dihydroergotoxine has been researched along with Cystic-Fibrosis* in 1 studies
1 other study(ies) available for dihydroergotoxine and Cystic-Fibrosis
Article | Year |
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The alpha 2-adrenergic system of the platelet in cystic fibrosis.
The ability of norepinephrine to inhibit prostaglandin E1 (PGE1)-stimulated accumulation of adenosine 3':5' cyclic monophosphate (cyclic AMP) in intact washed platelets was determined in 12 patients with cystic fibrosis, 6 parents of patients with cystic fibrosis, and a total of 21 healthy age-matched controls. Patients with cystic fibrosis and their parents did not differ from their age-matched controls in basal or PGE1-stimulated levels of cyclic AMP, nor in the dose dependent inhibition of cAMP accumulation by norepinephrine. Moreover, binding sites for [3H]-dihydroergocryptine were present in normal numbers and had normal ligand affinity in platelet membranes from patients with cystic fibrosis. In all measures tested, the alpha 2-adrenergic system in the platelet was normal in cystic fibrosis. Topics: Adolescent; Adult; Alprostadil; Blood Platelets; Cyclic AMP; Cystic Fibrosis; Dihydroergotoxine; Humans; In Vitro Techniques; Middle Aged; Norepinephrine; Prostaglandins E; Receptors, Adrenergic, alpha | 1984 |