dihydroergotoxine and Brain-Edema

Topics: Adenosine Triphosphate; Animals; Brain Edema; Brain Ischemia; Cerebral Cortex; Cyanides; Dihydroergotoxine; Disease Models, Animal; Hypoxia; Indoles; Indoramin; Rats

Dihydroergotoxine (DHET) perfused in the dog (100 microgram/kg) presenting a cerebral per-hypocapno-anemic syndrome reduces cerebral hyperemia, increases cerebral venous PO2, despite the rise in CMRO2 and favors glucose oxidation by the brain. DHET (20 mg/kg p.o.) is able to drop mean, diastolic and systolic arterial blood pressures in renal-hypertensive rats having a cerebral edema induced by triethyltin intoxication without affecting cerebral water and sodium levels which are increased in the controls. DHET (50 microgram/kg i.v.) can also improve EEG changes produced by a traumatic edema but does not exert (200 microgram/kg i.v.) any effect on EEG changes produced in the rabbit by lithium chloride intoxication.

Topics: Anemia; Animals; Blood Gas Analysis; Blood Glucose; Brain; Brain Edema; Cerebrovascular Circulation; Dihydroergotoxine; Disease Models, Animal; Dogs; Electroencephalography; Electrolytes; Hypertension, Renal; Hyperventilation; Hypoxia, Brain; Lactates; Lithium; Oxygen Consumption; Rabbits; Triethyltin Compounds

Topics: Brain Edema; Brain Injuries; Craniocerebral Trauma; Dihydroergotoxine; Drug Therapy; Ergoloid Mesylates; Ergot Alkaloids; Follow-Up Studies; Humans