ Specificity; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Sex Factors; Testosterone | 1976 |
Metal-androgen interrelationships in carcinoma and hyperplasia of the human prostate.
Topics: Adult; Aged; Androgens; Cadmium; Dihydrotestosterone; Environmental Exposure; Humans; Male; Middle Aged; Occupational Diseases; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Zinc | 1976 |
Androgen levels in the plasma and prostatic tissues of patients with benign hypertrophy and carcinoma of the prostate.
Topics: Aged; Androgens; Androstenedione; Dihydrotestosterone; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1976 |
In vitro uptake of 3H testosterone and its conversion to dihydrotestosterone by prostatic carcinoma and other tissues.
Topics: Aged; Culture Techniques; Diethylstilbestrol; Dihydrotestosterone; Flutamide; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Tritium | 1976 |
Formation of 5alpha-androstane-3alpha,17beta-diol by normal and hypertrophic human prostate.
Topics: Adult; Age Factors; Aged; Androstane-3,17-diol; Androstanes; Cytosol; Dihydrotestosterone; Female; Humans; Male; Microsomes; Middle Aged; NAD; NADP; Organ Size; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Time Factors | 1977 |
[Role of hormonal factors in the pathogenesis of prostatic hypertrophy].
Topics: Aged; Aging; Androgens; Dihydrotestosterone; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1977 |
Hormonal status in prostatic disease.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Androstenediols; Castration; Child; Chorionic Gonadotropin; Dihydrotestosterone; Estradiol; Female; Follicle Stimulating Hormone; Hormones; Humans; Luteinizing Hormone; Male; Medroxyprogesterone; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1976 |
Androgen receptors in male sex tissues of rats and humans.
Topics: Androstane-3,17-diol; Androstenedione; Animals; Dihydrotestosterone; Epididymis; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid; Testis; Testosterone | 1976 |
Prostatic adenoma and carcinoma in cell culture and heterotransplantation.
Topics: Acid Phosphatase; Animals; Cells, Cultured; Culture Media; Dihydrotestosterone; Epithelial Cells; Epithelium; Estrogens; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Receptors, Androgen; Testosterone; Transplantation, Heterologous | 1976 |
The influence of oestradiol on the metabolism of androgens by human prostatic tissue.
Topics: Aged; Androgens; Androstenedione; Dihydrotestosterone; Estradiol; Humans; Male; Middle Aged; Organ Culture Techniques; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1977 |
Characterization and measurement of the androgen receptor in human benign prostatic hyperplasia and prostatic hyperplasia and prostatic carcinoma.
Topics: Carcinoma; Cytosol; Dihydrotestosterone; Humans; In Vitro Techniques; Ligands; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Testosterone; Testosterone Congeners | 1977 |
Altered androgen metabolism in metastatic prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Dihydrotestosterone; Humans; In Vitro Techniques; Lymphatic Metastasis; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1978 |
The effect of human serum on 3H-thymidine incorporation in human prostate tumors in tissue culture.
Topics: Animals; Blood; Cattle; Culture Techniques; Dihydrotestosterone; DNA; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Thymidine; Tritium | 1978 |
[Tissue culture of the human prostate--effects of sex hormones on subcultures of cells from benign prostatic hyperplasia and carcinoma of the prostate (author's transl)].
Topics: Adenocarcinoma; Cell Count; Cell Division; Culture Techniques; Diethylstilbestrol; Dihydrotestosterone; Estrone; Gonadal Steroid Hormones; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1978 |
Androgen receptor assay in human benign and malignant prostatic tumour cytosol using protamine sulphate precipitation.
Topics: Adult; Animals; Chemical Precipitation; Cytosol; Dihydrotestosterone; Estrogens; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Protamines; Rats; Receptors, Androgen; Receptors, Steroid; Testosterone | 1978 |
Human prostatic carcinoma: significant differences in its androgen binding and metabolism compared to the human benign prostatic hypertrophy.
Topics: Adenocarcinoma; Aged; Androstanes; Carcinoma; Cytosol; Dihydrotestosterone; Estradiol; Humans; Male; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Steroid; Sex Hormone-Binding Globulin; Testosterone | 1978 |
Dihydrotestosterone concentration in prostate cancer tissue as a predictor of tumor differentiation and hormonal dependency.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen Antagonists; Cell Differentiation; Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid | 1978 |
Serum steroids in normal males and patients with prostatic diseases.
Topics: Adult; Aged; Aging; Androstenedione; Androsterone; Dihydrotestosterone; Estradiol; Humans; Hydroxyprogesterones; Male; Middle Aged; Pregnenolone; Progesterone; Prostatic Hyperplasia; Prostatic Neoplasms; Reference Values; Steroids; Testosterone | 1978 |
[Autoradiographic demonstration of sex hormones in the human prostate].
Topics: Animals; Autoradiography; Dihydrotestosterone; Dogs; Humans; Male; Mice; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Rats | 1978 |
Increased ratio of 5 alpha-reductase: 3 alpha (beta)-hydroxysteroid dehydrogenase activities in the hyperplastic human prostate.
Topics: 3-Hydroxysteroid Dehydrogenases; Aged; Androstane-3,17-diol; Chromatography, Thin Layer; Dihydrotestosterone; Humans; Male; Middle Aged; Oxidoreductases; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Time Factors | 1979 |
Cancer of the prostate: early diagnosis by zinc and hormone analysis?
Topics: Aged; Dihydrotestosterone; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Zinc | 1979 |
DHT concentrations in human prostate cancer tissue.
Topics: Castration; Dihydrotestosterone; Estrogens; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms | 1978 |
Receptor proteins for androgens in prostatic disease.
Topics: Dihydrotestosterone; Estrenes; Hydrocortisone; Male; Progesterone; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Testosterone Congeners | 1978 |
C19O2-Steroid transformations in the human normal, hyperplastic and cancerous prostate.
Topics: Androstane-3,17-diol; Androstanols; Dihydrotestosterone; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Male; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxidoreductases; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1979 |
A comparative study of binding, metabolism and endogenous levels of androgens in normal, hyperplastic and carcinomatous human prostate.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Androstane-3,17-diol; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Sex Hormone-Binding Globulin; Testosterone | 1979 |
Metabolism and action of steroid hormones on human benign prostatic hyperplasia and prostatic carcinoma grown in organ culture.
Topics: Adult; Aged; Dihydrotestosterone; DNA; Estradiol; Humans; Male; Middle Aged; Organ Culture Techniques; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; RNA; Testosterone | 1979 |
Steroid levels in cancer of the prostate--markers of tumor differentiation and adequacy of anti-androgen therapy.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Carcinoma; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms | 1979 |
Protamine sulfate precipitation of androgen receptors in cytosols of human benign and malignant prostatic tumors.
