dihydrotachysterol and Brain-Diseases

Topics: Aged; Brain Diseases; Calcinosis; Calcium; Dihydrotachysterol; Drug Therapy, Combination; Female; Humans; Hypoparathyroidism; Thyroidectomy; Tomography, X-Ray Computed

The neurological manifestations of idiopathic hypoparathyroidism in a father, his son, and his daughter are reported. In all three epilepsy was the first manifestation of the disease. Father and son also showed mental deterioration and striocerebellar symptoms; their CT scans revealed symmetrical calcification in the basal ganglia and dentate nuclei. The extent of this calcification increased during normocalcemia, which was produced by dihydrotachysterol therapy. This indicates that other factors than merely hypocalcemia influence the intracerebral calcifying process. Somatosensory evoked potentials (SSEP) showed an abnormal nonspecific complex, indicating dysfunction of the cortical gray matter. It is suggested that in the evaluation of idiopathic hypoparathyroidism one also must be beware of the possibility of epilepsy, mental deterioration, striocerebellar symptoms, intracerebral calcification and SSEP disturbances.

Topics: Adult; Basal Ganglia Diseases; Brain Diseases; Calcinosis; Cerebellar Diseases; Cerebellar Nuclei; Dihydrotachysterol; Evoked Potentials, Somatosensory; Female; Genes, Dominant; Humans; Hypoparathyroidism; Male; Middle Aged; Radiography

Topics: Acute Disease; Adult; Brain Diseases; Bromides; Calcium; Calcium Gluconate; Dihydrotachysterol; Disaccharides; Female; Gluconates; Humans; Hypercalcemia

Topics: Brain Diseases; Diagnosis, Differential; Dihydrotachysterol; Female; Humans; Hypocalcemia; Hypoparathyroidism; Mental Disorders; Middle Aged; Phosphorus; Vitamin D