dihydrotachysterol and Osteoporosis

Topics: Adult; Asthma; Bone and Bones; Calcium; Dihydrotachysterol; Glucocorticoids; Humans; Middle Aged; Nandrolone; Osteoporosis

A method for the quantitative estimation of dihydrotachysterol-2 is described using high performance liquid chromatography coupled to an UV monitor. Since radioactive labelled DHT2 is not available, recovery is based on the assumption that dihydrotachysterol-2 and cholecalciferol behave identically during chromatic procedures. Evidence is presented to support this assumption. In patients treated with DHT2 the serum concentrations of DHT2 rose in proportion to the administered dose.

Topics: Chromatography, High Pressure Liquid; Dihydrotachysterol; Female; Humans; Hypoparathyroidism; Male; Osteoporosis

Topics: Aged; Dihydrotachysterol; Female; Fluorides; Humans; Male; Middle Aged; Osteoporosis; Sodium Fluoride

Patients with steroid-induced, juvenile and senile osteoporosis were studied using balance techniques. The changes in calciun and phosphorus balance associated with glucocorticoid therapy were corrected with vitamin D and bendrofluazide given in combination. No hypercalcaemia occurred in osteoporotic patients who continued to receive glucocorticoids. Calcium and phosphorus balance was also improved in the osteoporotic subjects not receiving steroids, but these patients became hypercalcaemic during treatment. It is suggested that vitamin D, bendrofluazide and steroids antagonize the actions of one another on the renal tubule, gut and bone and in this way prevent the increased calciuria which occurs with glucocorticoid therapy. Since the increased calciuria and negative calcium balance induced by glucocorticoids is considered to be the result of excessive bone resorption, an adequate dose of bendrofluazide and vitamin D in combination might prevent the development of, or even reverse, steroid-induced osteoporosis.

Topics: Adult; Aged; Bendroflumethiazide; Calcium; Child; Dihydrotachysterol; Ergocalciferols; Female; Humans; Male; Middle Aged; Osteoporosis; Prednisolone

Topics: Acute Kidney Injury; Adult; Aged; Bone Cysts; Dihydrotachysterol; Female; Humans; Kidney Calculi; Middle Aged; Nephrocalcinosis; Osteoporosis; Time Factors; Vitamin D

In three women intoxication with vitamin D or dihydrotachysterol occurred. Two patients died from complications despite successful lowering of the serum calcium, the third died after a pulmonary embolus during hypercalcaemia 5 months after cessation of vitamin D. Correct observation of the narrow therapeutic range of vitamin D preparations appears most important in the treatment of hypoparathyroidism and other indications. Particular attention should be given to the prophylaxis of over dosage. Apart from regular serum calcium estimations instruction of the patient and relatives as to the dangers and symptoms of intoxication is recommended. The issuing of a therapy identity card would meet these requirements.

Topics: Aged; Biopsy; Bone and Bones; Calcium; Dihydrotachysterol; Dose-Response Relationship, Drug; Female; Humans; Hypercalcemia; Hypoparathyroidism; Middle Aged; Osteoporosis; Pulmonary Embolism; Vitamin D

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Dihydrotachysterol; Female; Growth Hormone; Hormones; Humans; Hypogonadism; Male; Middle Aged; Osteoporosis; Parathyroid Hormone; Thyroid Hormones; Time Factors

Topics: Adolescent; Adult; Aged; Aging; Animals; Calcitonin; Calcium; Calcium Isotopes; Child; Dihydrotachysterol; Edetic Acid; Estrogens; Female; Femur; Humans; Hypocalcemia; Iodine Isotopes; Kidney; Male; Middle Aged; Osteoporosis; Parathyroid Hormone; Rats; Thiazoles

Topics: Animals; Aorta; Body Weight; Calcinosis; Calcium; Dihydrotachysterol; Estrogens, Conjugated (USP); Female; Femur; Hypercalcemia; Kidney; Organ Size; Osteoporosis; Progeria; Rats; Tail

Topics: Aging; Allergy and Immunology; Bone and Bones; Bone Transplantation; Calcification, Physiologic; Calciphylaxis; Calcium; Dihydrotachysterol; Fluorescence; Growth Hormone; Humans; Metabolism; Microscopy; Microscopy, Fluorescence; Myositis Ossificans; Osteoporosis; Physiology; Regeneration; Tetracycline

Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Child; Dihydrotachysterol; Humans; Infant; Kidney; Osteoporosis; Urologic Diseases

Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Chronic Kidney Disease-Mineral and Bone Disorder; Dihydrotachysterol; Hydromorphone; Osteoporosis; Rickets