dihydropyridines and Hematoma

Elevated blood pressure (BP) causes rebleeding or enlargement of intracerebral hematomas.. How a long-acting oral calcium channel blocker, cilnidipine, could control BP in the acute stage of cerebral hemorrhage was evaluated.. Cilnidipine given within 3 days of hospitalization has more benefit than cilnidipine given after 4 days of hospitalization; it can reduce the amount of intravenous nicardipine, and it can help to maintain the BP below 80% of the initial BP. Surgical removal of the hematoma has no benefit in reducing the amount of intravenous nicardipine and maintaining the BP below 80% of the initial BP.. In order to reduce the total amount of intravenous nicardipine and to maintain the BP below 80% of the initial BP, oral administration of a long-acting N-type calcium channel blocker, cilnidipine, is useful and important, independent of whether the hematomas are surgically removed.

Topics: Acute Disease; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Female; Hematoma; Humans; Intracranial Hemorrhage, Hypertensive; Male; Middle Aged; Nicardipine; Treatment Outcome