Topics: Chemical Precipitation; Cytosol; Dihydrotestosterone; Humans; Ligands; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Protamines; Receptors, Androgen; Receptors, Steroid; Testosterone | 1979 |
Measurement and characterization of estrogen receptors in the human prostate.
Topics: Adult; Aged; Chromatography, DEAE-Cellulose; Cytosol; Diethylstilbestrol; Dihydrotestosterone; Epithelium; Humans; Kinetics; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Estrogen | 1979 |
Conversion of 3H-testosterone to dihydrotestosterone in human hypertrophic prostatic tissue.
Topics: Aged; Dihydrotestosterone; Humans; In Vitro Techniques; Male; Middle Aged; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Tritium | 1979 |
Androgen receptors in benign and malignant prostatic tissue.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen Antagonists; Animals; Cyproterone; Dihydrotestosterone; Estrenes; Flutamide; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Steroid | 1979 |
Steroid hormone receptors in the prostate.
Topics: Aged; Animals; Binding, Competitive; Cytosol; Dihydrotestosterone; Estradiol; Haplorhini; Humans; Male; Papio; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Steroid; Sex Hormone-Binding Globulin | 1979 |
The baboon prostate as a model for steroid hormone receptors in the human gland.
Topics: Adult; Aged; Animals; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Haplorhini; Humans; Male; Middle Aged; Papio; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Steroid; Sex Hormone-Binding Globulin; Testosterone; Testosterone Congeners | 1979 |
Biosynthesis and metabolism of androgenic hormones in cancer of the prostate.
Topics: Adenocarcinoma; Androgens; Androstenedione; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Testosterone | 1976 |
5alpha-dihydrotestosterone-binding proteins and androgen sensitivity in prostatic cancers of Copenhangen rats.
Topics: Androgens; Animals; Carcinoma, Squamous Cell; Castration; Cell Division; Cell Line; Chick Embryo; Cytoplasm; Dihydrotestosterone; Female; Male; Neoplasm Transplantation; Prostate; Prostatic Neoplasms; Protein Binding; Rats; Receptors, Cell Surface; Sex Factors | 1975 |
Percutaneous 17 beta-estradiol in treatment of cancer of prostate.
Topics: Adenocarcinoma; Dihydrotestosterone; Estradiol; Estrone; Follicle Stimulating Hormone; Humans; Lipoproteins, VLDL; Luteinizing Hormone; Male; Prostatic Neoplasms; Testosterone; Triglycerides | 1979 |
[Bromocriptine and prostatic carcinoma: testosterone metabolism in relation to tumor grading (author's transl)].
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aged; Androgens; Androstane-3,17-diol; Bromocriptine; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Testosterone | 1979 |
Serum testosterone and dihydrotestosterone in carcinoma of the prostate.
Topics: Aged; Carcinoma; Dihydrotestosterone; Humans; Male; Middle Aged; Prostatic Neoplasms; Testosterone | 1979 |
Adenocarcinoma of prostate: role of 17beta-estradiol and 5alpha-dihydrotestosterone binding proteins.
Topics: Adenocarcinoma; Castration; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Humans; Male; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Steroid | 1979 |
Steroid levels in cancer of the prostate--markers of tumour differentiation and adequacy of anti-androgen therapy.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androgen Antagonists; Castration; Dihydrotestosterone; Estrogens; Humans; Infant; Infant, Newborn; Male; Prostatic Neoplasms; Skin | 1979 |
The role of estrogen, androgen and progestogen receptors in the management of carcinoma of the prostate.
Topics: Adenocarcinoma; Castration; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid | 1979 |
Sucrose density gradient characterization of cytoplasmic [1,2-H3]-5alpha-dihydrotestosterone binding proteins in the accessory sexual glands of the male Syrian hamster.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Bulbourethral Glands; Centrifugation, Density Gradient; Cricetinae; Cytoplasm; Dihydrotestosterone; Male; Osmolar Concentration; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Seminal Vesicles; Temperature | 1978 |
An experimental approach to the optimum oestrogen dosage in prostatic carcinoma.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Cell Nucleus; Diethylstilbestrol; Dihydrotestosterone; Humans; In Vitro Techniques; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen | 1978 |
Hormone blood levels in patients with prostatic carcinoma and their relation to the type of carcinoma growth differentiation.
Topics: Adenocarcinoma; Age Factors; Aged; Androgens; Carcinoma; Dihydrotestosterone; Estradiol; Estrogens; Gonadotropins, Pituitary; Humans; Luteinizing Hormone; Male; Middle Aged; Prolactin; Prostatic Neoplasms; Radioimmunoassay; Testosterone | 1977 |
C19-steroid metabolism by spontaneous adenocarcinoma of the A X C rat ventral prostate.
Topics: 17-Ketosteroids; Adenocarcinoma; Androstenedione; Animals; Dihydrotestosterone; Hydroxysteroids; Hyperplasia; Male; Neoplasms, Experimental; Prostatic Neoplasms; Rats; Testosterone | 1977 |
Steroid receptors in the human prostate. Detection of tissue-specific androgen binding in prostate cancer.
Topics: Adenocarcinoma; Cytosol; Dihydrotestosterone; Humans; Lymph Nodes; Male; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid | 1977 |
Correlative study of the morphology and C19-steroid metabolism of benign and cancerous human prostatic tissue.
Topics: Androgens; Androstane-3,17-diol; Androstenedione; Carcinoma, Transitional Cell; Dihydrotestosterone; Humans; Hyperplasia; In Vitro Techniques; Male; Prostate; Prostatic Neoplasms; Testosterone | 1977 |
The simultaneous radioimmunoassay of seven steroids in human spermatic and peripheral venous blood.
Topics: Adult; Aged; Androstenedione; Androsterone; Dihydrotestosterone; Hormones; Humans; Male; Middle Aged; Pregnenolone; Progesterone; Prostatic Neoplasms; Radioimmunoassay; Steroids; Testis; Testosterone | 1977 |
Proceedings: Binding of 5 alpha-dihydrotestosterone in human prostatic cancer; examination by agar gel electrophoresis.
Topics: Dihydrotestosterone; Electrophoresis, Agar Gel; Humans; Male; Prostatic Neoplasms | 1976 |
A method for tissue extraction and determination of prostate concentrations of endogenous androgens by radioimmunoassay.
Topics: Androgens; Androstane-3,17-diol; Androstenedione; Dihydrotestosterone; Humans; Kidney; Male; Methods; Prostate; Prostatic Neoplasms; Radioimmunoassay; Spleen; Testosterone | 1976 |
The effects of diethylstilbestrol and medroxyprogesterone acetate on kinetics and production of testosterone and dihydrotestosterone in patients with prostatic carcinoma.
