dihydrotachysterol and Parathyroid-Diseases

Topics: Adult; Calcium; Carbimazole; Congenital Hypothyroidism; Dihydrotachysterol; Female; Humans; Hyperparathyroidism; Hyperthyroidism; Hypoparathyroidism; Hypothyroidism; Infant, Newborn; Parathyroid Diseases; Parathyroid Glands; Pregnancy; Pregnancy Complications; Propylthiouracil; Puerperal Disorders; Thyroid Diseases; Thyroxine

Topics: Adenoma; Child; Dihydrotachysterol; Female; Humans; Hypercalcemia; Hyperparathyroidism; Hypoparathyroidism; Infant, Newborn; Infant, Newborn, Diseases; Parathyroid Diseases; Parathyroid Neoplasms; Pregnancy; Pseudohypoparathyroidism; Vitamin D

Moderate dietary Na restriction (80 mmol/d for 7 days) during constant Ca intake can reduce high urinary Ca excretion to normal levels in idiopathic hypercalciuria (IH). A similar protocol was used to test its effect in primary hyperparathyroidism (PHPT) and also in hypoparathyroid subjects (HOPT) during treatment with dihydrotachysterol (DHT). Nine subjects with PHPT, 10 with HOPT, and one with pseudo-HOPT were evaluated after Na-restricted (80 mmol/d) and Na-supplemented (200 mmol/d) diets for 7 days each with dietary Ca constant. Na restriction resulted in a decrease in mean urinary 24-hour Ca excretion in PHPT subjects (10.6 v 7.6 mmol/d [424 v 304 mg], P less than 0.0001) and in one pseudo-HOPT subject, similar to the pattern seen previously in IH subjects. In contrast, Na restriction was not accompanied by significant change in Ca excretion in HOPT. There was no change in serum immunoreactive PTH (iPTH) or 1,25(OH)2 vitamin D levels in either group when Na intake was altered. Thus, the presence of parathyroid hormone (PTH) is necessary for sodium-related alterations in urinary Ca to occur. The effect of PTH appears to be "permissive" rather than "active." Dietary Na restriction may have a role in the management of hypercalciuria in mild PHPT cases when parathyroidectomy is contraindicated.

Topics: Calcitriol; Calcium; Diet, Sodium-Restricted; Dihydrotachysterol; Female; Humans; Hyperparathyroidism; Hypoparathyroidism; Male; Parathyroid Diseases; Parathyroid Hormone; Pseudohypoparathyroidism

Alteration of the metabolism of calcium and phosphate may be associated with symmetric cerebral calcification. Detailed investigations of the function of parathyroid glands including computer tomography of the brain are so far missing. In 6 patients with clinical and biochemical signs of altered function of the parathyroid glands symmetric cerebral calcification could be demonstrated by computer tomography. They are also visible by X-ray examination in one patient. Consequently, functional disturbances of the brain, cerebellum and of the extrapyramidal system may occur. Moreover, the combination of hypoparathyroidism and hypothyroidism also appears to result in the development of symmetric cerebral calcification. The pathogenesis of the calcification as well as therapeutic approaches will be discussed.

Topics: Adult; Calcinosis; Calcium; Dihydrotachysterol; Female; Humans; Magnesium; Male; Middle Aged; Parathyroid Diseases; Parathyroid Hormone; Phosphorus; Thyroid Diseases; Thyroxine; Tomography, X-Ray Computed; Vitamin D

Topics: Animals; Calcium; Cysts; Dihydrotachysterol; Female; Microscopy, Electron; Parathyroid Diseases; Parathyroid Glands; Rats

Topics: Adolescent; Dihydrotachysterol; Female; Humans; Hyperparathyroidism; Parathyroid Diseases; Pseudohypoparathyroidism; Radiography; Vitamin D

Topics: Carisoprodol; Dihydrotachysterol; Humans; Hyperparathyroidism; Hypoparathyroidism; Meprobamate; Parathyroid Diseases; Parathyroid Glands; Tissue Extracts; Vitamin D; Vitamins

Topics: Dihydrotachysterol; Disease; Humans; Hypoparathyroidism; Parathyroid Diseases; Parathyroid Glands; Vitamin D; Vitamins

Topics: Calcium; Calcium, Dietary; Dihydrotachysterol; Disease; Humans; Hypercalciuria; Hypoparathyroidism; Parathyroid Diseases; Parathyroid Glands; Vitamin D; Vitamins

Topics: Dihydrotachysterol; Disease; Humans; Hypoparathyroidism; Parathyroid Diseases; Parathyroid Glands

Topics: Dental Care; Dihydrotachysterol; Disease; Humans; Parathyroid Diseases; Parathyroid Glands

Topics: Autonomic Nervous System Diseases; Blood Pressure; Calcinosis; Dihydrotachysterol; Disease; Humans; Hypertension; Parathyroid Diseases; Parathyroid Glands

Topics: Dihydrotachysterol; Disease; Humans; Hypoparathyroidism; Parathyroid Diseases; Parathyroid Glands; Pseudohypoparathyroidism; Vitamin D; Vitamins

Topics: Dihydrotachysterol; Humans; Parathyroid Diseases; Parathyroid Glands; Paratyphoid Fever; Tetany