dihydrolycorine and Hypertension--Renovascular

dihydrolycorine has been researched along with Hypertension--Renovascular* in 1 studies

Other Studies

1 other study(ies) available for dihydrolycorine and Hypertension--Renovascular

Article	Year
[Hypotensive effect of dihydrolycorine]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:1 Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively. These results suggest that DL can block alpha 1-adrenoceptors. Topics: Alkaloids; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Cats; Female; Hypertension, Renovascular; Male; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Rats	1993

Article

Year

[Hypotensive effect of dihydrolycorine].

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:1

Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively. These results suggest that DL can block alpha 1-adrenoceptors.

Topics: Alkaloids; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Cats; Female; Hypertension, Renovascular; Male; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Rats

1993