dihydropyridines has been researched along with Esophageal-Neoplasms* in 1 studies
1 other study(ies) available for dihydropyridines and Esophageal-Neoplasms
| Article | Year |
|---|---|
Selective anticancer activity of the novel steroidal dihydropyridine spirooxindoles against human esophageal EC109 cells.
A series of small-molecule compounds built on steroidal dihydropyridine spirooxindoles has been reported previously. In this study, the compound 5l showed strong anti-cancer activity, especially in the esophageal cancer. Three esophageal squamous cell lines and paclitaxel-resistant cell line were investigated. The results demonstrated that compound 5l was most efficient in the EC109 cells, induced cell apoptosis through elevation of cellular ROS levels, caused G2/M phase arrest and mitochondrial dysfunction. Further study confirmed that the mechanism of 5l in esophageal cancer treatment was related to the Bcl-2 family and caspase receptor-mediated apoptotic pathway. Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Dihydropyridines; Drug Resistance; Esophageal Neoplasms; G2 Phase Cell Cycle Checkpoints; Humans; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Small Molecule Libraries | 2017 |