dihydroergotoxine and Hypotension--Orthostatic

It is reported on a group of 31 patients with pacemakers who were exposed to an orthostasis load without additional therapy as well as after an administration of nitrangin, euphyllin, rocornal and ergocomb. The lacking regulation of frequency in these patients can only limitedly be compensated by a volume regulation. Thus the simple standing experiment is already a considerable stress for these patients. Single applications of nitrangin and ergocomb led to an additional orthostatic decrease of blood pressure. This is particularly characterized after application of nitragin and also accompanied by subjective appearances up to the collapse. In the not doubted necessity to treat patients with pacemakers also conserning the coronary blood supply it seems important to take into consideration an additional iatrogenic disturbance of the orthostatic regulation.

Topics: Aminophylline; Dihydroergotoxine; Humans; Hypotension, Orthostatic; Methods; Nitroglycerin; Pacemaker, Artificial; Trapidil; Vasodilator Agents

Orthostatic hypotension of the Shy-Drager syndrome is a chronic incapacitating condition characterized by lack of an appropriate increase in the plasma norepinephrine level in response to standing. Recently, the somatostatin analogue octreotide has been reported to induce a pressor response in patients having this syndrome. We have reported a case of Shy-Drager syndrome in which octreotide was effective, but the rise in blood pressure was not accompanied by an increase in the plasma norepinephrine level. Hence, the pressor effect of octreotide is not mediated by stimulation of the sympathetic nervous system, but probably through splanchnic vasoconstriction.

Topics: Dihydroergotoxine; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hypotension, Orthostatic; Injections, Subcutaneous; Male; Middle Aged; Norepinephrine; Octreotide; Shy-Drager Syndrome; Time Factors

Topics: Blood Platelets; Cyclic AMP; Dihydroergotoxine; Humans; Hypertension; Hypotension, Orthostatic; Mood Disorders; Nervous System Diseases; Parkinson Disease; Platelet Aggregation; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Schizophrenia

Topics: Cardiovascular Agents; Dihydroergotoxine; Ergot Alkaloids; Hypotension; Hypotension, Orthostatic