Topics: Aged; Diethylstilbestrol; Dihydrotestosterone; Humans; Kinetics; Male; Medroxyprogesterone; Metabolic Clearance Rate; Middle Aged; Prostatic Neoplasms; Testosterone | 1976 |
Specific binding protein for 17 beta-estradiol in prostate with adenocarcinoma.
Topics: Adenocarcinoma; Centrifugation, Density Gradient; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Sex Hormone-Binding Globulin | 1976 |
Letter: The possible dangers of androgens used for male climacteric.
Topics: Adenocarcinoma; Climacteric; Dihydrotestosterone; Humans; Male; Mesterolone; Middle Aged; Prostatic Neoplasms | 1975 |
Mode of action of progesterone, gestonorone capronate (Depostat) and cyproterone acetate (Androcur) on the metabolism of testosterone in human prostatic adenoma: in vitro and in vivo investigations.
Topics: Adenoma; Androstane-3,17-diol; Cyproterone; Dihydrotestosterone; Gestonorone Caproate; Humans; Male; Muscles; Progesterone; Prostate; Prostatic Neoplasms; Testosterone | 1975 |
The distribution of PSA, cathepsin-D, and pS2 in BPH and cancer of the prostate.
Topics: Cathepsin D; Dihydrotestosterone; Humans; Male; Neoplasm Proteins; Osmolar Concentration; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Proteins; Testosterone; Tissue Distribution; Trefoil Factor-1; Tumor Suppressor Proteins | 1992 |
Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein.
Topics: Adenocarcinoma; Antigens, Neoplasm; Base Sequence; Cell Line; Cloning, Molecular; Dihydrotestosterone; Gene Expression Regulation, Enzymologic; Humans; Kallikreins; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Oligonucleotide Probes; Polymerase Chain Reaction; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Biosynthesis; Restriction Mapping; RNA, Messenger; Tissue Kallikreins | 1992 |
Androgens up-regulate the human prostate-specific antigen messenger ribonucleic acid (mRNA), but down-regulate the prostatic acid phosphatase mRNA in the LNCaP cell line.
Topics: Acid Phosphatase; Actins; Androgens; Antigens, Neoplasm; Base Sequence; Cell Line; Dihydrotestosterone; Estradiol; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kallikreins; Male; Metribolone; Molecular Sequence Data; Oligonucleotide Probes; Progesterone; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; RNA, Neoplasm; Tissue Kallikreins | 1992 |
Effects of extracellular matrix components and dihydrotestosterone on the structure and function of human prostate cancer cells.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Cell Movement; Cell Nucleus; Cell Survival; Collagen; Dihydrotestosterone; Elastin; Humans; Laminin; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Tumor Cells, Cultured | 1992 |
Expression of human prostatic acid phosphatase activity and the growth of prostate carcinoma cells.
Topics: Acid Phosphatase; Base Sequence; Carcinoma; Cell Division; Dihydrotestosterone; DNA; Gene Expression; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Prostatic Neoplasms; RNA, Messenger; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
Regulation of prostatic carcinoma cell proliferation and secretory activity by extracellular matrix and stromal secretions.
Topics: Acid Phosphatase; Analysis of Variance; Basement Membrane; Biomarkers, Tumor; Blotting, Western; Cell Differentiation; Cell Division; Cell Line; Culture Media; Dihydrotestosterone; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Extracellular Matrix; Gene Expression Regulation, Neoplastic; Humans; Male; Microscopy, Phase-Contrast; Prostate-Specific Antigen; Prostatic Neoplasms | 1992 |
Regulation of androgen receptor by androgen and epidermal growth factor in a human prostatic cancer cell line, LNCaP.
Topics: Androgens; Blotting, Northern; Blotting, Western; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Time Factors; Transfection; Tumor Cells, Cultured | 1992 |
[Analysis of anchorage independent growth of human prostate cancer cell line LNCap].
Topics: Cell Division; Culture Media; Dihydrotestosterone; Epidermal Growth Factor; Ethinyl Estradiol; Humans; Male; Prostatic Neoplasms; Testosterone; Transforming Growth Factor alpha; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
The effect of dihydrotestosterone and culture conditions on proliferation of the human prostatic cancer cell line LNCaP.
Topics: Biological Factors; Cell Count; Cell Division; Culture Media, Serum-Free; Dihydrotestosterone; Humans; Male; Nutritional Status; Prostatic Neoplasms; Thymidine; Tumor Cells, Cultured | 1992 |
Physical characteristics and factors related to sexual development and behaviour and the risk for prostatic cancer.
Topics: Age Factors; Aged; Body Constitution; Case-Control Studies; Dihydrotestosterone; Educational Status; Estradiol; Fathers; Hospitals, University; Humans; Male; Marital Status; Middle Aged; Netherlands; Prevalence; Prostatic Neoplasms; Religion; Risk Factors; Saliva; Sex Hormone-Binding Globulin; Sexual Behavior; Sexual Maturation; Testosterone | 1992 |
Local hyperthermia for prostatic disease: in vitro studies on human prostatic cancer cell lines.
Topics: Cell Division; Cell Survival; Dihydrotestosterone; DNA, Neoplasm; Flutamide; Humans; Hyperthermia, Induced; Male; Prostatic Neoplasms; Tumor Cells, Cultured | 1992 |
Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.
Topics: Animals; Base Sequence; Cell Division; Cells, Cultured; Connective Tissue; Connective Tissue Cells; Dihydrotestosterone; Epithelial Cells; Epithelium; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Fibroblasts; Gene Expression Regulation; Growth Substances; Male; Molecular Sequence Data; Neoplasms, Hormone-Dependent; Prostate; Prostatic Neoplasms; Protein-Tyrosine Kinases; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Testosterone; Tumor Cells, Cultured | 1992 |
Differential effects of diethylstilbestrol and estradiol-17 beta in combination with testosterone on rat prostate lobes.
Topics: Animals; Body Weight; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Hormones; Male; Organ Culture Techniques; Organ Size; Precancerous Conditions; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Testosterone; Tritium | 1992 |
Glucocorticoid regulation of transforming growth factor-beta activation in urogenital sinus mesenchymal cells.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Chemical Phenomena; Chemistry, Physical; Dexamethasone; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Estradiol; Male; Mesoderm; Organ Culture Techniques; Progesterone; Prostatic Neoplasms; Rats; Transforming Growth Factor beta; Urogenital System | 1992 |
Effect of orchidectomy on serum concentrations of testosterone and dihydrotestosterone in patients with prostatic cancer.
