dihydromorphine and Lung-Neoplasms

dihydromorphine has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for dihydromorphine and Lung-Neoplasms

Article	Year
Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release. Cancer letters, 1999, Nov-01, Volume: 146, Issue:1 The mu3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the mu3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific mu opioid receptor transcripts are present in lung carcinoma and other cells with the mu3 profile. Our findings identify a unique role for the mu3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression. Topics: Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Lung; Lung Neoplasms; Nitric Oxide; Receptors, Opioid, mu; RNA, Messenger	1999

Article

Year

Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release.

Cancer letters, 1999, Nov-01, Volume: 146, Issue:1

The mu3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the mu3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific mu opioid receptor transcripts are present in lung carcinoma and other cells with the mu3 profile. Our findings identify a unique role for the mu3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression.

Topics: Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Lung; Lung Neoplasms; Nitric Oxide; Receptors, Opioid, mu; RNA, Messenger

1999