dihydrohonokiol has been researched along with Neurodegenerative-Diseases* in 1 studies
1 other study(ies) available for dihydrohonokiol and Neurodegenerative-Diseases
| Article | Year |
|---|---|
Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan.
Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4'-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol. Topics: Animals; Biphenyl Compounds; Cells, Cultured; Cerebral Cortex; Fetus; Lignans; Nerve Growth Factors; Neurites; Neurodegenerative Diseases; Neurons; Rats; Structure-Activity Relationship | 2004 |