Topics: Aged; Aged, 80 and over; Dihydrotestosterone; Humans; Male; Middle Aged; Orchiectomy; Prostatic Neoplasms; Testosterone | 1992 |
Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Animals; Azasteroids; Dihydrotestosterone; Fatty Acids, Unsaturated; Female; Humans; Male; Microscopy, Electron; Microsomes, Liver; NADP; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Testosterone; Tumor Cells, Cultured | 1992 |
Response of rat and human prostatic cancers to the novel 5 alpha-reductase inhibitor, SK&F 105657.
Topics: 5-alpha Reductase Inhibitors; Androstadienes; Animals; Antineoplastic Agents; Dihydrotestosterone; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Substrate Specificity; Tumor Cells, Cultured | 1992 |
Peripheral hormone levels in controls and patients with prostatic cancer or benign prostatic hyperplasia: results from the Dutch-Japanese case-control study.
Topics: Age Factors; Body Weight; Case-Control Studies; Dihydrotestosterone; Estradiol; Humans; Japan; Male; Netherlands; Prostatic Hyperplasia; Prostatic Neoplasms; Saliva; Sex Hormone-Binding Globulin; Testosterone | 1991 |
Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP.
Topics: Antigens, Neoplasm; Cell Aggregation; Cell Division; Cell Line; Dihydrotestosterone; Genes, myc; Humans; Male; Phenotype; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Testosterone Congeners | 1991 |
Optimism expressed over prostate drug.
Topics: Androstenes; Antineoplastic Agents; Azasteroids; Dihydrotestosterone; Finasteride; Humans; Male; Pilot Projects; Prostatic Hyperplasia; Prostatic Neoplasms; Recurrence | 1991 |
Consideration of the use of 17 beta-N,N-diethylcarbamoyl-4-methyl-4-aza-5- alpha-androstan-3-one (4MA), a 5 alpha-reductase inhibitor, in prostate cancer therapy.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgens; Animals; Azasteroids; Cell Division; Cell Survival; Dihydrotestosterone; Female; Male; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Organ Size; Prostate; Prostatic Neoplasms; Rats; Steroids | 1992 |
Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells.
Topics: Androgens; Base Sequence; Blotting, Western; Cell Line; Dihydrotestosterone; DNA; Down-Regulation; Humans; Ligands; Male; Molecular Sequence Data; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Testosterone Congeners; Tumor Cells, Cultured | 1991 |
Stimulation of apolipoprotein D secretion by steroids coincides with inhibition of cell proliferation in human LNCaP prostate cancer cells.
Topics: Apolipoproteins; Apolipoproteins D; Biomarkers, Tumor; Carrier Proteins; Cell Division; Cell Line; Dexamethasone; Dihydrotestosterone; Estradiol; Glycoproteins; Humans; Immunoblotting; Kinetics; Male; Membrane Transport Proteins; Metribolone; Progesterone; Prostatic Neoplasms; Radioimmunoassay; Receptors, Androgen; Steroids; Structure-Activity Relationship | 1991 |
Effects of androgen on intracellular calcium of LNCaP cells.
Topics: Calcium; Cell Line; Dihydrotestosterone; Fura-2; Humans; Kinetics; Male; Nandrolone; Prostatic Neoplasms; Spectrometry, Fluorescence; Testosterone Congeners; Time Factors; Verapamil | 1991 |
Characteristics of the biphasic action of androgens and of the potent antiproliferative effects of the new pure antiestrogen EM-139 on cell cycle kinetic parameters in LNCaP human prostatic cancer cells.
Topics: Androgens; Androstane-3,17-diol; Binding, Competitive; Cell Cycle; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Antagonism; Estradiol; Estrogen Antagonists; Estrone; Flow Cytometry; Flutamide; Humans; In Vitro Techniques; Male; Metribolone; Piperidines; Prostatic Neoplasms; Raloxifene Hydrochloride; Tamoxifen; Testosterone; Time Factors; Tumor Cells, Cultured | 1991 |
Effects of estrogen on growth of androgen-responsive rat prostatic tumor (R 3327).
Topics: Animals; Castration; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Antagonism; Estradiol; Humans; Injections, Subcutaneous; Male; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Organ Size; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Seminal Vesicles; Sex Factors; Testosterone | 1991 |
Interferon and hormone-sensitivity of prostatic cancer cells.
Topics: Cell Division; Dihydrotestosterone; Humans; Interferon-beta; Male; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 1991 |
Growth factors in human prostate cancer cells: implications for an improved treatment of prostate cancer.
Topics: Cell Division; Culture Media, Serum-Free; Dihydrotestosterone; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Prostatic Neoplasms; Suramin; Tumor Cells, Cultured | 1991 |
Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma.
Topics: Biological Transport; Blotting, Northern; Cell Cycle; Cell Membrane; Dihydrotestosterone; Gene Expression; Humans; In Vitro Techniques; Male; Prostatic Neoplasms; RNA, Messenger; Sex Hormone-Binding Globulin; Testosterone; Tumor Cells, Cultured | 1991 |
Assessment of the critical level of androgen for growth response of transplantable human prostatic carcinoma (PC-82) in nude mice.
Topics: Animals; Dihydrotestosterone; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Testosterone | 1991 |
Establishment and characterization of a human prostatic carcinoma cell strain obtained from exfoliated tumor cells after prostatic massage.
Topics: Cell Division; Culture Media; Dihydrotestosterone; Estradiol; Humans; Immunohistochemistry; Male; Middle Aged; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1991 |
v-rasH expression confers hormone-independent in vitro growth to LNCaP prostate carcinoma cells.
Topics: Animals; Cadmium; Cell Division; Dihydrotestosterone; Gene Expression; Genes, ras; Humans; Male; Metallothionein; Mice; Mice, Nude; Neoplasm Transplantation; Oncogene Protein p21(ras); Phenotype; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1991 |
Biological effects of sex hormone-binding globulin on androgen-induced proliferation and androgen metabolism in LNCaP prostate cells.
Topics: Cell Division; Dihydrotestosterone; Humans; Male; Metribolone; Prostate; Prostatic Neoplasms; Protein Binding; Sex Hormone-Binding Globulin; Tumor Cells, Cultured | 1991 |
Effects of low testosterone levels and of adrenal androgens on growth of prostate tumor models in nude mice.
Topics: Animals; Cell Transformation, Neoplastic; Dehydroepiandrosterone; Dihydrotestosterone; Female; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1990 |
The synthetic androgen mibolerone induces transient suppression of the transformed phenotype in an androgen responsive human prostatic carcinoma cell line.
