dihydrotachysterol and Pulmonary-Embolism

In three women intoxication with vitamin D or dihydrotachysterol occurred. Two patients died from complications despite successful lowering of the serum calcium, the third died after a pulmonary embolus during hypercalcaemia 5 months after cessation of vitamin D. Correct observation of the narrow therapeutic range of vitamin D preparations appears most important in the treatment of hypoparathyroidism and other indications. Particular attention should be given to the prophylaxis of over dosage. Apart from regular serum calcium estimations instruction of the patient and relatives as to the dangers and symptoms of intoxication is recommended. The issuing of a therapy identity card would meet these requirements.

Topics: Aged; Biopsy; Bone and Bones; Calcium; Dihydrotachysterol; Dose-Response Relationship, Drug; Female; Humans; Hypercalcemia; Hypoparathyroidism; Middle Aged; Osteoporosis; Pulmonary Embolism; Vitamin D