dihydrotachysterol and Progeria

Although several etiological factors contribute to the complexity of the aging process, the ultimate component of macromolecular damage and consequent cell death involves the altered redox balance inclined towards increased ROS production and/or decreased antioxidant protection. Given that, the chronic dihydrotachysterol (DHT) intoxication in rats induce Hutchinson Gilford progeria like syndrome, the present study provides the evidence for altered redox balance as evidenced by alteration in parameters of oxidative stress in blood plasma and erythrocytes including MDA, GSH, FRAP AOPP PMRS, AGEs, AChE and osmotic fragility which substantiate the suitability of the model for aging studies.

Topics: Acetylcholinesterase; Advanced Oxidation Protein Products; Aging; Animals; Antioxidants; Dihydrotachysterol; Disease Models, Animal; Erythrocytes; Female; Glutathione; GPI-Linked Proteins; Humans; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; Progeria; Rats; Rats, Wistar; Reactive Oxygen Species

Topics: Animals; Calcium; Dihydrotachysterol; Female; Fluorides; Periodontium; Progeria; Rats; Rats, Inbred Strains

Topics: Aging; Animals; Bone and Bones; Calcinosis; Calcium; Dihydrotachysterol; Environment; Progeria; Rats; Syndrome

Topics: Alveolar Process; Animals; Dental Cementum; Dihydrotachysterol; Periodontal Ligament; Periodontium; Progeria; Rats

Interest in the pharmacological effects of drugs in the elderly has created a need for a laboratory model in which responses of aged animals to drugs can be studied. Dihydrotachysterol (DHT)-induced progeria, a syndrome with symptoms similar to those seen in normal aging, was evaluated as an old age model. DHT-treatment was shown to produce a decreased carbohydrate tolerance that was due to an impaired release of insulin from pancreatic islets and not due to a decreased sensitivity to insulin. These changes were unlike those observed with aging. Thus, DHT-induced progeria would not appear to be a good model for aging for the investigation of carbohydrate metabolism. Evidence is presented which indicates that glucose and tolbutamide act via different mechanism to stimulate insulin release.

Topics: Aging; Animals; Body Weight; Carbohydrate Metabolism; Dihydrotachysterol; Eating; Glucose; Insulin; Male; Models, Biological; Progeria; Rats; Time Factors; Tolbutamide

Topics: Androgens; Animals; Dihydrotachysterol; Disease Models, Animal; Female; Gonadotropin-Releasing Hormone; Progeria; Rats; Syndrome; Time Factors

Topics: Animals; Aorta; Body Weight; Calcium; Castration; Dihydrotachysterol; Estrogens; Female; Femur; Kidney; Myocardium; Organ Size; Progeria; Rats

Topics: Animals; Aorta; Body Weight; Calcinosis; Calcium; Dihydrotachysterol; Estrogens, Conjugated (USP); Female; Femur; Hypercalcemia; Kidney; Organ Size; Osteoporosis; Progeria; Rats; Tail

Topics: Adaptation, Physiological; Aging; Anabolic Agents; Animals; Calcium Metabolism Disorders; Chlorides; Dihydrotachysterol; Disease Models, Animal; Female; Humans; Magnesium; Myocardial Infarction; Necrosis; Potassium Chloride; Progeria; Rats; Sodium; Steroids; Stress, Physiological

Topics: Animals; Aorta; Arteries; Calcinosis; Calciphylaxis; Coronary Vessels; Dihydrotachysterol; Female; Male; Progeria; Rats; Testosterone; Vascular Diseases; Vitamin D

Topics: Animals; Basophils; Body Weight; Bone Marrow; Bone Marrow Examination; Dihydrotachysterol; Eosinophils; Leukocyte Count; Leukocytes; Neutrophils; Progeria; Rats

Topics: Animals; Cholecalciferol; Dehydration; Dihydrotachysterol; Ergocalciferols; Female; Hematocrit; Hemoglobinometry; Leukocyte Count; Progeria; Rats

Topics: Animals; Blood Proteins; Dihydrotachysterol; Hypercalcemia; Progeria; Rats

Topics: Animals; Bone Development; Calcinosis; Dihydrotachysterol; Ear Diseases; Ear Ossicles; Ear, Inner; Labyrinth Diseases; Otosclerosis; Progeria; Rats

Topics: Adipose Tissue; Alopecia; Aortic Diseases; Atrophy; Calcinosis; Cockayne Syndrome; Coronary Disease; Dihydrotachysterol; Emaciation; Kidney Diseases; Kyphosis; Muscular Atrophy; Osteosclerosis; Pathology; Pharmacology; Progeria; Rats; Research; Sex; Sex Characteristics; Skin Diseases; Tooth Abnormalities; Toxicology

Topics: Cockayne Syndrome; Dextrans; Dihydrotachysterol; Growth Hormone; Human Growth Hormone; Iron-Dextran Complex; Methyltestosterone; Progeria; Testosterone Congeners

Topics: Biomedical Research; Cockayne Syndrome; Dextrans; Dihydrotachysterol; Iron-Dextran Complex; Methyltestosterone; Progeria

Topics: Cockayne Syndrome; Dihydrotachysterol; Methyltestosterone; Pharmacology; Progeria; Rats; Research; Vitamin E

Topics: Aging; Animals; Calcinosis; Calciphylaxis; Dihydrotachysterol; Iron-Dextran Complex; Joint Diseases; Mice; Progeria; Rabbits