Topics: Androgen Antagonists; Androgens; Cell Division; Cell Transformation, Neoplastic; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Humans; Male; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Tumor Cells, Cultured | 1990 |
Phosphoinositide metabolism in human prostate cancer cells in vitro.
Topics: Androgen Antagonists; Dihydrotestosterone; Humans; Male; Phosphatidylinositols; Prostatic Neoplasms; Tumor Cells, Cultured; Type C Phospholipases | 1990 |
Biologically active steroids activate receptor-bound human sex hormone-binding globulin to cause LNCaP cells to accumulate adenosine 3',5'-monophosphate.
Topics: 2-Methoxyestradiol; Adenylyl Cyclases; Cell Line; Cell Membrane; Cyclic AMP; Dihydrotestosterone; Estradiol; Humans; Kinetics; Male; Prostatic Neoplasms; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Tumor Cells, Cultured | 1990 |
Anti-5 alpha-reductase autoantibodies in the serum of patients with prostatic cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Autoantibodies; Azasteroids; Dihydrotestosterone; Humans; Immunoglobulin G; Male; Microsomes, Liver; Middle Aged; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1990 |
The proliferative effect of "anti-androgens" on the androgen-sensitive human prostate tumor cell line LNCaP.
Topics: Androgens; Antibodies; Cell Division; Dihydrotestosterone; Estradiol; Flutamide; Humans; Male; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; Testosterone Congeners; Tumor Cells, Cultured | 1990 |
Production of epidermal growth factor and transforming growth factor-alpha by the androgen-responsive LNCaP human prostate cancer cell line.
Topics: Androgens; Chromatography, Gel; Dihydrotestosterone; Epidermal Growth Factor; Humans; Male; Prostatic Neoplasms; Radioimmunoassay; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |
Androgen receptor gene expression in human prostate carcinoma cell lines.
Topics: Cell Line; Dihydrotestosterone; Exons; Gene Expression; Humans; Kinetics; Male; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Tumor Cells, Cultured | 1990 |
[Hormone-dependency of the human prostate].
Topics: Dihydrotestosterone; Humans; Male; Neoplasms, Hormone-Dependent; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid | 1986 |
Comparison of nuclear 5 alpha-reductase activities in the stromal and epithelial fractions of human prostatic tissue.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Cell Nucleus; Dihydrotestosterone; Edetic Acid; Epithelium; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone; Zinc | 1987 |
The epithelial origin of a stromal cell population in adenocarcinoma of the rat prostate.
Topics: Acid Phosphatase; Adenocarcinoma; Animals; Autoradiography; Cell Nucleus; Cell Separation; Cytoplasm; Dihydrotestosterone; Epithelium; Flow Cytometry; Histocytochemistry; Immunoenzyme Techniques; Keratins; Male; Mice; Mice, Nude; Prostatic Neoplasms; Rats; Tritium | 1987 |
The partial dependency of human prostatic growth factor on steroid hormones in stimulating thymidine incorporation into DNA.
Topics: Adult; Aged; Dihydrotestosterone; DNA; DNA, Neoplasm; Electrophoresis, Polyacrylamide Gel; Estradiol; Growth Substances; Humans; Isoelectric Focusing; Male; Middle Aged; Molecular Weight; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Steroids; Thymidine | 1987 |
Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer.
Topics: Adrenal Glands; Animals; Chlormadinone Acetate; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; Megestrol; Megestrol Acetate; Organ Size; Ornithine Decarboxylase; Progesterone Congeners; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Spironolactone | 1987 |
Kinetic parameters of 5 alpha-reductase activity in stroma and epithelium of normal, hyperplastic, and carcinomatous human prostates.
Topics: Aged; Aged, 80 and over; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Epithelium; Humans; Kinetics; Male; Middle Aged; Oxidoreductases; Progesterone; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Radioimmunoassay | 1988 |
Effect of diethylstilbestrol diphosphate on activity of 5 alpha-reductase in human prostate.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Diethylstilbestrol; Dihydrotestosterone; Humans; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Time Factors | 1987 |
Dihydrotestosterone measured in core biopsies from prostatic tissues.
Topics: Aged; Aged, 80 and over; Biopsy; Cell Nucleus; Dihydrotestosterone; DNA; DNA, Neoplasm; Humans; Male; Middle Aged; Neoplasms, Hormone-Dependent; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms | 1988 |
[A study on usefulness of the crude nuclear DHT measurement in prostatic cancer patients].
Topics: Androgens; Cell Nucleus; Dihydrotestosterone; Humans; Male; Methods; Neoplasms, Hormone-Dependent; Predictive Value of Tests; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen | 1989 |
N-3-[18F]fluoropropylputrescine as potential PET imaging agent for prostate and prostate derived tumors.
Topics: Animals; Carbon Radioisotopes; Cell Line; Dihydrotestosterone; Eflornithine; Humans; Male; Prostate; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Tumor Cells, Cultured | 1989 |
Pharmacokinetics, endocrine and antitumour effects of leuprolide depot (TAP-144-SR) in advanced prostatic cancer: a dose-response evaluation.
Topics: Aged; Antineoplastic Agents; Delayed-Action Preparations; Dihydrotestosterone; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Leuprolide; Luteinizing Hormone; Male; Models, Theoretical; Prostatic Neoplasms; Radioimmunoassay; Testosterone | 1989 |
[Clinical and endocrinological studies of the luteinizing hormone-releasing hormone analogue therapy in prostatic cancer patients].
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgens; Antineoplastic Agents; Buserelin; Dihydrotestosterone; Drug Evaluation; Gonadotropin-Releasing Hormone; Goserelin; Humans; Leuprolide; Male; Middle Aged; Prostatic Neoplasms; Remission Induction; Testosterone | 1989 |
Decreased urinary 5 alpha-androstane-3 alpha,17 beta-diol glucuronide excretion in patients with benign prostatic hyperplasia.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aging; Androstane-3,17-diol; Androstanols; Androstenedione; Dihydrotestosterone; Humans; Male; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1985 |
Negative controls of cell proliferation: human prostate cancer cells and androgens.
Topics: Adenocarcinoma; Androgens; Animals; Cell Division; Culture Media; Dihydrotestosterone; Estradiol; Growth Inhibitors; Growth Substances; Male; Mice; Mice, Nude; Prostatic Neoplasms; Receptors, Androgen; Trypsin; Tumor Cells, Cultured | 1989 |
Estradiol and testosterone metabolism and production in men with prostatic cancer.
Topics: Androgens; Carbon Radioisotopes; Dihydrotestosterone; Estradiol; Estrogens; Humans; Male; Metabolic Clearance Rate; Middle Aged; Prostatic Neoplasms; Reference Values; Testosterone; Tritium | 1989 |
Role of transforming growth factor-alpha in human prostate cancer cell growth.
