dihydroergotoxine and Intermittent-Claudication

Topics: Arterial Occlusive Diseases; Cardiovascular Agents; Cinnarizine; Clinical Trials as Topic; Dihydroergotamine; Dihydroergotoxine; Drug Combinations; Exercise Test; Flunarizine; Humans; Intermittent Claudication; Nafronyl; Pentoxifylline; Placebos; Pyrrolidines; Secologanin Tryptamine Alkaloids; Yohimbine

Forty-five patients suffering from intermittent claudication were admitted to a double-blind non-crossover study. Three groups were constituted at random and treated for 2 months with either 100 mg suloctidil t.i.d. or 1.5 mg dihydroergotoxine methylate t.i.d. or placebo. From the results of measurements of pain-free walking distance and venous occlusion plethysmography recordings, suloctidil was shown to be active and significantly superior to dehydroergotoxine and placebo: in the two latter groups a decrease in calf blood perfusion after 2 months was also noted. The physician's overall assessment of response to treatment showed that suloctidil and dihydroergotoxine were significantly superior to placebo, and that suloctidil was significantly better than dihydroergotoxine.

Topics: Aged; Clinical Trials as Topic; Dihydroergotoxine; Female; Humans; Intermittent Claudication; Male; Propanolamines

The therapeutical effect of Defluina was studied in a selective open trial of 50 patients suffering from peripheral arterial occlusive diseases of different stages. All patients were treated with Defluina, 30 drops three times a day during a period of six weeks. Control parameters of 46 patients (18 males, 26 females, mean age of 59.8 +/- 1.7 years) were evaluated. After therapy a significant improvement of all applied parameters was observed. The positive effect of the Defluina-medication on the initial--partly severe--varicose ulcera, with gangrenous alterations, has to be pointed out. After 6 weeks the varicose ulcera were partly closed, at least they showed fresh granulations. During therapy no adverse reactions were registered. All patients estimated Defluina as very well tolerable. The therapeutic effect of Defluina on the carefully investigated group of 46 patients could be estimated in 38 cases with excellent/good, in 7 cases with good/moderate and only in 1 case with moderate.

Topics: Adult; Aged; Arterial Occlusive Diseases; Diabetes Complications; Dihydroergotamine; Dihydroergotoxine; Drug Combinations; Drug Evaluation; Ergotamines; Female; Gangrene; Humans; Intermittent Claudication; Leg Ulcer; Male; Middle Aged; Pulse; Yohimbine

Topics: Aged; Arteriosclerosis; Arteriosclerosis Obliterans; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Coronary Disease; Dihydroergotoxine; Ergoloid Mesylates; Female; Humans; Injections, Intra-Arterial; Injections, Intramuscular; Injections, Intravenous; Intermittent Claudication; Intracranial Arteriosclerosis; Male; Middle Aged; Skin Temperature

Topics: Arteriosclerosis Obliterans; Blood Flow Velocity; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Dihydroergotoxine; Epinephrine; Ergot Alkaloids; Exercise Therapy; Gangrene; Hot Temperature; Humans; Hyperemia; Injections, Intra-Arterial; Intermittent Claudication; Papaverine; Phenethylamines; Sympathectomy; Tolazoline; Vascular Surgical Procedures; Vasodilator Agents

Topics: Cardiovascular Agents; Dihydroergotoxine; Ergot Alkaloids; Gait; Humans; Intermittent Claudication; Movement Disorders; Oxytocics