dihydropyridines and Epilepsies--Partial

dihydropyridines has been researched along with Epilepsies--Partial* in 2 studies

Other Studies

2 other study(ies) available for dihydropyridines and Epilepsies--Partial

Article	Year
[The effect of the new amino acid-containing 1,4-dihydropyridine glutapyrone on penicillin-induced focal epileptic activity and convulsions induced by bicuculline and thiosemicarbazide]. Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:10 The experiments on focal penicillin-induced epileptic activity in the brain cortex (Wistar rats) and bicuculline- and thiosemicarbazide-induced seizures (Icr:Icl mice) showed that the glutapyrone possessed a significant antiepileptic activity. As previously shown, that glutapyrone has an influence on 45Ca2+ uptake by rat cortical synaptosomes (evoked by K+ depolarization) as compared with nifedipine and nimodipine, and it was effective in pentylenetetrazol-induced seizures in rats and mice. The mechanism of action of convulsants is associated with the disturbance of different links of GABAergic inhibition. It is suggested that the antiepileptic effects of glutapyrone are realized at least in part by the participation of GABAergic system. Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dihydropyridines; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsies, Partial; Glutamates; Male; Mice; Mice, Inbred ICR; Penicillins; Rats; Rats, Wistar; Seizures; Semicarbazides	1993
[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital]. Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:12 Antiepileptic effects of a novel amino acid-containing 1,4-dihydropyridine glutapyrone and sodium valproate during combined therapy on generalized pentylenetetrazol- and focal 4-aminopyridine-induced epileptic activity in rat brain cortex were studied, as were combined effects of glutapyrone and phenobarbital on maximal electroshock in mice. The results of these investigations suggest that combined treatment by glutapyrone and sodium valproate or phenobarbital is reasonable and helps potentiate the effect of each drug, thus significantly reducing their doses, and minimize the risk of side effects of the drugs id used in higher doses in case of long treatment. Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electroshock; Epilepsies, Partial; Epilepsy, Generalized; Glutamates; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenobarbital; Rats; Rats, Wistar; Valproic Acid	1993

Article

Year

[The effect of the new amino acid-containing 1,4-dihydropyridine glutapyrone on penicillin-induced focal epileptic activity and convulsions induced by bicuculline and thiosemicarbazide].

Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:10

The experiments on focal penicillin-induced epileptic activity in the brain cortex (Wistar rats) and bicuculline- and thiosemicarbazide-induced seizures (Icr:Icl mice) showed that the glutapyrone possessed a significant antiepileptic activity. As previously shown, that glutapyrone has an influence on 45Ca2+ uptake by rat cortical synaptosomes (evoked by K+ depolarization) as compared with nifedipine and nimodipine, and it was effective in pentylenetetrazol-induced seizures in rats and mice. The mechanism of action of convulsants is associated with the disturbance of different links of GABAergic inhibition. It is suggested that the antiepileptic effects of glutapyrone are realized at least in part by the participation of GABAergic system.

Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dihydropyridines; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsies, Partial; Glutamates; Male; Mice; Mice, Inbred ICR; Penicillins; Rats; Rats, Wistar; Seizures; Semicarbazides

1993

[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].

Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:12

Antiepileptic effects of a novel amino acid-containing 1,4-dihydropyridine glutapyrone and sodium valproate during combined therapy on generalized pentylenetetrazol- and focal 4-aminopyridine-induced epileptic activity in rat brain cortex were studied, as were combined effects of glutapyrone and phenobarbital on maximal electroshock in mice. The results of these investigations suggest that combined treatment by glutapyrone and sodium valproate or phenobarbital is reasonable and helps potentiate the effect of each drug, thus significantly reducing their doses, and minimize the risk of side effects of the drugs id used in higher doses in case of long treatment.

Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electroshock; Epilepsies, Partial; Epilepsy, Generalized; Glutamates; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenobarbital; Rats; Rats, Wistar; Valproic Acid

1993