Topics: Cell Division; Dihydrotestosterone; ErbB Receptors; Humans; Male; Prostatic Neoplasms; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
Comparison of dihydrotestosterone levels in prostatic cancer metastases and primary prostate cancer.
Topics: Dihydrotestosterone; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Pelvis; Prostate; Prostatic Neoplasms | 1989 |
Prevention and treatment of experimental prostate cancer in Lobund-Wistar rats. I. Effects of estradiol, dihydrotestosterone, and castration.
Topics: Adenocarcinoma; Animals; Dihydrotestosterone; Disease Models, Animal; Estradiol; Germ-Free Life; Male; Neoplasm Staging; Orchiectomy; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1989 |
Androgens, adrenal androgen precursors, and their metabolism in untreated primary tumors and lymph node metastases of human prostatic cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenal Glands; Androgens; Androstenediols; Androstenedione; Arylsulfatases; Cholestenone 5 alpha-Reductase; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Humans; Lymphatic Metastasis; Male; Neoplasms, Hormone-Dependent; Oxidoreductases; Prostate; Prostatic Neoplasms; Steryl-Sulfatase; Testosterone | 1988 |
Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer.
Topics: Aged; Androgens; Androstane-3,17-diol; Androstenediol; Androsterone; Dehydroepiandrosterone; Dihydrotestosterone; Glucuronates; Humans; Male; Middle Aged; Orchiectomy; Prostatic Neoplasms; Testosterone | 1986 |
Androgen-dependent growth regulation of and release of specific protein(s) by the androgen receptor containing human prostate tumor cell line LNCaP.
Topics: Androgens; Cell Division; Cell Line; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Estrenes; Humans; Male; Metribolone; Neoplasm Proteins; Prostate; Prostatic Neoplasms; Receptors, Androgen; Triamcinolone Acetonide | 1986 |
Characterization of androgen receptors in a transplantable human prostatic adenocarcinoma (PC-82).
Topics: Adenocarcinoma; Cell Line; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Estradiol; Estrenes; Humans; Male; Metribolone; Molecular Weight; Neoplasm Transplantation; Progesterone; Prostatic Neoplasms; Receptors, Androgen; Testosterone; Triamcinolone Acetonide | 1987 |
The contribution of animal models to the understanding of endocrine management of prostate cancer. Effect of androgen and estrogen.
Topics: Animals; Castration; Colony-Forming Units Assay; Diethylstilbestrol; Dihydrotestosterone; Disease Models, Animal; Estradiol; Estrogen Antagonists; Estrogens; Male; Neoplastic Stem Cells; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Cell Surface; Receptors, Estrogen; Stem Cells; Testosterone; Tumor Stem Cell Assay | 1985 |
Hormonal agents and treatment of cancer.
Topics: Androgens; Breast Neoplasms; Diethylstilbestrol; Dihydrotestosterone; Estrogens; Female; Flutamide; Hormones; Humans; Male; Neoplasms, Hormone-Dependent; Progestins; Prostatic Neoplasms; Receptors, Androgen; Receptors, Cell Surface; Receptors, Estrogen | 1986 |
The effects of external beam radiotherapy on endocrine function in patients with carcinoma of the prostate.
Topics: Adenocarcinoma; Dihydrotestosterone; Follicle Stimulating Hormone; Follow-Up Studies; Humans; Luteinizing Hormone; Male; Prospective Studies; Prostatic Neoplasms; Radiotherapy Dosage; Radiotherapy, High-Energy; Testis; Testosterone; Time Factors | 1986 |
Comparison of the efficacy of subcutaneous and nasal spray buserelin treatment in suppression of testicular steroidogenesis in men with prostate cancer.
Topics: Administration, Intranasal; Aged; Buserelin; Dihydrotestosterone; Drug Evaluation; Estradiol; Gonadal Steroid Hormones; Humans; Injections, Subcutaneous; Luteinizing Hormone; Male; Middle Aged; Neoplasms, Hormone-Dependent; Prospective Studies; Prostatic Neoplasms; Random Allocation; Testis; Testosterone | 1986 |
alpha-Difluoromethylornithine enhancement of 14C-putrescine uptake by an androgen-dependent prostatic tumor.
Topics: Adenocarcinoma; Androgens; Animals; Carbon Radioisotopes; Dexamethasone; Dihydrotestosterone; Eflornithine; Male; Neoplasms, Hormone-Dependent; Premedication; Prostatic Neoplasms; Putrescine; Radionuclide Imaging; Rats | 1986 |
Long-term endocrine profiles of prostatic carcinoma patients under pernasal as well as intramuscular Gn-RH analogue treatment.
Topics: Administration, Intranasal; Buserelin; Dihydrotestosterone; Follow-Up Studies; Gonadotropin-Releasing Hormone; Humans; Injections, Intramuscular; Male; Prostatic Neoplasms; Testosterone; Time Factors; Triptorelin Pamoate | 1985 |
Growth inhibiting effect of estramustine on two prostatic carcinoma cell lines, LNCaP and LNCaP-r.
Topics: Cell Division; Cell Line; Dihydrotestosterone; Drug Resistance; Drug Synergism; Estradiol; Estramustine; Humans; Male; Nitrogen Mustard Compounds; Prostatic Neoplasms; Tumor Cells, Cultured | 1988 |
Hormonal consequences of orchidectomy for carcinoma of the prostate. With special reference to the measurement of free testosterone in saliva and prostatic dihydrotestosterone levels.
Topics: Aged; Aged, 80 and over; Androgens; Carcinoma; Dihydrotestosterone; Humans; Male; Middle Aged; Orchiectomy; Prostatic Neoplasms; Saliva; Sex Hormone-Binding Globulin; Testosterone | 1988 |
Androgen-dependent human prostate cancer in nude mice. The PC-82 tumor model.
Topics: Adenocarcinoma; Animals; Dihydrotestosterone; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Testosterone | 1988 |
[Prognostic evaluation of prostatic cancer by Gleason's histopathologic grading and tissue DHT level].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Diethylstilbestrol; Dihydrotestosterone; Humans; Male; Medroxyprogesterone; Middle Aged; Neoplasm Staging; Prognosis; Prostatic Neoplasms | 1988 |
Testosterone-mediated increase in 5 alpha-dihydrotestosterone content, nuclear androgen receptor levels, and cell division in an androgen-independent prostate carcinoma of Noble rats.
