dihydrotachysterol and Fibrous-Dysplasia-of-Bone

We describe three patients with fibrous dysplasia of bone in whom there was evidence of hypophosphataemic osteomalacia or rickets. Two of the patients had polyostotic fibrous dysplasia and osteomalacia. The third was a child with fibrous dysplasia of the facial and cranial bones and rickets. In all cases the manifestations of osteomalacia or rickets were controlled with large doses of vitamin D. In the child the rickets and hypophosphataemia ceased when most of the bone affected by fibrous dysplasia was surgically resected. Previously reported cases of the association between fibrous dysplasia and hypophosphataemic osteomalacia are reviewed. We suggest that these cases are analogous to the syndrome of 'tumour rickets' where hypophosphataemia appears to be due to the presence of a mesenchymal tumour and regresses when the tumour is removed.

Topics: Adult; Calcium; Child; Dihydrotachysterol; Female; Fibrous Dysplasia of Bone; Humans; Male; Middle Aged; Osteomalacia; Phosphorus; Rickets; Vitamin D

Forty-one patients on our chronic hemodialysis program were assessed for the degree of progression of bone disease over an average period of 46 months. Seven patients were using a fluoridated dialysate. Four of these seven patients developed a marked increase in osteoid as judged by bone biopsy, while in the nonfluoridated group the amount of osteoid remained within normal limits.In the absence of fluoride, although osteitis fibrosa occurred, it was reversible in 10 out of 12 cases by dihydrotachysterol treatment, and overall there was no evidence of progression of bone disease at the end of the study period.

Topics: Adult; Alkaline Phosphatase; Biopsy; Bone and Bones; Dihydrotachysterol; Female; Fibrous Dysplasia of Bone; Fingers; Fluorides; Glomerulonephritis; Humans; Male; Radiography; Renal Dialysis

Topics: Cholecalciferol; Dihydrotachysterol; Fibrous Dysplasia of Bone; Humans; Neoplasms, Glandular and Epithelial; Osteitis; Tetany