dihydrotachysterol and Seizures

A 1.5-year-old ferret examined because of seizures was found to have low serum calcium, high serum phosphorus, and extremely high serum parathyroid hormone concentrations. Common causes of these abnormalities, including nutritional secondary hyperparathyroidism, chronic renal secondary hyperparathyroidism, tumor lysis syndrome, and hypomagnesemia, were ruled out, and a tentative diagnosis of pseudohypoparathyroidism was made. Pseudohypoparathyroidism is a hereditary condition in people that, to our knowledge, has not been identified in ferrets previously and is caused by a lack of response to high serum parathyroid hormone concentrations, rather than a deficiency of this hormone. The ferret improved after treatment with dihydrotachysterol (a vitamin D analog) and calcium carbonate. It was still doing well after 3.5 years of continued treatment.

Topics: Animals; Calcium; Calcium Carbonate; Diagnosis, Differential; Dihydrotachysterol; Ferrets; Male; Parathyroid Hormone; Phosphorus; Pseudohypoparathyroidism; Seizures; Thyroid Gland; Treatment Outcome

A patient with idiopathic hypoparathyroidism and a six-year history of a convulsive disorder was treated with 1 alpha-hydroxycholecalciferol and anticonvulsants. The calcemic response to 1 alpha-hydroxycholecalciferol was incomplete. However, normocalcemia was later attained during treatment with dihydrotachysterol. This delayed response suggests that the anticonvulsant therapy interfered with the peripheral effect of the vitamin D metabolite.

Topics: Adolescent; Anticonvulsants; Calcium; Dihydrotachysterol; Drug Interactions; Female; Humans; Hydroxycholecalciferols; Hypoparathyroidism; Phosphorus; Seizures

Topics: Alkalosis; Calcium; Celiac Disease; Dihydrotachysterol; Humans; Hypocalcemia; Hypoparathyroidism; Infant; Infant, Newborn; Laryngismus; Magnesium Deficiency; Pseudohypoparathyroidism; Pseudopseudohypoparathyroidism; Seizures; Tetany; Vitamin D

Topics: Calcium; Child; Dihydrotachysterol; Electrocardiography; Electromyography; Ergocalciferols; Female; Humans; Hypoparathyroidism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Seizures; Tetany

Topics: Calcium; Calcium, Dietary; Dihydrotachysterol; Drug Therapy; Epilepsy, Tonic-Clonic; Humans; Hypoparathyroidism; Psychotic Disorders; Seizures