dihydrotachysterol and Pneumonia

dihydrotachysterol has been researched along with Pneumonia* in 2 studies

Trials

1 trial(s) available for dihydrotachysterol and Pneumonia

Article	Year
Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity. Respiratory research, 2014, Apr-27, Volume: 15 We aimed to explore the association between vitamin D levels and the severity, mortality and microbiological etiology of community-acquired pneumonia.. Vitamin D levels (both, the reservoir form 25-OH and the activated form 1,25-OH2) of 300 randomly selected patients with community-acquired pneumonia due to pre-specified pathogens included in the German competence network (CAPNETZ) study were measured. Prior to statistical analysis, values of 25-OH and 1,25-OH2 were power-transformed to achieve parametric distribution. All further analyses were performed with seasonally and age adjusted values.. There was only a modest (Spearman Coefficient 0.38) positive correlation between 25-OH and 1,25-OH2. For 1,25-OH2 but not 25-OH, the general linear model revealed a significant inverse correlation between serum concentration and CURB score (p = 0.011). Liver and respiratory co-morbidity were associated with significantly lower 25-OH values and renal co-morbidity with significantly lower 1,25-OH2 values. No significant differences of 1,25-OH2 or 25-OH between different pathogens (influenza virus, Legionella spp., Streptococcus pneumoniae) were detected.. For 1,25-OH2, we found a significant and independent (controlled for age, season and pathogen) negative correlation to pneumonia severity. Therefore, supplementation of non-activated vitamin D to protect from pneumonia may be non-sufficient in patients that have a decreased capacity to hydroxylate 25-OH to 1,25-OH2. Topics: Adult; Aged; Biomarkers; Cohort Studies; Community-Acquired Infections; Cross-Sectional Studies; Dihydrotachysterol; Female; Humans; Male; Middle Aged; Pneumonia; Prospective Studies; Seasons; Severity of Illness Index; Vitamin D; Vitamin D Deficiency	2014

Article

Year

Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity.

Respiratory research, 2014, Apr-27, Volume: 15

We aimed to explore the association between vitamin D levels and the severity, mortality and microbiological etiology of community-acquired pneumonia.. Vitamin D levels (both, the reservoir form 25-OH and the activated form 1,25-OH2) of 300 randomly selected patients with community-acquired pneumonia due to pre-specified pathogens included in the German competence network (CAPNETZ) study were measured. Prior to statistical analysis, values of 25-OH and 1,25-OH2 were power-transformed to achieve parametric distribution. All further analyses were performed with seasonally and age adjusted values.. There was only a modest (Spearman Coefficient 0.38) positive correlation between 25-OH and 1,25-OH2. For 1,25-OH2 but not 25-OH, the general linear model revealed a significant inverse correlation between serum concentration and CURB score (p = 0.011). Liver and respiratory co-morbidity were associated with significantly lower 25-OH values and renal co-morbidity with significantly lower 1,25-OH2 values. No significant differences of 1,25-OH2 or 25-OH between different pathogens (influenza virus, Legionella spp., Streptococcus pneumoniae) were detected.. For 1,25-OH2, we found a significant and independent (controlled for age, season and pathogen) negative correlation to pneumonia severity. Therefore, supplementation of non-activated vitamin D to protect from pneumonia may be non-sufficient in patients that have a decreased capacity to hydroxylate 25-OH to 1,25-OH2.

Topics: Adult; Aged; Biomarkers; Cohort Studies; Community-Acquired Infections; Cross-Sectional Studies; Dihydrotachysterol; Female; Humans; Male; Middle Aged; Pneumonia; Prospective Studies; Seasons; Severity of Illness Index; Vitamin D; Vitamin D Deficiency

2014

Other Studies

1 other study(ies) available for dihydrotachysterol and Pneumonia

Article	Year
[A PATIENT WITH IDIOPATHIC HYPOPARATHYROIDISM ASSOCIATED WITH SARCOIDOSIS]. Nederlands tijdschrift voor geneeskunde, 1964, Dec-19, Volume: 108 Topics: Adrenal Cortex Hormones; Basal Ganglia; Calcinosis; Cataract; Cholecystectomy; Dihydrotachysterol; Drug Therapy; Ganglia; Humans; Hypocalcemia; Hypoparathyroidism; Pancreatitis; Pneumonia; Postoperative Complications; Radiography, Thoracic; Sarcoidosis; Tetanus; Tetanus Toxoid	1964

Article

Year

[A PATIENT WITH IDIOPATHIC HYPOPARATHYROIDISM ASSOCIATED WITH SARCOIDOSIS].

Nederlands tijdschrift voor geneeskunde, 1964, Dec-19, Volume: 108

Topics: Adrenal Cortex Hormones; Basal Ganglia; Calcinosis; Cataract; Cholecystectomy; Dihydrotachysterol; Drug Therapy; Ganglia; Humans; Hypocalcemia; Hypoparathyroidism; Pancreatitis; Pneumonia; Postoperative Complications; Radiography, Thoracic; Sarcoidosis; Tetanus; Tetanus Toxoid

1964