dihydropyridines has been researched along with Leishmaniasis--Visceral* in 2 studies
2 other study(ies) available for dihydropyridines and Leishmaniasis--Visceral
| Article | Year |
|---|---|
Leishmania donovani: oral therapy with glycosyl 1,4-dihydropyridine analogue showing apoptosis like phenotypes targeting pteridine reductase 1 in intracellular amastigotes.
Glycosyl 1,4-dihydropyridine analogue (2,6-dimethyl-4-(3-O-benzyl-1,2-O-isopropylidene-beta-l-threo pentofuranos-4-yl)-1-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester) synthesized in our laboratory, inhibited Leishmania donovani infection in vitro and in hamsters (Mesocricetus auratus) when administered orally. This analogue is nontoxic, cell-permeable and orally effective. This glycosyl dihydropyridine analogue functioned through arrest of cells in sub-G0/G1-phase, triggering mitochondrial membrane depolarization-mediated programmed cell death of the intracellular amastigotes. Topics: Administration, Oral; Animals; Antiprotozoal Agents; Apoptosis; Cell Cycle; Cell Line; Cricetinae; Dihydropyridines; Flow Cytometry; Glycosides; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis, Visceral; Macrophages; Male; Membrane Potential, Mitochondrial; Mesocricetus; Mice; Mice, Inbred BALB C; Mitochondrial Membranes; Oxidoreductases; Phenotype; Spleen | 2010 |
Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis.
Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites. Topics: Administration, Oral; Amlodipine; Animals; Antiprotozoal Agents; Dihydropyridines; Leishmania donovani; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Treatment Outcome | 2008 |