dihydrolipoic acid has been researched along with Colorectal Neoplasms in 1 studies
dihydrolipoic acid: RN given refers to parent cpd without isomeric designation
dihydrolipoic acid : A thio-fatty acid that is reduced form of lipoic acid. A potent antioxidant shown to directly destroy superoxide, hydroperoxy and hydroxyl radicals; also has neuroprotective and anti-tumour effects.
dihydrolipoate : The conjugate base of dihydrolipoic acid.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity." | 5.42 | Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015) |
| "Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity." | 1.42 | Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Göder, A | 1 |
| Nagel, G | 1 |
| Kraus, A | 1 |
| Dörsam, B | 1 |
| Seiwert, N | 1 |
| Kaina, B | 1 |
| Fahrer, J | 1 |
1 other study available for dihydrolipoic acid and Colorectal Neoplasms
| Article | Year |
|---|---|
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; | 2015 |