dihydrolipoic acid has been researched along with Diabetic Neuropathies in 2 studies
dihydrolipoic acid: RN given refers to parent cpd without isomeric designation
dihydrolipoic acid : A thio-fatty acid that is reduced form of lipoic acid. A potent antioxidant shown to directly destroy superoxide, hydroperoxy and hydroxyl radicals; also has neuroprotective and anti-tumour effects.
dihydrolipoate : The conjugate base of dihydrolipoic acid.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coppey, LJ | 1 |
| Gellett, JS | 1 |
| Davidson, EP | 1 |
| Yorek, MA | 1 |
| Smith, AR | 1 |
| Shenvi, SV | 1 |
| Widlansky, M | 1 |
| Suh, JH | 1 |
| Hagen, TM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for dihydrolipoic acid and Diabetic Neuropathies
| Article | Year |
|---|---|
Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.
Topics: Animals; Antioxidants; Chelation Therapy; Chronic Disease; Coenzymes; Diabetic Neuropathies; Free Ra | 2004 |
1 other study available for dihydrolipoic acid and Diabetic Neuropathies
| Article | Year |
|---|---|
Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation.
Topics: Animals; Arginine; Arterioles; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 2003 |