dihydroergotoxine and Postoperative-Complications

Forty adult patients, who developed postoperative hypertension (greater than 160/90 mm Hg) following major abdominal surgery were given double-blind, randomized either ketanserin 10 mg i.v. (n = 10), droperidol 5 mg i.v. (n = 10), hydergine 0.9 mg i.v. (n = 10) or placebo solution (n = 10). Following the injection of ketanserin or droperidol systolic and diastolic blood pressure decreased significantly (p less than 0.001 and p less than 0.01), but were no longer significantly lowered 30 minutes following the injection in 5 out of 10 ketanserin treated and in 8 out of ten droperidol treated patients. Neither hydergine nor placebo had a significant effect on blood pressure. It is concluded, that both ketanserin and droperidol have a moderate and short acting antihypertensive effect.

Topics: Abdomen; Adult; Aged; Antihypertensive Agents; Dihydroergotoxine; Double-Blind Method; Droperidol; Female; Humans; Hypertension; Ketanserin; Male; Middle Aged; Postoperative Complications; Random Allocation

A severe vasospastic reaction in both legs in the course of intensive-care therapy in a 16-year old patient with polytrauma is described. Since vasopathy was completely absent in the angiograph, a drug-induced cause is discussed. Dopamine and Hydergin, or a combination of both, were the mainly suspected drugs. Therapeutic measures included nitroglycerin given intravenously and lidocain intraarterially, leading eventually to "restitutio ad integrum".

Topics: Adolescent; Critical Care; Dihydroergotoxine; Dopamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hepatectomy; Humans; Ischemia; Leg; Liver; Male; Postoperative Complications; Rupture; Vasoconstriction

Though being not frequently seen now Sudeck's syndrome is still an undesirable painful complication of the healing and functional restitution in cases of injury to the wrist joint area. It is clear now that Sudeck's syndrome cannot be prevented only by correct surgical procedure, but that it is conditioned situationally and by the vegetative lability of the injured individual's personality and predisposed in this way. Besides routine rehabilitation the indication includes medication acting on the vegetative nervous system. Good healing conditions are obtained with a Chlorpromazine-Promethazine-Dihydroergotoxin combination for 6 to 8 weeks, blockade of the stellate ganglion and sufficient patience and consideration shown to the mentally upset and depressively reacting patient.

Topics: Chlorpromazine; Dihydroergotoxine; Finger Injuries; Humans; Male; Middle Aged; Postoperative Complications; Promethazine; Radiography; Radius Fractures; Reflex Sympathetic Dystrophy; Wrist Injuries

Topics: Adolescent; Adult; Aged; Aminobenzoates; Diethylamines; Dihydroergotoxine; Ergoloid Mesylates; Female; Germany, West; Humans; Male; Menisci, Tibial; Mesylates; Middle Aged; Postoperative Complications; Retrospective Studies; Thromboembolism

Topics: 4-Aminobenzoic Acid; Aminobenzoates; Anticoagulants; Dihydroergotoxine; Drug Therapy; Ergot Alkaloids; Humans; Male; Postoperative Complications; Prostatectomy; Thrombosis

Topics: 4-Aminobenzoic Acid; Dihydroergotoxine; Drug Combinations; Ergot Alkaloids; Postoperative Complications; Procaine; Thromboembolism