Topics: Animals; Carcinoma; Cell Division; Cell Nucleus; Cytosol; Dihydrotestosterone; Estrenes; Male; Metribolone; Mitotic Index; Orchiectomy; Prostatic Neoplasms; Rats; Receptors, Androgen; Testosterone | 1988 |
Basal and estrogen-stimulated hormone receptor profiles in four R3327 rat prostatic carcinoma sublines in relation to histopathology and androgen sensitivity.
Topics: Animals; Cell Fractionation; Cell Line; Cell Nucleus; Clone Cells; Cytosol; Diethylstilbestrol; Dihydrotestosterone; Estrenes; Kinetics; Male; Metribolone; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone | 1988 |
Growth factor involvement and oncogene expression in prostatic tumours.
Topics: Animals; Cell Division; Cell Line; Clone Cells; Dihydrotestosterone; Dogs; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Male; Oncogenes; Peptides; Prostate; Prostatic Neoplasms; Proto-Oncogene Mas; Transforming Growth Factors | 1988 |
Analysis of changes in rat prostate carcinoma following hormone deprivation.
Topics: Adenocarcinoma; Androgens; Animals; Autoradiography; Dihydrotestosterone; Epithelium; Histocytochemistry; Immunoenzyme Techniques; Male; Mice; Mice, Nude; Neoplasm Transplantation; Orchiectomy; Prostatic Neoplasms; Rats | 1987 |
Prostatic carcinogenesis evoked by cellular interaction.
Topics: Androgens; Animals; Dihydrotestosterone; Disease Models, Animal; Epithelium; Fibroblasts; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Rats; Tumor Cells, Cultured | 1988 |
Low androgen levels induce the development of androgen-hypersensitive cell clones in Shionogi mouse mammary carcinoma cells in culture.
Topics: Androgen Antagonists; Animals; Clone Cells; Dihydrotestosterone; Male; Mammary Neoplasms, Experimental; Mice; Prostatic Neoplasms; Tumor Cells, Cultured | 1988 |
Concentrations of unconjugated 5 alpha-androstane-3 alpha, 17 beta-diol and 5 alpha-androstane-3 beta, 17 beta-diol and their precursor in human testicular tissue. Comparison with testosterone, 5 alpha-dihydrotestosterone, estradiol-17 beta, and with ster
Topics: Aged; Aged, 80 and over; Androstane-3,17-diol; Androstanols; Dihydrotestosterone; Epididymis; Estradiol; Humans; Male; Prostatic Neoplasms; Testis; Testosterone | 1987 |
The effect of 4MA, a potent inhibitor of 5 alpha-reductase, on the growth of androgen-responsive human genitourinary tumors grown in athymic nude mice.
Topics: 5-alpha Reductase Inhibitors; Androgens; Animals; Azasteroids; Dihydrotestosterone; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Steroids, Heterocyclic; Transplantation, Heterologous | 1987 |
Dihydrotestosterone does not induce prostate adenocarcinoma in L-W rats.
Topics: Adenocarcinoma; Animals; Body Weight; Dihydrotestosterone; Male; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Species Specificity; Spermatogenesis; Testis; Testosterone | 1987 |
Biochemical markers in human prostate.
Topics: Biomarkers, Tumor; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Receptors, Androgen | 1987 |
Androgen dependence of the Dunning R3327G cell line in monolayer culture.
Topics: Androgen Antagonists; Androgens; Animals; Cell Division; Cell Line; Dihydrotestosterone; Flutamide; Male; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Rats; Tumor Cells, Cultured | 1987 |
A wide range of sensitivities to androgens develops in cloned Shionogi mouse mammary tumor cells.
Topics: Animals; Clone Cells; Dihydrotestosterone; Female; Humans; Male; Mammary Neoplasms, Experimental; Mice; Neoplasm Transplantation; Prostatic Neoplasms | 1986 |
Prostate adenocarcinoma: effects of castration on in situ androgen uptake by individual cell types.
Topics: Adenocarcinoma; Androgens; Animals; Autoradiography; Binding Sites; Dihydrotestosterone; Male; Orchiectomy; Prostate; Prostatic Neoplasms; Rats; Receptors, Androgen; Time Factors | 1987 |
C19-radiosteroid disposition in organ cultures of transplanted prostatic adenocarcinomas of the Noble rat.
Topics: Adenocarcinoma; Animals; Dihydrotestosterone; Male; Neoplasm Transplantation; Organ Culture Techniques; Prostatic Neoplasms; Rats; Receptors, Androgen; Testosterone; Tritium | 1987 |
Production, clearance, and metabolism of testosterone in men with prostatic cancer.
Topics: Age Factors; Dihydrotestosterone; Humans; Kinetics; Male; Middle Aged; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Testosterone | 1987 |
Development of androgen resistance in mouse mammary tumor cells can be prevented by the antiandrogen flutamide.
Topics: Anilides; Animals; Cells, Cultured; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Resistance; Flutamide; Male; Mammary Neoplasms, Experimental; Mice; Orchiectomy; Prostatic Neoplasms | 1987 |
Retardation of prostate tumor progression in the Noble rat by 4-methyl-4-aza-steroidal inhibitors of 5 alpha-reductase.
Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Castration; Dihydrotestosterone; Male; Organ Size; Oxidoreductases; Pregnanes; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Steroids, Heterocyclic | 1985 |
Mechanism of the glucocorticoid regulation of growth of the androgen-sensitive prostate-derived R3327H-G8-A1 tumor cell line.
Topics: Adenocarcinoma; Androgens; Animals; Blood; Cell Division; Cell Line; Cell Nucleus; Cycloheximide; Dihydrotestosterone; Epidermal Growth Factor; Estrenes; Glucocorticoids; Interphase; Kinetics; Male; Metribolone; Platelet-Derived Growth Factor; Prostatic Neoplasms; Rats; Receptors, Androgen; Receptors, Glucocorticoid; Triamcinolone Acetonide | 1985 |
Steroid hormone regulation of prostatic acid phosphatase expression in cultured human prostatic carcinoma cells.
Topics: Acid Phosphatase; Cells, Cultured; Dihydrotestosterone; Estradiol; Estrenes; Gonadal Steroid Hormones; Humans; Male; Metribolone; Prostate; Prostatic Neoplasms; Stimulation, Chemical; Testosterone; Triamcinolone Acetonide | 1985 |
Rationale for blockade of adrenal as well as testicular androgens in the treatment of advanced prostate cancer.
Topics: Adrenal Glands; Androgen Antagonists; Dihydrotestosterone; Estrogens; Flutamide; Gonadotropin-Releasing Hormone; Humans; Male; Megestrol; Megestrol Acetate; Prostatic Neoplasms; Testis | 1985 |
Evaluation of synthetic agonist analogue of gonadotropin-releasing hormone (leuprolide) on testicular androgen production in patients with carcinoma of prostate.
Topics: Adenocarcinoma; Antineoplastic Agents; Castration; Dihydrotestosterone; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hormones; Humans; Leuprolide; Luteinizing Hormone; Male; Prostatic Neoplasms; Testis; Testosterone | 1985 |
Proliferative response of the Dunning R3327H experimental model of prostatic adenocarcinoma to conditions of androgen depletion and repletion.
Topics: Adenocarcinoma; Adolescent; Androgens; Animals; Cell Cycle; Dihydrotestosterone; DNA, Neoplasm; Drug Administration Schedule; Flow Cytometry; Humans; Male; Prostatic Neoplasms; Rats; Testosterone | 1986 |
DHT in prostate cancer tissue--a guide to management and therapy.
Topics: Castration; Diethylstilbestrol; Dihydrotestosterone; Humans; Male; Megestrol; Megestrol Acetate; Prognosis; Prostatic Neoplasms | 1985 |
Familial factors affecting prostatic cancer risk and plasma sex-steroid levels.
Topics: Adult; Aged; Dihydrotestosterone; Gonadal Steroid Hormones; Humans; Male; Metabolic Clearance Rate; Middle Aged; Prostatic Neoplasms; Risk; Testosterone | 1985 |
Autoradiographic localization of estrogen and androgen target cells in human and rat prostate carcinoma.
Topics: Animals; Autoradiography; Carcinoma; Dihydrotestosterone; Epithelium; Estradiol; Humans; Male; Neoplasms, Experimental; Prostate; Prostatic Neoplasms; Rats; Receptors, Estradiol; Receptors, Estrogen; Tritium | 1985 |
Dietary and hormonal interrelationships among vegetarian Seventh-Day Adventists and nonvegetarian men.
Topics: Body Height; Body Weight; Diet; Diet, Vegetarian; Dihydrotestosterone; Energy Intake; Estradiol; Hormones; Humans; Luteinizing Hormone; Male; Middle Aged; Prolactin; Prostatic Neoplasms; Religion and Medicine; Risk; Testosterone | 1985 |
New principles in the management of metastatic prostatic cancer.
Topics: Animals; Castration; Combined Modality Therapy; Cyclophosphamide; Cyproterone; Dihydrotestosterone; Male; Neoplasm Metastasis; Prostatic Neoplasms; Rats; Testosterone | 1985 |
Effectiveness of complete versus partial androgen withdrawal therapy for the treatment of prostatic cancer as studied in the Dunning R-3327 system of rat prostatic adenocarcinomas.
Topics: Adenocarcinoma; Animals; Cell Division; Cyproterone; Dihydrotestosterone; Laminin; Male; Microscopy, Electron; Neoplasm Transplantation; Ovariectomy; Prostatic Neoplasms; Rats; Testosterone | 1985 |
[Which endocrine treatment is preferred today for prostatic carcinoma?].
Topics: Androgen Antagonists; Dihydrotestosterone; Drug Resistance; Estramustine; Estrogens; Humans; Luteinizing Hormone; Male; Orchiectomy; Progestins; Prostatic Neoplasms | 1985 |
The role of the steroid-sensitive cation-dependent ATPase in human prostatic tissue.
Topics: 17-Hydroxycorticosteroids; Adenosine Triphosphatases; Androgens; Androstanes; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Male; Microsomes; Oxidoreductases; Potassium; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Sodium; Sterols; Stimulation, Chemical; Tritium | 1972 |
Hormonal responsiveness of prostatic carcinoma. In vitro technique for prediction.
Topics: Androgens; Binding Sites; Castration; Dihydrotestosterone; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Remission, Spontaneous; Tritium | 1974 |
The determination in human males of specific testosterone and 5aplha-dihydrotestosterone binding to sex hormone binding globulin by a differential dissociation technique.
Topics: Adult; Aged; Aging; Androgens; Animals; Binding, Competitive; Carcinoma; Dihydrotestosterone; Estrogens; Humans; Hydrocortisone; Male; Methods; Middle Aged; Prostatectomy; Prostatic Hyperplasia; Prostatic Neoplasms; Protein Binding; Radioimmunoassay; Rats; Serum Globulins; Testosterone; Time Factors; Tritium | 1974 |
Testosterone metabolism in prostate; formation of androstan-17-beta-ol-3-one and androst-4-ene-3, 17-dione, and inhibitory effect of natural and synthetic estrogens.
Topics: Androgens; Animals; Dihydrotestosterone; Dogs; Estrogens; Humans; In Vitro Techniques; Male; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Testosterone | 1965 |
In vivo metabolism of testosterone-3H in R-3327, an androgen-sensitive rat prostatic adenocarcinoma.
Topics: Adenocarcinoma; Androstanes; Animals; Castration; Chromatography, Thin Layer; Dihydrotestosterone; Hydroxysteroids; Liver; Male; Muscles; Neoplasm Transplantation; Neoplasms, Experimental; Oxidation-Reduction; Prostate; Prostatic Neoplasms; Rats; Testosterone; Transplantation, Homologous; Tritium | 1974 |
Testosterone turnover in cancer of the prostate: suppression by gestagens in vitro.
Topics: Androstenediols; Androstenedione; Depression, Chemical; Dihydrotestosterone; Gestonorone Caproate; Humans; In Vitro Techniques; Kinetics; Male; Progesterone; Prostatic Neoplasms; Testosterone; Tritium | 1974 |
Proceedings: Androgen dynamics in vitro in the prostate gland.
Topics: Androgens; Animals; Cyproterone; Dihydrotestosterone; Dogs; Estradiol; Humans; Male; Prostate; Prostatic Neoplasms; Testosterone; Tritium | 1974 |
Kinetics of 3H-5 -dihydrotestosterone metabolism in normal men and women and men with prostatic carcinoma; effects of estrogen administration in men.
Topics: Administration, Oral; Adult; Aged; Carbon Isotopes; Carcinoma; Chromatography; Chromatography, Ion Exchange; Chromatography, Paper; Diethylstilbestrol; Dihydrotestosterone; Ethinyl Estradiol; Female; Humans; Male; Metabolic Clearance Rate; Prostatic Neoplasms; Sex Factors; Testosterone; Tritium | 1972 |
Steroids and the prostate.
Topics: Androstanes; Animals; Cell Nucleus; Diethylstilbestrol; Dihydrotestosterone; DNA Nucleotidyltransferases; Humans; Hyperplasia; Male; Prostate; Prostatic Diseases; Prostatic Neoplasms; Protein Binding; Rats; Testosterone | 1972 |